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Results: 13
Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.
Tessa Sinnige, Prashanth Ciryam, Samuel Casford, Christopher M Dobson, Mario de Bono, Michele Vendruscolo
Jun 20, 2019
Laplacian Likelihood-Based Generalized Additive Model for RNA-Seq Analysis of Oral Squamous Cell Carcinoma
The study's objective is to identify the non-linear relationship of differentially expressed genes that vary in terms of the tumour and normal tissue and correct for any variations among the RNA-Seq experiment focused on Oral...
Published by: IGI Global Scientific Publishing
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.
Rosie Freer, Pietro Sormanni, Prajwal Ciryam, Burkhard Rammner, Silvio O Rizzoli, Christopher M Dobson, Michele Vendruscolo
Jan 03, 2020
Neurodegenerative disorders progress across the brain in characteristic spatio-temporal patterns. A better understanding of the factors underlying the specific cell and tissue vulnerability responsible for such patterns could...
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.
Rosie Freer, Pietro Sormanni, Prajwal Ciryam, Burkhard Rammner, Silvio O Rizzoli, Christopher M Dobson, Michele Vendruscolo
Oct 08, 2019
Neurodegenerative disorders progress across the brain in characteristic spatio-temporal patterns. A better understanding of the factors underlying the specific cell and tissue vulnerability responsible for such patterns could...
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.
Prajwal Ciryam, Isabella A Lambert-Smith, Daniel M Bean, Rosie Freer, Fernando Cid, Gian Gaetano Tartaglia, Darren N Saunders, Mark R Wilson, Stephen G Oliver, Richard I Morimoto, Christopher M Dobson, Michele Vendruscolo, Giorgio Favrin, Justin J Yerbury
Dec 14, 2020
motor neuron disease protein aggregation Protein homeostasis protein misfolding supersaturation Amyotrophic Lateral Sclerosis Brain DNA-Binding Proteins Humans Inclusion Bodies Motor Neurons Mutation Protein Aggregates protein aggregation Pathological Protein Folding RNA-Binding Protein FUS Spinal Cord Spinal Nerves Superoxide Dismutase Superoxide Dismutase-1
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A Kley, Richard I Morimoto, Michele Vendruscolo, Conrad C Weihl
Jan 06, 2020
Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and...
A metastable subproteome underlies inclusion formation in muscle proteinopathies
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo, Conrad C. Weihl
Dec 02, 2020
Abstract: Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and...
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A Kley, Richard I Morimoto, Michele Vendruscolo, Conrad C Weihl
Feb 13, 2020
Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and...
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care
Aikaterini Kassavou, Venus Mirzaei, Sonia Shpendi, James Brimicombe, Jagmohan Chauhan, Debi Bhattacharya, Felix Naughton, Wendy Hardeman, Helen Eborall, Miranda Van Emmenis, Anna De Simoni, Amrit Takhar, Pankaj Gupta, Prashanth Patel, Cecilia Mascolo, Andrew Toby Prevost, Stephen Morris, Simon Griffin, Richard J. McManus, Jonathan Mant, Stephen Sutton
Apr 26, 2021
Abstract: The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean...
MetaBase--the wiki-database of biological databases.
Dan M Bolser, Pierre-Yves Chibon, Nicolas Palopoli, Sungsam Gong, Daniel Jacob, Victoria Dominguez Del Angel, Dan Swan, Sebastian Bassi, Virginia González, Prashanth Suravajhala, Seungwoo Hwang, Paolo Romano, Rob Edwards, Bryan Bishop, John Eargle, Timur Shtatland, Nicholas J Provart, Dave Clements, Daniel P Renfro, Daeui Bhak, Jong Bhak
Apr 16, 2019
Biology is generating more data than ever. As a result, there is an ever increasing number of publicly available databases that analyse, integrate and summarize the available data, providing an invaluable resource for the...
Divergent evolution of Corynebacterium diphtheriae in India
Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Dhivya Murugan, Ranjini Ranjan, Vikas Gautam, Prashanth Gupta, Jaichand Johnson, Naresh Chand Sharma, Ankur Mutreja, Pradeep Haldar, Arun Kumar, Pankaj Bhatnagar, Lucky Sangal, Balaji Veeraraghavan
Jan 05, 2022
Diphtheria is caused by a toxigenic bacterium Corynebacterium diphtheria which is being an emerging pathogen in India. Since diphtheria morbidity and mortality continues to be high in the country, the present study aimed to...
Divergent evolution of Corynebacterium diphtheriae in India
Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Dhivya Murugan, Ranjini Ranjan, Vikas Gautam, Prashanth Gupta, Jaichand Johnson, Naresh Chand Sharma, Ankur Mutreja, Pradeep Haldar, Arun Kumar, Pankaj Bhatnagar, Lucky Sangal, Balaji Veeraraghavan
Jan 28, 2022
Diphtheria is caused by a toxigenic bacterium Corynebacterium diphtheria which is being an emerging pathogen in India. Since diphtheria morbidity and mortality continues to be high in the country, the present study aimed to...
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care
Aikaterini Kassavou, Venus Mirzaei, Sonia Shpendi, James Brimicombe, Jagmohan Chauhan, Debi Bhattacharya, Felix Naughton, Wendy Hardeman, Helen Eborall, Miranda Van Emmenis, Anna De Simoni, Amrit Takhar, Pankaj Gupta, Prashanth Patel, Cecilia Mascolo, Andrew Toby Prevost, Stephen Morris, Simon Griffin, Richard J McManus, Jonathan Mant, Stephen Sutton
Apr 09, 2021