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Results: 33
Rapid Detection of Actinobacillus pleuropneumoniae From Clinical Samples Using Recombinase Polymerase Amplification.
Oliver W Stringer, Yanwen Li, Janine T Bossé, Matthew S Forrest, Juan Hernandez-Garcia, Alexander W Tucker, Tiago Nunes, Francisco Costa, Preben Mortensen, Eduardo Velazquez, Paul Penny, Jesus Rodriguez-Manzano, Pantelis Georgiou, Paul R Langford
Apr 08, 2022
Actinobacillus pleuropneumoniae (APP) is the causative agent of porcine pleuropneumonia, resulting in high economic impact worldwide. There are currently 19 known serovars of APP, with different ones being predominant in...
Rapid Detection of Actinobacillus pleuropneumoniae From Clinical Samples Using Recombinase Polymerase Amplification.
Oliver W Stringer, Yanwen Li, Janine T Bossé, Matthew S Forrest, Juan Hernandez-Garcia, Alexander W Tucker, Tiago Nunes, Francisco Costa, Preben Mortensen, Eduardo Velazquez, Paul Penny, Jesus Rodriguez-Manzano, Pantelis Georgiou, Paul R Langford
May 11, 2022
Actinobacillus pleuropneumoniae (APP) is the causative agent of porcine pleuropneumonia, resulting in high economic impact worldwide. There are currently 19 known serovars of APP, with different ones being predominant in...
Criterion validity of the Physical Activity Scale (PAS2) in Danish adults.
BACKGROUND: The Physical Activity Scale (PAS2) was developed to measure physical activity (PA) during work, transportation and leisure time, in the Danish adult population. The objective of this study was to assess the criterion...
Structural insights into the mechanism of negative regulation of single-box high mobility group proteins by the acidic tail domain.
Katherine Stott, Matthew Watson, Mark J Bostock, Simon A Mortensen, Andrew Travers, Klaus D Grasser, Jean O Thomas
Apr 13, 2015
Acidic Regulatory Domain Casein Kinase 2 (CK2) Chromatin HMGB Protein Intrinsically Disordered Protein Nuclear Magnetic Resonance (NMR) Paramagnetic Relaxation Enhancement Phosphorylation Protein Kinase C Protein Kinase C (PKC) Animals Drosophila Proteins Drosophila melanogaster High Mobility Group Proteins Magnetic Resonance Spectroscopy Models Molecular Mutant Proteins Phosphorylation Plant Proteins Protein Structure Tertiary Structure-Activity Relationship Zea mays
Prevalence and correlates of being overweight or obese in college.
Brian L Odlaug, Katherine Lust, Cathrine L Wimmelmann, Samuel R Chamberlain, Erik L Mortensen, Katherine Derbyshire, Gary Christenson, Jon E Grant
Dec 17, 2015
Strategies for the Diversity-Oriented Synthesis of Macrocycles.
Macrocycles have long been recognized as useful chemical entities for medicine, with naturally occurring and synthetic macrocycles clinically approved for use as prescription drugs. Despite this promise, the synthesis of...
Psychometric Properties and Validation of the EMOTICOM Test Battery in a Healthy Danish Population
Vibeke H. Dam, Christa K. Thystrup, Peter S. Jensen, Amy R. Bland, Erik L. Mortensen, Rebecca Elliott, Barbara J. Sahakian, Gitte M. Knudsen, Vibe G. Frokjaer, Dea S. Stenbæk
Dec 17, 2019
Disruptions in hot cognition, i.e., the processing of emotionally salient information, are prevalent in most neuropsychiatric disorders and constitute a potential treatment target. EMOTICOM is the first comprehensive...
Automated optimisation of solubility and conformational stability of antibodies and proteins
Angelo Rosace, Anja Bennett, Marc Oeller, Mie M Mortensen, Laila Sakhnini, Nikolai Lorenzen, Christian Poulsen, Pietro Sormanni
Apr 07, 2023
Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery.
Thomas A King, Hannah L Stewart, Kim T Mortensen, Andrew JP North, Hannah F Sore, David R Spring
Jul 12, 2019
In recent years the pharmaceutical industry has benefited from the advances made in fragment-based drug discovery (FBDD) with more than 30 fragment-derived drugs currently marketed or progressing through clinical trials. The...
Psychometric Properties and Validation of the EMOTICOM Test Battery in a Healthy Danish Population.
Vibeke H Dam, Christa K Thystrup, Peter S Jensen, Amy R Bland, Erik L Mortensen, Rebecca Elliott, Barbara J Sahakian, Gitte M Knudsen, Vibe G Frokjaer, Dea S Stenbæk
Feb 03, 2020
Disruptions in hot cognition, i.e., the processing of emotionally salient information, are prevalent in most neuropsychiatric disorders and constitute a potential treatment target. EMOTICOM is the first comprehensive...
The Power of Many
Collective efforts of masses provide access to funding and ideas. While such endeavors in a business-to-customer context are well-described, they are less well understood in other contexts such as business-to-business. A...
Published by: IGI Global Scientific Publishing
Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors.
Vikram Babu Kasaragod, Martin Mortensen, Steven Hardwick, Ayla Wahid, Valentina Dorovykh, Dima Chirgadze, Trevor G Smart, Paul Miller
Feb 16, 2022
Effects of limiting digital screen use on well-being, mood, and biomarkers of stress in adults
Abstract Studies have linked higher digital screen use with poorer mental health. However, there is limited experimental evidence to suggest a causal relationship. In this trial, we aimed to...
Jesper Pedersen, Martin Gillies Banke Rasmussen, Sarah Overgaard Sørensen, Sofie Rath Mortensen, Line Grønholt Olesen, Søren Brage, Peter Lund Kristensen, Eli Puterman, Anders Grøntved
Oct 12, 2022
Psychometric Properties and Validation of the EMOTICOM Test Battery in a Healthy Danish Population.
Vibeke H Dam, Christa K Thystrup, Peter S Jensen, Amy R Bland, Erik L Mortensen, Rebecca Elliott, Barbara J Sahakian, Gitte M Knudsen, Vibe G Frokjaer, Dea S Stenbæk
Jan 27, 2020
Disruptions in hot cognition, i.e., the processing of emotionally salient information, are prevalent in most neuropsychiatric disorders and constitute a potential treatment target. EMOTICOM is the first comprehensive...
Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors.
Vikram Babu Kasaragod, Martin Mortensen, Steven W Hardwick, Ayla A Wahid, Valentina Dorovykh, Dimitri Y Chirgadze, Trevor G Smart, Paul S Miller
Mar 31, 2022
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
Monika Mortensen, Elizabeth J Soilleux, Gordana Djordjevic, Rebecca Tripp, Michael Lutteropp, Elham Sadighi-Akha, Amanda J Stranks, Julie Glanville, Samantha Knight, Sten-Eirik W Jacobsen, Kamil R Kranc, Anna Katharina Simon
Dec 21, 2018
The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis...
L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.
Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M Gribble, Daniel J Drucker, Eelco JP de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W Schwartz, Natalia Petersen
Jan 29, 2020
An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia.
Theis Zetner Trolle Jensen, Arne Sjöström, Anders Fischer, Erika Rosengren, Liam Thomas Lanigan, Ole Bennike, Kristine Korzow Richter, Kurt Joseph Gron, Meaghan Mackie, Morten Fischer Mortensen, Lasse Sørensen, David Chivall, Katrine Højholt Iversen, Alberto John Taurozzi, Jesper Olsen, Hannes Schroeder, Nicky Milner, Mikkel Sørensen, Matthew James Collins
Sep 29, 2020
An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia
Theis Zetner Trolle Jensen, Arne Sjöström, Anders Fischer, Erika Rosengren, Liam Thomas Lanigan, Ole Bennike, Kristine Korzow Richter, Kurt Joseph Gron, Meaghan Mackie, Morten Fischer Mortensen, Lasse Sørensen, David Chivall, Katrine Højholt Iversen, Alberto John Taurozzi, Jesper Olsen, Hannes Schroeder, Nicky Milner, Mikkel Sørensen, Matthew James Collins
Oct 18, 2021
Abstract: The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied....
An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia
Theis Zetner Trolle Jensen, Arne Sjöström, Anders Fischer, Erika Rosengren, Liam Thomas Lanigan, Ole Bennike, Kristine Korzow Richter, Kurt Joseph Gron, Meaghan Mackie, Morten Fischer Mortensen, Lasse Sørensen, David Chivall, Katrine Højholt Iversen, Alberto John Taurozzi, Jesper Olsen, Hannes Schroeder, Nicky Milner, Mikkel Sørensen, Matthew James Collins
Oct 14, 2020
Abstract: The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied....
A 5700 year-old human genome and oral microbiome from chewed birch pitch
Theis Z. T. Jensen, Jonas Niemann, Katrine Højholt Iversen, Anna K. Fotakis, Shyam Gopalakrishnan, Åshild J. Vågene, Mikkel Winther Pedersen, Mikkel-Holger S. Sinding, Martin R. Ellegaard, Morten E. Allentoft, Liam T. Lanigan, Alberto J. Taurozzi, Sofie Holtsmark Nielsen, Michael W. Dee, Martin N. Mortensen, Mads C. Christensen, Søren A. Sørensen, Matthew J. Collins, M. Thomas P. Gilbert, Martin Sikora, Simon Rasmussen, Hannes Schroeder
Dec 22, 2020
Abstract: The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome...
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.
Alexander S Watson, Thomas Riffelmacher, Amanda Stranks, Owen Williams, Jasper de Boer, Kelvin Cain, Marion MacFarlane, Joanna McGouran, Benedikt Kessler, Shivani Khandwala, Onima Chowdhury, Daniel Puleston, Kanchan Phadwal, Monika Mortensen, David Ferguson, Elizabeth Soilleux, Petter Woll, Sten Eirik W Jacobsen, Anna Katharina Simon
May 13, 2021
Decreased autophagy contributes to malignancies, however it is unclear how autophagy impacts on tumour growth. Acute myeloid leukemia (AML) is an ideal model to address this as (i) patient samples are easily accessible, (ii) the...
Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study.
Sofus C Larsen, Lars Ängquist, Jane N Østergaard, Tarunveer S Ahluwalia, Karani S Vimaleswaran, Nina Roswall, Lotte M Mortensen, Birgit M Nielsen, Anne Tjønneland, Nicholas J Wareham, Domenico Palli, Giovanna Masala, Wim HM Saris, Daphne L van der A, Jolanda MA Boer, Edith JM Feskens, Heiner Boeing, Marianne U Jakobsen, Ruth JF Loos, Thorkild IA Sørensen, Kim Overvad
Aug 09, 2017
BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect...
Fatty Acids gene-diet interaction Genetics obesity weight change Adult Alleles Body Mass Index CCAAT-Enhancer-Binding Protein-beta Case-Control Studies Cohort Studies Diet Dietary Fats Fatty Acids Fatty Acids Monounsaturated Fatty Acids Unsaturated Female Follow-Up Studies Genotyping Techniques Humans Linkage Disequilibrium Male Middle Aged Nutrition Assessment PPAR gamma Phosphoenolpyruvate Carboxykinase (ATP) Polymorphism Single Nucleotide Sterol Regulatory Element Binding Protein 1 Waist Circumference Weight Gain White People
A 5700 year-old human genome and oral microbiome from chewed birch pitch.
Theis ZT Jensen, Jonas Niemann, Katrine Højholt Iversen, Anna K Fotakis, Shyam Gopalakrishnan, Åshild J Vågene, Mikkel Winther Pedersen, Mikkel-Holger S Sinding, Martin R Ellegaard, Morten E Allentoft, Liam T Lanigan, Alberto J Taurozzi, Sofie Holtsmark Nielsen, Michael W Dee, Martin N Mortensen, Mads C Christensen, Søren A Sørensen, Matthew J Collins, M Thomas P Gilbert, Martin Sikora, Simon Rasmussen, Hannes Schroeder
Feb 13, 2020
The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome sequenced...
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