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Results: 87
A Sustainable Model for Effective Employee Relations in Contemporary Organizations
Employee relation has emerged as a major point of concern for human resource practitioners. This paper investigated all the possible variables affecting employee relations in the organization through an extensive literature...
Published by: IGI Global Scientific Publishing
Modeling the Critical Success Factors for Business Intelligence Implementation
Business intelligence (BI) helps organizations to make better and quicker decisions. The primary requirement, as per previous studies, for any successful BI implementation in an organization and its' stakeholders, is to...
Published by: IGI Global Scientific Publishing
Forecasting Migration to the United States from Hong Kong and India
Priyanka pkogta@my.harrisburgu
Jan 01, 0001
This study investigates the forecasting of migration from India and Hong Kong to the United States. To study this, quantitative design is employed so numerical data can be used. The proposed research strategy uses the...
Migration Forecasting Quantitative Design Descriptive Analyses Inferential Analyses United States india Hong Kong Computer and Systems Architecture Demography, Population, and Ecology Migration Studies
Published by: Harrisburg University of Science and Technology
Mobile Shopping Apps Adoption
In this study, 22 research papers published on consumer behavior and electronic commerce journals were selected and reviewed based on inclusion criteria of high-quality journals; the aim of this exercise was to conduct an...
Published by: IGI Global Scientific Publishing
Shape-Based Features for Optimized Hand Gesture Recognition
Gesture recognition is the most intuitive form of human-computer interface. Hand gestures provide a natural way for humans to interact with computers to perform a variety of different applications. However, factors such as...
Published by: IGI Global Scientific Publishing
Handling Data Scarcity Through Data Augmentation in Training of Deep Neural Networks for 3D Data Processing
Due to the availability of cheap 3D sensors such as Kinect and LiDAR, the use of 3D data in various domains such as manufacturing, healthcare, and retail to achieve operational safety, improved outcomes, and enhanced customer...
Published by: IGI Global Scientific Publishing
Pathway and network analysis of more than 2500 whole cancer genomes.
Matthew A Reyna, David Haan, Marta Paczkowska, Lieven PC Verbeke, Miguel Vazquez, Abdullah Kahraman, Sergio Pulido-Tamayo, Jonathan Barenboim, Lina Wadi, Priyanka Dhingra, Raunak Shrestha, Gad Getz, Michael S Lawrence, Jakob Skou Pedersen, Mark A Rubin, David A Wheeler, Søren Brunak, Jose MG Izarzugaza, Ekta Khurana, Kathleen Marchal, Christian von Mering, S Cenk Sahinalp, Alfonso Valencia, PCAWG Drivers and Functional Interpretation Working Group, Jüri Reimand, Joshua M Stuart, Benjamin J Raphael, PCAWG Consortium
Feb 04, 2021
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding...
Mental health ecologies and urban wellbeing.
How might urban mental health be understood when animals reconfigure human wellbeing in the lived city? Drawing upon ethnographic fieldwork on people and macaques in New Delhi and forging novel conversations between urban...
Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold.
Anna Suchankova, Margarita Stampelou, Klontiana Koutsouki, Athanasios Pousias, Lakshiv Dhingra, Kerry Barkan, Nicole Pouli, Panagiotis Marakos, Roxane Tenta, Antonios Kolocouris, Nikolaos Lougiakis, Graham Ladds
Jul 17, 2022
Here we describe the design and synthesis of pyrazolo[3,4-d]pyridazines as adenosine receptor (AR) ligands. We demonstrate that the introduction of a 3-phenyl group, together with a 7-benzylamino and 1-methyl group at the...
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation.
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Michele Vendruscolo
Feb 17, 2023
Alzheimer's disease is characterized by the presence in the brain of amyloid plaques formed by the aberrant deposition of the amyloid-β peptide (Aβ). Since many vitamins are dysregulated in this disease, we explored whether...
G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. <i>thaliana</i>
Navjyoti Chakraborty, Priyanka Sharma, Kostya Kanyuka, Ravi Ramesh Pathak, Devapriya Choudhury, Richard Hooley, Nandula Raghuram
Dec 01, 2015
Heterotrimeric G-proteins are implicated in several plant processes, but the mechanisms of signal-response coupling and the roles of G-protein coupled receptors in general and GCR1 in particular, remain poorly understood. We...
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation.
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Michele Vendruscolo
Mar 05, 2023
G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. <i>thaliana</i>
Navjyoti Chakraborty, Priyanka Sharma, Kostya Kanyuka, Ravi Ramesh Pathak, Devapriya Choudhury, Richard Hooley, Nandula Raghuram
Dec 01, 2015
Heterotrimeric G-proteins are implicated in several plant processes, but the mechanisms of signal-response coupling and the roles of G-protein coupled receptors in general and GCR1 in particular, remain poorly understood. We...
Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M. Dobson, Michele Vendruscolo
Jul 07, 2021
Abstract: Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases....
The Detection and Partial Localisation of Heteroplasmic Mutations in the Mitochondrial Genome of Patients with Diabetic Retinopathy.
Afshan N Malik, Hannah S Rosa, Eliane S de Menezes, Priyanka Tamang, Zaidi Hamid, Anita Naik, Chandani Kiran Parsade, Sobha Sivaprasad
Dec 12, 2019
Diabetic retinopathy (DR) is a common complication of diabetes and a major cause of acquired blindness in adults. Mitochondria are cellular organelles involved in energy production which contain mitochondrial DNA (mtDNA). We...
Anti-thrombotic efficacy of S007-867
Ankita Misra, Prem Prakash, Hobby Aggarwal, Priyanka Dhankani, Sachin Kumar, Chandra Prakash Pandey, Nicholas Pugh, Dominique Bihan, Manoj Kumar Barthwal, Richard W Farndale, Dinesh Kumar Dikshit, Madhu Dikshit
Mar 15, 2018
Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867 is a novel synthetic inhibitor of collagen-induced platelet aggregation. It has shown...
Blood Flow Velocity Collagen Hemostasis Platelet Activation Thrombosis Animals Aspirin Blood Coagulation Chlorides Clopidogrel Dose-Response Relationship Drug Ferric Compounds Fibrinolytic Agents Male Mice Piperidines Platelet Adhesiveness Platelet Aggregation Pyrrolidines Rats Rats Sprague-Dawley Thrombosis
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Michele Vendruscolo
Jun 03, 2021
The miR156 juvenility factor and PLETHORA 2 form a regulatory network and influence timing of meristem growth and lateral root emergence.
Marta J Laskowski, Helene C Tiley, Yiling Fang, Anabel Epstein, Yuyang Fu, Roberto Ramos, Thomas J Drummond, Renze Heidstra, Priyanka Bhakhri, Tobias I Baskin, Ottoline Leyser
Oct 25, 2022
Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M. Dobson, Michele Vendruscolo
Jul 28, 2021
Abstract: Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases....
Secondary Complement Deficiency Impairs Anti-Microbial Immunity to Klebsiella pneumoniae and Staphylococcus aureus During Severe Acute COVID-19.
Youssif M Ali, Nicholas J Lynch, Priyanka Khatri, Ifeoluwa E Bamigbola, Andrew CY Chan, Munehisa Yabuki, Gregory A Demopulos, Jonathan L Heeney, Sumita Pai, Helen Baxendale, Wilhelm J Schwaeble
May 11, 2022
A high incidence of secondary Klebsiella pneumoniae and Staphylococcus aureus infection were observed in patients with severe COVID-19. The cause of this predisposition to infection is unclear. Our data demonstrate consumption...
Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M. Dobson, Michele Vendruscolo
Jul 28, 2021
Abstract: Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases....
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Michele Vendruscolo
Aug 11, 2021
Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Although...
Published by: Communications biology
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).
Kristina A Ganzinger, Priyanka Narayan, Seema S Qamar, Laura Weimann, Rohan T Ranasinghe, Adriano Aguzzi, Christopher M Dobson, James McColl, Peter St George-Hyslop, David Klenerman
Aug 22, 2014
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.
Johnny Habchi, Paolo Arosio, Michele Perni, Ana Rita Costa, Maho Yagi-Utsumi, Priyanka Joshi, Sean Chia, Samuel IA Cohen, Martin BD Müller, Sara Linse, Ellen AA Nollen, Christopher M Dobson, Tuomas PJ Knowles, Michele Vendruscolo
Feb 16, 2016
chemical kinetics molecular mechanisms neurodegeneration protein misfolding Alzheimer Disease Amino Acid Sequence Amyloid beta-Peptides Animals Animals Genetically Modified Antineoplastic Agents Bexarotene Caenorhabditis elegans Drug Discovery Humans In Vitro Techniques Kinetics Models Animal Molecular Sequence Data Peptide Fragments Protein Multimerization Recombinant Proteins Taurine Tetrahydronaphthalenes
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R. Kumita, Sara Linse, Johnny Habchi, Tuomas P. J. Knowles, Benedetta Mannini, Christopher M. Dobson, Michele Vendruscolo
Jan 04, 2021
Abstract: Aberrant soluble oligomers formed by the amyloid-β peptide (Aβ) are major pathogenic agents in the onset and progression of Alzheimer’s disease. A variety of biomolecules can influence the formation of these oligomers...
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