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Results: 641
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth.
Alessio Lepore, Pui Man Choy, Nathan CW Lee, Maria Annunziata Carella, Rosy Favicchio, Marco A Briones-Orta, Shannon S Glaser, Gianfranco Alpini, Clive D'Santos, Reuben M Tooze, Mihaela Lorger, Wing-Kin Syn, Athanasios Papakyriakou, Georgios Giamas, Concetta Bubici, Salvatore Papa
Sep 15, 2021
BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c-Jun N-terminal kinase (JNK) pathway is a key feature in ICC...
Animals Antineoplastic Agents Bile Duct Neoplasms Carcinogenesis Cell Line Tumor Cholangiocarcinoma Female Gene Knockdown Techniques Humans MAP Kinase Signaling System Mice Mice Inbred NOD Mice SCID Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 NIMA-Interacting Peptidylprolyl Isomerase Phosphorylation RNA Small Interfering Tretinoin Tumor Burden Xenograft Model Antitumor Assays
Rock Hill Man Charged with Five Burglaries of Campus Buildings
Winthrop University
Jan 01, 0001
Zedric Barr, 24, arrested for trespassing and now charged with several burglaries. Campus Police charged a second man for possessing property from the burglaries.
Published by: Winthrop University
Rock Hill Man Arrested for March 26 Assault on Student
Winthrop University
Jan 01, 0001
Winthrop University police have arrested a Rock Hill man in connection with a March 26 assault of a student outside of Kinard Hall.
Published by: Winthrop University
The COVID-19 pandemic and problematic usage of the internet
Christine Lochner, Lucy Albertella, Martin Kidd, Zelal Kilic, Konstantinos Ioannidis, Jon E Grant, Murat Yücel, Dan J Stein, Samuel R Chamberlain
Aug 16, 2022
BACKGROUND: The coronavirus disease 19 (COVID-19) has led to increased reliance on the internet. How problematic usage of the internet (PUI) and COVID-19 related stress and other clinical variables relate, is unknown. We...
Blind Man Who Survived 9/11 Attack to Tell His Story at United Way Event
Winthrop University
Jan 01, 0001
Blind since birth, Hingson wrote "Thunder Dog: A Blind Man, His Guide Dog, and the Triumph of Trust at Ground Zero," to encourage the importance of teamwork and trust. The United Way event is invitation-only. It begins at 8 a.m....
Published by: Winthrop University
Program for the Stage Production The Man Who Came to Dinner
Curtain Club
Jan 01, 0001
This eleven-page program details the Curtain Club of Ursinus College's production of The Man Who Came to Dinner, held May 10, 1947 in Thompson-Gay Gymnasium. It includes information about the directors, cast, production of the...
Moss Hart George S. Kaufman V-12 Dramatur Alpha Psi Omega Curtain Club Ursinus College theater program Thompson-Gay Gymnasium Theatre and Performance Studies Theatre History
Published by: Ursinus College
A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2.
Man-Hong Leung, Ho Tsoi, Chun Gong, Ellen PS Man, Stefania Zona, Shang Yao, Eric W-F Lam, Ui-Soon Khoo
Feb 27, 2020
Breast cancer is the most common type of female cancer. Reactive oxygen species (ROS) are vital in regulating signaling pathways that control cell survival and cell proliferation. Chemotherapeutic drugs such as anthracyclines...
Program for the Stage Production The Man Who Came to Dinner
Curtain Club
Jan 01, 0001
This twenty-four-page program details the Curtain Club of Ursinus College's production of The Man Who Came to Dinner, held May 6, 7, and 8, 1954 in Thompson-Gay Gymnasium. It includes information about the directors, cast...
George S. Kaufman Moss Hart Donald L. Helfferich Curtain Club Ursinus College theater program Thompson-Gay Gymnasium Theatre and Performance Studies Theatre History
Published by: Ursinus College
Repurposing hyperpolarization-activated cyclic nucleotide-gated channels as a novel therapy for breast cancer.
Ka-Chun Mok, Ho Tsoi, Ellen PS Man, Man-Hong Leung, Ka Man Chau, Lai-San Wong, Wing-Lok Chan, Sum-Yin Chan, Mai-Yee Luk, Jessie YW Chan, Jackie KM Leung, Yolanda HY Chan, Sellma Batalha, Virginia Lau, David CW Siu, Terence KW Lee, Chun Gong, Ui-Soon Khoo
Nov 04, 2021
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated cation channel family known to be expressed in the heart and central nervous system. Ivabradine, a small molecule HCN...
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man
Inaba, K., Steinman, R.M., Van Voorhis, W.C., and Muramatsu, S. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc. Natl. Acad. Sci. USA. 80: 6041-6045, 1983
Published by: The National Academy of Sciences
Measurement of the problematic usage of the Internet unidimensional quasitrait continuum with item response theory.
Jeggan Tiego, Christine Lochner, Konstantinos Ioannidis, Matthias Brand, Dan J Stein, Murat Yücel, Jon E Grant, Samuel R Chamberlain
Feb 19, 2021
Problematic usage of the internet (PUI) describes maladaptive use of online resources and is recognized as a growing worldwide issue. Here, we refined the Internet Addiction Test (IAT) for use as a screening tool to measure...
Molecular Energy Landscapes of Hardware-Efficient Ansätze in Quantum Computing.
Rapid advances in quantum computing have opened up new opportunities for solving the central electronic structure problem in computational chemistry. In the noisy intermediate-scale quantum (NISQ) era, where qubit coherence...
Published by: Journal of chemical theory and computation
Origen's Johannine Trinitarian Theology of Love
Pui Him Ip
Feb 28, 2022
Origen is the first Christian who proposed a systematically trinitarian theology of love. This has largely escaped the attention of theologians and remains underexplored. One notable consequence is that this has severely limited...
Adverse Childhood Experiences and Alcohol Consumption in Midlife and Early Old-Age.
AIMS: To examine the individual and cumulative effects of adverse childhood experiences (ACEs) on alcohol consumption in midlife and early old-age, and the role of ACEs in 10-year drinking trajectories across midlife. METHODS...
Problematic use of the internet during the COVID-19 pandemic
Biljana Gjoneska, Marc N Potenza, Julia Jones, Ornella Corazza, Natalie Hall, Célia MD Sales, Edna Grünblatt, Giovanni Martinotti, Julius Burkauskas, Anna Maria Werling, Susanne Walitza, Joseph Zohar, José M Menchón, Orsolya Király, Samuel R Chamberlain, Naomi A Fineberg, Zsolt Demetrovics
Jan 06, 2022
With the onset of the COVID-19 pandemic and the accelerated spread of the SARS-CoV-2 virus came jurisdictional limitations on mobility of citizens and distinct alterations in their daily routines. Confined to their homes, many...
Early diagnosis of symptomatic ovarian cancer in primary care in the UK
BACKGROUND: Ovarian cancer is the sixth most common cause of cancer-related death in the UK amongst women. Ovarian cancer presents particular challenges for general practitioners (GPs) to diagnose due to its rarity and...
Molecular Energy Landscapes of Hardware-Efficient Ansätze in Quantum Computing.
Rapid advances in quantum computing have opened up new opportunities for solving the central electronic structure problem in computational chemistry. In the noisy intermediate-scale quantum (NISQ) era, where qubit coherence...
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man
We report that dendritic cells (DC) are necessary and potent accessory cells for anti-sheep erythrocyte responses in both mouse and man. In mice, a small number of DC (0.3-1% of the culture) restores the response of...
antibody production blood and hemopoietic system Endocrine System langerhans cell Lymphatic System macrophage monocyte
Published by: Rockefeller University
Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.
Rhiannon S Morris, P Simon Jones, Josef A Alawneh, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, Elizabeth A Warburton, Jean-Claude Baron
Nov 06, 2018
Modern ischaemic stroke management involves intravenous thrombolysis followed by mechanical thrombectomy, which allows markedly higher rates of recanalization and penumbral salvage than thrombolysis alone. However, <50% of...
Case 267
History A 28-year-old man presented with lifelong anejaculation, which had become an issue because of family planning. The patient had a history of normal erections and experienced the sensation of orgasm without ever...
A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.
Ana Crespillo-Casado, Zander Claes, Meng S Choy, Wolfgang Peti, Mathieu Bollen, David Ron
Apr 30, 2018
G-actin Sephin1 enzyme inhibitor eukaryotic initiation factor 2 (eIF2) guanabenz integrated stress response phosphoprotein phosphatase 1 (PP1) protein synthesis Proteostasis Actins Animals Catalytic Domain Drug Resistance Eukaryotic Initiation Factor-2 Gene Expression Regulation Guanabenz HeLa Cells Humans Phosphorylation Protein Isoforms Protein Phosphatase 1 Proteolysis Rabbits
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