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A Systematic Review of Animal Models of NAFLD Finds High-Fat, High-Fructose Diets Most Closely Resemble Human NAFLD.
Yu Ri Im, Harriet Hunter, Dana de Gracia Hahn, Amedine Duret, Qinrong Cheah, Jiawen Dong, Madison Fairey, Clarissa Hjalmarsson, Alice Li, Hong Kai Lim, Lorcán McKeown, Claudia-Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Ian A Rowe, Jake P Mann
May 11, 2021
A Systematic Review of Animal Models of NAFLD Finds High‐Fat, High‐Fructose Diets Most Closely Resemble Human NAFLD
Yu Ri Im, Harriet Hunter, Dana de Gracia Hahn, Amedine Duret, Qinrong Cheah, Jiawen Dong, Madison Fairey, Clarissa Hjalmarsson, Alice Li, Hong Kai Lim, Lorcán McKeown, Claudia‐Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Ian A. Rowe, Jake P. Mann
Jun 17, 2021
Background and Aims: Animal models of human disease are a key component of translational hepatology research, yet there is no consensus on which model is optimal for NAFLD. Approach and Results: We generated a database of 3,920...
Published by: Hepatology
Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver.
Harriet Hunter, Dana de Gracia Hahn, Amedine Duret, Yu Ri Im, Qinrong Cheah, Jiawen Dong, Madison Fairey, Clarissa Hjalmarsson, Alice Li, Hong Kai Lim, Lorcán McKeown, Claudia-Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Ian A Rowe, Jake Mann
Oct 19, 2020
Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver
Harriet Hunter, Dana de Gracia Hahn, Amedine Duret, Yu Ri Im, Qinrong Cheah, Jiawen Dong, Madison Fairey, Clarissa Hjalmarsson, Alice Li, Hong Kai Lim, Lorcan McKeown, Claudia-Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Ian A Rowe, Jake P Mann
Nov 09, 2020
The classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however there is a low conversion rate from success in animals to humans. Non-alcoholic fatty...
Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test.
The Hargreaves test is specifically designed to assess thermal pain sensation in rodents such as rats and mice. This test has been used in experiments involving pain sensitization or recovery of thermal pain response following...
Evaluating shear test methods for stabilised rammed earth
Rammed earth is an accessible, sustainable, and increasingly popular building material. Due to a lack of research, current design standards for rammed earth have taken a conservative stance on material attributes like shear...
Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration.
Achieving axon regeneration after nervous system injury is a challenging task. As different parts of the central nervous system (CNS) differ from each other anatomically, it is important to identify an appropriate model to use...
Evaluating shear test methods for stabilised rammed earth
Rammed earth is an accessible, sustainable, and increasingly popular building material. Due to a lack of research, current design standards for rammed earth have taken a conservative stance on material attributes like shear...
Exploring Principals’ Instructional Leadership Practices in Malaysia
Purpose
The purpose of this paper is to outline the findings from a small-scale, exploratory, study of principals’ instructional leadership practice in Malaysian primary schools. The dimensions and functions of instructional...
The purpose of this paper is to outline the findings from a small-scale, exploratory, study of principals’ instructional leadership practice in Malaysian primary schools. The dimensions and functions of instructional...
Exploring Principals’ Instructional Leadership Practices in Malaysia
Purpose
The purpose of this paper is to outline the findings from a small-scale, exploratory, study of principals’ instructional leadership practice in Malaysian primary schools. The dimensions and functions of instructional...
The purpose of this paper is to outline the findings from a small-scale, exploratory, study of principals’ instructional leadership practice in Malaysian primary schools. The dimensions and functions of instructional...
Giant nonlinear optical activity of achiral origin in planar metasurfaces with quadratic and cubic nonlinearities
Shumei Chen, Franziska Zeuner, Martin Weismann, Bernhard Reinike, Guixin Li, Ventsislav Kolev Valev, Kok Wai Cheah, Nicolae Coriolan Panoiu, Thomas Zentgraf, Shuang Zhang
Apr 14, 2016
3D chirality is shown to be unnecessary for introducing strong circular dichroism for harmonic generations. Specifically, near-unity circular dichroism for both second-harmonic generation and third-harmonic generations is...
Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.
Menghon Cheah, Melissa R Andrews, Daniel J Chew, Elizabeth B Moloney, Joost Verhaagen, Reinhard Fässler, James W Fawcett
Sep 03, 2019
UNLABELLED: After CNS injury, axon regeneration is blocked by an inhibitory environment consisting of the highly upregulated tenascin-C and chondroitin sulfate proteoglycans (CSPGs). Tenascin-C promotes growth of axons if they...
adeno-associated virus alpha9 integrin Axon regeneration dorsal root ganglion kindlin-1 Spinal Cord Animals Axons Calcitonin Gene-Related Peptide Cells Cultured Chondroitin Sulfate Proteoglycans Disease Models Animal Female Functional Laterality Ganglia Spinal Gene Expression Regulation Integrins Nerve Regeneration Nerve Tissue Proteins Neurites Pressure Rats Rats Sprague-Dawley Spinal Cord Spinal Cord Injuries Walking
Giant nonlinear optical activity of achiral origin in planar metasurfaces with quadratic and cubic nonlinearities
Shumei Chen, Franziska Zeuner, Martin Weismann, Bernhard Reinike, Guixin Li, Ventsislav Kolev Valev, Kok Wai Cheah, Nicolae Coriolan Panoiu, Thomas Zentgraf, Shuang Zhang
Apr 14, 2016
3D chirality is shown to be unnecessary for introducing strong circular dichroism for harmonic generations. Specifically, near-unity circular dichroism for both second-harmonic generation and third-harmonic generations is...
Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent.
Melissa R Andrews, Sara Soleman, Menghon Cheah, David A Tumbarello, Matthew RJ Mason, Elizabeth Moloney, Joost Verhaagen, Jean-Charles Bensadoun, Bernard Schneider, Patrick Aebischer, James W Fawcett
May 09, 2018
The regenerative ability of CNS axons decreases with age, however, this ability remains largely intact in PNS axons throughout adulthood. These differences are likely to correspond with age-related silencing of proteins...
adeno-associated virus axon initial segment dorsal root ganglia integrin Retinal ganglion cell Sensorimotor Cortex Animals Animals Newborn Axons Brain Ganglia Spinal Genetic Vectors Integrin alpha Chains Integrin alpha6 Integrin beta1 Male Optic Nerve Rats Inbred Lew Rats Sprague-Dawley Sciatic Nerve Spinal Cord Spinal Cord Injuries
The delirium and population health informatics cohort study protocol
Daniel Davis, Sarah Richardson, Joanne Hornby, Helen Bowden, Katrin Hoffmann, Maryse Weston-Clarke, Fenella Green, Nishi Chaturvedi, Alun Hughes, Diana Kuh, Elizabeth Sampson, Ruth Mizoguchi, Khai Lee Cheah, Melanie Romain, Abhi Sinha, Rodric Jenkin, Carol Brayne, Alasdair MacLullich
Jun 20, 2018
Humans Dementia Delirium Prognosis Clinical Protocols Hospitalization Geriatric Assessment Incidence Prospective Studies Cognition Time Factors Aged Inpatients London Female Male Cognitive Dysfunction population health
Published by: BMC geriatrics
Study Protocol for a Randomized Controlled Trial of Choral Singing Intervention to Prevent Cognitive Decline in At-Risk Older Adults Living in the Community.
Jasmine Tan, FH Maurine Tsakok, Elisabeth K Ow, Bernard Lanskey, Kian Siong Darius Lim, Lee Gan Goh, Chay-Hoon Tan, Irwin Kee-Mun Cheah, Anis Larbi, Roger Foo, Marie Loh, Caroline Kai Yun Wong, John Suckling, Jialiang Li, Rathi Mahendran, Ee-Heok Kua, Lei Feng
Nov 06, 2018
Introduction: This study is a parallel-arm randomized controlled trial evaluating choral singing's efficacy and underlying mechanisms in preventing cognitive decline in at-risk older participants. Methods: Three-hundred and...
Relationship between microbiology of throat swab and clinical course among primary care patients with acute cough
José M Ordóñez-Mena, Thomas R Fanshawe, Chris C Butler, David Mant, Denise Longhurst, Peter Muir, Barry Vipond, Paul Little, Michael Moore, Beth Stuart, Alastair D Hay, Hannah V Thornton, Matthew J Thompson, Sue Smith, Ann Van den Bruel, Victoria Hardy, Laikin Cheah, Derrick Crook, Kyle Knox
Jan 27, 2020
BACKGROUND: Acute lower respiratory tract infections (ALRTIs) account for most antibiotics prescribed in primary care despite lack of efficacy, partly due to clinician uncertainty about aetiology and patient concerns about...
Umbralisib, a Dual PI3Kδ/CK1ε Inhibitor in Patients With Relapsed or Refractory Indolent Lymphoma.
Nathan H Fowler, Felipe Samaniego, Wojciech Jurczak, Nilanjan Ghosh, Enrico Derenzini, James A Reeves, Wanda Knopińska-Posłuszny, Chan Y Cheah, Tycel Phillips, Ewa Lech-Maranda, Bruce D Cheson, Paolo F Caimi, Sebastian Grosicki, Lori A Leslie, Julio C Chavez, Gustavo Fonseca, Sunil Babu, Daniel J Hodson, Spencer H Shao, John M Burke, Jeff P Sharman, Jennie Y Law, John M Pagel, Hari P Miskin, Peter Sportelli, Owen A O'Connor, Michael S Weiss, Pier Luigi Zinzani
Mar 18, 2021
PURPOSE: Phosphatidylinositol-3-kinase (PI3K) inhibitors have shown activity in relapsed or refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). PI3K inhibitors have been hampered by poor long-term tolerability and toxicity...
Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction.
Jan Bornschein, Lorenz Wernisch, Maria Secrier, Ahmad Miremadi, Juliane Perner, Shona MacRae, Maria O'Donovan, Richard Newton, Suraj Menon, Lawrence Bower, Matthew D Eldridge, Ginny Devonshire, Calvin Cheah, Richard Turkington, Richard H Hardwick, Michael Selgrad, Marino Venerito, Peter Malfertheiner, OCCAMS consortium, Rebecca C Fitzgerald
Jun 19, 2019
Effects of choral singing versus health education on cognitive decline and aging
Lei Feng, Rafael Romero-Garcia, John Suckling, Jasmine Tan, Anis Larbi, Irwin Cheah, Glenn Wong, Maurine Tsakok, Bernard Lanskey, Darius Lim, Jialiang Li, Joanna Yang, Benjamin Goh, Tristan Gwee Chen Teck, Allan Ho, Xiu Wang, Jin-Tai Yu, Can Zhang, Crystal Tan, Michelle Chua, Junhua Li, John J Totman, Caroline Wong, Marie Loh, Roger Foo, Chay Hoon Tan, Lee Gan Goh, Rathi Mahendran, Brian K Kennedy, Ee-Heok Kua
Feb 12, 2021
We conducted a randomized controlled trial to examine choral singing's effect on cognitive decline in aging. Older Singaporeans who were at high risk of future dementia were recruited: 47 were assigned to choral singing...
biological markers choral singing cognitive decline Health Education Randomized controlled trial Aged aging Brain Cognitive Dysfunction Female Health Education Humans immunosenescence Magnetic Resonance Imaging Male Middle Aged music therapy Neuropsychological Tests Oxidative Stress Singapore singing
Pf7
Muzamil Mahdi Abdel Hamid, Mohamed Hassan Abdelraheem, Desmond Omane Acheampong, Ambroise Ahouidi, Mozam Ali, Jacob Almagro-Garcia, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Ben Andagalu, Tim Anderson, Voahangy Andrianaranjaka, Ifeyinwa Aniebo, Enoch Aninagyei, Felix Ansah, Patrick O Ansah, Tobias Apinjoh, Paulo Arnaldo, Elizabeth Ashley, Sarah Auburn, Gordon A Awandare, Hampate Ba, Vito Baraka, Alyssa Barry, Philip Bejon, Gwladys I Bertin, Maciej F Boni, Steffen Borrmann, Teun Bousema, Marielle Bouyou-Akotet, Oralee Branch, Peter C Bull, Huch Cheah, Keobouphaphone Chindavongsa, Thanat Chookajorn, Kesinee Chotivanich, Antoine Claessens, David J Conway, Vladimir Corredor, Erin Courtier, Alister Craig, Umberto D'Alessandro, Souleymane Dama, Nicholas Day, Brigitte Denis, Mehul Dhorda, Mahamadou Diakite, Abdoulaye Djimde, Christiane Dolecek, Arjen Dondorp, Seydou Doumbia, Chris Drakeley, Eleanor Drury, Patrick Duffy, Diego F Echeverry, Thomas G Egwang, Sonia Maria Mauricio Enosse, Berhanu Erko, Rick M Fairhurst, Abdul Faiz, Caterina A Fanello, Mark Fleharty, Matthew Forbes, Mark Fukuda, Dionicia Gamboa, Anita Ghansah, Lemu Golassa, Sonia Goncalves, G L Abby Harrison, Sara Anne Healy, Jason A Hendry, Anastasia Hernandez-Koutoucheva, Tran Tinh Hien, Catherine A Hill, Francis Hombhanje, Amanda Hott, Ye Htut, Mazza Hussein, Mallika Imwong, Deus Ishengoma, Scott A Jackson, Chris G Jacob, Julia Jeans, Kimberly J Johnson, Claire Kamaliddin, Edwin Kamau, Jon Keatley, Theerarat Kochakarn, Drissa S Konate, Abibatou Konaté, Aminatou Kone, Dominic P Kwiatkowski, Myat P Kyaw, Dennis Kyle, Mara Lawniczak, Samuel K Lee, Martha Lemnge, Pharath Lim, Chanthap Lon, Kovana M Loua, Celine I Mandara, Jutta Marfurt, Kevin Marsh, Richard James Maude, Mayfong Mayxay, Oumou Maïga-Ascofaré, Olivo Miotto, Toshihiro Mita, Victor Mobegi, Abdelrahim Osman Mohamed, Olugbenga A Mokuolu, Jaqui Montgomery, Collins Misita Morang'a, Ivo Mueller, Kathryn Murie, Paul N Newton, Thang Ngo Duc, Thuy Nguyen, Thuy-Nhien Nguyen, Tuyen Nguyen Thi Kim, Hong Nguyen Van, Harald Noedl, Francois Nosten, Rintis Noviyanti, Vincent Ntui-Njock Ntui, Alexis Nzila, Lynette Isabella Ochola-Oyier, Harold Ocholla, Abraham Oduro, Irene Omedo, Marie A Onyamboko, Jean-Bosco Ouedraogo, Kolapo Oyebola, Wellington Aghoghovwia Oyibo, Richard Pearson, Norbert Peshu, Aung P Phyo, Christopher V Plowe, Ric N Price, Sasithon Pukrittayakamee, Huynh Hong Quang, Milijaona Randrianarivelojosia, Julian C Rayner, Pascal Ringwald, Anna Rosanas-Urgell, Eduard Rovira-Vallbona, Valentin Ruano-Rubio, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Victoria J Simpson, Mahamadou S Sissoko, Christen Smith, Xin-Zhuan Su, Colin Sutherland, Shannon Takala-Harrison, Arthur Talman, Livingstone Tavul, Ngo Viet Thanh, Vandana Thathy, Aung Myint Thu, Mahamoudou Toure, Antoinette Tshefu, Federica Verra, Joseph Vinetz, Thomas E Wellems, Jason Wendler, Nicholas J White, Georgia Whitton, William Yavo, Rob W van der Pluijm
Apr 02, 2023
We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries...
Published by: Wellcome open research