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Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants.
Rachel PJ Lai, Michael S Seaman, Paul Tonks, Frank Wegmann, David J Seilly, Simon DW Frost, Celia C LaBranche, David C Montefiori, Antu K Dey, Indresh K Srivastava, Quentin Sattentau, Susan W Barnett, Jonathan L Heeney
Nov 08, 2017
Adjuvant formulations capable of inducing high titer and high affinity antibody responses would provide a major advance in the development of vaccines to viral infections such as HIV-1. Although oil-in-water emulsions, such as...
Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs
Anton M Sholukh, Jennifer D Watkins, Hemant K Vyas, Sandeep Gupta, Samir K Lakhashe, Swati Thorat, Mingkui Zhou, Girish Hemashettar, Barbara C Bachler, Donald N Forthal, Francois Villinger, Quentin J Sattentau, Robin A Weiss, Gloria Agatic, Davide Corti, Antonio Lanzavecchia, Jonathan L Heeney, Ruth M Ruprecht
Jun 12, 2015
(6 max) Complete protection IgA IgG Passive immunization Rhesus monkey SHIV-C mucosal challenge Administration Intravenous Administration mucosal Animals Antibodies Monoclonal Antibodies Neutralizing HIV Antibodies HIV-1 Humans Immunity Cellular Immunity mucosal Immunization Passive Immunoglobulin A Immunoglobulin G Macaca mulatta Mucous Membrane RNA Viral Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus T-Lymphocytes
Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses
Alexandra Hauser, George Carnell, Kathrin Held, Guidenn Sulbaran, Nadine Tischbierek, Lisa Rogers, Georgios Pollakis, Paul Tonks, Michael Hoelscher, Song Ding, Rogier W. Sanders, Christof Geldmacher, Quentin Sattentau, Winfried Weissenhorn, Jonathan L. Heeney, David Peterhoff, Ralf Wagner
Jul 28, 2021
Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn...
Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses.
Alexandra Hauser, George Carnell, Kathrin Held, Guidenn Sulbaran, Nadine Tischbierek, Lisa Rogers, Georgios Pollakis, Paul Tonks, Michael Hoelscher, Song Ding, Rogier W Sanders, Christof Geldmacher, Quentin Sattentau, Winfried Weissenhorn, Jonathan L Heeney, David Peterhoff, Ralf Wagner
Sep 27, 2021
Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn...
The Idea of Liberty, 1600-1800
This article uses computational and statistical methods for analyzing the concept of liberty 1600-1800. Based on a bespoke set of tools for parsing conceptual structures it contributes to the literature on the concept of liberty...
Ciliate Codon Translator Program Manual
Quentin D. Altemose
Jan 01, 0001
Understanding the evolutionary history of organisms allows us to better comprehend selective pressures and their effects on larger populations. In our study, we focused on analyzing the DNA of ciliate groups, which are single...
Bio Informatics Computer Program DNA Translation Ciliates Codons Bioinformatics Biology mathematics Organisms Physical Sciences and Mathematics software engineering
Published by: Ursinus College
MUSE discovers perpendicular arcs in the inner filament of Cen A
Evidence of AGN interaction with the IGM is observed in some galaxies and many cool core clusters. Radio jets are suspected to dig large cavities into the surrounding gas. In most cases, very large optical filaments are seen...
Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function.
Beyond Bones: Applying Bioactive Glasses to Long-Term Drug Delivery
Ever since bioactive glasses were discovered in 1969, they have traditionally been used for bone repair and regeneration. However, they carry other useful purposes as well, and have shown they have potential in long-term drug...
bioactive glass beads Drug delivery Biomaterial materials science GLASS Physical Sciences and Mathematics Physics
Published by: Ursinus College
Hornsby Lecture Series Features Author Michael Bérubé on Agreeing to Disagree
Winthrop University
Jan 01, 0001
Bérubé will be hosted by Winthrop's Master of Liberal Arts program and its Hornsby Lecture Series, which brings thought-provoking thinkers and writers to campus to present public lectures on topics of particular significance....
Published by: Winthrop University
Paramutation-like features of multiple natural epialleles in tomato.
BACKGROUND: Freakish and rare or the tip of the iceberg? Both phrases have been used to refer to paramutation, an epigenetic drive that contravenes Mendel's first law of segregation. Although its underlying mechanisms are...
DNA Methylation Signatures of the Plant Chromomethyltransferases.
DNA methylation in plants is traditionally partitioned into CG, CHG and CHH contexts (with H any nucleotide but G). By investigating DNA methylation patterns in trinucleotide contexts in four angiosperm species, we show that...
Atomic-to-molecular gas phase transition triggered by the radio jet in Centaurus A
NGC 5128 (Centaurus A) is one of the best example to study AGN-feedback in the local Universe. At 13.5 kpc from the galaxy, optical filaments with recent star formation are lying along the radio-jet direction. We used the...
Atomic-to-molecular gas phase transition triggered by the radio jet in Centaurus A
NGC 5128 (Centaurus A) is one of the best example to study AGN-feedback in the local Universe. At 13.5 kpc from the galaxy, optical filaments with recent star formation are lying along the radio-jet direction. We used the...
Processing and Properties of GeSeSbTe Chalcogenide Thin-Films for Optical Applications
Quentin D. Altemose
Jan 01, 0001
Chalcogenide glasses have gained attention in recent years for their ability to transmit light throughout most of the infrared spectrum and for their ability to alter their structural conformation from amorphous to crystalline...
Chalcogenide glass dip-coating THIN-FILMS ART-FTIR optics Engineering Physics optics Physical Sciences and Mathematics Physics
Published by: Ursinus College
MUSE discovers perpendicular arcs in the inner filament of Cen A
Evidence of AGN interaction with the IGM is observed in some galaxies and many cool core clusters. Radio jets are suspected to dig large cavities into the surrounding gas. In most cases, very large optical filaments are seen...
Star formation efficiency along the radio jet in Centaurus A
Centaurus A is the most nearby powerful AGN, widely studied at all wavelengths. Molecular gas has been found in the halo at a distance of ~20 kpc from the galaxy centre, associated with HI shells. The molecular gas lies inside...
Polarity Sensitivity as a Potential Correlate of Neural Degeneration in Cochlear Implant Users.
Cochlear implant (CI) performance varies dramatically between subjects. Although the causes of this variability remain unclear, the electrode-neuron interface is thought to play an important role. Here we evaluate the...
Star formation efficiency along the radio jet in Centaurus A
Centaurus A is the most nearby powerful AGN, widely studied at all wavelengths. Molecular gas has been found in the halo at a distance of ~20 kpc from the galaxy centre, associated with HI shells. The molecular gas lies inside...
Environmental and epigenetic regulation of Rider retrotransposons in tomato.
Matthias Benoit, Hajk-Georg Drost, Marco Catoni, Quentin Gouil, Sara Lopez-Gomollon, David Baulcombe, Jerzy Paszkowski
Oct 29, 2019
Transposable elements in crop plants are the powerful drivers of phenotypic variation that has been selected during domestication and breeding programs. In tomato, transpositions of the LTR (long terminal repeat) retrotransposon...
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