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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp.
The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp). Combining...
Aminoacyltransferases Bacterial Proteins Biophysical Phenomena Chemistry Techniques Analytical Cysteine Endopeptidases Cytochromes c Electrophoresis Polyacrylamide Gel Heme Kinetics Maltose Maltose-Binding Proteins Point Mutation Protein Binding Protein Denaturation Protein Folding Protein Stability Protein Structure Tertiary Protein Unfolding Proteins Proteolysis Reproducibility of Results Temperature Thermolysin
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis
Matthew Thomas, Gavin Shaddick, Rachel Charlton, Charlotte Cavill, Richard Holland, Florenzo Iannone, Giovanni Lapadula, Simona Lopriore, Jakub Zavada, Michal Uher, Karel Pavelka, Lenka Szczukova, Prodromos Sidiropolous, Irini Flouri, Alexandros Drosos, Burkhard Möller, Michael Nissen, Rüdiger Müller, Almut Scherer, Neil McHugh, Alison Nightingale
Jan 01, 2021
Objective
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
Anatomy and behavior of Laternula elliptica, a keystone species of the Antarctic benthos (Bivalvia: Anomalodesmata
Laternula elliptica (P. P. King, 1832) is the sole representative of the anomalodesmatan family Laternulidae and the largest bivalve in the Antarctic and Subantarctic. A keystone species of the regional benthic communities, it...
Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.
Mutations in the central region of the signalling hub Adenomatous Polyposis Coli (APC) cause colorectal tumourigenesis. The structure of this region remained unknown. Here, we characterise the Mutation Cluster Region in APC...
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis.
Thorsten Boroviak, Remco Loos, Patrick Lombard, Junko Okahara, Rüdiger Behr, Erika Sasaki, Jennifer Nichols, Austin Smith, Paul Bertone
Nov 23, 2015
Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
Andrea I. Luppi, Daniel Golkowski, Andreas Ranft, Rüdiger Ilg, Denis Jordan, David K. Menon, Emmanuel A. Stamatakis
May 20, 2021
Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.
Andrea I Luppi, Daniel Golkowski, Andreas Ranft, Rüdiger Ilg, Denis Jordan, David K Menon, Emmanuel A Stamatakis
Mar 22, 2021
The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub-state where integration predominates, and a...
XAS and EPR in Situ Observation of Ru(V) Oxo Intermediate in a Ru Water Oxidation Complex.
Natalia Levin, Carla Casadevall, George E Cutsail, Julio Lloret-Fillol, Serena DeBeer, Olaf Rüdiger
Sep 02, 2022
In this study, we combine in situ spectroelectrochemistry coupled with electron paramagnetic resonance (EPR) and X-ray absorption spectroscopies (XAS) to investigate a molecular Ru-based water oxidation catalyst bearing a...
Published by: ChemElectroChem
Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis
Matthew Thomas, Gavin Shaddick, Rachel Charlton, Charlotte Cavill, Richard Holland, Florenzo Iannone, Giovanni Lapadula, Simona Lopriore, Jakub Zavada, Michal Uher, Karel Pavelka, Lenka Szczukova, Prodromos Sidiropolous, Irini Flouri, Alexandros Drosos, Burkhard Möller, Michael Nissen, Rüdiger Müller, Almut Scherer, Neil McHugh, Alison Nightingale
Jan 01, 2021
Objective
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA)...
Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching.
Mark Moeller, Misa Hirose, Sarah Mueller, Catrin Roolf, Simone Baltrusch, Saleh Ibrahim, Christian Junghanss, Olaf Wolkenhauer, Robert Jaster, Rüdiger Köhling, Manfred Kunz, Markus Tiedge, Paul N Schofield, Georg Fuellen
Aug 08, 2017
Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using longitudinal data sets from the large-scale inbred mouse strain study at the Jackson Laboratory Nathan Shock Center, we describe a...
Genetic control of cellular morphogenesis in Müller glia.
Small-Molecule Activation of YAP for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Small Molecule Activation of Yap for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Modelling Charcot-Marie-Tooth disease in a dish reveals common cell type-specific alterations.
This scientific commentary refers to ‘Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction’, by Van Lent et al. (doi:10.1093/brain/awab226).
Gedanken über die Religion: Der “stille” Krieg zwischen Schelling und Schleiermacher (1799–1807), by Ryan Scheerlinck, Stuttgart-Bad Cannstatt
Vicki Müller-Lüneschloß
Apr 05, 2022
The title of Scheerlinck’s study on the relationship between two of the most important thinkers of Romanticism, the philosopher F.W.J. Schelling and the theologian F.D.E. Schleiermacher, undoubtedly alludes to the latter’s main...
Published by: Memorial University Libraries
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