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Results: 585
The RA-MAP Consortium
Andrew P Cope, Michael R Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A Fisher, Carl S Goodyear, Paul Emery, Michael R Ehrenstein, Neil Gozzard, Ray Harris, Sally Hollis, Sarah Keidel, Marc Levesque, Catharina Lindholm, Michael F McDermott, Iain B McInnes, Christopher M Mela, Gerry Parker, Simon Read, Ayako Wakatsuki Pedersen, Frederique Ponchel, Duncan Porter, Ravi Rao, Anthony Rowe, Peter Schulz-Knappe, Matthew A Sleeman, Deborah Symmons, Peter C Taylor, Brian Tom, Wayne Tsuji, Denny Verbeeck, John D Isaacs, RA-MAP Consortium
Jun 19, 2018
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study)
Mariam Al-Laith, Marianna Jasenecova, Sonya Abraham, Aisla Bosworth, Ian N Bruce, Christopher D Buckley, Coziana Ciurtin, Maria-Antonietta D'Agostino, Paul Emery, Hill Gaston, John D Isaacs, Andrew Filer, Benjamin A Fisher, Thomas WJ Huizinga, Pauline Ho, Clare Jacklin, Heidi Lempp, Iain B McInnes, Arthur G Pratt, Andrew Östor, Karim Raza, Peter C Taylor, Dirkjan van Schaardenburg, Dharshene Shivapatham, Alison J Wright, Joana C Vasconcelos, Joanna Kelly, Caroline Murphy, A Toby Prevost, Andrew P Cope
Jul 14, 2020
TRIAL DESIGN: We present a study protocol for a multi-centre, randomised, double-blind, parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and effectiveness of a 52-week period of...
Abatacept Antibodies to citrullinated protein antigens At risk Autoantibodies Double-blind intervention Placebo-controlled Pre-clinical phase Randomised rheumatoid arthritis Abatacept Antirheumatic Agents Arthritis Rheumatoid Autoantibodies Biomarkers Double-Blind Method Drug Administration Schedule Feasibility Studies Female Humans Male Multicenter Studies as Topic Netherlands Pregnancy Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM).
Sofia Ramiro, Robert Bm Landewé, Désirée van der Heijde, Alexandre Sepriano, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Ori Elkayam, J Carter Thorne, Margaret Larche, Gianfranco Ferraccioli, Marina Backhaus, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain G Cantagrel, Cornelia F Allaart, Cheryl Barnabe, Clifton O Bingham, Paul P Tak, Dirkjan van Schaardenburg, Hilde Berner Hammer, Rana Dadashova, Edna Hutchings, Joel Paschke, Walter P Maksymowych
Feb 25, 2020
OBJECTIVES: To investigate whether following a treat-to-target (T2T)-strategy in daily clinical practice leads to more patients with rheumatoid arthritis (RA) meeting the remission target. METHODS: RA patients from 10 countries...
Remission rheumatoid arthritis treat-to-target Adult Aged Antirheumatic Agents Arthritis Rheumatoid Blood Sedimentation C-Reactive Protein Clinical Decision-Making Cohort Studies Female Humans Longitudinal Studies Male Middle Aged Patient Care Planning Remission Induction Rheumatoid Factor Tumor Necrosis Factor Inhibitors
Intestinal CD4+T Cell Responses to Food
Ainsley Lockhart
Jan 01, 0001
During routine digestion and absorption of food, massive quantities of diet-derived polypeptides pass through the intestine. The intestinal immune system must maintain tolerance to these dietary antigens while still protecting...
Published by: Rockefeller University
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
May 13, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
Estimating the diagnostic accuracy of rheumatoid factor in UK primary care
Anne Miller, Alison L. Nightingale, Cormac J. Sammon, Kamal R. Mahtani, Tim A. Holt, Neil J. McHugh, Raashid A. Luqmani
Oct 01, 2015
OBJECTIVE: To investigate the diagnostic accuracy of RF as a test for RA in primary care and its impact on referral times using the Clinical Practice Research Datalink.
METHODS: We identified all patients with a first...
GDF15
GDF15 has recently gained scientific and translational prominence with the discovery that its receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain. Activation of this receptor results in...
Human Lymph Node Stromal Cells Have the Machinery to Regulate Peripheral Tolerance during Health and Rheumatoid Arthritis.
Janine S Hähnlein, Reza Nadafi, Tineke A de Jong, Johanna F Semmelink, Ester BM Remmerswaal, Mary Safy, Krijn P van Lienden, Mario Maas, Danielle M Gerlag, Paul P Tak, Reina E Mebius, Heidi Wähämaa, Anca I Catrina, Lisa G M van Baarsen
Aug 10, 2020
BACKGROUND: In rheumatoid arthritis (RA) the cause for loss of tolerance and anti-citrullinated protein antibody (ACPA) production remains unidentified. Mouse studies showed that lymph node stromal cells (LNSCs) maintain...
D?vad?ra
Joanna Henry
Jan 01, 0001
Artwork
Magazine Literary Magazine Arts Magazine art poetry prose Creative Nonfiction Photography Creative Writing Art and Design Photography
Published by: Winthrop University
Predictors of heart rate recovery following exercise in patients with rheumatoid arthritis
Background Cardiovascular disease (CVD) is a major cause of death in rheumatoid arthritis patients (RA). The underlying mechanisms for the CVD increase risk in RA are not fully understood. However, poor parasympathetic function...
Fibrinogen marker C reactive protein triacylglycerol Lipid Heart Rate Exercise Patient human rheumatoid arthritis Rheumatology rheumatic disease Risk factor risk parasympathetic tone Quality of life parasympathetic function leukocyte Exercise Tolerance FITNESS breathing longitudinal study linear regression analysis treadmill Framingham risk score insulin sensitivity Oxygen Consumption Exercise Test cardiovascular disease POPULATION erythrocyte sedimentation rate Mortality Gender blood sampling Female gas analysis Cause of Death Quantitative Insulin Sensitivity Check Index electrocardiogram
Physical ability of people with rheumatoid arthritis and age-sex matched controls to use four commonly prescribed inhaler devices
Background Respiratory disease is a common co-morbidity with rheumatoid arthritis (RA). RA commonly affects the hands, but there is little research investigating whether these patients are physically able to operate inhalers....
Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.
Ann W Morgan, James I Robinson, Philip G Conaghan, Stephen G Martin, Elizabeth MA Hensor, Michael D Morgan, Lori Steiner, Henry A Erlich, Hock-Chye Gooi, Anne Barton, Jane Worthington, Paul Emery, UKRAG Consortium, YEAR Consortium
Mar 16, 2020
INTRODUCTION: This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception...
The Application of Big Data and Artificial Intelligence Technology in Enterprise Information Security Management and Risk Assessment
With the development of digitalization and Internet technology, enterprise information security is facing more and more challenges. Many enterprises have begun to adopt big data (BD) and artificial intelligence (AI) technology...
Published by: IGI Global Scientific Publishing
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
Mar 28, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
Autonomy support, light physical activity and psychological well-being in Rheumatoid Arthritis
Sally A M Fenton, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Peter C. Rouse, Chen-an Yu, George D Kitas, Joan L. Duda
Mar 01, 2018
Background Participation in physical activity may improve psychological well-being among people with Rheumatoid Arthritis (RA). This study examined the implications of autonomy support for physical activity, on objectively...
Estimating the diagnostic accuracy of rheumatoid factor in UK primary care
Anne Miller, Alison L. Nightingale, Cormac J. Sammon, Kamal R. Mahtani, Tim A. Holt, Neil J. McHugh, Raashid A. Luqmani
Oct 01, 2015
OBJECTIVE: To investigate the diagnostic accuracy of RF as a test for RA in primary care and its impact on referral times using the Clinical Practice Research Datalink.
METHODS: We identified all patients with a first...
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18 F-GE-180 and comparison with 18 F-FDG and DCE-MRI
Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer, Pilar Jimenez-Royo
Dec 22, 2020
Abstract: Purpose: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...
Physical ability of people with rheumatoid arthritis and age-sex matched controls to use four commonly prescribed inhaler devices
Background Respiratory disease is a common co-morbidity with rheumatoid arthritis (RA). RA commonly affects the hands, but there is little research investigating whether these patients are physically able to operate inhalers....
Associations between objective and self-reported physical activity data in rheumatoid arthritis patients
C.-A. Yu, P. Rouse, J. Veldhuijzen Van Zanten, G. Metsios, N. Ntoumanis, G. Kitas, J. Duda
Jun 01, 2014
Background Rheumatoid arthritis (RA) patients suffer from periodic flare-ups causing joint swelling, pain and potential bone destruction. In addition, RA patient are at greater risk of cardiovascular disease. Therefore, physical...
A prospective cohort study measuring cost-benefit analysis of the Otago Exercise Programme in community dwelling adults with rheumatoid arthritis.
Siyar Abdulrazaq, Jackie Oldham, Dawn A Skelton, Terence O'Neill, Luke Munford, Brenda Gannon, Mark Pilling, Chris Todd, Emma K Stanmore
Jun 01, 2018
BACKGROUND: Falls are one of the major health problems in adults with Rheumatoid Arthritis (RA). Interventions, such as the Otago Exercise Programme (OEP), can reduce falls in community dwelling adults by up to 35%. The...
A self-determination theory based intervention to promote autonomous motivation and physical activity engagement among patients with rheumatoid arthritis
J. L. Duda, P. C. Rouse, J. J. Veldhuijzen Van Zanten, G. S. Metsios, N. Ntoumanis, C-A. Yu, S. A. M. Fenton, Y. Koutedakis, G. D. Kitas
Jun 01, 2015
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that
causes joint pain, swelling and stiffness with eventual structural damage leading
to physical dysfunction. People with RA tend to experience...
causes joint pain, swelling and stiffness with eventual structural damage leading
to physical dysfunction. People with RA tend to experience...
Chronic administration of 13-<em>cis</em>-retinoic acid does not alter the number of serotoninergic neurons in the mouse raphe nuclei
The synthetic retinoid previous term13-cis-retinoicnext term acid (previous term13-cisnext term-RA), prescribed for the treatment of severe nodular acne, has been linked to an increased incidence of depression. previous...
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