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Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization.
Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in a variety of tumor types, most notably in Anaplastic Large Cell Lymphoma (ALCL) where a chromosomal translocation generates the oncogenic...
Anaplastic Lymphoma Kinase Animals Cell Adhesion Cell Cycle Cell Proliferation Cell Transformation Neoplastic Cells Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Embryo Mammalian FIBROBLASTS Humans Mice Models Biological Mutation Protein Processing Post-Translational Protein Stability Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Retinoblastoma Protein Transcription Genetic Tumor Suppressor Protein p53
Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.
Paula Kuo, Siok Min Teoh, Zewen K Tuong, Graham R Leggatt, Stephen R Mattarollo, Ian H Frazer
Aug 20, 2021
"High-risk" human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and disrupting cell cycle termination. Murine skin expressing...
APC CIN HPV16 Keratinocytes Retinoblastoma Protein skin grafting Animals Antigen-Presenting Cells Disease Models Animal epidermis Female Human papillomavirus 16 Humans Hyperplasia Keratinocytes Lymph Nodes Mice Mice Inbred C57BL Mice Transgenic Papillomavirus E7 Proteins Papillomavirus Infections Protein Binding Retinoblastoma Binding Proteins Retinoblastoma Protein
IPR Policy Brief - Revitalising UK manufacturing's image through brand-driven value
Following the global financial crisis in 2008, policy makers, realising the need to rebalance the economy, began looking towards the manufacturing sector and industrial policy. However, the sector must overcome a number of...
/dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure
Published by: University of Bath
IPR Policy Brief - Revitalising UK manufacturing's image through brand-driven value
Following the global financial crisis in 2008, policy makers, realising the need to rebalance the economy, began looking towards the manufacturing sector and industrial policy. However, the sector must overcome a number of...
/dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure
Published by: University of Bath
Recumbent vs. upright bicycles
Recumbent bicycles (RB) are high performance, human-powered vehicles. In comparison to normal/upright bicycles (NB) the RB may allow individuals to reach higher speeds due to aerodynamic advantages. The purpose of this...
Recumbent vs. upright bicycles
Recumbent bicycles (RB) are high performance, human-powered vehicles. In comparison to normal/upright bicycles (NB) the RB may allow individuals to reach higher speeds due to aerodynamic advantages. The purpose of this...
DREAM represses distinct targets by cooperating with different THAP domain proteins.
Csenge Gal, Francesco Nicola Carelli, Alex Appert, Chiara Cerrato, Ni Huang, Yan Dong, Jane Murphy, Andrea Frapporti, Julie Ahringer
Sep 27, 2021
The DREAM (dimerization partner [DP], retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell-cycle and other genes, but its mechanism of action is unclear. Here, we demonstrate that two...
dream H2A.Z H3K9me2 THAP lin-15B lin-35 lin-36 quiescence retinoblastoma TRANSCRIPTIONAL REPRESSION Animals Animals Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Proteins DNA Methylation E2F Transcription Factors Gene Expression Regulation Histones Promoter Regions Genetic Protein Binding Protein Interaction Domains and Motifs Retinoblastoma Protein Transcription Factors
Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.
Rongxin Chen, Shu Liu, Huijing Ye, Jiali Li, Yi Du, Lingyan Chen, Xiaoman Liu, Yungang Ding, Qian Li, Yuxiang Mao, Siming Ai, Ping Zhang, Wenfang Ma, Huasheng Yang
Nov 13, 2018
Single nucleotide polymorphisms (SNPs) of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270, all in the p53 pathway, which plays a crucial role in DNA damage and genomic instability, were reported to be associated with cancer risk...
Adult Asian People China Cyclin-Dependent Kinase Inhibitor p21 Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Kaplan-Meier Estimate Male Polymorphism Single Nucleotide Proportional Hazards Models Proto-Oncogene Proteins c-mdm2 retinoblastoma Risk Factors Tumor Suppressor Protein p53
A Study of Prevalence of Intestinal Helminthic Infections and Associated Risk Factors among the Tea Estates workers of Ilam District, Eastern Region of Nepal
Introduction: Intestinal parasites are widely prevalent in developing countries, probably due to poor sanitation and inadequate personal hygiene. It is estimated that as much as 60% of the world’s population is infected with...
Published by: IJHS Medical Association
Rubidium and caesium aluminyls
Thomas Gentner, Matt Evans, Alan Kennedy, Sam Neale, Claire McMullin, Martyn Coles, Robert Mulvey
Jan 28, 2022
Expanding knowledge of low valent aluminium chemistry, rubidium and caesium aluminyls are reported to complete the group 1 (Li–Cs) set of metal aluminyls. Both compounds crystallize as a contacted dimeric pair supported by...
Rubidium and caesium aluminyls
Thomas Gentner, Matt Evans, Alan Kennedy, Sam Neale, Claire McMullin, Martyn Coles, Robert Mulvey
Jan 28, 2022
Expanding knowledge of low valent aluminium chemistry, rubidium and caesium aluminyls are reported to complete the group 1 (Li–Cs) set of metal aluminyls. Both compounds crystallize as a contacted dimeric pair supported by...
A Study of Prevalence of Intestinal Helminthic Infections and Associated Risk Factors among the Tea Estates workers of Ilam District, Eastern Region of Nepal
Introduction: Intestinal parasites are widely prevalent in developing countries, probably due to poor sanitation and inadequate personal hygiene. It is estimated that as much as 60% of the world’s population is infected with...
Published by: IJHS Medical Association
Rayleigh instability of confined vortex droplets in critical superconductors
Igor Lukyanchuk, Valerie Vinokur, Andreas Rydh, R Xie, Milorad Milosevic, Ulrich Welp, M Zach, Z L Xiao, George Crabtree, Simon Bending, Francois Peeters, Wai-Kwong Kwok
Jan 01, 2015
Depending on the Ginzburg–Landau parameter K, superconductors can either be fully diamagnetic if K<1/SQRT(2) (type I superconductors) or allow magnetic flux to penetrate through Abrikosov vortices if K>1/SQRT(2) (type II...
Air Pollution and Migration
This paper investigates the impact of air pollution on China’s internal migration using the Migrant Population Dynamic Monitoring Survey and Air Quality Index (AQI) data in 2014. Binary response models suggest that, on average...
Published by: IGI Global Scientific Publishing
Modeling Inner Proton Belt Variability at Energies 1 to 10 MeV Using BAS-PRO
Abstract: Geomagnetically trapped protons forming Earth's proton radiation belt pose a hazard to orbiting spacecraft. In particular, solar cell degradation is caused by non‐ionising collisions with protons at energies of several...
Synergistic effects of combining ultrasound with the Fenton process in the degradation of Reactive Blue 19
The decoloration of reactive dye C.I. Reactive Blue 19 (RB 19) using combined ultrasound with the Fenton process has been investigated. The effect of varying the concentrations of hydrogen peroxide and iron sulfate, initial...
Synergistic effects of combining ultrasound with the Fenton process in the degradation of Reactive Blue 19
The decoloration of reactive dye C.I. Reactive Blue 19 (RB 19) using combined ultrasound with the Fenton process has been investigated. The effect of varying the concentrations of hydrogen peroxide and iron sulfate, initial...
Rayleigh instability of confined vortex droplets in critical superconductors
Igor Lukyanchuk, Valerie Vinokur, Andreas Rydh, R Xie, Milorad Milosevic, Ulrich Welp, M Zach, Z L Xiao, George Crabtree, Simon Bending, Francois Peeters, Wai-Kwong Kwok
Jan 01, 2015
Depending on the Ginzburg–Landau parameter K, superconductors can either be fully diamagnetic if K<1/SQRT(2) (type I superconductors) or allow magnetic flux to penetrate through Abrikosov vortices if K>1/SQRT(2) (type II...
Attention-Based Machine Vision Models and Techniques for Solar Wind Speed Forecasting Using Solar EUV Images
Abstract: Extreme ultraviolet images taken by the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory make it possible to use deep vision techniques to forecast solar wind speed—a difficult, high‐impact, and...
Variations in Observations of Geosynchronous Magnetopause and Last Closed Drift Shell Crossings With Magnetic Local Time
Abstract: We analyze a set of events in which both electron flux dropouts caused by magnetopause shadowing and geosynchronous magnetopause crossings (GMCs) are observed. These observations are compared to event‐specific last...
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