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Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization.
Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in a variety of tumor types, most notably in Anaplastic Large Cell Lymphoma (ALCL) where a chromosomal translocation generates the oncogenic...
Anaplastic Lymphoma Kinase Animals Cell Adhesion Cell Cycle Cell Proliferation Cell Transformation Neoplastic Cells Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Embryo Mammalian FIBROBLASTS Humans Mice Models Biological Mutation Protein Processing Post-Translational Protein Stability Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Retinoblastoma Protein Transcription Genetic Tumor Suppressor Protein p53
Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.
Paula Kuo, Siok Min Teoh, Zewen K Tuong, Graham R Leggatt, Stephen R Mattarollo, Ian H Frazer
Aug 20, 2021
"High-risk" human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and disrupting cell cycle termination. Murine skin expressing...
APC CIN HPV16 Keratinocytes Retinoblastoma Protein skin grafting Animals Antigen-Presenting Cells Disease Models Animal epidermis Female Human papillomavirus 16 Humans Hyperplasia Keratinocytes Lymph Nodes Mice Mice Inbred C57BL Mice Transgenic Papillomavirus E7 Proteins Papillomavirus Infections Protein Binding Retinoblastoma Binding Proteins Retinoblastoma Protein
Recumbent vs. upright bicycles
Recumbent bicycles (RB) are high performance, human-powered vehicles. In comparison to normal/upright bicycles (NB) the RB may allow individuals to reach higher speeds due to aerodynamic advantages. The purpose of this...
Recumbent vs. upright bicycles
Recumbent bicycles (RB) are high performance, human-powered vehicles. In comparison to normal/upright bicycles (NB) the RB may allow individuals to reach higher speeds due to aerodynamic advantages. The purpose of this...
Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.
Rongxin Chen, Shu Liu, Huijing Ye, Jiali Li, Yi Du, Lingyan Chen, Xiaoman Liu, Yungang Ding, Qian Li, Yuxiang Mao, Siming Ai, Ping Zhang, Wenfang Ma, Huasheng Yang
Nov 13, 2018
Single nucleotide polymorphisms (SNPs) of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270, all in the p53 pathway, which plays a crucial role in DNA damage and genomic instability, were reported to be associated with cancer risk...
Adult Asian People China Cyclin-Dependent Kinase Inhibitor p21 Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Kaplan-Meier Estimate Male Polymorphism Single Nucleotide Proportional Hazards Models Proto-Oncogene Proteins c-mdm2 retinoblastoma Risk Factors Tumor Suppressor Protein p53
DREAM represses distinct targets by cooperating with different THAP domain proteins.
Csenge Gal, Francesco Nicola Carelli, Alex Appert, Chiara Cerrato, Ni Huang, Yan Dong, Jane Murphy, Andrea Frapporti, Julie Ahringer
Sep 27, 2021
The DREAM (dimerization partner [DP], retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell-cycle and other genes, but its mechanism of action is unclear. Here, we demonstrate that two...
dream H2A.Z H3K9me2 THAP lin-15B lin-35 lin-36 quiescence retinoblastoma TRANSCRIPTIONAL REPRESSION Animals Animals Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Proteins DNA Methylation E2F Transcription Factors Gene Expression Regulation Histones Promoter Regions Genetic Protein Binding Protein Interaction Domains and Motifs Retinoblastoma Protein Transcription Factors
Narrative analysis in aging studies
This article seeks to expand our understanding on narrative and the analysis of stories researchers invite and collect in the domain of aging studies. To do so, we first offer an understanding of what narrative inquiry can be by...
A Study of Prevalence of Intestinal Helminthic Infections and Associated Risk Factors among the Tea Estates workers of Ilam District, Eastern Region of Nepal
Introduction: Intestinal parasites are widely prevalent in developing countries, probably due to poor sanitation and inadequate personal hygiene. It is estimated that as much as 60% of the world’s population is infected with...
Published by: IJHS Medical Association
Comparison of Autoregressive Moving Average and State Space Methods for Monthly Time Series Modelling of Labrador and South-East Quebec River Flows
Time series data such as monthly stream flows can be modelled using time series methods and then used to forecast flows for short term planning. Two methods of time series modelling were reviewed and compared; the well-known...
Rubidium and caesium aluminyls
Thomas Gentner, Matt Evans, Alan Kennedy, Sam Neale, Claire McMullin, Martyn Coles, Robert Mulvey
Jan 28, 2022
Expanding knowledge of low valent aluminium chemistry, rubidium and caesium aluminyls are reported to complete the group 1 (Li–Cs) set of metal aluminyls. Both compounds crystallize as a contacted dimeric pair supported by...
Rubidium and caesium aluminyls
Thomas Gentner, Matt Evans, Alan Kennedy, Sam Neale, Claire McMullin, Martyn Coles, Robert Mulvey
Jan 28, 2022
Expanding knowledge of low valent aluminium chemistry, rubidium and caesium aluminyls are reported to complete the group 1 (Li–Cs) set of metal aluminyls. Both compounds crystallize as a contacted dimeric pair supported by...
A Study of Prevalence of Intestinal Helminthic Infections and Associated Risk Factors among the Tea Estates workers of Ilam District, Eastern Region of Nepal
Introduction: Intestinal parasites are widely prevalent in developing countries, probably due to poor sanitation and inadequate personal hygiene. It is estimated that as much as 60% of the world’s population is infected with...
Published by: IJHS Medical Association
Qualitative research in physical therapy
This paper critically discusses mixed-method research. A case is first offered as to why it is relevant for physical therapists to engage with the mixing of quantitative and qualitative methods and engage in debates about the...
Comparison of Autoregressive Moving Average and State Space Methods for Monthly Time Series Modelling of Labrador and South-East Quebec River Flows
Time series data such as monthly stream flows can be modelled using time series methods and then used to forecast flows for short term planning. Two methods of time series modelling were reviewed and compared; the well-known...
Narrative analysis in aging studies
This article seeks to expand our understanding on narrative and the analysis of stories researchers invite and collect in the domain of aging studies. To do so, we first offer an understanding of what narrative inquiry can be by...
Young athletic bodies and narrative maps of aging
This paper draws on data generated by life history interviews with 22, university based, young athletes to explore their narrative maps of aging. Three key resources were seen to provide information that shaped individual...
Young athletic bodies and narrative maps of aging
This paper draws on data generated by life history interviews with 22, university based, young athletes to explore their narrative maps of aging. Three key resources were seen to provide information that shaped individual...
Air Pollution and Migration
This paper investigates the impact of air pollution on China’s internal migration using the Migrant Population Dynamic Monitoring Survey and Air Quality Index (AQI) data in 2014. Binary response models suggest that, on average...
Published by: IGI Global Scientific Publishing
Being Fred
This article is informed by recent trends in narrative research that focus on the meaning-making actions of those involved in describing the life course. Drawing upon data generated during a series of interactive interviews with...
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