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Results: 280
Cryo-EM structure of the Rhodospirillum rubrum RC-LH1 complex at 2.5 Å.
Pu Qian, Tristan I Croll, David JK Swainsbury, Pablo Castro-Hartmann, Nigel W Moriarty, Kasim Sader, C Neil Hunter
Nov 10, 2021
The reaction centre light-harvesting 1 (RC-LH1) complex is the core functional component of bacterial photosynthesis. We determined the cryo-electron microscopy (cryo-EM) structure of the RC-LH1 complex from Rhodospirillum...
Carotenoids cryo-electron microscopy light-harvesting Photosynthesis Quinone reaction centre Bacterial Proteins Bacteriochlorophylls Benzoquinones Binding Sites Cryoelectron Microscopy Crystallization Electron Transport Complex III Hydrogen Bonding Hydroquinones Ligands Light-Harvesting Protein Complexes Phospholipids Protein Conformation alpha-Helical Rhodospirillum rubrum
Quantifying moment redistribution in FRP-strengthened RC beams
Consideration of moment redistribution (MR) in the design of continuous reinforced concrete (RC) beams results in an efficient and economical design. Adding fibre-reinforced polymer (FRP) materials to RC structures to enhance...
Quantifying moment redistribution in FRP-strengthened RC beams
Consideration of moment redistribution (MR) in the design of continuous reinforced concrete (RC) beams results in an efficient and economical design. Adding fibre-reinforced polymer (FRP) materials to RC structures to enhance...
In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment
RC Ferreira, DB Rainbow, A Rubio García, ML Pekalski, L Porter, JJ Oliveira, F Waldron-Lynch, LS Wicker, JA Todd
Jul 04, 2017
We provide in this paper a detailed characterization of the human peripheral CD4$^+$ CD127$^{low}$CD25$^+$ regulatory T cell (Treg) compartment, with a particular emphasis in defining the population expressing higher levels of...
Prediction of capacity for moment redistribution in FRP-strengthened continuous RC T-beams
Due to the premature debonding of fiber-reinforced polymer (FRP) materials which results in a reduction in 14 ductility, the problem of how to exploit moment redistribution (MR) in FRP-strengthened continuous 15 reinforced...
Prediction of capacity for moment redistribution in FRP-strengthened continuous RC T-beams
Due to the premature debonding of fiber-reinforced polymer (FRP) materials which results in a reduction in 14 ductility, the problem of how to exploit moment redistribution (MR) in FRP-strengthened continuous 15 reinforced...
Primary care REFerral for EchocaRdiogram (REFER) in heart failure
Clare J Taylor, Andrea K Roalfe, Rachel Iles, FD Richard Hobbs, REFER investigators, P Barton, J Deeks, D McCahon, MR Cowie, G Sutton, RC Davis, J Mant, T McDonagh, L Tait
May 02, 2018
BACKGROUND: Symptoms of breathlessness, fatigue, and ankle swelling are common in general practice but deciding which patients are likely to have heart failure is challenging. AIM: To evaluate the performance of a clinical...
clinical decision rule Diagnostic Echocardiography General Practice Heart Failure Natriuretic Peptide Adult Aged Biomarkers Clinical Protocols Dyspnea Electrocardiography England fatigue Female Heart Failure Humans Male Middle Aged Natriuretic Peptide Brain Peptide Fragments Primary Health Care Prospective Studies ROC Curve Referral and Consultation Research Design
Influence of Photoplethysmogram Signal Quality on Pulse Arrival Time during Polysomnography.
Intervals of low-quality photoplethysmogram (PPG) signals might lead to significant inaccuracies in estimation of pulse arrival time (PAT) during polysomnography (PSG) studies. While PSG is considered to be a "gold standard"...
Attachment representations and socio-emotional difficulties in alternative care
Attachment has been assessed in children living in alternative care (AC) settings, such as Residential Homes (RC) and Foster Care (FC). However, no study has been conducted to compare attachment styles in residential, foster and...
Linear mixed models for replication data to efficiently allow for covariate measurement error
It is well known that measurement error in the covariates of regression models generally causes bias in parameter estimates. Correction for such biases requires information concerning the measurement error, which is often in...
An evaluation of the Johanson model for roller compaction process development for a high dose API
Kevin M. Moroney, Patrick Cronin, Opeyemi A. Adeleye, Barbara E. Schaller, Matthew A. Howard, Bernardo Castro-Dominguez, Rohit Ramachandran, Gavin M. Walker
Apr 15, 2020
Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation for high drug load formulations can be challenging due to flow issues and a high...
2.4-Å structure of the double-ring Gemmatimonas phototrophica photosystem.
Pu Qian, Alastair T Gardiner, Ivana Šímová, Katerina Naydenova, Tristan I Croll, Philip J Jackson, Nupur, Miroslav Kloz, Petra Čubáková, Marek Kuzma, Yonghui Zeng, Pablo Castro-Hartmann, Bart van Knippenberg, Kenneth N Goldie, David Kaftan, Pavel Hrouzek, Jan Hájek, Jon Agirre, C Alistair Siebert, David Bína, Kasim Sader, Henning Stahlberg, Roman Sobotka, Christopher J Russo, Tomáš Polívka, C Neil Hunter, Michal Koblížek
Mar 19, 2022
Phototrophic Gemmatimonadetes evolved the ability to use solar energy following horizontal transfer of photosynthesis-related genes from an ancient phototrophic proteobacterium. The electron cryo-microscopy structure of the...
An evaluation of the Johanson model for roller compaction process development for a high dose API
Kevin M. Moroney, Patrick Cronin, Opeyemi A. Adeleye, Barbara E. Schaller, Matthew A. Howard, Bernardo Castro-Dominguez, Rohit Ramachandran, Gavin M. Walker
Apr 15, 2020
Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation for high drug load formulations can be challenging due to flow issues and a high...
Respiratory chain deficiency in nonmitochondrial disease.
Angela Pyle, Helen J Nightingale, Helen Griffin, Angela Abicht, Janbernd Kirschner, Ivo Baric, Mario Cuk, Konstantinos Douroudis, Lea Feder, Markus Kratz, Birgit Czermin, Stephanie Kleinle, Mauro Santibanez-Koref, Veronika Karcagi, Elke Holinski-Feder, Patrick F Chinnery, Rita Horvath
Mar 07, 2019
OBJECTIVE: In this study, we report 5 patients with heterogeneous phenotypes and biochemical evidence of respiratory chain (RC) deficiency; however, the molecular diagnosis is not mitochondrial disease. METHODS: The reported...
Linear mixed models for replication data to efficiently allow for covariate measurement error
It is well known that measurement error in the covariates of regression models generally causes bias in parameter estimates. Correction for such biases requires information concerning the measurement error, which is often in...
Attachment representations and socio-emotional difficulties in alternative care
Attachment has been assessed in children living in alternative care (AC) settings, such as Residential Homes (RC) and Foster Care (FC). However, no study has been conducted to compare attachment styles in residential, foster and...
How good are GPs at adhering to a pragmatic trial protocol in primary care? Results from the ADDITION-Cambridge cluster-randomized pragmatic trial
Objective: To assess the fidelity of general practitioners’ (GP) adherence to a long term pragmatic trial protocol.
Design: Retrospective analyses of electronic primary care records of participants in the pragmatic...
The resistance-compliance product of the pulmonary circulation varies in health and pulmonary vascular disease.
Pulmonary vascular resistance (PVR) is traditionally used to describe pulmonary hemodynamic characteristics. However, it does not take into account pulmonary artery compliance (Ca) or pulsatile flow. The product of PVR and Ca is...
HELIX-RC
Simone Campanoni, Kevin Brownell, Svilen Kanev, Timothy M Jones, Gu-Yeon Wei, David Brooks
Mar 10, 2015
Rare variants in $\textit{GP1BB}$ are responsible for autosomal dominant macrothrombocytopenia
S Sivapalaratnam, SK Westbury, JC Stephens, D Greene, K Downes, AM Kelly, C Lentaigne, WJ Astle, EG Huizinga, P Nurden, S Papadia, K Peerlinck, CJ Penkett, DJ Perry, C Roughley, I Simeoni, K Stirrups, DP Hart, RC Tait, AD Mumford, NIHR BioResource, MA Laffan, K Freson, WH Ouwehand, S Kunishima, E Turro
Jan 30, 2017
Early diagnosis of oesophageal cancer.
Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to...
Grey matter volume and cortical structure in Prader-Willi syndrome compared to typically developing young adults.
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder of genomic imprinting, presenting with a characteristic overeating disorder, mild to moderate intellectual disability, and a variable range of social and behavioral...
ACC anterior cingulate cortex Ants Advanced Normalisation Tools Software BMI body mass index CamBA Cambridge Brain Analysis software Cortical thickness FA flip angle GLM general linear model GM grey matter Genomic Imprinting Grey matter IQ intelligence quotient MPM multiparameter mapping MRI magnetic resonance imaging MT magnetisation transfer Multiparameter mapping Myelination NHS National Health Service NSPN NeuroScience in Psychiatry Network OFC orbitofrontal cortex PD proton density PFC prefrontal cortex PWS Prader-Willi syndrome PWSA UK Prader-Willi Syndrome Association UK Prader-Willi syndrome TE echo time TIV Total Intracranial volume TR repetition time UPD uniparental disomy WM white matter Adolescent Adult Body Mass Index Brain Mapping Cerebral Cortex Female Gray Matter Humans Image Processing Computer-Assisted Intelligence Tests Magnetic Resonance Imaging Male Prader-Willi syndrome Psychiatric Status Rating Scales Young Adult
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