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Transcription of the apicoplast genome
Many members of the Apicomplexa contain a remnant chloroplast, known as an apicoplast. The apicoplast encodes numerous genes, and loss of the organelle is lethal. Here, we present a summary of what is known about apicoplast...
Rapid event-related, BOLD fMRI, non-human primates (NHP)
Vassilis Pelekanos, Robert M. Mok, Olivier Joly, Matthew Ainsworth, Diana Kyriazis, Maria G. Kelly, Andrew H. Bell, Nikolaus Kriegeskorte
May 04, 2021
Abstract: Human functional magnetic resonance imaging (fMRI) typically employs the blood-oxygen-level-dependent (BOLD) contrast mechanism. In non-human primates (NHP), contrast enhancement is possible using monocrystalline...
Rapid event-related, BOLD fMRI, non-human primates (NHP)
Vassilis Pelekanos, Robert M Mok, Olivier Joly, Matthew Ainsworth, Diana Kyriazis, Maria G Kelly, Andrew H Bell, Nikolaus Kriegeskorte
May 11, 2021
Human functional magnetic resonance imaging (fMRI) typically employs the blood-oxygen-level-dependent (BOLD) contrast mechanism. In non-human primates (NHP), contrast enhancement is possible using monocrystalline iron-oxide...
Integrated Genomic and Transcriptomic Analysis of the Peridinin Dinoflagellate Amphidinium carterae Plastid.
Richard G Dorrell, R Ellen R Nisbet, Adrian C Barbrook, Stephen JL Rowden, Christopher J Howe
Jul 01, 2019
In silico identification of Theileria parva surface proteins.
East Coast Fever is a devastating African cattle disease caused by the apicomplexan parasite, Theileria parva. Little is known about the cell surface, and few proteins have been identified. Here, we take an in silico approach to...
Helminths, hosts, and their microbiota
INTRODUCTION: Evidence is emerging of complex interactions occurring between gastrointestinal (GI) parasites of ruminants and the resident gut flora, with likely implications for the pathophysiology of worm infection and...
Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs
James Rooney, Alba Cortés, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Karen Fairlie-Clarke, Tom N. McNeilly, Alasdair J. Nisbet, Cinzia Cantacessi
Apr 07, 2021
Atmospheric methane and nitrous oxide
Euan G Nisbet, Edward J Dlugokencky, Rebecca E Fisher, James L France, David Lowry, Martin R Manning, Sylvia E Michel, Nicola J Warwick
Sep 27, 2021
The causes of methane's renewed rise since 2007, accelerated growth from 2014 and record rise in 2020, concurrent with an isotopic shift to values more depleted in 13C, remain poorly understood. This rise is the dominant...
Excretory-secretory products from the brown stomach worm, Teladorsagia circumcincta, exert antimicrobial activity in in vitro growth assays
James Rooney, Timothy L Williams, Holly M Northcote, Fiona E Karet Frankl, Daniel RG Price, Alasdair J Nisbet, Russell M Morphew, Cinzia Cantacessi
Oct 02, 2022
An essential pentatricopeptide repeat protein in the apicomplexan remnant chloroplast.
Joanna L Hicks, Imen Lassadi, Emma F Carpenter, Madeleine Eno, Alexandros Vardakis, Ross F Waller, Christopher J Howe, R Ellen R Nisbet
Aug 29, 2019
The malaria parasite Plasmodium and other apicomplexans such as Toxoplasma evolved from photosynthetic organisms and contain an essential, remnant plastid termed the apicoplast. Transcription of the apicoplast genome is...
Progressive and Biased Divergent Evolution Underpins the Origin and Diversification of Peridinin Dinoflagellate Plastids.
Richard G Dorrell, Christen M Klinger, Robert J Newby, Erin R Butterfield, Elisabeth Richardson, Joel B Dacks, Christopher J Howe, Ellen R Nisbet, Chris Bowler
Sep 08, 2018
Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson's Disease.
Vanessa Penna, Niamh Moriarty, Yi Wang, Kevin CL Law, Carlos W Gantner, Richard J Williams, David R Nisbet, Clare L Parish
Apr 25, 2022
Clinical studies have provided evidence for dopamine (DA) cell replacement therapy in Parkinson's Disease. However, grafts derived from foetal tissue or pluripotent stem cells (PSCs) remain heterogeneous, with a high proportion...
Parkinson’s disease SDF1 biomaterials Dopamine Hydrogel Laminin self-assembling peptide Stem Cells stromal cell-derived factor 1 Transplantation Animals Biomimetics Cell Differentiation Chemokine CXCL12 Dopamine Dopaminergic Neurons Extracellular Matrix Fetus Hydrogels Laminin Parkinson Disease Rodentia
Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs.
James Rooney, Alba Cortés, Riccardo Scotti, Daniel RG Price, Yvonne Bartley, Karen Fairlie-Clarke, Tom N McNeilly, Alasdair J Nisbet, Cinzia Cantacessi
Mar 15, 2021
BACKGROUND: Growing evidence points towards a role of gastrointestinal (GI) helminth parasites of ruminants in modifying the composition of the host gut flora, with likely repercussions on the pathophysiology of worm infection...
Gastrointestinal helminth Microbiome Prevotella spp. Ruminant Teladorsagia circumcincta vaccine Animals Antibodies Helminth Bacteria Feces Gastrointestinal Microbiome Intestinal Diseases Parasitic Ostertagia Parasite Egg Count RNA Ribosomal 16S Reproducibility of Results Sheep Sheep Diseases Trichostrongyloidiasis Vaccination
Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs
James Rooney, Alba Cortés, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Karen Fairlie-Clarke, Tom N. McNeilly, Alasdair J. Nisbet, Cinzia Cantacessi
Nov 12, 2021
Physiological responses to moderate intensity continuous and high-intensity interval exercise in persons with paraplegia
Study design: Randomized crossover. Objectives: To test differences in the duration and magnitude of physiological response to isocaloric moderate intensity continuous (MICE) and high-intensity interval exercise (HIIE)...
Physiological responses to moderate intensity continuous and high-intensity interval exercise in persons with paraplegia
Study design: Randomized crossover. Objectives: To test differences in the duration and magnitude of physiological response to isocaloric moderate intensity continuous (MICE) and high-intensity interval exercise (HIIE)...
Genetic transformation of the dinoflagellate chloroplast.
Isabel C Nimmo, Adrian C Barbrook, Imen Lassadi, Jit Ern Chen, Katrin Geisler, Alison G Smith, Manuel Aranda, Saul Purton, Ross F Waller, R Ellen R Nisbet, Christopher J Howe
Jul 15, 2019
Coral reefs are some of the most important and ecologically diverse marine environments. At the base of the reef ecosystem are dinoflagellate algae, which live symbiotically within coral cells. Efforts to understand the...
Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts.
Alba Cortés, John Wills, Xiaopei Su, Rachel E Hewitt, Jack Robertson, Riccardo Scotti, Daniel RG Price, Yvonne Bartley, Tom N McNeilly, Lutz Krause, Jonathan J Powell, Alasdair J Nisbet, Cinzia Cantacessi
Feb 25, 2020
BACKGROUND: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships. In spite...
Automated in situ cell counting Bacterial 16S rRNA gene sequencing Gastrointestinal helminth Gut microbiota Parasite gastroenteritis Pathobiont T cell Teladorsagia circumcincta vaccine Animals Bacteria Feces Gastrointestinal Microbiome Intestinal Diseases Parasitic Nematode Infections Sheep Trichostrongyloidea
Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts
Alba Cortés, John Wills, Xiaopei Su, Rachel E. Hewitt, Jack Robertson, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Tom N. McNeilly, Lutz Krause, Jonathan J. Powell, Alasdair J. Nisbet, Cinzia Cantacessi
Jun 06, 2020
Abstract: Background: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships....
Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts
Alba Cortés, John Wills, Xiaopei Su, Rachel E. Hewitt, Jack Robertson, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Tom N. McNeilly, Lutz Krause, Jonathan J. Powell, Alasdair J. Nisbet, Cinzia Cantacessi
Apr 30, 2021
Abstract: Background: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships....
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