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LeMMINGs - IV. The X-ray properties of a statistically complete sample of the nuclei in active and inactive galaxies from the Palomar sample
DRA Williams, M Pahari, RD Baldi, IM McHardy, S Mathur, RJ Beswick, A Beri, P Boorman, S Aalto, A Alberdi, MK Argo, BT Dullo, DM Fenech, DA Green, JH Knapen, I Martí-Vidal, J Moldon, CG Mundell, TWB Muxlow, F Panessa, M Pérez-Torres, P Saikia, F Shankar, IR Stevens, P Uttley
Nov 22, 2021
All 280 of the statistically-complete Palomar sample of nearby (<120 Mpc)
galaxies dec > 20 degrees have been observed at 1.5 GHz as part of the LeMMINGs
e-MERLIN legacy survey. Here, we present Chandra X-ray observations of...
Antimicrobial and Cell-Penetrating Peptides
Andreas Hadjicharalambous, Nikolaos Bournakas, Hector Newman, Michael J Skynner, Paul Beswick
Dec 08, 2022
Antimicrobial and Cell-Penetrating Peptides
Andreas Hadjicharalambous, Nikolaos Bournakas, Hector Newman, Michael J Skynner, Paul Beswick
Dec 24, 2022
Antimicrobial peptides (AMPs) are short oligopeptides that can penetrate the bacterial inner and outer membranes. Together with cell-penetrating peptides (CPPs), they are called membrane active peptides; peptides which can...
Nonparametric, tuning-free estimation of S-shaped functions
We consider the nonparametric estimation of an S-shaped regression function.
The least squares estimator provides a very natural, tuning-free approach, but
results in a non-convex optimisation problem, since the inflection point...
A challenge finding P2X1 and P2X4 ligands.
Paul Beswick, Ben Wahab, Mark A Honey, Michael Paradowski, Ke Jiang, Martin Lochner, Ruth D Murrell-Lagnado, Andrew J Thompson
Jul 05, 2019
Identifying novel small-molecule P2X1 and P2X4 ligands with sub-type specificity and high-affinity remains a pharmacological challenge. Here we use computational methods, electrophysiology and fluorescent microplate assays to...
Agonist Antagonist Function Ion channel ligand Microplate P2X1 P2X4 screen Two-electrode voltage clamp Animals Biguanides Cells Cultured Computer Simulation Drug Discovery Humans Ligands Molecular Docking Simulation Oocytes Patch-Clamp Techniques Purinergic Agonists Purinergic Antagonists Receptors Purinergic P2X1 Receptors Purinergic P2X4 Structure-Activity Relationship Xenopus laevis
A web-database of mammalian morphology and a reanalysis of placental phylogeny
RJ Asher
Jun 13, 2011
Background: Recent publications concerning the interordinal phylogeny of placental mammals have converged on a common signal, consisting of four major radiations with some ambiguity regarding the placental root. The DNA data...
Is statistical learning a mechanism?
RJ Betzler
Jan 25, 2016
The Authenticity of Demosthenes 13, Again
RJ Sing
Mar 07, 2017
The deliberative speech known by us as On Organization (Περὶ συντάξεως) focusses on financial organization and political economy more than any other speech in the Demosthenic corpus. The assembly is to decide the fate of an...
Seeking contact
RJ McVey
Dec 26, 2022
High-dimensional change point estimation via sparse projection
Changepoints are a very common feature of Big Data that arrive in the form of a data stream. In this paper, we study high-dimensional time series in which, at certain time points, the mean structure changes in a sparse subset...
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