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The importance of values in evidence-based medicine
Abstract
Background
Evidence-based medicine (EBM) has always required integration of patient values with ‘best’ clinical evidence. It is widely recognized that scientific practices...
Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions
The suitability of using the selectivity factor, s, as a metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC...
Referral management centres as a means of reducing outpatients attendances
BACKGROUND: The rising volume of referrals to secondary care is a continuing concern in the NHS in England, with considerable resource implications. Referral management centres (RMCs) are one of a range of initiatives brought in...
Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions
The suitability of using the selectivity factor, s, as a metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC...
The UK EndoVascular Aneurysm Repair (EVAR) randomised controlled trials
Rajesh Patel, Janet T Powell, Michael J Sweeting, David M Epstein, Jessica K Barrett, Roger M Greenhalgh
Apr 04, 2018
Aged Aged 80 and over Aortic Aneurysm Abdominal Cost-Benefit Analysis Endovascular Procedures Female Follow-Up Studies Humans Male Middle Aged Postoperative Complications Proportional Hazards Models Quality-Adjusted Life Years Technology Assessment Biomedical Tomography X-Ray Computed United Kingdom
Frameworks for supporting patient and public involvement in research
Trisha Greenhalgh, Lisa Hinton, Teresa Finlay, Alastair Macfarlane, Nick Fahy, Ben Clyde, Alan Chant
Mar 09, 2020
BACKGROUND: Numerous frameworks for supporting, evaluating and reporting patient and public involvement in research exist. The literature is diverse and theoretically heterogeneous. OBJECTIVES: To identify and synthesize...
Development of directed global inhibition, competitive inhibition and behavioural inhibition during the transition between infancy and toddlerhood.
Alexandra Hendry, Isobel Greenhalgh, Rhiannon Bailey, Abigail Fiske, Henrik Dvergsdal, Karla Holmboe
Dec 24, 2021
Inhibitory control (IC) is a core executive function integral to self-regulation and cognitive control, yet is itself multi-componential. Directed global inhibition entails stopping an action on demand. Competitive inhibition is...
Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa.
Yassmin Abdelhamid, Paul Brear, Jack Greenhalgh, Xavier Chee, Taufiq Rahman, Martin Welch
Aug 29, 2019
Entner-Doudoroff Pathway Pseudomonas Pseudomonas aeruginosa PykA X-ray crystallography allostery bacterial metabolism Glycolysis pentose phosphate pathway (PPP) Pyruvate Kinase Allosteric Regulation Allosteric Site Bacterial Proteins Catalytic Domain Glucose-6-Phosphate Isoenzymes Models Molecular pentose phosphate pathway Pseudomonas aeruginosa Pyruvate Kinase
Covid-19 in the UK
Deepti Gurdasani, Christina Pagel, Martin McKee, Susan Michie, Trisha Greenhalgh, Kit Yates, Gabriel Scally, Hisham Ziauddeen
Aug 31, 2022
Key messages
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
JT Powell, MJ Sweeting, P Ulug, JD Blankensteijn, FA Lederle, J-P Becquemin, RM Greenhalgh, DREAM, OVER and ACE Trialists EVAR-1
Nov 13, 2017
BACKGROUND: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS: An...
Comparative clinical effectiveness and cost effectiveness of endovascular strategy vs open repair for ruptured abdominal aortic aneurysm
MJ Sweeting, P Ulug, MJ Sweeting, M Gomes, RJ Hinchliffe, MM Thompson, SG Thompson, R Grieve, RM Greenhalgh
Nov 18, 2017
Aged Aneurysm Ruptured Aortic Aneurysm Abdominal Canada Cause of Death Cost-Benefit Analysis Endovascular Procedures Female Health Care Costs Humans Kaplan-Meier Estimate Logistic Models Male Middle Aged Outcome Assessment Health Care Postoperative Complications Proportional Hazards Models Quality-Adjusted Life Years Risk Assessment Survival Analysis United Kingdom Vascular Surgical Procedures
Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair
Michael J Sweeting, Rajesh Patel, Janet T Powell, Roger M Greenhalgh, EVAR Trial Investigators
Dec 06, 2017
OBJECTIVE: The aim of the study was to compare long-term total and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) randomized to either early endovascular aneurysm repair (EVAR) or...
Unanticipated Silyl Transfer in Enantioselective α,β-Unsaturated Acyl Ammonium Catalysis Using Silyl Nitronates
Anastassia Matviitsuk, Mark D. Greenhalgh, James E. Taylor, Xuan B. Nguyen, David B. Cordes, Alexandra M.Z. Slawin, David W. Lupton, Andrew D. Smith
Jan 03, 2020
The use of silyl nitronates is reported for the isothiourea-catalyzed synthesis of γ-nitro-substituted silyl esters containing up to two contiguous stereocenters in good yields with excellent enantioselectivities (up to 93%...
Anomalously Large Spectral Shifts near the Quantum Tunnelling Limit in Plasmonic Rulers with Subatomic Resolution.
Charlie Readman, Bart de Nijs, István Szabó, Angela Demetriadou, Ryan Greenhalgh, Colm Durkan, Edina Rosta, Oren A Scherman, Jeremy J Baumberg
Feb 15, 2019
The resonance wavelength of a coupled plasmonic system is extremely sensitive to the distance between its metallic surfaces, resulting in "plasmon rulers". We explore this behavior in the subnanometer regime using self-assembled...
Unanticipated Silyl Transfer in Enantioselective α,β-Unsaturated Acyl Ammonium Catalysis Using Silyl Nitronates
Anastassia Matviitsuk, Mark D. Greenhalgh, James E. Taylor, Xuan B. Nguyen, David B. Cordes, Alexandra M.Z. Slawin, David W. Lupton, Andrew D. Smith
Jan 03, 2020
The use of silyl nitronates is reported for the isothiourea-catalyzed synthesis of γ-nitro-substituted silyl esters containing up to two contiguous stereocenters in good yields with excellent enantioselectivities (up to 93%...
Effective cell membrane tension is independent of polyacrylamide substrate stiffness
Eva Kreysing, Jeffrey Mc Hugh, Sarah K Foster, Kurt Andresen, Ryan D Greenhalgh, Eva Pillai, Andrea Dimitracopoulos, Ultrich Keyser, Kristian Franze
Mar 05, 2023
Most animal cells are surrounded by a cell membrane and an underlying actomyosin cortex. Both structures are linked, and they are under tension. In-plane membrane tension and cortical tension both influence many cellular...
Covid-19 in the UK
Deepti Gurdasani, Christina Pagel, Martin McKee, Susan Michie, Trisha Greenhalgh, Kit Yates, Gabriel Scally, Hisham Ziauddeen
Aug 31, 2022
Key messages
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
Pandemic policy on children and schools reflected UK based scientific narratives that did not align with global scientific consensus
Government relied on evidence that downplayed the seriousness of covid-19...
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