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Results: 98
Ventriculo-arterial coupling detects occult RV dysfunction in chronic thromboembolic pulmonary vascular disease.
Richard G Axell, Simon J Messer, Paul A White, Colm McCabe, Andrew Priest, Thaleia Statopoulou, Maja Drozdzynska, Jamie Viscasillas, Elizabeth C Hinchy, James Hampton-Till, Hatim I Alibhai, Nicholas Morrell, Joanna Pepke-Zaba, Stephen R Large, Stephen P Hoole
Jun 20, 2018
Chronic thromboembolic disease (CTED) is suboptimally defined by a mean pulmonary artery pressure (mPAP) <25 mmHg at rest in patients that remain symptomatic from chronic pulmonary artery thrombi. To improve identification of...
Chronic thromboembolic disease Chronic thromboembolic pulmonary hypertension right ventricular dysfunction ventriculo‐arterial coupling Adult Aged Animals Chronic Disease Female Humans Hypertension Pulmonary Male Middle Aged Pulmonary Circulation pulmonary embolism Swine Ventricular Dysfunction Right
Neoadjuvant FOLFIRI+bevacizumab in patients with resectable liver metastases from colorectal cancer
G Nasti, MC Piccirillo, F Izzo, A Ottaiano, V Albino, P Delrio, C Romano, P Giordano, S Lastoria, C Caracò, E de Lutio di Castelguidone, R Palaia, G Daniele, L Aloj, G Romano, RV Iaffaioli
Dec 21, 2018
BACKGROUND: Preoperative treatment of resectable liver metastases from colorectal cancer (CRC) is a matter of debate. The aim of this study was to assess the feasibility and activity of bevacizumab plus FOLFIRI in this setting....
Adult Aged Antibodies Monoclonal Humanized Antineoplastic Combined Chemotherapy Protocols Bevacizumab camptothecin Chemotherapy Adjuvant Colorectal Neoplasms Disease-Free Survival Female Fluorouracil Humans Kaplan-Meier Estimate Leucovorin Liver Neoplasms Male Middle Aged Neoadjuvant Therapy Survival Rate
Viroplasms
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers...
Crispr-Csy4 Genome Editing Nsp2 Nsp5 liquid-liquid phase separation Protein-Rna Condensates Replication Cycle Reverse Genetics Rotavirus Viroplasm Animals Capsid Proteins Cytoplasm Cytosol Humans Phosphorylation RNA-Binding Proteins Rotavirus Rotavirus Infections Viral Nonstructural Proteins Viral Replication Compartments Virus Assembly Virus Replication
Viroplasms
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers...
Unsigned Magnetic Flux as a Proxy for Radial-velocity Variations in Sun-like Stars
RD Haywood, TW Milbourne, SH Saar, A Mortier, D Phillips, D Charbonneau, AC Cameron, HM Cegla, N Meunier, MLP Iii
Aug 08, 2022
We estimate disc-averaged RV variations of the Sun over the last magnetic
cycle, from the single Fe I line observed by SDO/HMI, using a physical model
for rotationally modulated magnetic activity that was previously...
Testing the consistency of dust laws in SN Ia host galaxies
Abstract
We apply BayeSN, our new hierarchical Bayesian model for the SEDs of Type Ia supernovae (SNe Ia), to analyse the griz light curves of 157 nearby SNe Ia (0.015 < z...
Viroplasms
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers...
Reverse Genetics Rotavirus Replication Cycle Nsp2 liquid-liquid phase separation Viroplasm Protein-Rna Condensates Nsp5 Crispr-Csy4 Genome Editing
Published by: Viruses
Identifying Exoplanets with Deep Learning. IV. Removing Stellar Activity Signals from Radial Velocity Measurements Using Neural Networks
ZL De Beurs, A Vanderburg, CJ Shallue, X Dumusque, AC Cameron, C Leet, LA Buchhave, R Cosentino, A Ghedina, RD Haywood, N Langellier, DW Latham, M López-Morales, M Mayor, G Micela, TW Milbourne, A Mortier, E Molinari, F Pepe, DF Phillips, M Pinamonti, G Piotto, K Rice, D Sasselov, A Sozzetti, S Udry, CA Watson
Jul 14, 2022
Exoplanet detection with precise radial velocity (RV) observations is
currently limited by spurious RV signals introduced by stellar activity. We
show that machine learning techniques such as linear regression and...
Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/- hearts.
Y Zhang, L Guzadhur, K Jeevaratnam, SC Salvage, GDK Matthews, WJ Lammers, M Lei, CL-H Huang, JA Fraser
Jul 03, 2020
AIM: To test a hypothesis attributing arrhythmia in Brugada Syndrome to right ventricular (RV) outflow tract (RVOT) conduction abnormalities arising from Nav 1.5 insufficiency and fibrotic change. METHODS: Arrhythmic properties...
Brugada Syndrome Na+ channel conduction velocity right ventricular outflow tract Action Potentials Animals Arrhythmias Cardiac Blotting Western Brugada Syndrome Disease Models Animal Electrophysiology Female Heart Heart Conduction System Male Mice Mice Mutant Strains NAV1.5 Voltage-Gated Sodium Channel Organ Culture Techniques
Challenges in the Identification of 'the General Principles of Law Recognized by Civilized Nations'
RV Yotova
Oct 22, 2019
This article reassesses the legal character of 'the general principles of law recognized by civilized nations', being one of the two unwritten sources of international law. The general principles of law are, however, the most...
Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling.
Jonathan R Weir-McCall, Patrick Sk Liu-Shiu-Cheong, Allan D Struthers, Brian J Lipworth, J Graeme Houston
Oct 03, 2019
BACKGROUND: Pulmonary pulse wave velocity (PWV) allows the non-invasive measurement of pulmonary arterial stiffening, but has not previously been assessed in COPD. The aim of the current study was to assess PWV in COPD and its...
Heart Ventricles Magnetic Resonance Imaging Pulmonary arteries Pulmonary Disease Chronic Obstructive Pulse-wave analysis Aged Female Heart Ventricles Humans Magnetic Resonance Imaging Male Middle Aged Pulmonary Artery Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Respiratory Function Tests Ventricular Remodeling
Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago
Apr 01, 2021
Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties...
A Comparative Study of Systolic and Diastolic Mechanical Synchrony in Canine, Primate, and Healthy and Failing Human Hearts.
Tiangang Zhu, Ming Lei, Zhilong Wang, Rongli Zhang, Yan Zhang, Wenying Jin, Chao Yu, Christopher L-H Huang, Dongyue Liu, Wen Zheng, Yuli Liu, Xin Quan, Lingyun Kong, Siying Liang, Xiuqin Zhang
Nov 12, 2021
Aim: Mechanical dyssynchrony (MD) is associated with heart failure (HF) and may be prognostically important in cardiac resynchronization therapy (CRT). Yet, little is known about its patterns in healthy or diseased hearts. We...
Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction.
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago
Jun 18, 2021
Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties...
The resistance-compliance product of the pulmonary circulation varies in health and pulmonary vascular disease.
Pulmonary vascular resistance (PVR) is traditionally used to describe pulmonary hemodynamic characteristics. However, it does not take into account pulmonary artery compliance (Ca) or pulsatile flow. The product of PVR and Ca is...
Inkjet printing infiltration of Ni-Gd
ABSTRACT: The effect of inkjet printing infiltration of Gd0.1Ce0.9O2-x in NiO-Gd0.1Ce0.9O2-x anodes on the performance of symmetrical and button cells was investigated. The anodes were fabricated by inkjet printing of suspension...
The EXPRES Stellar Signals Project II. State of the Field in Disentangling Photospheric Velocities
Lily L. Zhao, Debra A. Fischer, Eric B. Ford, Alex Wise, Michaël Cretignier, Suzanne Aigrain, Oscar Barragan, Megan Bedell, Lars A. Buchhave, João D. Camacho, Heather M. Cegla, Jessi Cisewski-Kehe, Andrew Collier Cameron, Zoe L. de Beurs, Sally Dodson-Robinson, Xavier Dumusque, João P. Faria, Christian Gilbertson, Charlotte Haley, Justin Harrell, David W. Hogg, Parker Holzer, Ancy Anna John, Baptiste Klein, Marina Lafarga, Florian Lienhard, Vinesh Maguire-Rajpaul, Annelies Mortier, Belinda Nicholson, Michael L., III Palumbo, Victor Ramirez Delgado, Christopher J. Shallue, Andrew Vanderburg, Pedro T. P. Viana, Jinglin Zhao, Norbert Zicher, Samuel H. C. Cabot, Gregory W. Henry, Rachael M. Roettenbacher, John M. Brewer, Joe Llama, Ryan R. Petersburg, Andrew E. Szymkowiak
Mar 15, 2022
Abstract: Measured spectral shifts due to intrinsic stellar variability (e.g., pulsations, granulation) and activity (e.g., spots, plages) are the largest source of error for extreme-precision radial-velocity (EPRV) exoplanet...
Unmasking the hidden NGTS-3Ab
Maximilian N Günther, Didier Queloz, Edward Gillen, Laetitia Delrez, Francois Bouchy, James McCormac, Barry Smalley, Yaseen Almleaky, David J Armstrong, Daniel Bayliss, Artem Burdanov, Matthew Burleigh, Juan Cabrera, Sarah L Casewell, Benjamin F Cooke, Szillard Csizmadia, Elsa Ducrot, Philipp Eigmueller, Anders Erikson, Boris T Gaensicke, Neale P Gibson, Michael Gillon, Michael R Goad, Emmanuel Jehin, James S Jenkins, Tom Louden, Maximiliano Moyano, Catriona Murray, Don Pollacco, Katja Poppenhaeger, Heike Rauer, Liam Raynard, Alexis MS Smith, Sandrine Sohy, Samantha J Thompson, Stephane Udry, Christopher A Watson, Richard G West, Peter J Wheatley
Jan 09, 2019
We present the discovery of NGTS-3Ab, a hot Jupiter found transiting the
primary star of an unresolved binary system. We develop a joint analysis of
multi-colour photometry, centroids, radial velocity (RV)...
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.
Denise van Uden, Thomas Koudstaal, Jennifer AC van Hulst, Ingrid M Bergen, Chelsea Gootjes, Nicholas W Morrell, Geert van Loo, Jan H von der Thüsen, Thierry PP van den Bosch, Maria-Rosa Ghigna, Frédéric Perros, David Montani, Mirjam Kool, Karin A Boomars, Rudi W Hendriks
Apr 26, 2021
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old...
BMPR2 Tnfaip3 Toll-like receptor Dendritic Cells Inflammation pulmonary arterial hypertension Animals Bone Morphogenetic Protein Receptors Type II Dendritic Cells Familial Primary Pulmonary Hypertension Gene Deletion Heart Ventricles Humans Immunity Innate Mice Mutation Toll-Like Receptor 4 Tumor Necrosis Factor alpha-Induced Protein 3
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