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Results: 51
Engineering the protein dynamics of an ancestral luciferase.
Andrea Schenkmayerova, Gaspar P Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T Bornscheuer, Jiri Damborsky
Jul 28, 2021
Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral protein...
NIH 3T3 Cells Animals Mammals Mice Luciferases Luciferases Renilla Protein Engineering Enzyme Stability Temperature Mutagenesis Binding Sites Protein Conformation Kinetics Mutation Catalysis Molecular Dynamics Simulation
Published by: Nature Communications
Engineering the protein dynamics of an ancestral luciferase.
Andrea Schenkmayerova, Gaspar P Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T Bornscheuer, Jiri Damborsky
Jul 05, 2021
Engineering the protein dynamics of an ancestral luciferase
Andrea Schenkmayerova, Gaspar P. Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T. Bornscheuer, Jiri Damborsky
Jun 14, 2021
Abstract: Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral...
Improving local prevalence estimates of SARS-CoV-2 infections using a causal debiasing framework
Improving local prevalence estimates of SARS-CoV-2 infections using a causal debiasing framework.
George Nicholson, Brieuc Lehmann, Tullia Padellini, Koen B Pouwels, Radka Jersakova, James Lomax, Ruairidh E King, Ann-Marie Mallon, Peter J Diggle, Sylvia Richardson, Marta Blangiardo, Chris Holmes
Feb 01, 2022
Improving local prevalence estimates of SARS-CoV-2 infections using a causal debiasing framework.
CYP2D6 gene variants
Jean E Abraham, Mel J Maranian, Kristy E Driver, Radka Platte, Bolot Kalmyrzaev, Caroline Baynes, Craig Luccarini, Mitul Shah, Susan Ingle, David Greenberg, Helena M Earl, Alison M Dunning, Paul DP Pharoah, Carlos Caldas
Jun 17, 2011
Adult Aged Antineoplastic Agents Hormonal Breast Neoplasms Chemotherapy Adjuvant Cohort Studies Cytochrome P-450 CYP2D6 Female Gene Frequency Genotype Humans Middle Aged Polymorphism Single Nucleotide Proportional Hazards Models Survival Analysis Tamoxifen Treatment Outcome United Kingdom Young Adult
Highlights from ASCO-GI 2021 from EORTC Gastrointestinal tract cancer group.
Thibaud Koessler, Maria Alsina, Dirk Arnold, Irit Ben-Aharon, Manfred P Lutz, Radka Obermannova, Mark Peeters, Francesco Sclafani, Elizabeth Smyth, Juan W Valle, Anna Dorothea Wagner, Lucjan Wyrwicz, Elisa Fontana, Markus Moehler
Sep 24, 2021
Last year the field of immunotherapy was finally introduced to GI oncology, with several changes in clinical practice such as advanced hepatocellular carcinoma or metastatic colorectal MSI-H. At the virtual ASCO-GI symposium...
Published by: British journal of cancer
Highlights from ASCO-GI 2021 from EORTC Gastrointestinal tract cancer group.
Thibaud Koessler, Maria Alsina, Dirk Arnold, Irit Ben-Aharon, Manfred P Lutz, Radka Obermannova, Mark Peeters, Francesco Sclafani, Elizabeth Smyth, Juan W Valle, Anna Dorothea Wagner, Lucjan Wyrwicz, Elisa Fontana, Markus Moehler
Sep 28, 2021
Last year the field of immunotherapy was finally introduced to GI oncology, with several changes in clinical practice such as advanced hepatocellular carcinoma or metastatic colorectal MSI-H. At the virtual ASCO-GI symposium...
Time varying association between deprivation, ethnicity and SARS-CoV-2 infections in England
Tullia Padellini, Radka Jersakova, Peter J Diggle, Chris Holmes, Ruairidh E King, Brieuc CL Lehmann, Ann-Marie Mallon, George Nicholson, Sylvia Richardson, Marta Blangiardo
Mar 28, 2022
BACKGROUND: Ethnically diverse and socio-economically deprived communities have been differentially affected by the COVID-19 pandemic in the UK. METHOD: Using a multilevel regression model we assessed the time-varying...
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Belinda M Kumpel, Radka Saldova, Carolien AM Koeleman, Jodie L Abrahams, Agnes Hipgrave Ederveen, Kathryn L Armour, Natalia I Olovnikova, Gestur Vidarsson, Rick Kapur, Pauline M Rudd, Manfred Wuhrer
Jan 29, 2021
Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays...
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Belinda M Kumpel, Radka Saldova, Carolien A M Koeleman, Jodie L Abrahams, Agnes Hipgrave Ederveen, Kathryn L Armour, Natalia I Olovnikova, Gestur Vidarsson, Rick Kapur, Pauline M Rudd, Manfred Wuhrer
Mar 02, 2020
Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays...
Published by: Scientific reports
Carolina Bonilla, Sarah J Lewis, Mari-Anne Rowlands, Tom R Gaunt, George Davey Smith, David Gunnell, Tom Palmer, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Grönberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Mark Lathrop, Richard M Martin, Jeff MP Holly
May 17, 2016
ALSPAC IGFBP3 Mendelian randomization PRACTICAL ProtecT UKHLS insulin-like growth factor-binding proteins insulin-like growth factors prostate cancer SINGLE NUCLEOTIDE POLYMORPHISMS Aged Case-Control Studies Genome-Wide Association Study Humans Insulin-Like Growth Factor Binding Proteins Longitudinal Studies Male Mendelian Randomization Analysis Middle Aged Neoplasm Grading Neoplasm Staging Polymorphism Single Nucleotide Prostatic Neoplasms Somatomedins United Kingdom
Height, selected genetic markers and prostate cancer risk
Artitaya Lophatananon, Sarah Stewart-Brown, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Liesel M Fitzgerald, Melissa C Southey, Paul Pharoah, Nora Pashayan, Henrik Gronberg, Fredrik Wiklund, Markus Aly, Janet L Stanford, Hermann Brenner, Aida K Dieffenbach, Volker Arndt, Jong Y Park, Hui-Yi Lin, Thomas Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Amanda Spurdle, Judith A Clements, APCB BioResource, PRACTICAL Consortium, Douglas Easton, Rosalind A Eeles, Kenneth Muir
Dec 07, 2018
This corrects the article DOI: 10.1038/bjc.2017.231.
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Hui-Yi Lin, Po-Yu Huang, Dung-Tsa Chen, Heng-Yuan Tung, Thomas A Sellers, Julio M Pow-Sang, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Freddie Hamdy, David E Neal, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Yong-Jie Lu, PRACTICAL Consortium, Jong Y Park
Sep 21, 2018
MOTIVATION: The use of single nucleotide polymorphism (SNP) interactions to predict complex diseases is getting more attention during the past decade, but related statistical methods are still immature. We previously proposed...
Polyunsaturated fatty acids and prostate cancer risk
Nikhil K Khankari, Harvey J Murff, Chenjie Zeng, Wanqing Wen, Rosalind A Eeles, Douglas F Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Jenny L Donovan, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Wei Zheng, PRACTICAL Consortium
Dec 01, 2017
BACKGROUND: Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been...
Height, selected genetic markers and prostate cancer risk
Artitaya Lophatananon, Sarah Stewart-Brown, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Liesel M Fitzgerald, Melissa C Southey, Paul Pharoah, Nora Pashayan, Henrik Gronberg, Fredrik Wiklund, Markus Aly, Janet L Stanford, Hermann Brenner, Aida K Dieffenbach, Volker Arndt, Jong Y Park, Hui-Yi Lin, Thomas Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Amanda Spurdle, Judith A Clements, APCB BioResource, PRACTICAL Consortium, Douglas Easton, Rosalind A Eeles, Kenneth Muir
Dec 08, 2017
BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed data...
Urban and rural differences in frequency of fruit, vegetable, and soft drink consumption among 6–9-year-old children from 19 countries from the WHO European region
Mirjam M. Heinen, Silvia Bel-Serrat, Cecily C. Kelleher, Marta Buoncristiano, Angela Spinelli, Paola Nardone, Sanja Musić Milanović, Ana Isabel Rito, A. Tülay Bağci Bosi, Enrique Gutiérrrez-González, Iveta Pudule, Shynar Abdrakhmanova, Zulfiya Abdurrahmonova, Lacramioara Aurelia Brinduse, Alexandra Cucu, Vesselka Duleva, Anna Fijałkowska, Andrea Gualtieri, Tatjana Hejgaard, Jolanda Hyska, Enisa Kujundžić, Ausra Petrauskiene, Elena Sacchini, Lela Shengelia, Maya Tanrygulyyeva, Zhamilya Usupova, Ingunn Holden Bergh, Daniel Weghuber, Radka Taxová Braunerová, Marie Kunešová, Victoria Farrugia Sant'Angelo, Eha Nurk, Sergej M. Ostojic, Igor Spiroski, Ľubica Tichá, Harry Rutter, Julianne Williams, Khadichamo Boymatova, Ivo Rakovac, Martin W. Weber, João Breda
Nov 30, 2021
In order to address the paucity of evidence on the association between childhood eating habits and urbanization, this cross-sectional study describes urban–rural differences in frequency of fruit, vegetable, and soft drink...
children Fruit rural soft drinks urban Vegetables /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.
Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Ali Amin Al Olama, Sara Benlloch, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Borge G Nordestgaard, Ruth C Travis, David Neal, Nora Pasayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Koveela Govindasami, Ken Muir, UK Genetic Prostate Cancer Study Collaborators, UK ProtecT Study Collaborators, PRACTICAL Consortium, Douglas F Easton, Rosalind A Eeles, Zsofia Kote-Jarai
May 13, 2016
BRCA1 Protein Case-Control Studies Cell Cycle Proteins DNA DNA Repair DNA Repair Enzymes DNA-Binding Proteins Genes BRCA2 Genetic Predisposition to Disease Genome-Wide Association Study Genotype Germ-Line Mutation Humans Male Polymorphism Single Nucleotide Prospective Studies Prostatic Neoplasms risk
SNP interaction pattern identifier (SIPI)
Hui-Yi Lin, Dung-Tsa Chen, Po-Yu Huang, Yung-Hsin Liu, Augusto Ochoa, Jovanny Zabaleta, Donald E Mercante, Zhide Fang, Thomas A Sellers, Julio M Pow-Sang, Chia-Ho Cheng, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Freddie Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Yong-Jie Lu, PRACTICAL Consortium, Jong Y Park
Jan 12, 2017
KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness.
Hui-Yi Lin, Po-Yu Huang, Chia-Ho Cheng, Heng-Yuan Tung, Zhide Fang, Anders E Berglund, Ann Chen, Jennifer French-Kwawu, Darian Harris, Julio Pow-Sang, Kosj Yamoah, John L Cleveland, Shivanshu Awasthi, Robert J Rounbehler, Travis Gerke, Jasreman Dhillon, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, UKGPCS collaborators, Johanna Schleutker, Nora Pashayan, APCB (Australian Prostate Cancer BioResource), David E Neal, Sune F Nielsen, Børge G Nordestgaard, Henrik Gronberg, Fredrik Wiklund, Graham G Giles, Christopher A Haiman, Ruth C Travis, Janet L Stanford, Adam S Kibel, Cezary Cybulski, Kay-Tee Khaw, Christiane Maier, Stephen N Thibodeau, Manuel R Teixeira, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Hardev Pandha, PRACTICAL Consortium, Srilakshmi Srinivasan, Judith Clements, Jyotsna Batra, Jong Y Park
Apr 29, 2021
Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. To identify SNP-SNP...
Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.
Amy E Taylor, Richard M Martin, Milan S Geybels, Janet L Stanford, Irene Shui, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Nora Pashayan, Kay-Tee Khaw, William Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Jenny Donovan, Marcus R Munafò
Oct 26, 2016
Alcohol consumption and prostate cancer incidence and progression
Clair Brunner, Neil M Davies, Richard M Martin, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Jenny Donovan, Freddie C Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Luisa Zuccolo
Sep 22, 2016
Mendelian randomisation Alcohol alcohol metabolising genes prostate cancer Aged Aged 80 and over Alcohol Drinking Aldehyde Dehydrogenase Aldehyde Dehydrogenase 1 Family Aldehyde Dehydrogenase Mitochondrial Case-Control Studies Disease Progression Humans Incidence Linkage Disequilibrium Male Middle Aged Neoplasm Grading Polymorphism Single Nucleotide Prostatic Neoplasms Regression Analysis Retinal Dehydrogenase Survival Analysis
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