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Inducing High Ionic Conductivity in the Lithium Superionic Argyrodites Li<sub>6+<i>x</i></sub>P<sub>1-<i>x</i></sub>Ge<sub><i>x</i></sub>S<sub>5</sub>I for All-Solid-State Batteries
Marvin Kraft, Saneyuki Ohni, Tatiana Zinkevich, Raimund Koerver, Sean Culver, Till Fuchs, Anatoliy Senyshyn, Sylvio Indris, Benjamin Morgan, Wolfgang Zeier
Nov 28, 2018
Solid-state batteries with inorganic solid electrolytes are currently being discussed as a more reliable and safer future alternative to the current lithium-ion battery technology. To compete with state-of-the-art lithium-ion...
Inducing High Ionic Conductivity in the Lithium Superionic Argyrodites Li<sub>6+<i>x</i></sub>P<sub>1-<i>x</i></sub>Ge<sub><i>x</i></sub>S<sub>5</sub>I for All-Solid-State Batteries
Marvin Kraft, Saneyuki Ohni, Tatiana Zinkevich, Raimund Koerver, Sean Culver, Till Fuchs, Anatoliy Senyshyn, Sylvio Indris, Benjamin Morgan, Wolfgang Zeier
Nov 28, 2018
Solid-state batteries with inorganic solid electrolytes are currently being discussed as a more reliable and safer future alternative to the current lithium-ion battery technology. To compete with state-of-the-art lithium-ion...
Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury
Cecilia AI Åkerlund, Joseph Donnelly, Frederick A Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W Nelson, CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators
Nov 25, 2020
Magnitude of intracranial pressure (ICP) elevations and their duration have been associated with worse outcomes in patients with traumatic brain injuries (TBI), however published thresholds for injury vary and uncertainty about...
Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic
Andrea Lavinio, Ari Ercole, Denise Battaglini, Sandra Magnoni, Rafael Badenes, Fabio Silvio Taccone, Raimund Helbok, William Thomas, Paolo Pelosi, Chiara Robba, collaborators
Mar 15, 2021
INTRODUCTION: Critical illness from SARS-CoV-2 infection (COVID-19) is associated with a high burden of pulmonary embolism (PE) and thromboembolic events despite standard thromboprophylaxis. Available guidance is discordant...
Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury
Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury
Cecilia AI Åkerlund, Joseph Donnelly, Frederick A. Zeiler, Raimund Helbok, Anders Holst, Manuel Cabeleira, Fabian Güiza, Geert Meyfroidt, Marek Czosnyka, Peter Smielewski, Nino Stocchetti, Ari Ercole, David W. Nelson, the CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators
Dec 22, 2020
Magnitude of intracranial pressure (ICP) elevations and their duration have been associated with worse outcomes in patients with traumatic brain injuries (TBI), however published thresholds for injury vary and uncertainty about...
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jul 22, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
Prediction of individualized lifetime benefit from cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people.
Nicole EM Jaspers, Michael J Blaha, Kunihiro Matsushita, Yvonne T van der Schouw, Nicholas J Wareham, Kay-Tee Khaw, Marie H Geisel, Nils Lehmann, Raimund Erbel, Karl-Heinz Jöckel, Yolanda van der Graaf, WM Monique Verschuren, Jolanda MA Boer, Vijay Nambi, Frank LJ Visseren, Jannick AN Dorresteijn
Aug 07, 2019
AIMS: The benefit an individual can expect from preventive therapy varies based on risk-factor burden, competing risks, and treatment duration. We developed and validated the LIFEtime-perspective CardioVascular Disease...
Incidence and prevalence of coma in the UK and the USA.
Daniel Kondziella, Moshgan Amiri, Marwan H Othman, Ettore Beghi, Yelena G Bodien, Giuseppe Citerio, Joseph T Giacino, Stephan A Mayer, Thomas N Lawson, David K Menon, Verena Rass, Tarek Sharshar, Robert D Stevens, Lorenzo Tinti, Paul Vespa, Molly McNett, Chethan P Venkatasubba Rao, Raimund Helbok, Curing Coma Campaign collaborators
Oct 24, 2022
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jun 06, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
The Curing Coma Campaign International Survey on Coma Epidemiology, Evaluation, and Therapy (COME TOGETHER).
Raimund Helbok, Verena Rass, Ettore Beghi, Yelena G Bodien, Giuseppe Citerio, Joseph T Giacino, Daniel Kondziella, Stephan A Mayer, David Menon, Tarek Sharshar, Robert D Stevens, Hanno Ulmer, Chethan P Venkatasubba Rao, Paul Vespa, Molly McNett, Jennifer Frontera, Curing Coma Campaign and its Contributing Members
Jul 15, 2022
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G Boutelle, Eszter Farkas, Jens P Dreier, Martin Fabricius, C William Shuttleworth, Andrew Carlson
Jul 29, 2019
The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, "What should a clinician do when spreading depolarizations are...
Cortical Spreading Depression Electroencephalography Intracerebral hemorrhage ischemic stroke outcome Subarachnoid Hemorrhage Traumatic brain injury Brain Injuries Traumatic Cortical Spreading Depression Electrocorticography Electroencephalography Excitatory Amino Acid Antagonists Humans Ketamine Outcome Assessment Health Care Precision Medicine stroke Subarachnoid Hemorrhage
Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury
Anatole Harrois, James R Anstey, Mathieu van der Jagt, Fabio S Taccone, Andrew A Udy, Giuseppe Citerio, Jacques Duranteau, Carole Ichai, Rafael Badenes, John R Prowle, Ari Ercole, Mauro Oddo, Antoine Schneider, Stefan Wolf, Raimund Helbok, David W Nelson, D Jamie Cooper, Rinaldo Bellomo, TBI Collaborative
Sep 18, 2020
BACKGROUND/OBJECTIVE: Dysnatremia is common in severe traumatic brain injury (TBI) patients and may contribute to mortality. However, serum sodium variability has not been studied in TBI patients. We hypothesized that such...
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.
Chaolie Huang, Sara Wagner-Valladolid, Amberley D Stephens, Raimund Jung, Chetan Poudel, Tessa Sinnige, Marie C Lechler, Nicole Schlörit, Meng Lu, Romain F Laine, Claire H Michel, Michele Vendruscolo, Clemens F Kaminski, Gabriele S Kaminski Schierle, Della C David
May 09, 2019
Reduced protein homeostasis leading to increased protein instability is a common molecular feature of aging, but it remains unclear whether this is a cause or consequence of the aging process. In neurodegenerative diseases and...
Long-term life history predicts current gut microbiome in a population-based cohort study
Jiyeon Si, Jorge F Vázquez-Castellanos, Ann C Gregory, Lindsey Decommer, Leen Rymenans, Sebastian Proost, Javier Centelles Lodeiro, Martin Weger, Marlene Notdurfter, Christoph Leitner, Peter Santer, Gregorio Rungger, Johann Willeit, Peter Willeit, Raimund Pechlaner, Felix Grabherr, Stefan Kiechl, Herbert Tilg, Jeroen Raes
Oct 24, 2022
Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe
Jilske A Huijben, Eveline JA Wiegers, Hester F Lingsma, Giuseppe Citerio, Andrew IR Maas, David K Menon, Ari Ercole, David Nelson, Mathieu van der Jagt, Ewout W Steyerberg, Raimund Helbok, Fiona Lecky, Wilco Peul, Tatiana Birg, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, CENTER-TBI Investigators and Participants
Feb 12, 2020
PURPOSE: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. METHODS: This is a prospective...
Fluid therapy in neurointensive care patients
Mauro Oddo, Daniele Poole, Raimund Helbok, Geert Meyfroidt, Nino Stocchetti, Pierre Bouzat, Maurizio Cecconi, Thomas Geeraerts, Ignacio Martin-Loeches, Hervé Quintard, Fabio Silvio Taccone, Romergryko G Geocadin, Claude Hemphill, Carole Ichai, David Menon, Jean-François Payen, Anders Perner, Martin Smith, José Suarez, Walter Videtta, Elisa R Zanier, Giuseppe Citerio
Jun 22, 2018
OBJECTIVE: To report the ESICM consensus and clinical practice recommendations on fluid therapy in neurointensive care patients. DESIGN: A consensus committee comprising 22 international experts met in October 2016 during ESICM...
Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care
Peter Le Roux, David K Menon, Giuseppe Citerio, Paul Vespa, Mary Kay Bader, Gretchen M Brophy, Michael N Diringer, Nino Stocchetti, Walter Videtta, Rocco Armonda, Neeraj Badjatia, Julian Böesel, Randall Chesnut, Sherry Chou, Jan Claassen, Marek Czosnyka, Michael De Georgia, Anthony Figaji, Jennifer Fugate, Raimund Helbok, David Horowitz, Peter Hutchinson, Monisha Kumar, Molly McNett, Chad Miller, Andrew Naidech, Mauro Oddo, DaiWai Olson, Kristine O'Phelan, J Javier Provencio, Corinna Puppo, Richard Riker, Claudia Robertson, Michael Schmidt, Fabio Taccone, Neurocritical Care Society, European Society of Intensive Care Medicine
Jan 09, 2019
Neurocritical care depends, in part, on careful patient monitoring but as yet there are little data on what processes are the most important to monitor, how these should be monitored, and whether monitoring these processes is...
Inhibition of profibrotic microRNA-21 affects platelets and their releasate.
Temo Barwari, Seda Eminaga, Ursula Mayr, Ruifang Lu, Paul C Armstrong, Melissa V Chan, Mahnaz Sahraei, Marta Fernández-Fuertes, Thomas Moreau, Javier Barallobre-Barreiro, Marc Lynch, Xiaoke Yin, Christian Schulte, Ferheen Baig, Raimund Pechlaner, Sarah R Langley, Anna Zampetaki, Peter Santer, Martin Weger, Roberto Plasenzotti, Markus Schosserer, Johannes Grillari, Stefan Kiechl, Johann Willeit, Ajay M Shah, Cedric Ghevaert, Timothy D Warner, Carlos Fernández-Hernando, Yajaira Suárez, Manuel Mayr
Jan 09, 2019
Fibrosis is a major contributor to organ disease for which no specific therapy is available. MicroRNA-21 (miR-21) has been implicated in the fibrogenetic response, and inhibitors of miR-21 are currently undergoing clinical...
Cardiology Cell Biology Fibrosis NONCODING RNAS platelets Aged Aged 80 and over Animals Blood Platelets Clinical Trials as Topic Extracellular Matrix Female FIBROBLASTS Fibrosis Humans Male Mice Mice Inbred C57BL MicroRNAs Middle Aged Myocardium Prospective Studies Proteomics RNA Untranslated Transforming Growth Factor beta1 Wiskott-Aldrich Syndrome Protein
Early Osmotherapy in Severe Traumatic Brain Injury
James R Anstey, Fabio S Taccone, Andrew A Udy, Giuseppe Citerio, Jacques Duranteau, Carole Ichai, Rafael Badenes, John R Prowle, Ari Ercole, Mauro Oddo, Antoine G Schneider, Mathieu van der Jagt, Stefan Wolf, Raimund Helbok, David W Nelson, Marius B Skrifvars, Anatole Harrois, Jeffrey Presneill, D Jamie Cooper, Michael Bailey, Rinaldo Bellomo, TBI Collaborative
Jul 02, 2019
The optimal osmotic agent to treat intracranial hypertension in patients with severe traumatic brain injury (TBI) remains uncertain. We aimed to test whether the choice of mannitol or hypertonic saline (HTS) as early (first...
Descriptive analysis of low versus elevated intracranial pressure on cerebral physiology in adult traumatic brain injury
Frederick A. Zeiler, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter J. Hutchinson, Peter Smielewski, Marek Czosnyka, Audny Anke, Ronny Beer, Bo-Michael Bellander, Erta Beqiri, Andras Buki, Marco Carbonara, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Endre Czeiter, Bart Depreitere, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Ana Kowark, David K. Menon, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Oliver Sakowitz, Nina Sundström, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Andreas Unterberg, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf, Alexander Younsi, Frederick A. Zeiler
Sep 08, 2021
Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities
Edoardo Picetti, Fausto Catena, Fikri Abu-Zidan, Luca Ansaloni, Rocco A Armonda, Miklosh Bala, Zsolt J Balogh, Alessandro Bertuccio, Walt L Biffl, Pierre Bouzat, Andras Buki, Davide Cerasti, Randall M Chesnut, Giuseppe Citerio, Federico Coccolini, Raul Coimbra, Carlo Coniglio, Enrico Fainardi, Deepak Gupta, Jennifer M Gurney, Gregory WJ Hawrylux, Raimund Helbok, Peter JA Hutchinson, Corrado Iaccarino, Angelos Kolias, Ronald W Maier, Matthew J Martin, Geert Meyfroidt, David O Okonkwo, Frank Rasulo, Sandro Rizoli, Andres Rubiano, Juan Sahuquillo, Valerie G Sams, Franco Servadei, Deepak Sharma, Lori Shutter, Philip F Stahel, Fabio S Taccone, Andrew Udy, Tommaso Zoerle, Vanni Agnoletti, Francesca Bravi, Belinda De Simone, Yoram Kluger, Costanza Martino, Ernest E Moore, Massimo Sartelli, Dieter Weber, Chiara Robba
Feb 10, 2023
BACKGROUND: Severe traumatic brain-injured (TBI) patients should be primarily admitted to a hub trauma center (hospital with neurosurgical capabilities) to allow immediate delivery of appropriate care in a specialized...
Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury
Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, Audny Anke, Ronny Beer, Bo-Michael Bellander, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Ana Stevanovic, Nina Sundström, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf
May 26, 2021
Abstract: Background: After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed “optimal CPP” values based...
Descriptive analysis of low versus elevated intracranial pressure on cerebral physiology in adult traumatic brain injury
Frederick A. Zeiler, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter J. Hutchinson, Peter Smielewski, Marek Czosnyka, Audny Anke, Ronny Beer, Bo-Michael Bellander, Erta Beqiri, Andras Buki, Marco Carbonara, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Endre Czeiter, Bart Depreitere, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Ana Kowark, David K. Menon, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Oliver Sakowitz, Nina Sundström, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Andreas Unterberg, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf, Alexander Younsi
Oct 12, 2020
Proceedings of the Second Curing Coma Campaign NIH Symposium
Shraddha Mainali, Venkatesh Aiyagari, Sheila Alexander, Yelena Bodien, Varina Boerwinkle, Melanie Boly, Emery Brown, Jeremy Brown, Jan Claassen, Brian L Edlow, Ericka L Fink, Joseph J Fins, Brandon Foreman, Jennifer Frontera, Romergryko G Geocadin, Joseph Giacino, Emily J Gilmore, Olivia Gosseries, Flora Hammond, Raimund Helbok, J Claude Hemphill, Karen Hirsch, Keri Kim, Steven Laureys, Ariane Lewis, Geoffrey Ling, Sarah L Livesay, Victoria McCredie, Molly McNett, David Menon, Erika Molteni, DaiWai Olson, Kristine O'Phelan, Soojin Park, Len Polizzotto, Jose Javier Provencio, Louis Puybasset, Chethan P Venkatasubba Rao, Courtney Robertson, Benjamin Rohaut, Michael Rubin, Tarek Sharshar, Lori Shutter, Gisele Sampaio Silva, Wade Smith, Robert D Stevens, Aurore Thibaut, Paul Vespa, Amy K Wagner, Wendy C Ziai, Elizabeth Zink, Jose I Suarez, Curing Coma Campaign collaborators
Jul 15, 2022
This proceedings article presents actionable research targets on the basis of the presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) symposium held from May 3 to May 5, 2021. Here, we...
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