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Results: 5
DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children.
Assessment of human leukocyte antigen immunogenicity
PURPOSE OF REVIEW: Donor-recipient human leukocyte antigen (HLA) matching improves outcomes after solid-organ transplantation, but current assessment of HLA incompatibility is inadequate as it does not consider the relative...
Allosteric Targeting of Aurora A Kinase Using Small Molecules
BACKGROUND: Aurora A (AurA) kinase is a key mitotic protein implicated in cancer. Several small molecule inhibitors targeting the ATP binding site of this enzyme are in various stages of clinical development. However, these...
AURKA AurA-TPX2 inhibition Aurora A TPX2 allosteric inhibition Kinase inhibitors proteinprotein
interaction type IV inhibitors. Allosteric Regulation Allosteric Site Anacardic Acids Aurora Kinase A Cell Cycle Proteins Cell Line Tumor Felodipine Humans Microtubule-Associated Proteins Nuclear Proteins Protein Binding Protein Kinase Inhibitors
Cyber Threat Hunting
Muhammad Khan, Rene Richard, Heather Molyneaux, Danick Cote-Martel, Henry Kamalanathan Elango, Steve Livingstone, Manon Gaudet, Dave Trask
Oct 01, 2021
Security and Information Event Management (SIEM) systems require significant manual input; SIEM tools with machine learning minimizes this effort but are reactive and only effective if known attack patterns are captured by the...
Published by: IGI Global Scientific Publishing
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Duncan E Scott, Nicola J Francis-Newton, May E Marsh, Anthony G Coyne, Gerhard Fischer, Tommaso Moschetti, Andrew R Bayly, Timothy D Sharpe, Kalina T Haas, Lorraine Barber, Chiara R Valenzano, Rajavel Srinivasan, David J Huggins, MiYoung Lee, Amy Emery, Bryn Hardwick, Matthias Ehebauer, Claudio Dagostin, Alessandro Esposito, Luca Pellegrini, Trevor Perrior, Grahame McKenzie, Tom L Blundell, Marko Hyvönen, John Skidmore, Ashok R Venkitaraman, Chris Abell
Feb 08, 2021