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Results: 1033
Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma
Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa
Mar 05, 2021
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal...
Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma.
Esperanza M Algarín, Dalia Quwaider, Francisco J Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M Ocio, Mercedes Garayoa
May 17, 2021
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal...
ROS-Scavenging Enzymes as an Antioxidant Response to High Concentration of Anthracene in the Liverwort Marchantia polymorpha L
Nahuel Spinedi, Romina Storb, Elisabet Aranda, Facundo Romani, Maya Svriz, Santiago A. Varela, Javier E. Moreno, Sebastian Fracchia, Juan Cabrera, Ramón Alberto Batista-García, Inés Ponce de León, J. Martín Scervino
Jul 28, 2021
Marchantia polymorpha L. responds to environmental changes using a myriad set of physiological responses, some unique to the lineage related to the lack of a vascular- and root-system. This study investigates the physiological...
Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Javier Macías-León, Iris A Bermejo, Alicia Asín, Ana García-García, Ismael Compañón, Ester Jiménez-Moreno, Helena Coelho, Vincenzo Mangini, Inês S Albuquerque, Filipa Marcelo, Juan L Asensio, Gonçalo JL Bernardes, Hiren J Joshi, Roberto Fiammengo, Ola Blixt, Ramón Hurtado-Guerrero, Francisco Corzana
Nov 13, 2020
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of...
ROS-Scavenging Enzymes as an Antioxidant Response to High Concentration of Anthracene in the Liverwort <i>Marchantia polymorpha</i> L.
Nahuel Spinedi, Romina Storb, Elisabet Aranda, Facundo Romani, Maya Svriz, Santiago A Varela, Javier E Moreno, Sebastian Fracchia, Juan Cabrera, Ramón Alberto Batista-García, Inés Ponce de León, J Martín Scervino
Sep 10, 2021
Marchantia polymorpha L. responds to environmental changes using a myriad set of physiological responses, some unique to the lineage related to the lack of a vascular- and root-system. This study investigates the...
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo JL Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Sep 15, 2020
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their...
Synthesis, conformational analysis and <i>in vivo</i> assays of an anti-cancer vaccine that features an unnatural antigen based on an sp<sup>2</sup>-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo J L Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Jul 28, 2021
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to...
Published by: Chemical science
ROS-Scavenging Enzymes as an Antioxidant Response to High Concentration of Anthracene in the Liverwort Marchantia polymorpha L.
Nahuel Spinedi, Romina Storb, Elisabet Aranda, Facundo Romani, Maya Svriz, Santiago A Varela, Javier E Moreno, Sebastian Fracchia, Juan Cabrera, Ramón Alberto Batista-García, Inés Ponce de León, J Martín Scervino
Aug 05, 2021
Marchantia polymorpha L. responds to environmental changes using a myriad set of physiological responses, some unique to the lineage related to the lack of a vascular- and root-system. This study investigates the physiological...
Expression of Urocortin 3 mRNA in the Central Nervous System of the Sea Lamprey Petromyzon marinus.
In this study, we analyzed the organization of urocortin 3 (Ucn3)-expressing neuronal populations in the brain of the adult sea lamprey by means of in situ hybridization. We also studied the brain of larval sea lampreys to...
GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo.
Parmanand Singh, Silvia González-Ramos, Marina Mojena, César Eduardo Rosales-Mendoza, Hamed Emami, Jeffrey Swanson, Alex Morss, Zahi A Fayad, James HF Rudd, Jeffrey Gelfand, Marta Paz-García, Paloma Martín-Sanz, Lisardo Boscá, Ahmed Tawakol
Mar 10, 2016
18F-FDG-PET GM-CSF Glycolysis Inflammation macrophage Animals Arteritis Cells Cultured Fluorodeoxyglucose F18 Glycolysis Granulocyte-Macrophage Colony-Stimulating Factor Humans Image Enhancement MACROPHAGES Male Mice Positron-Emission Tomography Rabbits Radiopharmaceuticals Reproducibility of Results Sensitivity and Specificity
Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source
We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide...
A Multi‑Center, Open‑Label, Single‑Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency.
Manuel Santamaria, Olaf Neth, Jo A Douglass, Gergely Krivan, Robin Kobbe, Ewa Bernatowska, Sofia Grigoriadou, Claire Bethune, Anita Chandra, Gerd Horneff, Michael Borte, Anja Sonnenschein, Pavlina Kralickova, Silvia Sánchez Ramón, Daman Langguth, Luis Ignacio Gonzalez-Granado, Laia Alsina, Montse Querolt, Rhonda Griffin, Carrie Hames, Elsa Mondou, Jeffrey Price, Ana Sanz, Jiang Lin
Apr 19, 2022
PURPOSE: The purpose of this phase 3 study was to evaluate the efficacy, pharmacokinetics (PK), and safety of Immune Globulin Subcutaneous (Human), 20% Caprylate/Chromatography Purified (IGSC 20%) in patients with primary...
Dynamic Identification of thermodynamic parameters for Turbocharger Compressor Models
A novel experimental procedure is presented which allows simultaneous identification of heat and work transfer parameters for turbocharger compressor models. The method introduces a thermally transient condition and uses...
A mechanistic model of the neural entropy increase elicited by psychedelic drugs.
Rubén Herzog, Pedro AM Mediano, Fernando E Rosas, Robin Carhart-Harris, Yonatan Sanz Perl, Enzo Tagliazucchi, Rodrigo Cofre
Sep 24, 2021
Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological...
A mechanistic model of the neural entropy increase elicited by psychedelic drugs.
Rubén Herzog, Pedro AM Mediano, Fernando E Rosas, Robin Carhart-Harris, Yonatan Sanz Perl, Enzo Tagliazucchi, Rodrigo Cofre
Sep 20, 2022
Clonal haematopoiesis is not prevalent in survivors of childhood cancer
G Collord, N Park, M Podestà, M Dagnino, D Cilloni, D Jones, I Varela, F Frassoni, GS Vassiliou
May 03, 2017
This project was funded by the Wellcome Trust Sanger Institute (grant number WT098051). G.S.V. is funded by a Wellcome Trust Senior Fellowship in Clinical Science (WT095663MA). F.F. is funded by Compagnia di San Paolo Grant: “Le...
Organization of the corticotropin-releasing hormone and corticotropin-releasing hormone-binding protein systems in the central nervous system of the sea lamprey Petromyzon marinus.
The expression of the corticotropin-releasing hormone (PmCRH) and the CRH-binding protein (PmCRHBP) mRNAs was studied by in situ hybridization in the brain of prolarvae, larvae, and adults of the sea lamprey Petromyzon marinus....
What Neanderthals and AMH ate
ABSTRACT: Recent research in northern Spain has revealed the disappearance of Neanderthal populations in the Vasco‐Cantabrian region a few millennia earlier than in eastern and southern Iberia and discovered a short period of...
Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source
We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide...
Top, Higgs, diboson and electroweak fit to the Standard Model effective field theory
Abstract: The search for effective field theory deformations of the Standard Model (SM) is a major goal of particle physics that can benefit from a global approach in the framework of the Standard Model Effective Field Theory...
A selective hydration of nitriles catalysed by a Pd(OAc)<sub>2</sub>-based system in water
In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide...
A selective hydration of nitriles catalysed by a Pd(OAc)<sub>2</sub>-based system in water
In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide...
Expression of Urocortin 3 mRNA in the Central Nervous System of the Sea Lamprey Petromyzon marinus.
In this study, we analyzed the organization of urocortin 3 (Ucn3)-expressing neuronal populations in the brain of the adult sea lamprey by means of in situ hybridization. We also studied the brain of larval sea lampreys to...
Top, Higgs, diboson and electroweak fit to the Standard Model effective field theory
Abstract: The search for effective field theory deformations of the Standard Model (SM) is a major goal of particle physics that can benefit from a global approach in the framework of the Standard Model Effective Field Theory...
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