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The use of hyperpolarised 13 C-MRI in clinical body imaging to probe cancer metabolism
Abstract: Metabolic reprogramming is one of the hallmarks of cancer and includes the Warburg effect, which is exhibited by many tumours. This can be exploited by positron emission tomography (PET) as part of routine clinical...
The use of hyperpolarised 13C-MRI in clinical body imaging to probe cancer metabolism.
Metabolic reprogramming is one of the hallmarks of cancer and includes the Warburg effect, which is exhibited by many tumours. This can be exploited by positron emission tomography (PET) as part of routine clinical cancer...
Improving the image quality of DWI in breast cancer
Gabrielle C Baxter, Andrew J Patterson, Ramona Woitek, Iris Allajbeu, Martin J Graves, Fiona Gilbert
Sep 15, 2020
OBJECTIVE: To compare diffusion-weighted images (DWI) acquired using single-shot echo-planar imaging (ss-EPI) and multiplexed sensitivity encoding (MUSE) in breast cancer. METHODS: 20 females with pathologically confirmed breast...
Diffusion tensor imaging of the normal-appearing deep gray matter in primary and secondary progressive multiple sclerosis.
Background Despite strongly overlapping patterns of clinical and histopathologic findings in primary and secondary progressive multiple sclerosis, differences concerning motor symptoms...
Ramona Woitek, Fritz Leutmezer, Assunta Dal-Bianco, Julia Furtner, Gregor Kasprian, Daniela Prayer, Veronika Schöpf
Sep 10, 2019
T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells.
Judith Leitner, Werner Kuschei, Katharina Grabmeier-Pfistershammer, Ramona Woitek, Ernst Kriehuber, Otto Majdic, Gerhard Zlabinger, Winfried F Pickl, Peter Steinberger
Jan 02, 2019
It is well established that full activation of T cells requires the interaction of the TCR complex with the peptide-MHC complex (Signal 1) and additional signals (Signal 2). These second signals are generated by the interaction...
Animals Antibodies Antigens CD Biological Assay Cell Line Tumor Humans Immunologic Factors Lymphocyte Activation Major Histocompatibility Complex Mice Peptides Receptor-CD3 Complex Antigen T-Cell Receptors Cell Surface Signaling Lymphocytic Activation Molecule Family Member 1 T-Lymphocytes Tumor Necrosis Factor Ligand Superfamily Member 15
The relationship between eye movement and vision develops before birth.
Veronika Schöpf, Thomas Schlegl, Andras Jakab, Gregor Kasprian, Ramona Woitek, Daniela Prayer, Georg Langs
Jan 02, 2019
While the visuomotor system is known to develop rapidly after birth, studies have observed spontaneous activity in vertebrates in visually excitable cortical areas already before extrinsic stimuli are present. Resting state...
Breast lesion detection and characterization with contrast-enhanced magnetic resonance imaging
Paola Clauser, Thomas H Helbich, Panagiotis Kapetas, Katja Pinker, Maria Bernathova, Ramona Woitek, Andreas Kaneider, Pascal AT Baltzer
Sep 09, 2019
BACKGROUND: Contrast-enhanced magnetic resonance imaging (CE-MRI) of the breast is highly sensitive for breast cancer detection. Multichannel coils and 3T scanners can increase signal, spatial, and temporal resolution. In...
Type 2 Endoleaks
Richard Nolz, Asenbaum Ulrika, Julia Furtner, Ramona Woitek, Sylvia Unterhumer, Andreas Wibmer, Alexander Prusa, Christian Loewe, Maria Schoder
Dec 20, 2018
PURPOSE: To define the diagnostic precision of non-specialized readers in the detection of type 2 endoleaks (T2EL) in arterial versus venous phase acquisitions, and to evaluate an approach for radiation dose reduction. METHODS...
A simple classification system (the Tree flowchart) for breast MRI can reduce the number of unnecessary biopsies in MRI-only lesions.
Ramona Woitek, Claudio Spick, Melanie Schernthaner, Margaretha Rudas, Panagiotis Kapetas, Maria Bernathova, Julia Furtner, Katja Pinker, Thomas H Helbich, Pascal AT Baltzer
Dec 20, 2018
OBJECTIVES: To assess whether using the Tree flowchart obviates unnecessary magnetic resonance imaging (MRI)-guided biopsies in breast lesions only visible on MRI. METHODS: This retrospective IRB-approved study evaluated...
Breast Cancer Image-guided biopsy Magnetic Resonance Imaging ROC Curve Scoring system Adult Aged Area Under Curve Breast Neoplasms Cross-Sectional Studies Decision Support Techniques Female Humans Image-guided biopsy Magnetic Resonance Imaging Middle Aged ROC Curve Reproducibility of Results Retrospective Studies Sensitivity and Specificity Unnecessary Procedures
Tissue-specific and interpretable sub-segmentation of whole tumour burden on CT images by unsupervised fuzzy clustering.
Leonardo Rundo, Lucian Beer, Stephan Ursprung, Paula Martin-Gonzalez, Florian Markowetz, James D Brenton, Mireia Crispin-Ortuzar, Evis Sala, Ramona Woitek
Apr 09, 2020
BACKGROUND: Cancer typically exhibits genotypic and phenotypic heterogeneity, which can have prognostic significance and influence therapy response. Computed Tomography (CT)-based radiomic approaches calculate quantitative...
Virtual Touch IQ elastography reduces unnecessary breast biopsies by applying quantitative "rule-in" and "rule-out" threshold values.
Panagiotis Kapetas, Paola Clauser, Ramona Woitek, Katja Pinker, Maria Bernathova, Thomas H Helbich, Pascal A Baltzer
Dec 20, 2018
Our purpose was to evaluate Virtual Touch IQ (VTIQ) elastography and identify quantitative "rule-in" and "rule-out" thresholds for the probability of malignancy, which can help avoid unnecessary breast biopsies. 189 patients...
Academic Medical Centers Austria Biopsy Breast Breast Neoplasms Cross-Sectional Studies Data Accuracy Diagnosis Differential Elasticity Imaging Techniques Feasibility Studies Female Follow-Up Studies Humans ROC Curve Retrospective Studies Sensitivity and Specificity statistics Nonparametric Ultrasonography Mammary
A Simple Ultrasound Based Classification Algorithm Allows Differentiation of Benign from Malignant Breast Lesions by Using Only Quantitative Parameters.
Panagiotis Kapetas, Ramona Woitek, Paola Clauser, Maria Bernathova, Katja Pinker, Thomas H Helbich, Pascal A Baltzer
Dec 20, 2018
PURPOSE: We hypothesized that different quantitative ultrasound (US) parameters may be used as complementary diagnostic criteria and aimed to develop a simple classification algorithm to distinguish benign from malignant breast...
A Simultaneous Multiparametric 18F-FDG PET/MRI Radiomics Model for the Diagnosis of Triple Negative Breast Cancer.
Valeria Romeo, Panagiotis Kapetas, Paola Clauser, Pascal AT Baltzer, Sazan Rasul, Peter Gibbs, Marcus Hacker, Ramona Woitek, Katja Pinker, Thomas H Helbich
Sep 25, 2022
PURPOSE: To investigate whether a machine learning (ML)-based radiomics model applied to 18F-FDG PET/MRI is effective in molecular subtyping of breast cancer (BC) and specifically in discriminating triple negative (TN) from...
Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging
Fulvio Zaccagna, James T Grist, Surrin S Deen, Ramona Woitek, Laura Mt Lechermann, Mary A McLean, Bristi Basu, Ferdia A Gallagher
Mar 07, 2018
Glucose metabolism in tumours is reprogrammed away from oxidative metabolism, even in the presence of oxygen. Non-invasive imaging techniques can probe these alterations in cancer metabolism providing tools to detect tumours and...
Integrative radiogenomics for virtual biopsy and treatment monitoring in ovarian cancer
Paula Martin-Gonzalez, Mireia Crispin-Ortuzar, Leonardo Rundo, Maria Delgado-Ortet, Marika Reinius, Lucian Beer, Ramona Woitek, Stephan Ursprung, Helen Addley, James D. Brenton, Florian Markowetz, Evis Sala
Aug 17, 2020
Abstract: Background: Ovarian cancer survival rates have not changed in the last 20 years. The majority of cases are High-grade serous ovarian carcinomas (HGSOCs), which are typically diagnosed at an advanced stage with multiple...
Fetal diffusion tensor quantification of brainstem pathology in Chiari II malformation.
Ramona Woitek, Daniela Prayer, Michael Weber, Gabriele Amann, Rainer Seidl, Dieter Bettelheim, Veronika Schöpf, Peter C Brugger, Julia Furtner, Ulrika Asenbaum, Gregor Kasprian
Aug 05, 2019
OBJECTIVES: This prenatal MRI study evaluated the potential of diffusion tensor imaging (DTI) metrics to identify changes in the midbrain of fetuses with Chiari II malformations compared to fetuses with mild ventriculomegaly...
Staging Breast Cancer with MRI, the T. A Key Role in the Neoadjuvant Setting.
Camilla Panico, Francesca Ferrara, Ramona Woitek, Anna D'Angelo, Valerio Di Paola, Enida Bufi, Marco Conti, Simone Palma, Stefano Lo Cicero, Giovanni Cimino, Paolo Belli, Riccardo Manfredi
Jan 10, 2023
Breast cancer (BC) is the most common cancer among women worldwide. Neoadjuvant chemotherapy (NACT) indications have expanded from inoperable locally advanced to early-stage breast cancer. Achieving a pathological complete...
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