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Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use
Jonathan Scott, Loredana Trevi, Hannah McNeil, Tom Ewen, Phil Mawson, David McDonald, Andrew Filby, Ranjit Lall, Katie Booth, Gert Boschman, Vesna Melkebeek, Gavin Perkins, Ronan McMullan, Daniel F McAuley, Iain J McCullagh, Timothy Walsh, Anthony Rostron, Manu Shankar-Hari, Paul Dark, A John Simpson, Andrew Conway Morris, Thomas P Hellyer
Feb 09, 2023
INTRODUCTION: Sepsis is characterised by a dysregulated immune response to infection, with exaggerated pro-inflammatory and anti-inflammatory responses. A predominant immunosuppressive profile affecting both innate and adaptive...
Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use
Jonathan Scott, Loredana Trevi, Hannah McNeil, Tom Ewen, Phil Mawson, David McDonald, Andrew Filby, Ranjit Lall, Katie Booth, Gert Boschman, Vesna Melkebeek, Gavin Perkins, Ronan McMullan, Daniel F McAuley, Iain J McCullagh, Timothy Walsh, Anthony Rostron, Manu Shankar-Hari, Paul Dark, A John Simpson, Andrew Conway Morris, Thomas P Hellyer
Dec 23, 2022
Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries
Abstract: As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and can be...
Management of Dental Fluorosis-A Case Report
Dental fluorosis is a developmental disturbance of dental enamel. Chronic ingestion of excessive fluoride during enamel development lower mineral content and increased porosity. Fluorosis can be categorized as mild, moderate and...
Published by: IJHS Medical Association
Management of Dental Fluorosis-A Case Report
Dental fluorosis is a developmental disturbance of dental enamel. Chronic ingestion of excessive fluoride during enamel development lower mineral content and increased porosity. Fluorosis can be categorized as mild, moderate and...
Published by: IJHS Medical Association
Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries.
As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and can be crippling to a...
Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries.
As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and can be crippling to a...
Published by: Neural development
An Improved and Adaptive Approach in ANFIS to Predict Knee Diseases
Artificial intelligence is emerging as a persuasive tool in the field of medical science. This research work also primarily focuses on the development of a tool to automate the diagnosis of inflammatory diseases of the knee...
Published by: IGI Global Scientific Publishing
Current detection rates and time-to-detection of all identifiable BRCA carriers in the Greater London population.
Ranjit Manchanda, Oleg Blyuss, Faiza Gaba, Vladimir Sergeevich Gordeev, Chris Jacobs, Matthew Burnell, Carmen Gan, Rohan Taylor, Clare Turnbull, Rosa Legood, Alexey Zaikin, Antonis C Antoniou, Usha Menon, Ian Jacobs
Jun 18, 2018
BACKGROUND: BRCA carrier identification offers opportunities for early diagnoses, targeted treatment and cancer prevention. We evaluate BRCA- carrier detection rates in general and Ashkenazi Jewish (AJ) populations across...
An Efficient Fog Layer Task Scheduling Algorithm for Multi-Tiered IoT Healthcare Systems
IoT-based healthcare systems are becoming popular due to the extreme benefits patients, families, physicians, hospitals, and insurance companies are getting. Cloud is used traditionally for almost every IoT application, but...
Published by: IGI Global Scientific Publishing
Transcriptomal Insights of Heart Failure from Normality to Recovery.
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y Al-Halees, Maie AlShahid, Kate S Collison, Stephen Westaby, Futwan Al-Mohanna
Jun 29, 2022
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more...
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors
Jake P. Mann, Paul Carter, Matthew J. Armstrong, Hesham K. Abdelaziz, Hardeep Uppal, Billal Patel, Suresh Chandran, Ranjit More, Philip N. Newsome, Rahul Potluri
Oct 27, 2020
Non-alcoholic fatty liver disease (NAFLD) is common and strongly associated with the metabolic syndrome. Though NAFLD may progress to end-stage liver disease, the top cause of mortality in NAFLD is cardiovascular disease (CVD)....
Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women.
Shreeya Patel, Rosa Legood, D Gareth Evans, Clare Turnbull, Antonis C Antoniou, Usha Menon, Ian Jacobs, Ranjit Manchanda
Mar 09, 2018
BACKGROUND: Population-based BRCA1/BRCA2 founder-mutation testing has been demonstrated as cost effective compared with family history based testing in Ashkenazi Jewish women. However, only 1 of the 3 Ashkenazi Jewish...
BRCA Sephardi Jewish cost effectiveness population testing Adult Cost-Benefit Analysis Female Genes BRCA1 Genetic Testing Hereditary Breast and Ovarian Cancer Syndrome Heterozygote Hormone Replacement Therapy Humans Jews Life Expectancy Magnetic Resonance Imaging Mammography Markov Chains Middle Aged Mutation Ovariectomy Prophylactic Mastectomy Prophylactic Surgical Procedures Quality-Adjusted Life Years United Kingdom United States
Transcriptomal Insights of Heart Failure from Normality to Recovery.
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y Al-Halees, Maie AlShahid, Kate S Collison, Stephen Westaby, Futwan Al-Mohanna
May 24, 2022
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more...
A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects.
Sarah Jervis, Honglin Song, Andrew Lee, Ed Dicks, Patricia Harrington, Caroline Baynes, Ranjit Manchanda, Douglas F Easton, Ian Jacobs, Paul PD Pharoah, Antonis C Antoniou
Jun 01, 2015
Lifetime risk of diabetes in metropolitan cities in India.
Shammi Luhar, Dimple Kondal, Rebecca Jones, Ranjit M Anjana, Shivani A Patel, Sanjay Kinra, Lynda Clarke, Mohammed K Ali, Dorairaj Prabhakaran, M Masood Kadir, Nikhil Tandon, Viswanathan Mohan, KM Venkat Narayan
Feb 05, 2021
AIMS/HYPOTHESIS: We aimed to estimate the lifetime risk of diabetes and diabetes-free life expectancy in metropolitan cities in India among the population aged 20 years or more, and their variation by sex, age and BMI. METHODS...
Body Mass Index Diabetes Diabetes-free life expectancy india lifetime risk Metropolitan cities urban Adult Age Distribution Diabetes mellitus Disease-Free Survival Female Humans Incidence india Life Expectancy Male Markov Chains Middle Aged Models Theoretical obesity prevalence Risk Assessment Risk Factors Sex Distribution Time Factors Urban Health Young Adult
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors.
Jake P Mann, Paul Carter, Matthew J Armstrong, Hesham K Abdelaziz, Hardeep Uppal, Billal Patel, Suresh Chandran, Ranjit More, Philip N Newsome, Rahul Potluri
Oct 15, 2020
Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Apr 21, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Jun 29, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.
Tamara Muliaditan, Jonathan Caron, Mary Okesola, James W Opzoomer, Paris Kosti, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava M Kuzeva, Luisa Pedro, Jacqueline D Shields, Cheryl E Gillett, Sandra S Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, James N Arnold
Nov 06, 2018
Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs...
Animals Breast Neoplasms Cell Line Tumor Cell Survival Collagen Cytokines Endopeptidases Female Gelatinases Gene Expression Regulation Neoplastic Heme Oxygenase-1 Humans Interleukin-6 MACROPHAGES Membrane Proteins Mice Mice Inbred BALB C Mice Mutant Strains Neoplasm Metastasis Phenotype Prognosis Serine Endopeptidases Skin Tumor Microenvironment Wound Healing
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 12, 2020
UNLABELLED: Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk...
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C. Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 16, 2020
Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification of...
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