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Published by: Nature Communications
Mapping human development at single-cell resolution.
Human development is regulated by spatiotemporally restricted molecular programmes and is pertinent to many areas of basic biology and human medicine, such as stem cell biology, reproductive medicine and childhood cancer....
A three-dimensional atlas of human dermal leukocytes, lymphatics, and blood vessels.
Xiao-Nong Wang, Naomi McGovern, Merry Gunawan, Connor Richardson, Martin Windebank, Tee-Wei Siah, Hwee-Ying Lim, Katja Fink, Jackson L Yao Li, Lai G Ng, Florent Ginhoux, Veronique Angeli, Matthew Collin, Muzlifah Haniffa
Jun 29, 2018
Dendritic cells (DCs), macrophages (Mφ), and T cells are major components of the skin immune system, but their interstitial spatial organization is poorly characterized. Using four-channel whole-mount immunofluorescence staining...
Adolescent Adult Aged ANISOTROPY CD11c Antigen Carrier Proteins Cell Movement Dermis Female Flow Cytometry Humans Langerhans Cells Leukocytes Lymphatic System Lymphatic Vessels Lymphocytes Lymphoma T-Cell Cutaneous MACROPHAGES Microfilament Proteins Middle Aged Phenotype Platelet Endothelial Cell Adhesion Molecule-1 Skin Young Adult
Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults.
Paul Milne, Venetia Bigley, Chris M Bacon, Antoine Néel, Naomi McGovern, Simon Bomken, Muzlifah Haniffa, Eli L Diamond, Benjamin H Durham, Johannes Visser, David Hunt, Harsha Gunawardena, Mac Macheta, Kenneth L McClain, Carl Allen, Omar Abdel-Wahab, Matthew Collin
Mar 18, 2019
Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are rare histiocytic disorders induced by somatic mutation of MAPK pathway genes. BRAFV600E mutation is the most common mutation in both conditions and also...
Adult Alleles Antigens CD Antigens CD1 Bone Marrow Cells Cell Differentiation Dendritic Cells Diagnosis Differential Erdheim-Chester Disease Female foam cells Gene Expression Glycoproteins Granulocyte-Macrophage Colony-Stimulating Factor Hematopoietic Stem Cells Histiocytosis Langerhans-Cell Humans Immunophenotyping Lectins C-Type Lipopolysaccharide Receptors Male Mannose-Binding Lectins Monocytes Mutation Proto-Oncogene Proteins B-raf Receptors Notch Transforming Growth Factor beta
Inherent mosaicism and extensive mutation of human placentas.
The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study.
Edward Palmer, Benjamin Post, Roman Klapaukh, Giampiero Marra, Niall S MacCallum, David Brealey, Ari Ercole, Andrew Jones, Simon Ashworth, Peter Watkinson, Richard Beale, Stephen J Brett, J Duncan Young, Claire Black, Aasiyah Rashan, Daniel Martin, Mervyn Singer, Steve Harris
Sep 16, 2019
Rationale: There is conflicting evidence on harm related to exposure to supraphysiologic PaO2 (hyperoxemia) in critically ill patients.Objectives: To examine the association between longitudinal exposure to hyperoxemia and...
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.
Ricardo J Miragaia, Tomás Gomes, Agnieszka Chomka, Laura Jardine, Angela Riedel, Ahmed N Hegazy, Natasha Whibley, Andrea Tucci, Xi Chen, Ida Lindeman, Guy Emerton, Thomas Krausgruber, Jacqueline Shields, Muzlifah Haniffa, Fiona Powrie, Sarah A Teichmann
Mar 05, 2019
Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4+ regulatory (Treg) and memory (Tmem) T cells in mouse...
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
MultiMAP
Mika Sarkin Jain, Krzysztof Polanski, Cecilia Dominguez Conde, Xi Chen, Jongeun Park, Lira Mamanova, Andrew Knights, Rachel A Botting, Emily Stephenson, Muzlifah Haniffa, Austen Lamacraft, Mirjana Efremova, Sarah A Teichmann
Jan 28, 2022
Multimodal data is rapidly growing in many fields of science and engineering, including single-cell biology. We introduce MultiMAP, a novel algorithm for dimensionality reduction and integration. MultiMAP can integrate any...
Single-cell roadmap of human gonadal development.
Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen, Vladimir Yu Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chédotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Jul 20, 2022
Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. Historically, limited tissue accessibility, a lack of reliable in vitro models and...
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
Eleonora Khabirova, Laura Jardine, Tim HH Coorens, Simone Webb, Taryn D Treger, Justin Engelbert, Tarryn Porter, Elena Prigmore, Grace Collord, Alice Piapi, Sarah A Teichmann, Sarah Inglott, Owen Williams, Olaf Heidenreich, Matthew D Young, Karin Straathof, Simon Bomken, Jack Bartram, Muzlifah Haniffa, Sam Behjati
Apr 20, 2022
Single-cell roadmap of human gonadal development.
Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen, Vladimir Yu Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chédotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Aug 06, 2022
Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. Historically, limited tissue accessibility, a lack of reliable in vitro models and...
Animals Cell Lineage Chromatin Female Germ Cells granulosa cells Humans Immunoglobulins MACROPHAGES Male Membrane Glycoproteins Membrane Proteins Mice Microscopy Fluorescence Ovary PAX8 Transcription Factor Pregnancy Pregnancy Trimester First Pregnancy Trimester Second Receptors Immunologic Sex Differentiation Single-Cell Analysis Testis Transcriptome
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
Eleonora Khabirova, Laura Jardine, Tim HH Coorens, Simone Webb, Taryn D Treger, Justin Engelbert, Tarryn Porter, Elena Prigmore, Grace Collord, Alice Piapi, Sarah Teichmann, Sarah Inglott, Owen Williams, Olaf Heidenreich, Matthew D Young, Karin Straathof, Simon Bomken, Jack Bartram, Muzlifah Haniffa, Sam Behjati
Apr 19, 2022
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A Teichmann, Fan Bai, Yang Wang
Apr 03, 2022
Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment...
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophages.
Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner, Kile Green, Rachel Dickinson, Xiao-Nong Wang, Donovan Low, Katie Best, Samuel Covins, Paul Milne, Sarah Pagan, Khadija Aljefri, Martin Windebank, Diego Miranda-Saavedra, Anis Larbi, Pavandip Singh Wasan, Kaibo Duan, Michael Poidinger, Venetia Bigley, Florent Ginhoux, Matthew Collin, Muzlifah Haniffa
Jun 18, 2018
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs...
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators, Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Marc JM Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Allen C Cheng, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, Francois Lamontagne, Patrick R Lawler, Helen L Leavis, Kelsey M Linstrum, Edward Litton, Elizabeth Lorenzi, John C Marshall, Florian B Mayr, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Srinivas Murthy, Katrina Orr, Rachael L Parke, Jane C Parker, Asad E Patanwala, Ville Pettilä, Emma Rademaker, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Wendy I Sligl, Alexis F Turgeon, Anne M Turner, Frank L van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Colin J McArthur, Scott Berry, Steve A Webb, Lennie PG Derde
Oct 04, 2021
BACKGROUND: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS: We evaluated tocilizumab and sarilumab in an ongoing international...
Gene expression variability across cells and species shapes innate immunity.
Tzachi Hagai, Xi Chen, Ricardo J Miragaia, Raghd Rostom, Tomás Gomes, Natalia Kunowska, Johan Henriksson, Jong-Eun Park, Valentina Proserpio, Giacomo Donati, Lara Bossini-Castillo, Felipe A Vieira Braga, Guy Naamati, James Fletcher, Emily Stephenson, Peter Vegh, Gosia Trynka, Ivanela Kondova, Mike Dennis, Muzlifah Haniffa, Armita Nourmohammad, Michael Lässig, Sarah A Teichmann
May 14, 2019
As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have...
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah Teichmann, Fan Bai, Yang Wang
Mar 03, 2022
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses.
Andreas Schlitzer, Naomi McGovern, Pearline Teo, Teresa Zelante, Koji Atarashi, Donovan Low, Adrian WS Ho, Peter See, Amanda Shin, Pavandip Singh Wasan, Guillaume Hoeffel, Benoit Malleret, Alexander Heiseke, Samantha Chew, Laura Jardine, Harriet A Purvis, Catharien MU Hilkens, John Tam, Michael Poidinger, E Richard Stanley, Anne B Krug, Laurent Renia, Baalasubramanian Sivasankar, Lai Guan Ng, Matthew Collin, Paola Ricciardi-Castagnoli, Kenya Honda, Muzlifah Haniffa, Florent Ginhoux
Jun 18, 2018
Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but precise interspecies correlation is currently incomplete. Here, we showed that murine lung and gut lamina propria CD11b+ DC populations...
Single-cell reconstruction of the early maternal-fetal interface in humans.
Roser Vento-Tormo, Mirjana Efremova, Rachel A Botting, Margherita Y Turco, Miquel Vento-Tormo, Kerstin B Meyer, Jong-Eun Park, Emily Stephenson, Krzysztof Polański, Angela Goncalves, Lucy Gardner, Staffan Holmqvist, Johan Henriksson, Angela Zou, Andrew M Sharkey, Ben Millar, Barbara Innes, Laura Wood, Anna Wilbrey-Clark, Rebecca P Payne, Martin A Ivarsson, Steve Lisgo, Andrew Filby, David H Rowitch, Judith N Bulmer, Gavin J Wright, Michael JT Stubbington, Muzlifah Haniffa, Ashley Moffett, Sarah A Teichmann
Dec 10, 2018
Mapping the developing human immune system across organs.
Chenqu Suo, Emma Dann, Issac Goh, Laura Jardine, Vitalii Kleshchevnikov, Jong-Eun Park, Rachel A Botting, Emily Stephenson, Justin Engelbert, Zewen Kelvin Tuong, Krzysztof Polanski, Nadav Yayon, Chuan Xu, Ondrej Suchanek, Rasa Elmentaite, Cecilia Domínguez Conde, Peng He, Sophie Pritchard, Mohi Miah, Corina Moldovan, Alexander S Steemers, Pavel Mazin, Martin Prete, Dave Horsfall, John C Marioni, Menna R Clatworthy, Muzlifah Haniffa, Sarah A Teichmann
Jun 13, 2022
Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine...
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
Naomi McGovern, Amanda Shin, Gillian Low, Donovan Low, Kaibo Duan, Leong Jing Yao, Rasha Msallam, Ivy Low, Nurhidaya Binte Shadan, Hermi R Sumatoh, Erin Soon, Josephine Lum, Esther Mok, Sandra Hubert, Peter See, Edwin Huang Kunxiang, Yie Hou Lee, Baptiste Janela, Mahesh Choolani, Citra Nurfarah Zaini Mattar, Yiping Fan, Tony Kiat Hon Lim, Dedrick Kok Hong Chan, Ker-Kan Tan, John Kit Chung Tam, Christopher Schuster, Adelheid Elbe-Bürger, Xiao-Nong Wang, Venetia Bigley, Matthew Collin, Muzlifah Haniffa, Andreas Schlitzer, Michael Poidinger, Salvatore Albani, Anis Larbi, Evan W Newell, Jerry Kok Yen Chan, Florent Ginhoux
Jun 18, 2018
During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food...
Cells of the human intestinal tract mapped across space and time
Rasa Elmentaite, Natsuhiko Kumasaka, Kenny Roberts, Aaron Fleming, Emma Dann, Hamish W. King, Vitalii Kleshchevnikov, Monika Dabrowska, Sophie Pritchard, Liam Bolt, Sara F. Vieira, Lira Mamanova, Ni Huang, Francesca Perrone, Issac Goh Kai’En, Steven N. Lisgo, Matilda Katan, Steven Leonard, Thomas R. W. Oliver, C. Elizabeth Hook, Komal Nayak, Lia S. Campos, Cecilia Domínguez Conde, Emily Stephenson, Justin Engelbert, Rachel A. Botting, Krzysztof Polanski, Stijn van Dongen, Minal Patel, Michael D. Morgan, John C. Marioni, Omer Ali Bayraktar, Kerstin B. Meyer, Xiaoling He, Roger A. Barker, Holm H. Uhlig, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Matthias Zilbauer, Menna R. Clatworthy, Muzlifah Haniffa, Kylie R. James, Sarah A. Teichmann
Oct 01, 2021
Abstract: The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell...
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