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GDF15 mediates the effects of metformin on body weight and energy balance.
Anthony P Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John A Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A Goldspink, Emily L Miedzybrodzka, Adam R Konopka, Raul Ruiz Esponda, Jeffrey T-J Huang, YC Loraine Tung, Sergio Rodriguez-Cuenca, Rute A Tomaz, Heather P Harding, Audrey Melvin, Giles SH Yeo, David Preiss, Antonio Vidal-Puig, Ludovic Vallier, K Sreekumaran Nair, Nicholas J Wareham, David Ron, Fiona M Gribble, Frank Reimann, Naveed Sattar, David B Savage, Bernard B Allan, Stephen O'Rahilly
Dec 19, 2019
Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk1,2. More than 60% of this effect is attributable to the ability of metformin to lower body weight...
Administration Oral Adult Aged Animals Blood Glucose Body Weight Diet High-Fat Double-Blind Method Energy Intake Energy Metabolism Enterocytes Female Glial Cell Line-Derived Neurotrophic Factor Receptors Growth Differentiation Factor 15 Homeostasis Humans Intestines Male Metformin Mice Mice Obese Middle Aged Weight Loss
Determinants and Consequences of Citizens' E-Participation
This article aims to discuss the determinants of digital active citizenship behaviors such as the e-participation using reporting urban apps. The article makes a comparative analysis between two groups of citizens: a) 98 users...
Published by: IGI Global Scientific Publishing
The VARILEX Project - Spanish Lexical Variation
Spanish is a multinational language, spoken in very different geographical regions,that is developing with surprising vitality. Due to distance, there are many issuesthat cannot be adequately addressed by a small number of...
Published by: Atlantic Provinces Linguistic Association
Music, Subjects, Creativity
Emma Ruiz Martin del Campo
Oct 29, 2013
Published by: Faculty of Education
The VARILEX Project - Spanish Lexical Variation
Spanish is a multinational language, spoken in very different geographical regions,that is developing with surprising vitality. Due to distance, there are many issuesthat cannot be adequately addressed by a small number of...
Published by: Atlantic Provinces Linguistic Association
Strong Zero Modes from Geometric Chirality in Quasi-One-Dimensional Mott Insulators.
Strong zero modes provide a paradigm for quantum many-body systems to encode local degrees of freedom that remain coherent far from the ground state. Example systems include Z_{n} chiral quantum clock models with strong zero...
Music, Subjects, Creativity
Emma Ruiz Martin del Campo
Oct 29, 2013
Published by: Faculty of Education
Entropic bonding of the type 1 pilus from experiment and simulation.
Fabiano Corsetti, Alvaro Alonso-Caballero, Simon Poly, Raul Perez-Jimenez, Emilio Artacho
Jun 15, 2020
The type 1 pilus is a bacterial filament consisting of a long coiled proteic chain of subunits joined together by non-covalent bonding between complementing β -strands. Its strength and structural stability are critical for its...
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.
Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Feb 04, 2019
Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle.
The mitotic spindle distributes chromosomes evenly to daughter cells during mitosis. The orientation of the spindle, guided by internal and external cues, determines the axis of cell division and thereby contributes to tissue...
Scene memory and spatial inhibition in visual search
Raul Grieben, Jan Tekülve, Stephan KU Zibner, Jonas Lins, Sebastian Schneegans, Gregor Schöner
Feb 10, 2021
Any object-oriented action requires that the object be first brought into the attentional foreground, often through visual search. Outside the laboratory, this would always take place in the presence of a scene representation...
Scene memory and spatial inhibition in visual search
Raul Grieben, Jan Tekülve, Stephan K. U. Zibner, Jonas Lins, Sebastian Schneegans, Gregor Schöner
Jul 10, 2020
Abstract: Any object-oriented action requires that the object be first brought into the attentional foreground, often through visual search. Outside the laboratory, this would always take place in the presence of a scene...
40 Years of Feature Integration: Special Issue in Memory of Anne Treisman Visual search visual working memory Neural network modeling
Published by: Springer US
Scene memory and spatial inhibition in visual search
Raul Grieben, Jan Tekülve, Stephan K. U. Zibner, Jonas Lins, Sebastian Schneegans, Gregor Schöner
Jun 06, 2020
Abstract: Any object-oriented action requires that the object be first brought into the attentional foreground, often through visual search. Outside the laboratory, this would always take place in the presence of a scene...
40 Years of Feature Integration: Special Issue in Memory of Anne Treisman Visual search visual working memory Neural network modeling
Published by: Springer US
Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms
Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, agouti-signalling...
Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells.
Burak Okumus, Dirk Landgraf, Ghee Chuan Lai, Somenath Bakshi, Juan Carlos Arias-Castro, Sadik Yildiz, Dann Huh, Raul Fernandez-Lopez, Celeste N Peterson, Erdal Toprak, Meriem El Karoui, Johan Paulsson
Jan 31, 2020
Many key regulatory proteins in bacteria are present in too low numbers to be detected with conventional methods, which poses a particular challenge for single-cell analyses because such proteins can contribute greatly to...
Energy-Dependent π^{+}π^{+}π^{+} Scattering Amplitude from QCD.
Maxwell T Hansen, Raul A Briceño, Robert G Edwards, Christopher E Thomas, David J Wilson, Hadron Spectrum Collaboration
Nov 09, 2020
Focusing on three-pion states with maximal isospin (π^{+}π^{+}π^{+}), we present the first nonperturbative determination of an energy-dependent three-hadron scattering amplitude from first-principles QCD. The calculation...
Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms
Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, agouti-signalling...
Nature of the low magnetization decay on stacks of second generation superconducting tapes under crossed and rotating magnetic field experiments
The extremely low decay factor on the trapped magnetic field by stacks of second-generation high-temperature superconducting tapes reported in Appl. Phys. Lett. 104, 232602 (2014), is in apparent contradiction with the classical...
Computational simulation of the lifetime of the methoxymethyl cation in water. A simple model for a glycosyl cation
A two-dimensional free-energy surface is constructed for transfer of the methoxymethyl cation between two water molecules. These atoms are treated quantum mechanically within a box of >1000 classical solvent water molecules...
An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization.
Bo-Yong Park, Richard AI Bethlehem, Casey Paquola, Sara Larivière, Raul Rodríguez-Cruces, Reinder Vos de Wael, NeuroScience in Psychiatry Network (NSPN) Consortium, Edward T Bullmore, Boris C Bernhardt
Jun 17, 2021
Adolescence is a critical time for the continued maturation of brain networks. Here, we assessed structural connectome development in a large longitudinal sample ranging from childhood to young adulthood. By projecting...
adolescence Connectome human longitudinal multi-scale Neurodevelopment Neuroimaging neuroscience Adolescent Adolescent Behavior Adolescent Development Adult Age Factors Brain Cognition Connectome Female Gene Expression Profiling Gene Expression Regulation Developmental Humans Longitudinal Studies Magnetic Resonance Imaging Male Models Neurological Nerve Tissue Proteins Neural Pathways Neurogenesis Transcriptome Young Adult
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