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Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?
Jason K Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Gregg Wallis, Roshani Patel, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray Kruse Iles
May 30, 2022
The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is...
Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?
Jason K Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Gregg Wallis, Roshani Patel, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray Kruse Iles
Jul 10, 2022
The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is...
A How to Guide
Applying MALDI-ToF mass spectrometry as a clinical diagnostic test for viruses is different from that of bacteria, fungi and other micro-organisms. This is because the systems biology of viral infections, the size and chemical...
Development of a Clinical MALDI-ToF Mass Spectrometry Assay for SARS-CoV-2
Ray K. Iles, Raminta Zmuidinaite, Jason K. Iles, George Carnell, Alex Sampson, Jonathan L. Heeney
Sep 25, 2020
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has stretched national testing capacities to breaking points in almost all countries of the world. The need to rapidly screen vast numbers of a country’s population in...
Development of a Clinical MALDI-ToF Mass Spectrometry Assay for SARS-CoV-2
Ray K Iles, Raminta Zmuidinaite, Jason K Iles, George Carnell, Alex Sampson, Jonathan L Heeney
Dec 14, 2020
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has stretched national testing capacities to breaking points in almost all countries of the world. The need to rapidly screen vast numbers of a country's population in...
SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases.
Jason Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Jernej Ule, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray K Iles
May 24, 2022
The immune response to SARS-CoV-2 infection requires antibody recognition of the spike protein. In a study designed to examine the molecular features of anti-spike and anti-nucleocapsid antibodies, patient plasma proteins...
SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases.
Jason Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Jernej Ule, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray K Iles
Apr 09, 2022
The immune response to SARS-CoV-2 infection requires antibody recognition of the spike protein. In a study designed to examine the molecular features of anti-spike and anti-nucleocapsid antibodies, patient plasma proteins...
Short Report
Jessica Hayton, Atiqah Azhari, Gianluca Esposito, Ray Iles, Michaella Chadiarakos, Giulio Gabrieli, Dagmara Dimitriou, Stephen Mangar
Apr 17, 2023
Objective
The aim of the current study was to examine the potential relationship between sleep patterns, cortisol levels, and anxiety profiles in adolescents with Williams Syndrome (WS) compared to typically developing...
Exploring the relationship of sleep, cognition, and cortisol in sickle cell disease.
Melanie Kölbel, Fenella J Kirkham, Ray K Iles, Hanne Stotesbury, Elizabeth Halstead, Celia Brenchley, Sati Sahota, Dagmara Dimitriou
Jul 27, 2022
BACKGROUND: Neurocognitive impairment is common in people with Sickle Cell Disease (SCD) and evidence is accumulating that sleep disturbances play a role. The interaction between cortisol and sleep in the general population is...
Actigraphy car Cortisol awakening response Cognition Cortisol DCR Diurnal cortisol ratio FCP Flat cortisol profile FI Fragmentation index NCP Normal cortisol profile OSA Obstructive sleep apnoea PLMS Periodic limb movement syndrome PRI Perceptual Reasoning Index PSI Processing Speed Index SCD Sickle cell disease SDB Sleep disordered breathing SES socioeconomic status SOL Sleep onset latency Sickle cell Sleep Sleep disorders VCI Verbal Comprehension Index WMI Working Memory Index
Printable Perovskite Diodes for Broad-Spectrum Multienergy X-Ray Detection.
Babar Shabbir, Jae Choul Yu, Tharindu Warnakula, RAW Ayyubi, James A Pollock, M Mosarof Hossain, Jueng-Eun Kim, Nasiruddin Macadam, Leonard WT Ng, Tawfique Hasan, Doojin Vak, Marcus J Kitchen, Jacek J Jasieniak
Mar 30, 2023
Multienergy X-ray detection is critical to effectively differentiate materials in a variety of diagnostic radiology and nondestructive testing applications. Silicon and selenium X-ray detectors are the most common for...
Cosmological distances with general-relativistic ray tracing
Abstract
In this work we present the first results from a new ray-tracing tool to calculate
cosmological distances in the context of fully nonlinear general relativity. We use...
Hayley J Macpherson
Mar 07, 2023
Dynamic structure elucidation of chemical reactivity by laser pulses and X-ray probes
Visualising chemical reactions by X-ray methods is a tantalising prospect. New light sources provide the prospect for studying atomic, electronic and energy transfers accompanying chemical change by X-ray spectroscopy and...
Searching for axion-like particles with X-ray polarimeters
X-ray telescopes are an exceptional tool for searching for new fundamental physics. In particular, X-ray observations have already placed world-leading bounds on the interaction between photons and axion-like particles (ALPs)....
A long-lived neutron star merger remnant in GW170817
L. Piro, Bing Zhang, Eleanora Troja, Geoffrey Ryan, Hendrik Van Eerten, R Ricci, M. H. Wieringa, A. Tiengo, N Butler, S. B. Cenko, O. D. Fox, H. G. Khandrika, G. Novara, T. Sakamoto
Feb 01, 2019
Multimessenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field B ≈ 1012 G is fully...
A long-lived neutron star merger remnant in GW170817
L. Piro, Bing Zhang, Eleanora Troja, Geoffrey Ryan, Hendrik Van Eerten, R Ricci, M. H. Wieringa, A. Tiengo, N Butler, S. B. Cenko, O. D. Fox, H. G. Khandrika, G. Novara, T. Sakamoto
Feb 01, 2019
Multimessenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field B ≈ 1012 G is fully...
The First High-contrast Images of X-Ray Binaries
Abstract
X-ray binaries provide exceptional laboratories for understanding the physics of matter under the most extreme conditions. Until recently, there were few, if any...
M Prasow-Émond, J Hlavacek-Larrondo, K Fogarty, J Rameau, L-S Guité, D Mawet, P Gandhi, A Rao, JF Steiner, É Artigau, D Lafrenière, AC Fabian, DJ Walton, LM Weiss, R Doyon, BB Ren 任彬, CL Rhea, T Bégin, B Vigneron, M-E Naud
Jun 13, 2022
Relativistic X-Ray Reverberation from Super-Eddington Accretion Flow
X-ray reverberation is a powerful technique which maps out the structure of
the inner regions of accretion disks around black holes using the echoes of the
coronal emission reflected by the disk. While the theory of X-ray...
The hyperluminous X‐ray source population
We have recently published a catalog of 1843 candidate ultraluminous X‐ray sources (ULXs). This is the largest catalog of ULXs to date and was built by cross‐correlating recent serendipitous source catalogs from the XMM‐Newton...
Super-Eddington accretion on to the neutron star NGC7793 P13
DJ Walton, F Furst, FA Harrison, D Stern, M Bachetti, D Barret, M Brightman, AC Fabian, MJ Middleton, A Ptak, L Tao
Jun 13, 2018
We present a detailed, broad-band X-ray spectral analysis of the ultraluminous X-ray source (ULX) pulsar NGC 7793 P13, a known super-Eddington source, utilizing data from the XMM–Newton, NuSTAR and Chandra observatories. The...
Radio flares from gamma-ray bursts
D. Kopac, C. G. Mundell, S. Kobayashi, F. J. Virgili, Roger Harrison, J. Japelj, C. Guidorzi, A. Melandri, A. Gomboc
Jun 20, 2015
We present predictions of centimeter and millimeter radio emission from reverse shocks in the early afterglows of gamma-ray bursts with the goal of determining their detectability with current and future radio facilities. Using...
Ab initio nonrigid X-ray nanotomography
Michal Odstrcil, Mirko Holler, Jörg Raabe, Alessandro Sepe, Xiaoyuan Sheng, Silvia Vignolini, Christian G. Schroer, Manuel Guizar-Sicairos
Jun 12, 2020
Abstract: Reaching the full potential of X-ray nanotomography, in particular for biological samples, is limited by many factors, of which one of the most serious is radiation damage. Although sample deformation caused by...
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