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Mapping whole brain connectivity changes
In neurosurgery there are several situations that require transgression of the temporal cortex. For example, a subset of patients with temporal lobe epilepsy require surgical resection (most typically, en-bloc anterior temporal...
Microclustering-Based Multi-Class Classification on Imbalanced Multi-Relational Datasets
In a relational database, classification algorithms are used to look for patterns across several interconnected relations. Most of the methods for multi-relational classification algorithms implicitly assume that the classes in...
Published by: IGI Global Scientific Publishing
Assessing executive functions in post-stroke aphasia-utility of verbally based tests.
It is increasingly acknowledged that, often, patients with post-stroke aphasia not only have language impairments but also deficits in other cognitive domains (e.g. executive functions) that influence recovery and response to...
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia.
There is growing awareness that aphasia following a stroke can include deficits in other cognitive functions and that these are predictive of certain aspects of language function, recovery and rehabilitation. However, data on...
Aphasia Attention executive functions principal components univariate and multivariate brain-behaviour mapping Aged Aged 80 and over Aphasia Attention Brain Brain Mapping Cognition Comprehension Executive Function Female Humans Image Processing Computer-Assisted language Language Tests Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests principal component analysis semantics speech stroke
The cognitive and neural underpinnings of discourse coherence in post-stroke aphasia.
Although impaired discourse production is one of the prominent features of aphasia, only a handful of investigations have addressed the cognitive, linguistic and neural processes that support the production of coherent...
A unified model of post-stroke language deficits including discourse production and their neural correlates.
The clinical profiles of individuals with post-stroke aphasia demonstrate considerable variation in the presentation of symptoms. Recent aphasiological studies have attempted to account for this individual variability using a...
Characterising factors underlying praxis deficits in chronic left hemisphere stroke patients.
Limb apraxia, a disorder of skilled action not consequent on primary motor or sensory deficits, has traditionally been defined according to errors patients make on neuropsychological tasks. Previous models of the disorder have...
Impact of Price-Sensitive Demand and Premium Payment Scheme on Bullwhip Effect
Bullwhip effect reduces the efficiency, responsiveness, and value of the supply chain. There are some indirect causes like lead time, the number of echelons, and some direct causes of bullwhip effect such as rationing or price...
Published by: IGI Global Scientific Publishing
Integrating Keyword Segmentation and Budget Allocation Decisions in Sponsored Search Advertising
Budget constrained sponsored search advertisers must decide how to allocate their advertisement budget across ad campaigns and individual keywords. In this paper, a simulation model that integrates the complex issues involved in...
Published by: IGI Global Scientific Publishing
Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands.
Zhiyao Gao, Li Zheng, Katya Krieger-Redwood, Ajay Halai, Daniel S Margulies, Jonathan Smallwood, Elizabeth Jefferies
Oct 29, 2022
Understanding how thought emerges from the topographical structure of the cerebral cortex is a primary goal of cognitive neuroscience. Recent work has revealed a principal gradient of intrinsic connectivity capturing the...
Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
Ruth U Ingram, Ajay D Halai, Gorana Pobric, Seyed Sajjadi, Karalyn Patterson, Matthew A Lambon Ralph
Jun 29, 2020
Language impairments caused by stroke (post-stroke aphasia, PSA) and neurodegeneration (primary progressive aphasia, PPA) have overlapping symptomatology, nomenclature and are classically divided into categorical subtypes....
Adaptive-Sunflower-Based Grey Wolf Algorithm for Multipath Routing in IoT Networks
This paper devises a routing method for providing multipath routing in an IoT network. Here the fractional artificial bee colony(FABC) algorithm is devised for initiating the clustering process. Moreover, the multipath routing...
Published by: IGI Global Scientific Publishing
Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach
Reena Devi, Graham Martin, Jay Banerjee, Louise Butler, Tim Pattison, Lesley Cruickshank, Caroline Maries-Tillott, Tracie Wilson, Sarah Damery, Julienne Meyer, Antonius Poot, Peter Chamberlain, Debbie Harvey, Clarissa Giebel, Kathryn Hinsliff-Smith, Neil Chadborn, Adam Lee Gordon
Oct 20, 2020
The Breakthrough Series Quality Improvement Collaborative (QIC) initiative is a well-developed and widely used approach, but most of what we know about it has come from healthcare settings. In this article, those leading QICs to...
Preparing for pandemics
Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W Horby, Louise Sigfrid
Dec 09, 2022
BACKGROUND: The COVID-19 pandemic has highlighted the importance of evidence-based clinical decision-making. Clinical management guidelines (CMGs) may help reduce morbidity and mortality by improving the quality of clinical...
Preparing for pandemics
Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W Horby, Louise Sigfrid
Nov 08, 2022
BACKGROUND: The COVID-19 pandemic has highlighted the importance of evidence-based clinical decision-making. Clinical management guidelines (CMGs) may help reduce morbidity and mortality by improving the quality of clinical...
Common genetic variation drives molecular heterogeneity in human iPSCs.
Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Kaur Alasoo, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver J Culley, Petr Danecek, Adam Faulconbridge, Peter W Harrison, Annie Kathuria, Davis McCarthy, Shane A McCarthy, Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal Patel, Alistair White, Sharad R Patel, Laura Clarke, Reena Halai, Christopher M Kirton, Anja Kolb-Kokocinski, Philip Beales, Ewan Birney, Davide Danovi, Angus I Lamond, Willem H Ouwehand, Ludovic Vallier, Fiona M Watt, Richard Durbin, Oliver Stegle, Daniel J Gaffney
Nov 20, 2018
Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease. However, variable genetic and phenotypic characterization of many existing iPS...
A 'Mini Linguistic State Examination' to classify primary progressive aphasia.
Nikil Patel, Katie A Peterson, Ruth U Ingram, Ian Storey, Stefano F Cappa, Eleonora Catricala, Ajay Halai, Karalyn E Patterson, Matthew A Lambon Ralph, James B Rowe, Peter Garrard
Apr 13, 2022
There are few available methods for qualitatively evaluating patients with primary progressive aphasia. Commonly adopted approaches are time-consuming, of limited accuracy or designed to assess different patient populations....
Fuzzy Modelling of Clinical and Epidemiological Factors for COVID-19
During this pandemic outbreak of COVID-19, the whole world is getting severely affected in respect of population health and economy. This novel virus has brought the whole world including the most developed countries to a...
Published by: IGI Global Scientific Publishing
In-depth phenotyping for clinical stratification of Gaucher disease.
Simona D'Amore, Kathleen Page, Aimée Donald, Khadijeh Taiyari, Brian Tom, Patrick Deegan, Chong Y Tan, Kenneth Poole, Simon A Jones, Atul Mehta, Derralynn Hughes, Reena Sharma, Robin H Lachmann, Anupam Chakrapani, Tarekegn Geberhiwot, Saikat Santra, Siddarth Banka, Timothy M Cox, MRC GAUCHERITE Consortium
Sep 23, 2021
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Anna S. E. Cuomo, Daniel D. Seaton, Davis J. McCarthy, Iker Martinez, Marc Jan Bonder, Jose Garcia-Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner, Andrew Knights, Kedar Nath Natarajan, Ludovic Vallier, John C. Marioni, Mariya Chhatriwala, Oliver Stegle, Chukwuma A. Agu, Alex Alderton, Petr Danecek, Rachel Denton, Richard Durbin, Daniel J. Gaffney, Angela Goncalves, Reena Halai, Sarah Harper, Christopher M. Kirton, Anja Kolb-Kokocinski, Andreas Leha, Shane A. McCarthy, Yasin Memari, Minal Patel, Ewan Birney, Francesco Paolo Casale, Laura Clarke, Peter W. Harrison, Helena Kilpinen, Ian Streeter, Davide Denovi, Ruta Meleckyte, Natalie Moens, Fiona M. Watt, Willem H. Ouwehand, Angus I. Lamond, Dalila Bensaddek, Philip Beales
Feb 09, 2021
Abstract: Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals...
Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial).
Stuart Little, Thomas Chadwick, Pratik Choudhary, Cath Brennand, Julia Stickland, Shalleen Barendse, Tolulope Olateju, Lalantha Leelarathna, Emma Walkinshaw, Horng K Tan, Sally M Marshall, Reena M Thomas, Simon Heller, Mark Evans, David Kerr, Daniel Flanagan, Jane Speight, James Am Shaw
Jan 25, 2013
In-depth phenotyping for clinical stratification of Gaucher disease.
Simona D'Amore, Kathleen Page, Aimée Donald, Khadijeh Taiyari, Brian Tom, Patrick Deegan, Chong Y Tan, Kenneth Poole, Simon A Jones, Atul Mehta, Derralynn Hughes, Reena Sharma, Robin H Lachmann, Anupam Chakrapani, Tarekegn Geberhiwot, Saikat Santra, Siddarth Banka, Timothy M Cox
Nov 22, 2021
Background
The Gaucher Investigative Therapy Evaluation is a national clinical cohort of 250 patients aged 5-87 years with Gaucher disease in the United Kingdom-an ultra-rare genetic disorder. To inform clinical...
cohort Gaucher Disease Enzyme Replacement Therapy substrate reduction therapy Disease-modifying Therapies Gaucherite
Published by: Orphanet journal of rare diseases
Natural history of epilepsy in argininosuccinic aciduria provides new insights into pathophysiology
Nour Elkhateeb, Giorgia Olivieri, Barbara Siri, Stewart Boyd, Karolina M Stepien, Reena Sharma, Andrew AM Morris, Thomas Hartley, Laura Crowther, Stephanie Grunewald, Maureen Cleary, Helen Mundy, Anupam Chakrapani, Robin Lachmann, Elaine Murphy, Saikat Santra, Mari-Liis Uudelepp, Mildrid Yeo, Isaac Bernhardt, Sniya Sudakhar, Alicia Chan, Philippa Mills, Debora Ridout, Paul Gissen, Carlo Dionisi-Vici, Julien Baruteau
Apr 10, 2023
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