MOTIVATION: Molecular pathways and networks play a key role in basic and disease biology. An emerging notion is that networks encoding patterns of molecular interplay may themselves differ between contexts, such as cell type...
Social media big data offers insights that can be used to make predictions of products' future demand and add value to the supply chain performance. The paper presents a framework for improvement of demand forecasting in a...
Since the inception of mankind, sleep has been regarded as one of the most vital necessity for the human body needed for rejuvenation after a tiresome day’s work. Social activities, stressful relationships and academic...
Since the inception of mankind, sleep has been regarded as one of the most vital necessity for the human body needed for rejuvenation after a tiresome day’s work. Social activities, stressful relationships and academic...
Protein levels and function are poorly predicted by genomic and transcriptomic analysis of patient tumours. Therefore, direct study of the functional proteome has the potential to provide a wealth of information that complements...
Abstract: Structural health monitoring (SHM) using self‐sensing cement‐based materials has been reported before, where nano‐fillers have been incorporated in cementitious matrices as functional sensing elements. A percolation...
Haemorrhoid is a life style disorder, it is increasing day by day hectically. Now days it is burning issue among different strata in the community. Throughout history man has been searching haemorrhoid cures and treatment.In...
Haemorrhoid is a life style disorder, it is increasing day by day hectically. Now days it is burning issue among different strata in the community. Throughout history man has been searching haemorrhoid cures and treatment.In...
Ageing is natural process. As the world is witnessing the phenomenon of global ageing, geriatric care has attracted wide attention. The main issue in geriatric care is not merely concerned with the physiological phenomenon but...
Ageing is natural process. As the world is witnessing the phenomenon of global ageing, geriatric care has attracted wide attention. The main issue in geriatric care is not merely concerned with the physiological phenomenon but...
Swine flu is a respiratory disease of pigs caused by influenza virus. The known SIV strains include influenza C and the subtypes of influenza A known ...
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations...
Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and...
In ancient days, the word exercise (Riyazat) was defined only in medical books and common man was not aware of its health benefits, but in the era of modern medicine and social media, even a common man has become aware of the...
In ancient days, the word exercise (Riyazat) was defined only in medical books and common man was not aware of its health benefits, but in the era of modern medicine and social media, even a common man has become aware of the...
Swine flu is a respiratory disease of pigs caused by influenza virus. The known SIV strains include influenza C and the subtypes of influenza A known ...
In the cyclic guanosine monophosphate (cGMP) signaling pathway, phosphodiesterase 6 (PDE6) maintains a critical balance of the intracellular concentration of cGMP by catalyzing it to 5' guanosine monophosphate (5'-GMP). To gain...
BACKGROUND: Radio-frequency ablation (RFA) for Barrett's oesophagus (BE)-related neoplasia is currently used after endoscopic resection of visible neoplasia. The HALO 360 balloon has been used to ablate long segment BE. The...
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of...
Introduction: Endoscopic therapy for the management of patients with Barrett's oesophagus (BE) neoplasia has significantly developed in the past decade; however, significant variation in clinical practice exists. The aim of this...
BACKGROUND: Barrett's esophagus (BE) is a commonly undiagnosed condition that predisposes to esophageal adenocarcinoma. Routine endoscopic screening for BE is not recommended because of the burden this would impose on the health...
Abstract: The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning...