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Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Editorial
Published by: Memorial University of Newfoundland
Editorial
Published by: Memorial University of Newfoundland
Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke.
Matthew Traylor, Ali Amin Al Olama, Leo-Pekka Lyytikäinen, Sandro Marini, Jaeyoon Chung, Rainer Malik, Martin Dichgans, Mika Kähönen, Terho Lehtimäki, Christopher D Anderson, Olli T Raitakari, Hugh S Markus
Dec 09, 2019
Cyclic Nucleotide Phosphodiesterases Type 3 Genetics Genome-Wide Association Study stroke vascular endothelium Adolescent Adult Brain Ischemia Child Cyclic Nucleotide Phosphodiesterases Type 3 Endothelium Vascular Female Follow-Up Studies Genetic Predisposition to Disease genetic variation Humans Hypertension Male Middle Aged Polymorphism Single Nucleotide Pregnancy Pregnancy Complications Cardiovascular Retrospective Studies Risk Factors Vasodilation Young Adult
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition
Qin Wang, Clare Oliver-Williams, Olli T Raitakari, Jorma Viikari, Terho Lehtimäki, Mika Kähönen, Marjo-Riitta Järvelin, Veikko Salomaa, Markus Perola, John Danesh, Johannes Kettunen, Adam S Butterworth, Michael V Holmes, Mika Ala-Korpela
Nov 05, 2020
ANGPTL3 ANGPTL4 Amino Acids Drug targets Glycoprotein acetyls LPL lipoprotein lipids Lipoprotein subclasses Mendelian randomization Angiopoietin-Like Protein 3 Angiopoietin-Like Protein 4 Angiopoietin-like Proteins Angiopoietins Diabetes mellitus Type 2 Humans Mendelian Randomization Analysis Pharmaceutical Preparations
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 27, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients.
Johannes Kettunen, Scott C Ritchie, Olga Anufrieva, Leo-Pekka Lyytikäinen, Jussi Hernesniemi, Pekka J Karhunen, Pekka Kuukasjärvi, Jari Laurikka, Mika Kähönen, Terho Lehtimäki, Aki S Havulinna, Veikko Salomaa, Satu Männistö, Mika Ala-Korpela, Markus Perola, Michael Inouye, Peter Würtz
Apr 15, 2019
BACKGROUND: Integration of systems-level biomolecular information with electronic health records has led to recent interest in the glycoprotein acetyls (GlycA) biomarker-a serum- or plasma-derived nuclear magnetic resonance...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
Johannes Kettunen, Michael V. Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D. Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T. Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Mika Ala-Korpela
Jan 06, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 10, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Adolescent Adult Alleles Apolipoproteins B Cholesterol Ester Transfer Proteins Cholesterol LDL Cohort Studies Coronary Disease Female Follow-Up Studies genetic variation Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipoproteins Male Middle Aged Triglycerides Young Adult
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Eliana Portilla-Fernández, Shih-Jen Hwang, Rory Wilson, Jane Maddock, W David Hill, Alexander Teumer, Pashupati P Mishra, Jennifer A Brody, Roby Joehanes, Symen Ligthart, Mohsen Ghanbari, Maryam Kavousi, Anton JM Roks, AH Jan Danser, Daniel Levy, Annette Peters, Sahar Ghasemi, Ulf Schminke, Marcus Dörr, Hans J Grabe, Terho Lehtimäki, Mika Kähönen, Mikko A Hurme, Traci M Bartz, Nona Sotoodehnia, Joshua C Bis, Joachim Thiery, Wolfgang Koenig, Kenneth Ong, Jordana T Bell, Christine Meisinger, Joanna M Wardlaw, John M Starr, Jochen Seissler, Cornelia Then, Wolfgang Rathmann, M Arfan Ikram, Bruce M Psaty, Olli T Raitakari, Henry Völzke, Ian J Deary, Andrew Wong, Melanie Waldenberger, Christopher J O'Donnell, Abbas Dehghan
Jun 14, 2021
Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study...
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Würtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
Oct 04, 2019
GWAS blood cell traits cardiometabolic diseases colocalisation analysis Cytokines eQTLs metabolites Multivariate Analysis protein QTLs Adolescent Adult Aged Biomarkers Blood Proteins Cardiovascular Diseases Child Cytokines Female Follow-Up Studies Gene Regulatory Networks Genetic Pleiotropy Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Longitudinal Studies Male Middle Aged Polymorphism Single Nucleotide Prognosis Prospective Studies Quantitative Trait Loci Young Adult
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Eliana Portilla-Fernández, Shih-Jen Hwang, Rory Wilson, Jane Maddock, W David Hill, Alexander Teumer, Pashupati P Mishra, Jennifer A Brody, Roby Joehanes, Symen Ligthart, Mohsen Ghanbari, Maryam Kavousi, Anton JM Roks, AH Jan Danser, Daniel Levy, Annette Peters, Sahar Ghasemi, Ulf Schminke, Marcus Dörr, Hans J Grabe, Terho Lehtimäki, Mika Kähönen, Mikko A Hurme, Traci M Bartz, Nona Sotoodehnia, Joshua C Bis, Joachim Thiery, Wolfgang Koenig, Ken K Ong, Jordana T Bell, Christine Meisinger, Joanna M Wardlaw, John M Starr, Jochen Seissler, Cornelia Then, Wolfgang Rathmann, M Arfan Ikram, Bruce M Psaty, Olli T Raitakari, Henry Völzke, Ian J Deary, Andrew Wong, Melanie Waldenberger, Christopher J O'Donnell, Abbas Dehghan
Dec 15, 2021
cardiovascular risk factors Common carotid intima-media thickness DNA Methylation Differentially methylated regions Epigenome-wide association studies Mendelian randomization Vascular outcomes Carotid Intima-Media Thickness Coronary Artery Disease Cross-Sectional Studies epigenome Humans Risk Factors
A genome-wide association study of total child psychiatric problems scores.
Alexander Neumann, Ilja M Nolte, Irene Pappa, Tarunveer S Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew Whitehouse, Catharina EM van Beijsterveldt, Beben Benyamin, Anke R Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter J van der Most, Teemu Palviainen, Beate St Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla MT Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany, Hans Bisgaard, Klaus Bønnelykke, Gareth E Davies, Christian Hakulinen, Anjali K Henders, Elina Hyppönen, Jakob Stokholm, Meike Bartels, Jouke-Jan Hottenga, Joachim Heinrich, John Hewitt, Liisa Keltikangas-Järvinen, Tellervo Korhonen, Jaakko Kaprio, Jari Lahti, Marius Lahti-Pulkkinen, Terho Lehtimäki, Christel M Middeldorp, Jackob M Najman, Craig Pennell, Chris Power, Albertine J Oldehinkel, Robert Plomin, Katri Räikkönen, Olli T Raitakari, Kaili Rimfeld, Lærke Sass, Harold Snieder, Marie Standl, Jordi Sunyer, Gail M Williams, Marian J Bakermans-Kranenburg, Dorret I Boomsma, Marinus H van IJzendoorn, Catharina A Hartman, Henning Tiemeier
Aug 22, 2022
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood...
Genetically determined height and coronary artery disease.
Christopher P Nelson, Stephen E Hamby, Danish Saleheen, Jenna C Hopewell, Lingyao Zeng, Themistocles L Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O Boehm, Robert J Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W Franks, Leif Groop, Alistair S Hall, Anders Hamsten, Christian Hengstenberg, G Kees Hovingh, Erik Ingelsson, Sekar Kathiresan, Frank Kee, Inke R König, Jaspal Kooner, Terho Lehtimäki, Winifred März, Ruth McPherson, Andres Metspalu, Markku S Nieminen, Christopher J O'Donnell, Colin NA Palmer, Annette Peters, Markus Perola, Muredach P Reilly, Samuli Ripatti, Robert Roberts, Veikko Salomaa, Svati H Shah, Stefan Schreiber, Agneta Siegbahn, Unnur Thorsteinsdottir, Giovani Veronesi, Nicholas Wareham, Cristen J Willer, Pierre A Zalloua, Jeanette Erdmann, Panos Deloukas, Hugh Watkins, Heribert Schunkert, John Danesh, John R Thompson, Nilesh J Samani, CARDIoGRAM+C4D Consortium
Jun 03, 2015
A genome-wide association study of total child psychiatric problems scores.
Alexander Neumann, Ilja M Nolte, Irene Pappa, Tarunveer S Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew Whitehouse, Catharina EM van Beijsterveldt, Beben Benyamin, Anke R Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter J van der Most, Teemu Palviainen, Beate St Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla MT Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany, Hans Bisgaard, Klaus Bønnelykke, Gareth E Davies, Christian Hakulinen, Anjali K Henders, Elina Hyppönen, Jakob Stokholm, Meike Bartels, Jouke-Jan Hottenga, Joachim Heinrich, John Hewitt, Liisa Keltikangas-Järvinen, Tellervo Korhonen, Jaakko Kaprio, Jari Lahti, Marius Lahti-Pulkkinen, Terho Lehtimäki, Christel M Middeldorp, Jackob M Najman, Craig Pennell, Chris Power, Albertine J Oldehinkel, Robert Plomin, Katri Räikkönen, Olli T Raitakari, Kaili Rimfeld, Lærke Sass, Harold Snieder, Marie Standl, Jordi Sunyer, Gail M Williams, Marian J Bakermans-Kranenburg, Dorret I Boomsma, Marinus H van IJzendoorn, Catharina A Hartman, Henning Tiemeier
Sep 22, 2022
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood...
Distribution and medical impact of loss-of-function variants in the Finnish founder population.
Elaine T Lim, Peter Würtz, Aki S Havulinna, Priit Palta, Taru Tukiainen, Karola Rehnström, Tõnu Esko, Reedik Mägi, Michael Inouye, Tuuli Lappalainen, Yingleong Chan, Rany M Salem, Monkol Lek, Jason Flannick, Xueling Sim, Alisa Manning, Claes Ladenvall, Suzannah Bumpstead, Eija Hämäläinen, Kristiina Aalto, Mikael Maksimow, Marko Salmi, Stefan Blankenberg, Diego Ardissino, Svati Shah, Benjamin Horne, Ruth McPherson, Gerald K Hovingh, Muredach P Reilly, Hugh Watkins, Anuj Goel, Martin Farrall, Domenico Girelli, Alex P Reiner, Nathan O Stitziel, Sekar Kathiresan, Stacey Gabriel, Jeffrey C Barrett, Terho Lehtimäki, Markku Laakso, Leif Groop, Jaakko Kaprio, Markus Perola, Mark I McCarthy, Michael Boehnke, David M Altshuler, Cecilia M Lindgren, Joel N Hirschhorn, Andres Metspalu, Nelson B Freimer, Tanja Zeller, Sirpa Jalkanen, Seppo Koskinen, Olli Raitakari, Richard Durbin, Daniel G MacArthur, Veikko Salomaa, Samuli Ripatti, Mark J Daly, Aarno Palotie, Sequencing Initiative Suomi (SISu) Project
Sep 10, 2018
Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in...
A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
Matthew Traylor, Kari-Matti Mäkelä, Laura L Kilarski, Elizabeth G Holliday, William J Devan, Mike A Nalls, Kerri L Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2) METASTROKE, Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M Maguire, Matthew Walters, Ale Algra, Pankaj Sharma, John R Attia, Giorgio B Boncoraglio, Peter M Rothwell, Paul IW de Bakker, Joshua C Bis, Danish Saleheen, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, James F Meschia, Christopher Levi, Martin Dichgans, Terho Lehtimäki, Cathryn M Lewis, Hugh S Markus
Nov 08, 2018
Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of...
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.
Danielle E Haslam, Gina M Peloso, Melanie Guirette, Fumiaki Imamura, Traci M Bartz, Achilleas N Pitsillides, Carol A Wang, Ruifang Li-Gao, Jason M Westra, Niina Pitkänen, Kristin L Young, Mariaelisa Graff, Alexis C Wood, Kim VE Braun, Jian'an Luan, Mika Kähönen, Jessica C Kiefte-de Jong, Mohsen Ghanbari, Nathan Tintle, Rozenn N Lemaitre, Dennis O Mook-Kanamori, Kari North, Mika Helminen, Yasmin Mossavar-Rahmani, Linda Snetselaar, Lisa W Martin, Jorma S Viikari, Wendy H Oddy, Craig E Pennell, Frits R Rosendall, M Arfan Ikram, Andre G Uitterlinden, Bruce M Psaty, Dariush Mozaffarian, Jerome I Rotter, Kent D Taylor, Terho Lehtimäki, Olli T Raitakari, Kara A Livingston, Trudy Voortman, Nita G Forouhi, Nick J Wareham, Renée de Mutsert, Steven S Rich, JoAnn E Manson, Samia Mora, Paul M Ridker, Jordi Merino, James B Meigs, Hassan S Dashti, Daniel I Chasman, Alice H Lichtenstein, Caren E Smith, Josée Dupuis, Mark A Herman, Nicola M McKeown
Jul 20, 2021
BACKGROUND: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have...
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
Matthias Wielscher, Pooja R Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M Psaty, Marie Loh, Joshua C Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J Deary, Marc Chadeau-Hyam, Jennifer A Brody, Alexia Cardona, Elizabeth Selvin, Alicia K Smith, Andrew H Miller, Mylin A Torres, Eirini Marouli, Xin Gào, Joyce BJ van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao ZHANG, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A Hurme, Olli T Raitakari, Elena Colicino, Andrea A Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS Consortium, Karen N Conneely, Jaspal S Kooner, Anna Köttgen, Bastiaan T Heijmans, Panos Deloukas, Caroline Relton, Kenneth Ong, Jordana T Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C Chambers, Abbas Dehghan, Marjo-Riitta Järvelin
May 09, 2022
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent...
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Bram P Prins, Timothy J Mead, Jennifer A Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T Klena, George C Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, Antonietta Robino, Molly Schwartz, Jessica van Setten, Albert V Smith, Niek Verweij, Helen R Warren, Stefan Weiss, Alvaro Alonso, David O Arnar, Michiel L Bots, Rudolf A de Boer, Anna F Dominiczak, Mark Eijgelsheim, Patrick T Ellinor, Xiuqing Guo, Stephan B Felix, Tamara B Harris, Caroline Hayward, Susan R Heckbert, Paul L Huang, JW Jukema, Mika Kähönen, Jan A Kors, Pier D Lambiase, Lenore J Launer, Man Li, Allan Linneberg, Christopher P Nelson, Oluf Pedersen, Marco Perez, Annette Peters, Ozren Polasek, Bruce M Psaty, Olli T Raitakari, Kenneth M Rice, Jerome I Rotter, Moritz F Sinner, Elsayed Z Soliman, Tim D Spector, Konstantin Strauch, Unnur Thorsteinsdottir, Andrew Tinker, Stella Trompet, André Uitterlinden, Ilonca Vaartjes, Peter van der Meer, Uwe Völker, Henry Völzke, Melanie Waldenberger, James G Wilson, Zhijun Xie, Folkert W Asselbergs, Marcus Dörr, Cornelia M van Duijn, Paolo Gasparini, Daniel F Gudbjartsson, Vilmundur Gudnason, Torben Hansen, Stefan Kääb, Jørgen K Kanters, Charles Kooperberg, Terho Lehtimäki, Henry J Lin, Steven A Lubitz, Dennis O Mook-Kanamori, Francesco J Conti, Christopher H Newton-Cheh, Jonathan Rosand, Igor Rudan, Nilesh J Samani, Gianfranco Sinagra, Blair H Smith, Hilma Holm, Bruno H Stricker, Sheila Ulivi, Nona Sotoodehnia, Suneel S Apte, Pim van der Harst, Kari Stefansson, Patricia B Munroe, Dan E Arking, Cecilia W Lo, Yalda Jamshidi
Sep 17, 2018
ADAMTS6 Conduction exome chip Meta-Analysis ADAMTS Proteins Animals Black People Connexin 43 Electrocardiography Exome Female Gene Expression Gene Expression Profiling Genetic Loci Genome-Wide Association Study Heart Conduction System Humans Male Mice Middle Aged Myocardium Open Reading Frames Polymorphism Single Nucleotide White People Exome Sequencing
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Mathias Gorski, Peter J van der Most, Alexander Teumer, Audrey Y Chu, Man Li, Vladan Mijatovic, Ilja M Nolte, Massimiliano Cocca, Daniel Taliun, Felicia Gomez, Yong Li, Bamidele Tayo, Adrienne Tin, Mary F Feitosa, Thor Aspelund, John Attia, Reiner Biffar, Murielle Bochud, Eric Boerwinkle, Ingrid Borecki, Erwin P Bottinger, Ming-Huei Chen, Vincent Chouraki, Marina Ciullo, Josef Coresh, Marilyn C Cornelis, Gary C Curhan, Adamo Pio d'Adamo, Abbas Dehghan, Laura Dengler, Jingzhong Ding, Gudny Eiriksdottir, Karlhans Endlich, Stefan Enroth, Tõnu Esko, Oscar H Franco, Paolo Gasparini, Christian Gieger, Giorgia Girotto, Omri Gottesman, Vilmundur Gudnason, Ulf Gyllensten, Stephen J Hancock, Tamara B Harris, Catherine Helmer, Simon Höllerer, Edith Hofer, Albert Hofman, Elizabeth G Holliday, Georg Homuth, Frank B Hu, Cornelia Huth, Nina Hutri-Kähönen, Shih-Jen Hwang, Medea Imboden, Åsa Johansson, Mika Kähönen, Wolfgang König, Holly Kramer, Bernhard K Krämer, Ashish Kumar, Zoltan Kutalik, Jean-Charles Lambert, Lenore J Launer, Terho Lehtimäki, Martin de Borst, Gerjan Navis, Morris Swertz, Yongmei Liu, Kurt Lohman, Ruth JF Loos, Yingchang Lu, Leo-Pekka Lyytikäinen, Mark A McEvoy, Christa Meisinger, Thomas Meitinger, Andres Metspalu, Marie Metzger, Evelin Mihailov, Paul Mitchell, Matthias Nauck, Albertine J Oldehinkel, Matthias Olden, Brenda Wjh Penninx, Giorgio Pistis, Peter P Pramstaller, Nicole Probst-Hensch, Olli T Raitakari, Rainer Rettig, Paul M Ridker, Fernando Rivadeneira, Antonietta Robino, Sylvia E Rosas, Douglas Ruderfer, Daniela Ruggiero, Yasaman Saba, Cinzia Sala, Helena Schmidt, Reinhold Schmidt, Rodney J Scott, Sanaz Sedaghat, Albert V Smith, Rossella Sorice, Benedicte Stengel, Sylvia Stracke, Konstantin Strauch, Daniela Toniolo, Andre G Uitterlinden, Sheila Ulivi, Jorma S Viikari, Uwe Völker, Peter Vollenweider, Henry Völzke, Dragana Vuckovic, Melanie Waldenberger, Jie Jin Wang, Qiong Yang, Daniel I Chasman, Gerard Tromp, Harold Snieder, Iris M Heid, Caroline S Fox, Anna Köttgen, Cristian Pattaro, Carsten A Böger, Christian Fuchsberger
Nov 21, 2018
HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation...
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
Milly S Tedja, Robert Wojciechowski, Pirro G Hysi, Nicholas Eriksson, Nicholas A Furlotte, Virginie JM Verhoeven, Adriana I Iglesias, Magda A Meester-Smoor, Stuart W Tompson, Qiao Fan, Anthony P Khawaja, Ching-Yu Cheng, René Höhn, Kenji Yamashiro, Adam Wenocur, Clare Grazal, Toomas Haller, Andres Metspalu, Juho Wedenoja, Jost B Jonas, Ya Xing Wang, Jing Xie, Paul Mitchell, Paul J Foster, Barbara EK Klein, Ronald Klein, Andrew D Paterson, S Mohsen Hosseini, Rupal L Shah, Cathy Williams, Yik Ying Teo, Yih Chung Tham, Preeti Gupta, Wanting Zhao, Yuan Shi, Woei-Yuh Saw, E-Shyong Tai, Xue Ling Sim, Jennifer E Huffman, Ozren Polašek, Caroline Hayward, Goran Bencic, Igor Rudan, James F Wilson, CREAM Consortium, 23andMe Research Team, UK Biobank Eye and Vision Consortium, Peter K Joshi, Akitaka Tsujikawa, Fumihiko Matsuda, Kristina N Whisenhunt, Tanja Zeller, Peter J van der Spek, Roxanna Haak, Hanne Meijers-Heijboer, Elisabeth M van Leeuwen, Sudha K Iyengar, Jonathan H Lass, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Johannes R Vingerling, Terho Lehtimäki, Olli T Raitakari, Ginevra Biino, Maria Pina Concas, Tae-Hwi Schwantes-An, Robert P Igo, Gabriel Cuellar-Partida, Nicholas G Martin, Jamie E Craig, Puya Gharahkhani, Katie M Williams, Abhishek Nag, Jugnoo S Rahi, Phillippa M Cumberland, Cécile Delcourt, Céline Bellenguez, Janina S Ried, Arthur A Bergen, Thomas Meitinger, Christian Gieger, Tien Yin Wong, Alex W Hewitt, David A Mackey, Claire L Simpson, Norbert Pfeiffer, Olavi Pärssinen, Paul N Baird, Veronique Vitart, Najaf Amin, Cornelia M van Duijn, Joan E Bailey-Wilson, Terri L Young, Seang-Mei Saw, Dwight Stambolian, Stuart MacGregor, Jeremy A Guggenheim, Joyce Y Tung, Christopher J Hammond, Caroline CW Klaver
Jul 29, 2019
Refractive errors, including myopia, are the most frequent eye disorders worldwide and an increasingly common cause of blindness. This genome-wide association meta-analysis in 160,420 participants and replication in 95,505...
Physical activity attenuates the influence of FTO variants on obesity risk
Tuomas O Kilpeläinen, Lu Qi, Soren Brage, Stephen J Sharp, Emily Sonestedt, Ellen Demerath, Tariq Ahmad, Samia Mora, Marika Kaakinen, Camilla Helene Sandholt, Christina Holzapfel, Christine S Autenrieth, Elina Hyppönen, Stéphane Cauchi, Meian He, Zoltan Kutalik, Meena Kumari, Alena Stančáková, Karina Meidtner, Beverley Balkau, Jonathan T Tan, Massimo Mangino, Nicholas J Timpson, Yiqing Song, M Carola Zillikens, Kathleen A Jablonski, Melissa E Garcia, Stefan Johansson, Jennifer L Bragg-Gresham, Ying Wu, Jana V van Vliet-Ostaptchouk, N Charlotte Onland-Moret, Esther Zimmermann, Natalia V Rivera, Toshiko Tanaka, Heather M Stringham, Günther Silbernagel, Stavroula Kanoni, Mary F Feitosa, Soren Snitker, Jonatan R Ruiz, Jeffery Metter, Maria Teresa Martinez Larrad, Mustafa Atalay, Maarit Hakanen, Najaf Amin, Christine Cavalcanti-Proença, Anders Grøntved, Göran Hallmans, John-Olov Jansson, Johanna Kuusisto, Mika Kähönen, Pamela L Lutsey, John J Nolan, Luigi Palla, Oluf Pedersen, Louis Pérusse, Frida Renström, Robert A Scott, Dmitry Shungin, Ulla Sovio, Tuija H Tammelin, Tapani Rönnemaa, Timo A Lakka, Matti Uusitupa, Manuel Serrano Rios, Luigi Ferrucci, Claude Bouchard, Aline Meirhaeghe, Mao Fu, Mark Walker, Ingrid B Borecki, George V Dedoussis, Andreas Fritsche, Claes Ohlsson, Michael Boehnke, Stefania Bandinelli, Cornelia M van Duijn, Shah Ebrahim, Debbie A Lawlor, Vilmundur Gudnason, Tamara B Harris, Thorkild IA Sørensen, Karen L Mohlke, Albert Hofman, André G Uitterlinden, Jaakko Tuomilehto, Terho Lehtimäki, Olli Raitakari, Bo Isomaa, Pål R Njølstad, Jose C Florez, Simin Liu, Andy Ness, Timothy D Spector, E Shyong Tai, Philippe Froguel, Heiner Boeing, Markku Laakso, Michael Marmot, Sven Bergmann, Chris Power, Kay-Tee Khaw, Daniel Chasman, Paul Ridker, Torben Hansen, Keri L Monda, Thomas Illig, Marjo-Riitta Järvelin, Nicholas J Wareham, Frank B Hu, Leif C Groop, Marju Orho-Melander, Ulf Ekelund, Paul W Franks, Ruth JF Loos
Nov 16, 2017
BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have...
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
Ming-Huei Chen, Laura M Raffield, Abdou Mousas, Saori Sakaue, Jennifer E Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L Bao, Xue Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, Ken Sin Lo, Huijun Qian, Caleb A Lareau, Mélissa Beaudoin, Karen A Hunt, Masato Akiyama, Traci M Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P Bottinger, Jennifer A Brody, Frank JA van Rooij, Kumaraswamynaidu Chitrala, Kelly Cho, Hélène Choquet, Adolfo Correa, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K Evans, James S Floyd, Linda Broer, Niels Grarup, Michael H Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna MM Howson, Qin Qin Huang, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotis Koskeridis, Leslie A Lange, Terho Lehtimäki, Markus M Lerch, Allan Linneberg, Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Hilary C Martin, Koichi Matsuda, Karen L Mohlke, Nina Mononen, Yoshinori Murakami, Girish N Nadkarni, Matthias Nauck, Kjell Nikus, Willem H Ouwehand, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M Psaty, Olli T Raitakari, David J Roberts, Stephen S Rich, Benjamin AT Rodriguez, Jonathan D Rosen, Jerome I Rotter, Petra Schubert, Cassandra N Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Richard C Trembath, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A Watkins, Alan B Zonderman, VA Million Veteran Program, Peter WF Wilson, Yun Li, Adam S Butterworth, Jean-François Gauchat, Charleston WK Chiang, Bingshan Li, Ruth JF Loos, William J Astle, Evangelos Evangelou, David A van Heel, Vijay G Sankaran, Yukinori Okada, Nicole Soranzo, Andrew D Johnson, Alexander P Reiner, Paul L Auer, Guillaume Lettre
Jun 18, 2020
Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified...
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