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Results: 106
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows...
Animals Biomarkers Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Lineage Cell Proliferation Clone Cells Embryo Culture Techniques Embryo Implantation Embryonic Stem Cells Extracellular Signal-Regulated MAP Kinases Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Gestational Age Laminin Mice Mice 129 Strain Mice Inbred C57BL Mice Inbred CBA Phenotype Pluripotent Stem Cells Transcription Factors
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis.
Thorsten Boroviak, Remco Loos, Patrick Lombard, Junko Okahara, Rüdiger Behr, Erika Sasaki, Jennifer Nichols, Austin Smith, Paul Bertone
Nov 23, 2015
Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex.
Anzy Miller, Meryem Ralser, Susan L Kloet, Remco Loos, Ryuichi Nishinakamura, Paul Bertone, Michiel Vermeulen, Brian Hendrich
Sep 08, 2016
Co-repressor ES CELLS ENHANCER NuRD Sall4 Transcription factor Animals Cell Differentiation Cell Line Chromatin Immunoprecipitation Computational Biology DNA-Binding Proteins Gene Expression Regulation Developmental Mass Spectrometry Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Nucleosomes Pluripotent Stem Cells Reverse Transcriptase Polymerase Chain Reaction Transcription Factors
The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression.
Susanne Bornelöv, Nicola Reynolds, Maria Xenophontos, Sarah Gharbi, Ewan Johnstone, Robin Floyd, Meryem Ralser, Jason Signolet, Remco Loos, Sabine Dietmann, Paul Bertone, Brian Hendrich
Oct 10, 2018
Mediator NuRD RNA Polymerase II Chromatin Embryonic Stem Cells ENHANCER Transcription Transcription factor Acetylation Animals Cell Line Gene Expression Regulation Histones Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Mouse embryonic stem cells Nucleosomes RNA Polymerase II Transcription Initiation Site Transcription Genetic
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik, Paul Bertone, Austin Smith
Nov 28, 2018
Citrullination regulates pluripotency and histone H1 binding to chromatin.
Maria A Christophorou, Gonçalo Castelo-Branco, Richard P Halley-Stott, Clara Slade Oliveira, Remco Loos, Aliaksandra Radzisheuskaya, Kerri A Mowen, Paul Bertone, José CR Silva, Magdalena Zernicka-Goetz, Michael L Nielsen, John B Gurdon, Tony Kouzarides
Mar 17, 2016
Animals Arginine Binding Sites Cellular Reprogramming Chromatin Chromatin Assembly and Disassembly Citrulline DNA Embryo Mammalian Gene Expression Regulation Histones Hydrolases Mice Pluripotent Stem Cells Protein Binding Protein Processing Post-Translational Protein-Arginine Deiminase Type 4 Protein-Arginine Deiminases Proteomics Substrate Specificity Transcription Genetic
The genetics of obesity
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct...
Development and initial validation of the role strain questionnaire for junior athletes (RSQ-JA)
Fleur E. C. A. Van Rens, Erika Borkoles, Damian Farrow, Thomas Curran, Remco C. J. Polman
May 01, 2016
In a series of related studies, the relevance of a role strain framework to interpret the difficulties junior elite athletes experience in their multiple life domains was assessed. Here, the Role Strain Questionnaire for Junior...
GWAS for BMI
Muller et al. [1] have provided a strong critique of the Genome-Wide Association Studies (GWAS) of body-mass index (BMI), arguing that the GWAS approach for the study of BMI is flawed, and has provided us with few biological...
Complex adiabatic connection
Processes related to electronically excited states are central in many areas of science; however, accurately determining excited-state energies remains a major challenge in theoretical chemistry. Recently, higher energy...
Development and initial validation of the role strain questionnaire for junior athletes (RSQ-JA)
Fleur E. C. A. Van Rens, Erika Borkoles, Damian Farrow, Thomas Curran, Remco C. J. Polman
May 01, 2016
In a series of related studies, the relevance of a role strain framework to interpret the difficulties junior elite athletes experience in their multiple life domains was assessed. Here, the Role Strain Questionnaire for Junior...
Mendelian Randomisation Study of Childhood BMI and Early Menarche.
Hannah S Mumby, Cathy E Elks, Shengxu Li, Stephen J Sharp, Kay-Tee Khaw, Robert N Luben, Nicholas J Wareham, Ruth JF Loos, Ken K Ong
Oct 03, 2017
Visualizing trypanosomes in a vertebrate host reveals novel swimming behaviours, adaptations and attachment mechanisms.
Éva Dóró, Sem H Jacobs, Ffion R Hammond, Henk Schipper, Remco Pm Pieters, Mark Carrington, Geert F Wiegertjes, Maria Forlenza
Oct 28, 2019
Trypanosomes are important disease agents of humans, livestock and cold-blooded species, including fish. The cellular morphology of trypanosomes is central to their motility, adaptation to the host's environments and...
MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai.
Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies
Janina Jamasbi, Remco TA Megens, Mariaelvy Bianchini, Götz Münch, Martin Ungerer, Alexander Faussner, Shachar Sherman, Adam Walker, Pankaj Goyal, Stephanie Jung, Richard Brandl, Christian Weber, Reinhard Lorenz, Richard Farndale, Natalie Elia, Wolfgang Siess
Jun 01, 2015
High-throughput elucidation of thrombus formation reveals sources of platelet function variability.
Johanna P van Geffen, Sanne LN Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance CFMJ Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke JE Kuijpers, Willem H Ouwehand, Kate Downes, Johan WM Heemskerk
Oct 31, 2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in...
Outcome prediction of head and neck squamous cell carcinoma by MRI radiomic signatures.
Steven W Mes, Floris HP van Velden, Boris Peltenburg, Carel FW Peeters, Dennis E Te Beest, Mark A van de Wiel, Joost Mekke, Doriene C Mulder, Roland M Martens, Jonas A Castelijns, Frank A Pameijer, Remco de Bree, Ronald Boellaard, C René Leemans, Ruud H Brakenhoff, Pim de Graaf
Jun 04, 2021
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by a variety of quantitative features extracted from diagnostic images, termed radiomics. The aim...
Factor Analysis Head and Neck Neoplasms Magnetic Resonance Imaging Prognosis Aged Area Under Curve Biomarkers Comorbidity Disease-Free Survival Factor Analysis Statistical Female Head and Neck Neoplasms Humans Kaplan-Meier Estimate Magnetic Resonance Imaging Male Middle Aged Neoplasm Recurrence Local Observer Variation Prognosis Radiometry Reproducibility of Results Retrospective Studies Squamous Cell Carcinoma of Head and Neck Treatment Outcome
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.
Sanne LN Brouns, Johanna P van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W Farndale, Kenneth J Clemetson, Henri MH Spronk, Paola EJ van der Meijden, Rachel Cavill, Marijke JE Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan WM Heemskerk
Sep 09, 2020
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet...
Germline TERT promoter mutations are rare in familial melanoma.
Mark Harland, Mia Petljak, Carla Daniela Robles-Espinoza, Zhihao Ding, Nelleke A Gruis, Remco van Doorn, Karen A Pooley, Alison M Dunning, Lauren G Aoude, Karin AW Wadt, Anne-Marie Gerdes, Kevin M Brown, Nicholas K Hayward, Julia A Newton-Bishop, David J Adams, D Timothy Bishop
Oct 07, 2015
Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study.
Sofus C Larsen, Lars Ängquist, Jane N Østergaard, Tarunveer S Ahluwalia, Karani S Vimaleswaran, Nina Roswall, Lotte M Mortensen, Birgit M Nielsen, Anne Tjønneland, Nicholas J Wareham, Domenico Palli, Giovanna Masala, Wim HM Saris, Daphne L van der A, Jolanda MA Boer, Edith JM Feskens, Heiner Boeing, Marianne U Jakobsen, Ruth JF Loos, Thorkild IA Sørensen, Kim Overvad
Aug 09, 2017
BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect...
Fatty Acids gene-diet interaction Genetics obesity weight change Adult Alleles Body Mass Index CCAAT-Enhancer-Binding Protein-beta Case-Control Studies Cohort Studies Diet Dietary Fats Fatty Acids Fatty Acids Monounsaturated Fatty Acids Unsaturated Female Follow-Up Studies Genotyping Techniques Humans Linkage Disequilibrium Male Middle Aged Nutrition Assessment PPAR gamma Phosphoenolpyruvate Carboxykinase (ATP) Polymorphism Single Nucleotide Sterol Regulatory Element Binding Protein 1 Waist Circumference Weight Gain White People
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