Search
Results: 76
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
Compliance, noncompliance, and the in-between
Abstract: Objectives: Police legitimacy can hinge on what happens in police–civilian encounters, yet much remains unknown about the socio-psychological processes involved in these bilateral interactions, especially those...
Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation.
Mustapha Abubakar, Jenny Chang-Claude, H Raza Ali, Nilanjan Chatterjee, Penny Coulson, Frances Daley, Fiona Blows, Javier Benitez, Roger L Milne, Hermann Brenner, Christa Stegmaier, Arto Mannermaa, Anja Rudolph, Peter Sinn, Fergus J Couch, Peter Devilee, Rob AEM Tollenaar, Caroline Seynaeve, Jonine Figueroa, Jolanta Lissowska, Stephen Hewitt, Maartje J Hooning, Antoinette Hollestelle, Renée Foekens, Linetta B Koppert, kConFab Investigators, Manjeet K Bolla, Qin Wang, Michael E Jones, Minouk J Schoemaker, Renske Keeman, Douglas F Easton, Anthony J Swerdlow, Mark E Sherman, Marjanka K Schmidt, Paul D Pharoah, Montserrat Garcia-Closas
Apr 13, 2018
Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+...
Ki67 Breast Cancer EPIDEMIOLOGY grade hormone therapy nulliparity obesity Proliferation Adult Aged Biomarkers Tumor Body Mass Index Breast Neoplasms Case-Control Studies Cell Proliferation Contraceptives Oral Hormonal Female Humans Ki-67 Antigen Middle Aged Neoplasm Grading obesity Parity Receptors Estrogen Receptors Progesterone Risk Factors
Intrusive memories of trauma
Lalitha Iyadurai, Renée M Visser, Alex Lau-Zhu, Kate Porcheret, Antje Horsch, Emily A Holmes, Ella L James
Nov 20, 2018
Intrusive memories of a traumatic event can be distressing and disruptive, and comprise a core clinical feature of post-traumatic stress disorder (PTSD). Intrusive memories involve mental imagery-based impressions that intrude...
The influence of acoustic startle probes on fear learning in humans.
Michelle IC de Haan, Sonja van Well, Renée M Visser, H Steven Scholte, Guido A van Wingen, Merel Kindt
Jan 11, 2019
Even though human fear-conditioning involves affective learning as well as expectancy learning, most studies assess only one of the two distinct processes. Commonly used read-outs of associative fear learning are the...
Objectively Measured Physical Activity and Body Fatness
Esther Winters-VAN Eekelen, Jeroen HPM VAN DER Velde, Sebastiaan C Boone, Kate Westgate, Søren Brage, Hildo J Lamb, Frits R Rosendaal, Renée de Mutsert
Jun 07, 2021
PURPOSE: It remains unclear to what extent habitual physical activity and sedentary time (ST) are associated with visceral fat and liver fat. We studied the substitution of ST with time spent physically active and total body fat...
Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial).
Martin Knapp, Derek King, Renée Romeo, Jessica Adams, Ashley Baldwin, Clive Ballard, Sube Banerjee, Robert Barber, Peter Bentham, Richard G Brown, Alistair Burns, Tom Dening, David Findlay, Clive Holmes, Tony Johnson, Robert Jones, Cornelius Katona, James Lindesay, Ajay Macharouthu, Ian McKeith, Rupert McShane, John T O'Brien, Patrick PJ Phillips, Bart Sheehan, Robert Howard
Nov 12, 2018
OBJECTIVE: Most investigations of pharmacotherapy for treating Alzheimer's disease focus on patients with mild-to-moderate symptoms, with little evidence to guide clinical decisions when symptoms become severe. We examined...
Alzheimer's Disease cost-effectiveness Donepezil Memantine Activities of Daily Living Aged Aged 80 and over Alzheimer Disease Cholinesterase Inhibitors Cognition Cost-Benefit Analysis Donepezil Double-Blind Method England Female Health Care Costs Humans Indans Memantine Piperidines Quality of life Wales
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation
Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata‐Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
Oct 07, 2021
Published by: The EMBO journal
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
Olga Sin, Tristan de Jong, Alejandro Mata-Cabana, Michelle Kudron, Mohamad Amr Zaini, Francesco A Aprile, Renée I Seinstra, Esther Stroo, Roméo Willinge Prins, Céline N Martineau, Hai Hui Wang, Wytse Hogewerf, Anne Steinhof, Erich E Wanker, Michele Vendruscolo, Cornelis F Calkhoven, Valerie Reinke, Victor Guryev, Ellen AA Nollen
Sep 09, 2019
Protein aggregation is associated with age-related neurodegenerative disorders, such as Alzheimer's and polyglutamine diseases. As a causal relationship between protein aggregation and neurodegeneration remains elusive...
C. elegans MOAG-2/LIR-3 RNA Polymerase III Non-coding RNA polyglutamine protein aggregation Protein homeostasis protein quality control snoRNA tRNA Active Transport Cell Nucleus Animals Animals Genetically Modified Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Nucleus Cytosol Disease Models Animal Neurodegenerative Diseases Peptides Promoter Regions Genetic Protein Aggregates protein aggregation Pathological Protein Binding RNA Interference RNA Polymerase III RNA Small Untranslated Transcription Factors Transcription Genetic
Analysing the attributes of Comprehensive Cancer Centres and Cancer Centres across Europe to identify key hallmarks.
Sebastian Kehrloesser, Simon Oberst, Willien Westerhuis, Astrid Wendler, Anke Wind, Harriët Blaauwgeers, Jean-Benoit Burrion, Péter Nagy, Gunnar Saeter, Eva Gustafsson, Paolo De Paoli, József Lovey, Claudio Lombardo, Thierry Philip, Dominique de Valeriola, Marjet Docter, Femke Boomsma, Mahasti Saghatchian, Marek Svoboda, Irene Philip, Francesco Monetti, Henk Hummel, Gordon McVie, Renée Otter, Wim van Harten
May 05, 2021
There is a persistent variation in cancer outcomes among and within European countries suggesting (among other causes) inequalities in access to or delivery of high-quality cancer care. European policy (EU Cancer Mission and...
accreditation Clinical Trials comprehensive cancer center multidisciplinarity quality standard Translational Research Academies and Institutes Biomedical Research Cancer Care Facilities Cohort Studies Europe Humans Medical Oncology Neoplasms Patient Care Team Patient-Centered Care Quality of Health Care Translational Research Biomedical
Socioecology shapes child and adolescent time allocation in twelve hunter-gatherer and mixed-subsistence forager societies.
Sheina Lew-Levy, Rachel Reckin, Stephen M Kissler, Ilaria Pretelli, Adam H Boyette, Alyssa N Crittenden, Renée V Hagen, Randall Haas, Karen L Kramer, Jeremy Koster, Matthew J O'Brien, Koji Sonoda, Todd A Surovell, Jonathan Stieglitz, Bram Tucker, Noa Lavi, Kate Ellis-Davies, Helen E Davis
May 16, 2022
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen AA Nollen
Nov 25, 2021
While aggregation-prone proteins are known to accelerate aging and cause age-related diseases, the cellular mechanisms that drive their cytotoxicity remain unresolved. The orthologous proteins MOAG-4, SERF1A, and SERF2 have...
MOAG-4 SERF Amyloid protein aggregation protein quality control Amino Acid Sequence Amyloid Amyloidogenic Proteins Animals Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Gene Expression Regulation HEK293 Cells Humans Hydrophobic and Hydrophilic Interactions Intracellular Signaling Peptides and Proteins Nerve Tissue Proteins Peptides Protein Aggregates Protein Array Analysis Protein Binding Signal Transduction Static Electricity ALPHA-SYNUCLEIN
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.
Arie B Brinkman, Serena Nik-Zainal, Femke Simmer, F Germán Rodríguez-González, Marcel Smid, Ludmil B Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J van de Vijver, Anne-Lise Børresen-Dale, Andrea L Richardson, GIlles Thomas, Ivo G Gut, John WM Martens, John A Foekens, Michael R Stratton, Hendrik G Stunnenberg
May 03, 2019
Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the...
Development and validation of circulating CA125 prediction models in postmenopausal women.
Naoko Sasamoto, Ana Babic, Bernard A Rosner, Renée T Fortner, Allison F Vitonis, Hidemi Yamamoto, Raina N Fichorova, Linda J Titus, Anne Tjønneland, Louise Hansen, Marina Kvaskoff, Agnès Fournier, Francesca Romana Mancini, Heiner Boeing, Antonia Trichopoulou, Eleni Peppa, Anna Karakatsani, Domenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Valentina Fiano, N Charlotte Onland-Moret, Elisabete Weiderpass, Inger T Gram, J Ramón Quirós, Leila Lujan-Barroso, Maria-Jose Sánchez, Sandra Colorado-Yohar, Aurelio Barricarte, Pilar Amiano, Annika Idahl, Eva Lundin, Hanna Sartor, Kay-Tee Khaw, Timothy J Key, David Muller, Elio Riboli, Marc Gunter, Laure Dossus, Britton Trabert, Nicolas Wentzensen, Rudolf Kaaks, Daniel W Cramer, Shelley S Tworoger, Kathryn L Terry
Nov 25, 2020
BACKGROUND: Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals....
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
Michele Perni, Annemieke van der Goot, Ryan Limbocker, Tjakko J van Ham, Francesco A Aprile, Catherine K Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco, Serene W Chen, Pavan K Challa, Julius B Kirkegaard, Romain F Laine, Kai Yu Ma, Martin BD Müller, Tessa Sinnige, Janet R Kumita, Samuel IA Cohen, Renée Seinstra, Gabriele S Kaminski Schierle, Clemens F Kaminski, Denise Barbut, Alfonso De Simone, Tuomas PJ Knowles, Michael Zasloff, Ellen AA Nollen, Michele Vendruscolo, Christopher M Dobson
May 07, 2021
The aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are associated with familial forms of the...
External Validation of a Predictive Model for Acute Skin Radiation Toxicity in the REQUITE Breast Cohort
Tim Rattay, Petra Seibold, Miguel E. Aguado-Barrera, Manuel Altabas, David Azria, Gillian C. Barnett, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Charlotte E. Coles, Alison M. Dunning, Rebecca M. Elliott, Marie-Pierre Farcy Jacquet, Sara Gutiérrez-Enríquez, Kerstie Johnson, Anusha Müller, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S. Rosenstein, Dirk de Ruysscher, Maria C. de Santis, Elena Sperk, Hilary Stobart, R. Paul Symonds, Begoña Taboada-Valladares, Ana Vega, Liv Veldeman, Adam J. Webb, Catharine M. West, Riccardo Valdagni, Christopher J. Talbot, REQUITE consortium
Nov 13, 2020
Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of...
Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study.
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra Hm Peeters, Carla H van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Sep 26, 2018
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to...
Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort.
Adam J Webb, Emily Harper, Tim Rattay, Miguel E Aguado-Barrera, David Azria, Celine Bourgier, Muriel Brengues, Erik Briers, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Alessandro Cicchetti, Dirk de Ruysscher, Maria Carmen De Santis, Alison M Dunning, Rebecca M Elliott, Laura Fachal, Antonio Gómez-Caamaño, Sara Gutiérrez-Enríquez, Kerstie Johnson, Ramón Lobato-Busto, Sarah L Kerns, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S Rosenstein, Petra Seibold, Alejandro Seoane, Paloma Sosa-Fajardo, Elena Sperk, Begoña Taboada-Valladares, Riccardo Valdagni, Ana Vega, Liv Veldeman, Tim Ward, Catharine M West, R Paul Symonds, Christopher J Talbot, REQUITE consortium
Oct 24, 2022
BACKGROUND: Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time...
Osteoprotegerin and breast cancer risk by hormone receptor subtype
Renée T Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H Bas Bueno-De-Mesquita, Petra Hm Peeters, Carla H van Gils, Elisabete Weiderpass, Eiliv Lund, J Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A Merritt, Elio Riboli, Rudolf Kaaks
Feb 08, 2017
BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and...
Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma
Raul Zamora-Ros, Muath A Alghamdi, Valerie Cayssials, Silvia Franceschi, Martin Almquist, Joakim Hennings, Maria Sandström, Konstantinos K Tsilidis, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Kristina En Petersen, Francesca Romana Mancini, Yahya Mahamat-Saleh, Fabrice Bonnet, Tilman Kühn, Renée T Fortner, Heiner Boeing, Antonia Trichopoulou, Christina Bamia, Georgia Martimianaki, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Francesca Fasanelli, Guri Skeie, Tonje Braaten, Cristina Lasheras, Elena Salamanca-Fernández, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Peter Wallström, H Bas Bueno-De-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Julie A Schmidt, Dagfinn Aune, Graham Byrnes, Augustin Scalbert, Antonio Agudo, Sabina Rinaldi
Jan 02, 2019
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
Michele Perni, Annemieke van der Goot, Ryan Limbocker, Tjakko J. van Ham, Francesco A. Aprile, Catherine K. Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco, Serene W. Chen, Pavan K. Challa, Julius B. Kirkegaard, Romain F. Laine, Kai Yu Ma, Martin B. D. Müller, Tessa Sinnige, Janet R. Kumita, Samuel I. A. Cohen, Renée Seinstra, Gabriele S. Kaminski Schierle, Clemens F. Kaminski, Denise Barbut, Alfonso De Simone, Tuomas P. J. Knowles, Michael Zasloff, Ellen A. A. Nollen, Michele Vendruscolo, Christopher M. Dobson
Apr 05, 2021
The aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are associated with familial forms of the...
|
|< |
< |
1 |