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Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Using false discovery rates to benchmark SNP-callers in next-generation sequencing projects
Sequence alignments form the basis for many comparative and population genomic studies. Alignment
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
Using false discovery rates to benchmark SNP-callers in next-generation sequencing projects
Sequence alignments form the basis for many comparative and population genomic studies. Alignment
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
Rapid Manufacturing of Functional Engineering Components
This report details the work undertaken with the end goal of creating a machine capable of additive manufacturing of functional components using various materials. The research focuses on the manufacture of functional...
Published by: University of Bath
Rapid Manufacturing of Functional Engineering Components
This report details the work undertaken with the end goal of creating a machine capable of additive manufacturing of functional components using various materials. The research focuses on the manufacture of functional...
Published by: University of Bath
Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii.
Kerstin Voelz, Hansong Ma, Sujal Phadke, Edmond J Byrnes, Pinkuan Zhu, Olaf Mueller, Rhys A Farrer, Daniel A Henk, Yonathan Lewit, Yen-Ping Hsueh, Matthew C Fisher, Alexander Idnurm, Joseph Heitman, Robin C May
Oct 22, 2019
Since 1999 a lineage of the pathogen Cryptococcus gattii has been infecting humans and other animals in Canada and the Pacific Northwest of the USA. It is now the largest outbreak of a life-threatening fungal infection in a...
Transmission of hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen<em> Cryptococcus gattii</em>
Kerstin Voelz, Hansong Ma, Sujal Phadke, Edmond J. Byrnes, Pinkuan Zhu, Olaf Mueller, Rhys A. Farrer, Daniel A. Henk, Yonathan Lewit, Yen-Ping Hsueh, Matthew C. Fisher, Alexander Idnurm, Joseph Heitman, Robin C. May
Sep 05, 2013
Since 1999 a lineage of the pathogen Cryptococcus gattii has been infecting humans and other animals in Canada and the Pacific Northwest of the USA. It is now the largest outbreak of a life-threatening fungal infection in a...
Transmission of hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen<em> Cryptococcus gattii</em>
Kerstin Voelz, Hansong Ma, Sujal Phadke, Edmond J. Byrnes, Pinkuan Zhu, Olaf Mueller, Rhys A. Farrer, Daniel A. Henk, Yonathan Lewit, Yen-Ping Hsueh, Matthew C. Fisher, Alexander Idnurm, Joseph Heitman, Robin C. May
Sep 05, 2013
Since 1999 a lineage of the pathogen Cryptococcus gattii has been infecting humans and other animals in Canada and the Pacific Northwest of the USA. It is now the largest outbreak of a life-threatening fungal infection in a...
Spiking computation and stochastic amplification in a neuron-like semiconductor microstructure
We have demonstrated the proof of principle of a semiconductor neuron, which has dendrites, axon, and a soma and computes information encoded in electrical pulses in the same way as biological neurons. Electrical impulses...
CHINESE COVERBS AND ARGUMENT STRUCTURE
Catrin Sian Rhys
Jul 30, 2013
This paper provides an analysis of a set of verbs that are licensed either as main verbs or in a more preposition-like use as 'coverbs'. The aim of the paper is to address the lexical representation of these verbs and avoid...
Published by: Atlantic Provinces Linguistic Association
CHINESE COVERBS AND ARGUMENT STRUCTURE
Catrin Sian Rhys
Jul 30, 2013
This paper provides an analysis of a set of verbs that are licensed either as main verbs or in a more preposition-like use as 'coverbs'. The aim of the paper is to address the lexical representation of these verbs and avoid...
Published by: Atlantic Provinces Linguistic Association
Reproducibility of magnetic resonance fingerprinting-based T1 mapping of the healthy prostate at 1.5 and 3.0 T
Facilitating clinical translation of quantitative imaging techniques has been suggested as means of improving interobserver agreement and diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) of the prostate....
The biodiversity intactness index may underestimate losses.
The Biodiversity Intactness Index (BII) is a high-profile metric of an area’s average abundance of wild species relative to that in pre-modern times1 or in primary vegetation under current climatic conditions2. It has been...
Spiking computation and stochastic amplification in a neuron-like semiconductor microstructure
We have demonstrated the proof of principle of a semiconductor neuron, which has dendrites, axon, and a soma and computes information encoded in electrical pulses in the same way as biological neurons. Electrical impulses...
The architecture and stabilisation of flagellotropic tailed bacteriophages.
Joshua M Hardy, Rhys A Dunstan, Rhys Grinter, Matthew J Belousoff, Jiawei Wang, Derek Pickard, Hariprasad Venugopal, Gordon Dougan, Trevor Lithgow, Fasséli Coulibaly
Sep 21, 2020
Flagellotropic bacteriophages engage flagella to reach the bacterial surface as an effective means to increase the capture radius for predation. Structural details of these viruses are of great interest given the substantial...
Predicting materials properties without crystal structure
Abstract: Machine learning has the potential to accelerate materials discovery by accurately predicting materials properties at a low computational cost. However, the model inputs remain a key stumbling block. Current methods...
How to spare half a planet.
James Watson and Oscar Venter discuss the practicalities of conserving half of Earth's terrestrial ecosystems (Nature 550, 48-49; 2017). But could the non-conserved half be sufficient to support the growing food needs of the...
Predicting materials properties without crystal structure
Machine learning has the potential to accelerate materials discovery by accurately predicting materials properties at a low computational cost. However, the model inputs remain a key stumbling block. Current methods typically...
Regulation of mitochondrial dynamics by Aurora A kinase
Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here we...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Single-photon emission from single-electron transport in a SAW-driven lateral light-emitting diode.
Tzu-Kan Hsiao, Antonio Rubino, Yousun Chung, Seok-Kyun Son, Hangtian Hou, Jorge Pedrós, Ateeq Nasir, Gabriel Éthier-Majcher, Megan J Stanley, Richard T Phillips, Thomas A Mitchell, Jonathan P Griffiths, Ian Farrer, David A Ritchie, Christopher J B Ford
Mar 17, 2020
The long-distance quantum transfer between electron-spin qubits in semiconductors is important for realising large-scale quantum computing circuits. Electron-spin to photon-polarisation conversion is a promising technology for...
Published by: Nature Communications
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