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Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
The architecture and stabilisation of flagellotropic tailed bacteriophages.
Joshua M Hardy, Rhys A Dunstan, Rhys Grinter, Matthew J Belousoff, Jiawei Wang, Derek Pickard, Hariprasad Venugopal, Gordon Dougan, Trevor Lithgow, Fasséli Coulibaly
Sep 21, 2020
Flagellotropic bacteriophages engage flagella to reach the bacterial surface as an effective means to increase the capture radius for predation. Structural details of these viruses are of great interest given the substantial...
Rapid Manufacturing of Functional Engineering Components
This report details the work undertaken with the end goal of creating a machine capable of additive manufacturing of functional components using various materials. The research focuses on the manufacture of functional...
Published by: University of Bath
Rapid Manufacturing of Functional Engineering Components
This report details the work undertaken with the end goal of creating a machine capable of additive manufacturing of functional components using various materials. The research focuses on the manufacture of functional...
Published by: University of Bath
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health.
Michael J Wheeler, Paddy C Dempsey, Megan S Grace, Kathryn A Ellis, Paul A Gardiner, Daniel J Green, David W Dunstan
Dec 18, 2019
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very...
CHINESE COVERBS AND ARGUMENT STRUCTURE
Catrin Sian Rhys
Jul 30, 2013
This paper provides an analysis of a set of verbs that are licensed either as main verbs or in a more preposition-like use as 'coverbs'. The aim of the paper is to address the lexical representation of these verbs and avoid...
Published by: Atlantic Provinces Linguistic Association
CHINESE COVERBS AND ARGUMENT STRUCTURE
Catrin Sian Rhys
Jul 30, 2013
This paper provides an analysis of a set of verbs that are licensed either as main verbs or in a more preposition-like use as 'coverbs'. The aim of the paper is to address the lexical representation of these verbs and avoid...
Published by: Atlantic Provinces Linguistic Association
Reproducibility of magnetic resonance fingerprinting-based T1 mapping of the healthy prostate at 1.5 and 3.0 T
Facilitating clinical translation of quantitative imaging techniques has been suggested as means of improving interobserver agreement and diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) of the prostate....
Rise and Recharge
Abigail S Morris, Kelly A Mackintosh, David Dunstan, Neville Owen, Paddy Dempsey, Thomas Pennington, Melitta A McNarry
Dec 12, 2020
This feasibility study evaluated the effects of an individual-level intervention to target office workers total and prolonged sedentary behaviour during working hours, using an e-health smartphone application. A three-arm...
Sitting Less and Moving More
Through a hypertension lens, this review focuses on the serious health implications and potential counter-measures for the high volumes of uninterrupted sitting that characterises modern lifestyles. Reducing and breaking up...
The biodiversity intactness index may underestimate losses.
The Biodiversity Intactness Index (BII) is a high-profile metric of an area’s average abundance of wild species relative to that in pre-modern times1 or in primary vegetation under current climatic conditions2. It has been...
Predicting materials properties without crystal structure
Abstract: Machine learning has the potential to accelerate materials discovery by accurately predicting materials properties at a low computational cost. However, the model inputs remain a key stumbling block. Current methods...
Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity
Michael J Wheeler, Daniel J Green, Ester Cerin, Kathryn A Ellis, Ilkka Heinonen, Jaye Lewis, Louise H Naylor, Neale Cohen, Robyn Larsen, Paddy C Dempsey, Bronwyn A Kingwell, Neville Owen, David W Dunstan
Dec 22, 2020
BACKGROUND: Postprandial glucose, insulin, and triglyceride metabolism is impaired by prolonged sitting, but enhanced by exercise. The aim of this study was to assess the effects of a continuous exercise bout with and without...
How to spare half a planet.
James Watson and Oscar Venter discuss the practicalities of conserving half of Earth's terrestrial ecosystems (Nature 550, 48-49; 2017). But could the non-conserved half be sufficient to support the growing food needs of the...
Predicting materials properties without crystal structure
Machine learning has the potential to accelerate materials discovery by accurately predicting materials properties at a low computational cost. However, the model inputs remain a key stumbling block. Current methods typically...
Rise and Recharge
Abigail S Morris, Kelly A Mackintosh, Neville Owen, Paddy C Dempsey, David W Dunstan, Melitta A McNarry
Sep 14, 2021
This feasibility study explored the contextual factors influencing office workers' adherence to an e-health intervention targeting total and prolonged sedentary time over 12 weeks. A three-arm quasi-randomized intervention...
Regulation of mitochondrial dynamics by Aurora A kinase
Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here we...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Acute effects of breaking up prolonged sitting on fatigue and cognition
Patrik Wennberg, Carl-Johan Boraxbekk, Michael Wheeler, Bethany Howard, Paddy C Dempsey, Gavin Lambert, Nina Eikelis, Robyn Larsen, Parneet Sethi, Jessica Occleston, Jenny Hernestål-Boman, Kathryn A Ellis, Neville Owen, David W Dunstan
Feb 08, 2019
OBJECTIVES: To compare the acute effects of uninterrupted sitting with sitting interrupted by brief bouts of light-intensity walking on self-reported fatigue, cognition, neuroendocrine biomarkers and cardiometabolic risk markers...
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