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Results: 74
Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.
Netta Mäkinen, Mervi Aavikko, Tuomas Heikkinen, Minna Taipale, Jussi Taipale, Riitta Koivisto-Korander, Ralf Bützow, Pia Vahteristo
Jan 03, 2020
Uterine leiomyosarcomas (ULMSs) are aggressive smooth muscle tumors associated with poor clinical outcome. Despite previous cytogenetic and molecular studies, their molecular background has remained elusive. To examine somatic...
Adaptor Proteins Signal Transducing Aged Aged 80 and over Co-Repressor Proteins DNA Helicases Exome Female Gene Expression Regulation Neoplastic High-Throughput Nucleotide Sequencing Humans Leiomyosarcoma Mediator Complex Middle Aged Molecular Chaperones Mutation Rate Nuclear Proteins Telomere Homeostasis Tumor Suppressor Protein p53 Uterine Neoplasms X-linked Nuclear Protein
Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity.
Obesity is a constantly increasing health problem worldwide. It is associated with a systemic low-grade inflammation, which contributes to the development of metabolic disorders and comorbidities such as type 2 diabetes. Diet...
A computationally efficient Bayesian seemingly unrelated regressions model for high‐dimensional quantitative trait loci discovery
Leonardo Bottolo, Marco Banterle, Sylvia Richardson, Mika Ala‐Korpela, Marjo‐Riitta Järvelin, Alex Lewin
May 09, 2021
Specific adolescent prodromal symptoms associated with onset of psychosis in the Northern Finland Birth Cohort 1986.
Johanna Palomäki, Sebastian Therman, Martta Kerkelä, Marjo-Riitta Järvelin, Peter Jones, Graham K Murray, Tanja Nordström, Markus Heinimaa, Jouko Miettunen, Juha Veijola, Tiina Riekki
Oct 11, 2022
BACKGROUND: Several psychological symptoms in adolescence associate with later development of psychosis. However, it is unclear which symptoms specifically predict psychotic disorders rather than psychiatric disorders in...
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
Jun 08, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
May 23, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
Published by: Scientific reports
Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts.
Hugh Ramsay, Jennifer H Barnett, Graham K Murray, Jouko Miettunen, Pirjo Mäki, Marjo-Riitta Järvelin, George Davey Smith, Mika Ala-Korpela, Juha Veijola
Nov 22, 2018
BACKGROUND: Psychoses, especially schizophrenia, are often preceded by cognitive deficits and psychosis risk states. Altered metabolic profiles have been found in schizophrenia. However, the associations between metabolic...
Dopamine and Opioid Neurotransmission in Behavioral Addictions
Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Kati Alakurtti, Riitta Parkkola, Tuuli Lahti, Hannu Alho, Jussi Hirvonen, Eveliina Arponen, Sarita Forsback, Valtteri Kaasinen
Feb 07, 2017
Stability of the associations between early life risk indicators and adolescent overweight over the evolving obesity epidemic.
Lise Graversen, Thorkild IA Sørensen, Liselotte Petersen, Ulla Sovio, Marika Kaakinen, Annelli Sandbæk, Jaana Laitinen, Anja Taanila, Anneli Pouta, Marjo-Riitta Järvelin, Carsten Obel
Aug 19, 2020
BACKGROUND: Pre- and perinatal factors and preschool body size may help identify children developing overweight, but these factors might have changed during the development of the obesity epidemic. OBJECTIVE: We aimed to assess...
Preschool weight and body mass index in relation to central obesity and metabolic syndrome in adulthood.
Lise Graversen, Thorkild IA Sørensen, Liselotte Petersen, Ulla Sovio, Marika Kaakinen, Annelli Sandbæk, Jaana Laitinen, Anja Taanila, Anneli Pouta, Marjo-Riitta Järvelin, Carsten Obel
Aug 19, 2020
BACKGROUND: If preschool measures of body size routinely collected at preventive health examinations are associated with adult central obesity and metabolic syndrome, a focused use of these data for the identification of high...
Serotonergic and dopaminergic control of impulsivity in gambling disorder.
Valtteri Kaasinen, Emma A Honkanen, Kari Lindholm, Elina Jaakkola, Joonas Majuri, Riitta Parkkola, Tommi Noponen, Tero Vahlberg, Valerie Voon, Luke Clark, Juho Joutsa, Marko Seppänen
Jan 10, 2023
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition
Qin Wang, Clare Oliver-Williams, Olli T Raitakari, Jorma Viikari, Terho Lehtimäki, Mika Kähönen, Marjo-Riitta Järvelin, Veikko Salomaa, Markus Perola, John Danesh, Johannes Kettunen, Adam S Butterworth, Michael V Holmes, Mika Ala-Korpela
Nov 05, 2020
ANGPTL3 ANGPTL4 Amino Acids Drug targets Glycoprotein acetyls LPL lipoprotein lipids Lipoprotein subclasses Mendelian randomization Angiopoietin-Like Protein 3 Angiopoietin-Like Protein 4 Angiopoietin-like Proteins Angiopoietins Diabetes mellitus Type 2 Humans Mendelian Randomization Analysis Pharmaceutical Preparations
Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood
Stephen A Metcalf, Peter B Jones, Tanja Nordstrom, Markku Timonen, Pirjo Mäki, Jouko Miettunen, Erika Jääskeläinen, Marjo-Riitta Järvelin, Jan Stochl, Graham K Murray, Juha Veijola, Golam M Khandaker
Nov 03, 2016
Adolescent Adult C-Reactive Protein Inflammatory markers longitudinal study Psychotic Disorders Schizophrenia Systemic inflammation Adolescent Adult Age of Onset C-Reactive Protein Cohort Studies Cross-Sectional Studies Female Finland Humans International Classification of Diseases Longitudinal Studies Male Prospective Studies Psychiatric Status Rating Scales Psychotic Disorders Registries risk Schizophrenia Young Adult
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity
Tom A Bond, Rebecca C Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C Yang, Marc J Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M Evans, Alex M Lewin, Paul F O'Reilly, Deborah A Lawlor, Marjo-Riitta Järvelin
Feb 01, 2022
BACKGROUND: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms...
Metabolic Traits and Stroke Risk in Individuals of African Ancestry
Segun Fatumo, Ville Karhunen, Tinashe Chikowore, Toure Sounkou, Brenda Udosen, Chisom Ezenwa, Mariam Nakabuye, Opeyemi Soremekun, Iyas Daghlas, David K Ryan, Amybel Taylor, Amy M Mason, Scott M Damrauer, Marijana Vujkovic, Keith L Keene, Myriam Fornage, Marjo-Riitta Järvelin, Stephen Burgess, Dipender Gill
Mar 31, 2021
BACKGROUND AND PURPOSE: Metabolic traits affect ischemic stroke (IS) risk, but the degree to which this varies across different ethnic ancestries is not known. Our aim was to apply Mendelian randomization to investigate the...
Cholesterol ischemic stroke Lipid Mortality Risk factor Adult Black People Cholesterol HDL Cholesterol LDL Diabetes mellitus Type 2 Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Risk Factors stroke Triglycerides United Kingdom
The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).
Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Jaana Lindström, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Jul 15, 2022
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 27, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
Johannes Kettunen, Michael V. Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D. Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T. Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Mika Ala-Korpela
Jan 06, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 10, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Adolescent Adult Alleles Apolipoproteins B Cholesterol Ester Transfer Proteins Cholesterol LDL Cohort Studies Coronary Disease Female Follow-Up Studies genetic variation Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipoproteins Male Middle Aged Triglycerides Young Adult
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity
Tom A Bond, Rebecca C Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C Yang, Marc J Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M Evans, Alex M Lewin, Paul F O'Reilly, Deborah A Lawlor, Marjo-Riitta Järvelin
Mar 05, 2022
BACKGROUND: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms...
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.
Amir-Babak Sioofy-Khojine, Sarah J Richardson, Jonathan M Locke, Sami Oikarinen, Noora Nurminen, Antti-Pekka Laine, Kate Downes, Johanna Lempainen, John A Todd, Riitta Veijola, Jorma Ilonen, Mikael Knip, Noel G Morgan, Heikki Hyöty, Mark Peakman, Martin Eichmann
Sep 15, 2022
Autoimmunity Enterovirus genetic risk IFIH-1 Interferon induced with helicase C domain 1 MDA5 Melanoma differentiation-associated protein 5 Pancreatic islets type 1 diabetes rs1990760 Adult Alleles Autoantibodies Child DEAD-box RNA Helicases Diabetes mellitus Type 1 Enterovirus Enterovirus Infections Genetic Predisposition to Disease Humans Insulins Interferon-Induced Helicase IFIH1 Leukocytes Mononuclear RNA
Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.
Eeva Sliz, Johannes Kettunen, Michael V Holmes, Clare Oliver Williams, Charles Boachie, Qin Wang, Minna Männikkö, Sylvain Sebert, Robin Walters, Kuang Lin, Iona Y Millwood, Robert Clarke, Liming Li, Naomi Rankin, Paul Welsh, Christian Delles, J Wouter Jukema, Stella Trompet, Ian Ford, Markus Perola, Veikko Salomaa, Marjo-Riitta Järvelin, Zhengming Chen, Debbie A Lawlor, Mika Ala-Korpela, John Danesh, George Davey Smith, Naveed Sattar, Adam Butterworth, Peter Würtz
Feb 08, 2019
BACKGROUND: Both statins and PCSK9 inhibitors lower blood low-density lipoprotein cholesterol (LDL-C) levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these two...
Mendelian randomization PCSK9 lipids and lipoprotein metabolism Metabolomics statin therapy Aged Aged 80 and over Amino Acids Cardiovascular Diseases Cholesterol LDL Cholesterol VLDL Double-Blind Method Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Mendelian Randomization Analysis Metabolomics PCSK9 Inhibitors Placebo Effect Pravastatin Proprotein Convertase 9
Published by: Circulation
Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior.
Jorim J Tielbeek, Ada Johansson, Tinca JC Polderman, Marja-Riitta Rautiainen, Philip Jansen, Michelle Taylor, Xiaoran Tong, Qing Lu, Alexandra S Burt, Henning Tiemeier, Essi Viding, Robert Plomin, Nicholas G Martin, Andrew C Heath, Pamela AF Madden, Grant Montgomery, Kevin M Beaver, Irwin Waldman, Joel Gelernter, Henry R Kranzler, Lindsay A Farrer, John RB Perry, Marcus Munafò, Devon LoParo, Tiina Paunio, Jari Tiihonen, Sabine E Mous, Irene Pappa, Christiaan de Leeuw, Kyoko Watanabe, Anke R Hammerschlag, Jessica E Salvatore, Fazil Aliev, Tim B Bigdeli, Danielle Dick, Stephen V Faraone, Arne Popma, Sarah E Medland, Danielle Posthuma, Broad Antisocial Behavior Consortium collaborators
Nov 21, 2018
IMPORTANCE: Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not...
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