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Results: 46
Targeting non-coding RNA family members with artificial endonuclease XNAzymes.
Non-coding RNAs (ncRNAs) offer a wealth of therapeutic targets for a range of diseases. However, secondary structures and high similarity within sequence families make specific knockdown challenging. Here, we engineer a series...
Unzipping Amyloid Fibrils: How a Novel Calcium-Binding Protein, NUCB1, Prevents the Formation of Amyloid Fibrils
Neeraj Kapoor
Jan 01, 0001
Nucleobindin 1 (NUCB1) is a widely expressed multi-domain Ca2+-binding protein whose precise physiological and biochemical functions are not well understood. We engineered and heterologously expressed a soluble form of NUCB1...
nucleobindin 1 (NUCB1) g proteins Amyloid-β 42 (Aβ42) Calcium-Binding Proteins amyloid fibrils Life Sciences
Published by: Rockefeller University
Influencer Review Effect on Customer Purchase Intention
Presently, the web is the fundamental product information source for some customer goods, for the most part on account of the irruption of customer reviews dependent on blogging. The purpose of this study is to explore the...
Published by: IGI Global Scientific Publishing
Targeting non-coding RNA family members with artificial endonuclease XNAzymes.
Non-coding RNAs (ncRNAs) offer a wealth of therapeutic targets for a range of diseases. However, secondary structures and high similarity within sequence families make specific knockdown challenging. Here, we engineer a series...
Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression
James W Mackay, Geeta Kapoor, Jeffrey B Driban, Grace H Lo, Timothy E McAlindon, Andoni P Toms, Andrew W McCaskie, Fiona J Gilbert
Jun 18, 2018
OBJECTIVES: To assess whether initial or 12-18-month change in magnetic resonance imaging (MRI) subchondral bone texture is predictive of radiographic knee osteoarthritis (OA) progression over 36 months. METHODS: This was a...
Optical Flow-Based Weighted Magnitude and Direction Histograms for the Detection of Abnormal Visual Events Using Combined Classifier
Movement information of persons is a very vital feature for abnormality detection in crowded scenes. In this paper, a new method for detection of crowd escape event in video surveillance system is proposed. The proposed method...
Published by: IGI Global Scientific Publishing
Ranking Mobile Wallet Service Providers Using Fuzzy Multi-Criteria Decision-Making Approach
The aim of this paper is to identify key dimensions of mobile wallet (m-wallet) service quality and to prioritize mobile wallet service providers on the basis of these dimensions. Based on extensive literature review and...
Published by: IGI Global Scientific Publishing
Deep Neural Network Regularization (DNNR) on Denoised Image
Image dehazing in supervised learning models suffers from overfitting and underfitting problems. To avoid overfitting, the authors use regularization techniques like dropout and L2 norm. Dropout helps in reducing overfitting and...
Published by: IGI Global Scientific Publishing
Foresight science in conservation
Gabrielle Ednie, Tyreen Kapoor, Olga Koppel, Morgan L Piczak, Jessica L Reid, Alyssa D Murdoch, Carly N Cook, William J Sutherland, Steven J Cooke
Nov 26, 2022
Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability.
David Paling, Esben Thade Petersen, Daniel J Tozer, Daniel R Altmann, Claudia AM Wheeler-Kingshott, Raju Kapoor, David H Miller, Xavier Golay
Jun 22, 2018
Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In...
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme.
Luis F Duarte, Andrew RJ Young, Zichen Wang, Hsan-Au Wu, Taniya Panda, Yan Kou, Avnish Kapoor, Dan Hasson, Nicholas R Mills, Avi Ma'ayan, Masashi Narita, Emily Bernstein
Sep 11, 2014
Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium.
Pooja Middha Kapoor, Sara Lindström, Sabine Behrens, Xiaoliang Wang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Alison M Dunning, Paul DP Pharoah, Marjanka K Schmidt, Peter Kraft, Montserrat García-Closas, Douglas F Easton, Roger L Milne, Jenny Chang-Claude, Breast Cancer Association Consortium
Sep 04, 2019
BACKGROUND: Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we performed a comprehensive assessment of potential...
Europeans Gene-Environment Interaction Breast Cancer EPIDEMIOLOGY Risk Factors single nucleotide polymorphism Alleles Breast Neoplasms Case-Control Studies Europe Factor XIII Female Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Polymorphism Single Nucleotide Receptors Estrogen Risk Factors White People
External validation of a predictive model of survival after cytoreductive nephrectomy for metastatic renal cell carcinoma.
Lorenzo Marconi, Roderick de Bruijn, Erik Van Werkhoven, Christian Beisland, Kate Fife, Axel Heidenreich, Anil Kapoor, Jose Karam, Caroline Kauffmann, Tobias Klatte, Boerje Ljungberg, Surena Matin, Daniel Sjoberg, Michael Staehler, Grant D Stewart, Simon Tanguay, Robert Uzzo, Sarah Welsh, Lori Wood, Chris Wood, Axel Bex
Sep 08, 2018
INTRODUCTION: Recent trials have emphasized the importance of a precise patient selection for cytoreductive nephrectomy (CN). In 2013, a nomogram was developed for pre- and postoperative prediction of the probability of death...
cytoreductive nephrectomy Metastatic renal cancer Nomogram selection targeted therapy validation Adrenal Gland Neoplasms Aged Antineoplastic Agents Area Under Curve Blood Transfusion Bone Neoplasms Brain Neoplasms Carcinoma Renal Cell Cytoreduction Surgical Procedures Female Humans Intraoperative Care Kaplan-Meier Estimate Kidney Neoplasms L-Lactate Dehydrogenase Liver Neoplasms Lung Neoplasms Male Middle Aged Molecular Targeted Therapy Neoplasm Metastasis Neoplasm Staging Nephrectomy Nomograms Patient Selection Prognosis Reproducibility of Results Serum Albumin Survival Rate
Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia
RJ Haidry, MA Butt, JM Dunn, A Gupta, G Lipman, HL Smart, P Bhandari, L Smith, R Willert, G Fullarton, M di Pietro, C Gordon, I Penman, H Barr, P Patel, N Kapoor, J Hoare, R Narayanasamy, Y Ang, A Veitch, K Ragunath, M Novelli, LB Lovat, UK RFA Registry
Aug 20, 2020
BACKGROUND: Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by...
BARRETT'S OESOPHAGUS ENDOSCOPIC PROCEDURES OESOPHAGEAL CANCER Adenocarcinoma Adult Aged Aged 80 and over Barrett Esophagus Catheter Ablation Disease Progression Esophageal Neoplasms Esophagoscopy Female Follow-Up Studies Humans Male Middle Aged Precancerous Conditions Prospective Studies Registries Time Factors Treatment Outcome United Kingdom
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis
Nick Cunniffe, Khue Anh Vuong, Debbie Ainslie, David Baker, Judy Beveridge, Sorrel Bickley, Patrick Camilleri, Matthew Craner, Denise Fitzgerald, Alerie G de la Fuente, Gavin Giovannoni, Emma Gray, Lorraine Hazlehurst, Raj Kapoor, Ranjit Kaur, David Kozlowski, Brooke Lumicisi, Don Mahad, Björn Neumann, Alan Palmer, Luca Peruzzotti-Jametti, Stefano Pluchino, Jennifer Robertson, Alan Rothaul, Lyndsey Shellard, Kenneth J Smith, Alastair Wilkins, Anna Williams, Alasdair Coles
Nov 16, 2020
Objective: To establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS). Methods: We...
Published by: BMJ Publishing Group
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.
Nick Cunniffe, Khue Anh Vuong, Debbie Ainslie, David Baker, Judy Beveridge, Sorrel Bickley, Patrick Camilleri, Matthew Craner, Denise Fitzgerald, Alerie G de la Fuente, Gavin Giovannoni, Emma Gray, Lorraine Hazlehurst, Raj Kapoor, Ranjit Kaur, David Kozlowski, Brooke Lumicisi, Don Mahad, Björn Neumann, Alan Palmer, Luca Peruzzotti-Jametti, Stefano Pluchino, Jennifer Robertson, Alan Rothaul, Lyndsey Shellard, Kenneth J Smith, Alastair Wilkins, Anna Williams, Alasdair Coles
Oct 20, 2020
Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women
Abstract Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully...
Xiaoliang Wang, Pooja Middha Kapoor, Paul L Auer, Joe Dennis, Alison M Dunning, Qin Wang, Michael Lush, Kyriaki Michailidou, Manjeet K Bolla, Kristan J Aronson, Rachel A Murphy, Angela Brooks-Wilson, Derrick G Lee, Emilie Cordina-Duverger, Pascal Guénel, Thérèse Truong, Claire Mulot, Lauren R Teras, Alpa V Patel, Laure Dossus, Rudolf Kaaks, Reiner Hoppe, Wing-Yee Lo, Thomas Brüning, Ute Hamann, Kamila Czene, Marike Gabrielson, Per Hall, Mikael Eriksson, Audrey Jung, Heiko Becher, Fergus J Couch, Nicole L Larson, Janet E Olson, Kathryn J Ruddy, Graham G Giles, Robert J Macinnis, Melissa C Southey, Loic Le Marchand, Lynne R Wilkens, Christopher A Haiman, Håkan Olsson, Annelie Augustinsson, Ute Krüger, Philippe Wagner, Christopher Scott, Stacey J Winham, Celine M Vachon, Charles M Perou, Andrew F Olshan, Melissa A Troester, David J Hunter, Heather A Eliassen, Rulla M Tamimi, Kristen Brantley, Irene L Andrulis, Jonine Figueroa, Stephen J Chanock, Thomas U Ahearn, Montserrat García-Closas, Gareth D Evans, William G Newman, Elke M van Veen, Anthony Howell, Alicja Wolk, Niclas Håkansson, Hoda Anton-Culver, Argyrios Ziogas, Michael E Jones, Nick Orr, Minouk J Schoemaker, Anthony J Swerdlow, Cari M Kitahara, Martha Linet, Ross L Prentice, Douglas F Easton, Roger L Milne, Peter Kraft, Jenny Chang-Claude, Sara Lindström
Apr 19, 2022
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.
David M Brazel, Yu Jiang, Jordan M Hughey, Valérie Turcot, Xiaowei Zhan, Jian Gong, Chiara Batini, J Dylan Weissenkampen, Mengzhen Liu, CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour, Daniel R Barnes, Sarah Bertelsen, Yi-Ling Chou, A Mesut Erzurumluoglu, Jessica D Faul, Jeff Haessler, Anke R Hammerschlag, Chris Hsu, Manav Kapoor, Dongbing Lai, Nhung Le, Christiaan A de Leeuw, Anu Loukola, Massimo Mangino, Carl A Melbourne, Giorgio Pistis, Beenish Qaiser, Rebecca Rohde, Yaming Shao, Heather Stringham, Leah Wetherill, Wei Zhao, Arpana Agrawal, Laura Bierut, Chu Chen, Charles B Eaton, Alison Goate, Christopher Haiman, Andrew Heath, William G Iacono, Nicholas G Martin, Tinca J Polderman, Alex Reiner, John Rice, David Schlessinger, H Steven Scholte, Jennifer A Smith, Jean-Claude Tardif, Hilary A Tindle, Andries R van der Leij, Michael Boehnke, Jenny Chang-Claude, Francesco Cucca, Sean P David, Tatiana Foroud, Joanna MM Howson, Sharon LR Kardia, Charles Kooperberg, Markku Laakso, Guillaume Lettre, Pamela Madden, Matt McGue, Kari North, Danielle Posthuma, Timothy Spector, Daniel Stram, Martin D Tobin, David R Weir, Jaakko Kaprio, Gonçalo R Abecasis, Dajiang J Liu, Scott Vrieze
Feb 01, 2019
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
Maria Escala-Garcia, Jean Abraham, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L. Auer, Päivi Auvinen, Matthias W. Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y. Brucker, Barbara Burwinkel, Carlos Caldas, Federico Canzian, Jenny Chang-Claude, Stephen J. Chanock, Suet-Feung Chin, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Janet A. Dunn, Alison M. Dunning, Miriam Dwek, Helena M. Earl, Diana M. Eccles, A. Heather Eliassen, Carolina Ellberg, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Susan M. Gapstur, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Angela George, Graham G. Giles, David E. Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Qi Guo, Christopher A. Haiman, Niclas Håkansson, Ute Hamann, Patricia A. Harrington, Louise Hiller, Maartje J. Hooning, John L. Hopper, Anthony Howell, Chiun-Sheng Huang, Guanmengqian Huang, David J. Hunter, Anna Jakubowska, Esther M. John, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Cari M. Kitahara, Linetta B. Koppert, Peter Kraft, Vessela N. Kristensen, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Alfons Meindl, Roger L. Milne, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, William G. Newman, Andrew F. Olshan, Janet E. Olson, Håkan Olsson, Nick Orr, Paolo Peterlongo, Christos Petridis, Ross L. Prentice, Nadege Presneau, Kevin Punie, Dhanya Ramachandran, Gad Rennert, Atocha Romero, Mythily Sachchithananthan, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Lukas Schwentner, Christopher Scott, Jacques Simard, Christof Sohn, Melissa C. Southey, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Manuel R. Teixeira, Mary Beth Terry, Heather Thorne, Rob A. E. M. Tollenaar, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Clare Turnbull, Celine M. Vachon, Lizet E. van der Kolk, Qin Wang, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Argyrios Ziogas, Paul D. P. Pharoah, Per Hall, Lodewyk F. A. Wessels, Georgia Chenevix-Trench, Gary D. Bader, Thilo Dörk, Douglas F. Easton, Sander Canisius, Marjanka K. Schmidt
Jan 15, 2021
Abstract: Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the...
Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk.
Pooja Middha Kapoor, Nasim Mavaddat, Parichoy Pal Choudhury, Amber N Wilcox, Sara Lindström, Sabine Behrens, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Qin Wang, Audrey Jung, Zomoroda Abu-Ful, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Leslie Bernstein, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Qiuyin Cai, Daniele Campa, Federico Canzian, Angel Carracedo, Brian D Carter, Jose E Castelao, Stephen J Chanock, Nilanjan Chatterjee, Georgia Chenevix-Trench, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, James Y Dai, H Shelton Earp, Arif B Ekici, A Heather Eliassen, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Chi Gao, Susan M Gapstur, Mia M Gaudet, Graham G Giles, Anna González-Neira, Pascal Guénel, Lothar Haeberle, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sigrid Hatse, Jane Heyworth, Bernd Holleczek, Robert N Hoover, John L Hopper, Anthony Howell, David J Hunter, ABCTB Investigators, kConFab/AOCS Investigators, Esther M John, Michael E Jones, Rudolf Kaaks, Renske Keeman, Cari M Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W Kurian, Diether Lambrechts, Loic Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Martha Linet, Jolanta Lissowska, Ana Llaneza, Robert J Macinnis, Maria Elena Martinez, Tabea Maurer, Catriona Mclean, Susan L Neuhausen, William G Newman, Aaron Norman, Katie M O'Brien, Andrew F Olshan, Janet E Olson, Håkan Olsson, Nick Orr, Charles M Perou, Guillermo Pita, Eric C Polley, Ross L Prentice, Gad Rennert, Hedy S Rennert, Kathryn J Ruddy, Dale P Sandler, Christobel Saunders, Minouk J Schoemaker, Ben Schöttker, Fredrick Schumacher, Christopher Scott, Rodney J Scott, Xiao-Ou Shu, Ann Smeets, Melissa C Southey, John J Spinelli, Jennifer Stone, Anthony J Swerdlow, Rulla M Tamimi, Jack A Taylor, Melissa A Troester, Celine M Vachon, Elke M van Veen, Xiaoliang Wang, Clarice R Weinberg, Caroline Weltens, Walter Willett, Stacey J Winham, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Argyrios Ziogas, Alison M Dunning, Paul DP Pharoah, Marjanka K Schmidt, Peter Kraft, Douglas F Easton, Roger L Milne, Montserrat García-Closas, Jenny Chang-Claude
Apr 14, 2020
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer...
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Maria Escala-Garcia, Jean Abraham, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L Auer, Päivi Auvinen, Matthias W Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y Brucker, Barbara Burwinkel, Carlos Caldas, Federico Canzian, Jenny Chang-Claude, Stephen J Chanock, Suet-Feung Chin, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Janet A Dunn, Alison M Dunning, Miriam Dwek, Helena M Earl, Diana M Eccles, A Heather Eliassen, Carolina Ellberg, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Angela George, Graham G Giles, David E Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Qi Guo, Christopher A Haiman, Niclas Håkansson, Ute Hamann, Patricia A Harrington, Louise Hiller, Maartje J Hooning, John L Hopper, Anthony Howell, Chiun-Sheng Huang, Guanmengqian Huang, David J Hunter, Anna Jakubowska, Esther M John, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Cari M Kitahara, Linetta B Koppert, Peter Kraft, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Alfons Meindl, Roger L Milne, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, William G Newman, Andrew F Olshan, Janet E Olson, Håkan Olsson, Nick Orr, Paolo Peterlongo, Christos Petridis, Ross L Prentice, Nadege Presneau, Kevin Punie, Dhanya Ramachandran, Gad Rennert, Atocha Romero, Mythily Sachchithananthan, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Lukas Schwentner, Christopher Scott, Jacques Simard, Christof Sohn, Melissa C Southey, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Manuel R Teixeira, Mary Beth Terry, Heather Thorne, Rob AEM Tollenaar, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Clare Turnbull, Celine M Vachon, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Argyrios Ziogas, Paul DP Pharoah, Per Hall, Lodewyk FA Wessels, Georgia Chenevix-Trench, Gary D Bader, Thilo Dörk, Douglas F Easton, Sander Canisius, Marjanka K Schmidt
Jan 06, 2020
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential...
Breast Cancer Risk Factors and Survival by Tumor Subtype
Anna Morra, Audrey Y Jung, Sabine Behrens, Renske Keeman, Thomas U Ahearn, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Päivi K Auvinen, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Ignacio Briceno, Sara Y Brucker, Nicola J Camp, Daniele Campa, Federico Canzian, Jose E Castelao, Stephen J Chanock, Ji-Yeob Choi, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Thilo Dörk, Alison M Dunning, Miriam Dwek, Douglas F Easton, Diana M Eccles, Kathleen M Egan, D Gareth Evans, Peter A Fasching, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Mervi Grip, Pascal Guénel, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny N Han, Steven N Hart, Mikael Hartman, Jane S Heyworth, Reiner Hoppe, John L Hopper, David J Hunter, Hidemi Ito, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Cari M Kitahara, Stella Koutros, Peter Kraft, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Jan Lubiński, Michael Lush, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Shivaani Mariapun, Keitaro Matsuo, Dimitrios Mavroudis, Roger L Milne, Taru A Muranen, William G Newman, Dong-Young Noh, Børge G Nordestgaard, Nadia Obi, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Christos Petridis, Paul DP Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Muhammad U Rashid, Gad Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Andreas Schneeweiss, Lukas Schwentner, Christopher Scott, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Melissa C Southey, Daniel O Stram, Rulla M Tamimi, William Tapper, Rob AEM Tollenaar, Ian Tomlinson, Diana Torres, Melissa A Troester, Thérèse Truong, Celine M Vachon, Qin Wang, Sophia S Wang, Justin A Williams, Robert Winqvist, Alicja Wolk, Anna H Wu, Keun-Young Yoo, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Xiaohong R Yang, A Heather Eliassen, Michelle D Holmes, Montserrat García-Closas, Soo Hwang Teo, Marjanka K Schmidt, Jenny Chang-Claude, ABCTB Investigators, NBCS Collaborators
Feb 16, 2021
BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in...
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Maria Escala-Garcia, Jean Abraham, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L Auer, Päivi Auvinen, Matthias W Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y Brucker, Barbara Burwinkel, Carlos Caldas, Federico Canzian, Jenny Chang-Claude, Stephen J Chanock, Suet-Feung Chin, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Janet A Dunn, Alison M Dunning, Miriam Dwek, Helena M Earl, Diana M Eccles, A Heather Eliassen, Carolina Ellberg, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Angela George, Graham G Giles, David E Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Qi Guo, Christopher A Haiman, Niclas Håkansson, Ute Hamann, Patricia A Harrington, Louise Hiller, Maartje J Hooning, John L Hopper, Anthony Howell, Chiun-Sheng Huang, Guanmengqian Huang, David J Hunter, Anna Jakubowska, Esther M John, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Cari M Kitahara, Linetta B Koppert, Peter Kraft, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Alfons Meindl, Roger L Milne, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, William G Newman, Andrew F Olshan, Janet E Olson, Håkan Olsson, Nick Orr, Paolo Peterlongo, Christos Petridis, Ross L Prentice, Nadege Presneau, Kevin Punie, Dhanya Ramachandran, Gad Rennert, Atocha Romero, Mythily Sachchithananthan, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Lukas Schwentner, Christopher Scott, Jacques Simard, Christof Sohn, Melissa C Southey, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Manuel R Teixeira, Mary Beth Terry, Heather Thorne, Rob A E M Tollenaar, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Clare Turnbull, Celine M Vachon, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Argyrios Ziogas, Paul D P Pharoah, Per Hall, Lodewyk F A Wessels, Georgia Chenevix-Trench, Gary D Bader, Thilo Dörk, Douglas F Easton, Sander Canisius, Marjanka K Schmidt
Feb 19, 2020
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential...
Published by: Nature Communications
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, Muriel A Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J Aronson, Banu K Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Caroline Baynes, Heiko Becher, Marina Bermisheva, Leslie Bernstein, Katarzyna Białkowska, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Ake Borg, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Daniele Campa, Brian D Carter, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Wendy K Chung, Kathleen BM Claes, Christine L Clarke, GEMO Study Collaborators, EMBRACE Collaborators, J Margriet Collée, Don M Conroy, Kamila Czene, Mary B Daly, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Isabel dos-Santos-Silva, Alison M Dunning, Miriam Dwek, Diana M Eccles, A Heather Eliassen, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Manuela Gago-Dominguez, Susan M Gapstur, Judy Garber, Vanesa Garcia-Barberan, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Simon A Gayther, Andrea Gehrig, Vassilios Georgoulias, Graham G Giles, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mark H Greene, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A Harrington, Steven N Hart, Wei He, Frans BL Hogervorst, Antoinette Hollestelle, John L Hopper, Darling J Horcasitas, Peter J Hulick, David J Hunter, Evgeny N Imyanitov, kConFab Investigators, HEBON Investigators, ABCTB Investigators, Agnes Jager, Anna Jakubowska, Paul A James, Uffe Birk Jensen, Esther M John, Michael E Jones, Rudolf Kaaks, Pooja Middha Kapoor, Beth Y Karlan, Renske Keeman, Elza Khusnutdinova, Johanna I Kiiski, Yon-Dschun Ko, Veli-Matti Kosma, Peter Kraft, Allison W Kurian, Yael Laitman, Diether Lambrechts, Loic Le Marchand, Jenny Lester, Fabienne Lesueur, Tricia Lindstrom, Adria Lopez-Fernández, Jennifer T Loud, Craig Luccarini, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, John WM Martens, Noura Mebirouk, Alfons Meindl, Austin Miller, Roger L Milne, Marco Montagna, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Finn C Nielsen, Katie M O'Brien, Olufunmilayo I Olopade, Janet E Olson, Håkan Olsson, Ana Osorio, Laura Ottini, Tjoung-Won Park-Simon, Michael T Parsons, Inge Sokilde Pedersen, Beth Peshkin, Paolo Peterlongo, Julian Peto, Paul DP Pharoah, Kelly-Anne Phillips, Eric C Polley, Bruce Poppe, Nadege Presneau, Miquel Angel Pujana, Kevin Punie, Paolo Radice, Johanna Rantala, Muhammad U Rashid, Gad Rennert, Hedy S Rennert, Mark Robson, Atocha Romero, Maria Rossing, Emmanouil Saloustros, Dale P Sandler, Regina Santella, Maren T Scheuner, Marjanka K Schmidt, Gunnar Schmidt, Christopher Scott, Priyanka Sharma, Penny Soucy, Melissa C Southey, John J Spinelli, Zoe Steinsnyder, Jennifer Stone, Dominique Stoppa-Lyonnet, Anthony Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Mary Beth Terry, Alex Teulé, Darcy L Thull, Marc Tischkowitz, Amanda E Toland, Diana Torres, Alison H Trainer, Thérèse Truong, Nadine Tung, Celine M Vachon, Ana Vega, Joseph Vijai, Qin Wang, Barbara Wappenschmidt, Clarice R Weinberg, Jeffrey N Weitzel, Camilla Wendt, Alicja Wolk, Siddhartha Yadav, Xiaohong R Yang, Drakoulis Yannoukakos, Wei Zheng, Argyrios Ziogas, Kristin K Zorn, Sue K Park, Mads Thomassen, Kenneth Offit, Rita K Schmutzler, Fergus J Couch, Jacques Simard, Georgia Chenevix-Trench, Douglas F Easton, Nadine Andrieu, Antonis C Antoniou
Nov 24, 2020
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general...
Mendelian randomisation study of smoking exposure in relation to breast cancer risk.
Hanla A Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Adinda Baten, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Sara Y Brucker, Barbara Burwinkel, Daniele Campa, Federico Canzian, Jose E Castelao, Stephen J Chanock, Georgia Chenevix-Trench, Christine L Clarke, NBCS Collaborators, Don M Conroy, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Isabel dos-Santos-Silva, Miriam Dwek, Diana M Eccles, A Heather Eliassen, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Henrik Flyger, Lin Fritschi, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Gord Glendon, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny Han, Elaine F Harkness, Steven N Hart, Wei He, Bernadette AM Heemskerk-Gerritsen, John L Hopper, David J Hunter, ABCTB Investigators, kConFab Investigators, Agnes Jager, Anna Jakubowska, Esther M John, Audrey Jung, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Linetta B Koppert, Stella Koutros, Vessela N Kristensen, Allison W Kurian, James Lacey, Diether Lambrechts, Loic Le Marchand, Wing-Yee Lo, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Dimitrios Mavroudis, Alfons Meindl, Usha Menon, Roger L Milne, Taru A Muranen, Heli Nevanlinna, William G Newman, Børge G Nordestgaard, Kenneth Offit, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Nadege Presneau, Paolo Radice, Gad Rennert, Hedy S Rennert, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Minouk J Schoemaker, Lukas Schwentner, Christopher Scott, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Ann Smeets, Melissa C Southey, John J Spinelli, Victoria Stevens, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Mary Beth Terry, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Celine M Vachon, Elke M van Veen, Joseph Vijai, Sophia Wang, Camilla Wendt, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Alison M Dunning, Paul DP Pharoah, Douglas F Easton, Wei Zheng, Peter Kraft, Jenny Chang-Claude
Aug 20, 2021
BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. METHODS: We...
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