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Results: 46
Methodology for the analysis and comparison of protocols for glycaemic control in intensive care.
Rocío Fernández-Méndez, Sancho Rodríguez-Villar, Pablo F Méndez, Richard Windle, Gary George Adams
Feb 18, 2019
RATIONALE, AIMS, AND OBJECTIVES: The practice of glycaemic control of critically ill patients admitted to intensive care units (ICUs) is guided by clinical management protocols, designed locally by the ICUs. These protocols...
Transforming students' attitudes towards learning through the use of successful educational actions.
Previous research shows that there is a correlation between attitudes and academic achievement. In this article, we analyze for the first time the impact of interactive groups (IG) and dialogic literary gatherings (DLG) on the...
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley, Juan Cadiñanos
Oct 27, 2020
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional...
Animals Cell Line Cell Movement DNA Transposable Elements Epithelial Cells Gene Dosage Genes Tumor Suppressor Genetic Predisposition to Disease Humans Kaplan-Meier Estimate Male Mice Knockout Mice Transgenic Mutagenesis Insertional Mutation PTEN Phosphohydrolase Prostate Prostatic Neoplasms RNA Interference Signal Transduction
Current epidemiology of cerebrospinal fluid shunt surgery in the UK and Ireland (2004-2013).
Rocío Fernández-Méndez, Hugh K Richards, Helen M Seeley, John D Pickard, Alexis J Joannides, UKSR collaborators
Feb 18, 2019
The practice of glycaemic control in intensive care units
Improvement of the Efficiency and Completeness of Neuro-Oncology Patient Referrals to a Tertiary Center Through the Implementation of an Electronic Referral System
Rocío Fernández-Méndez, Mei Yin Wong, Rebecca J Rastall, Samuel Rebollo-Díaz, Ingela Oberg, Stephen J Price, Alexis J Joannides
Dec 19, 2019
Resting and postprandial serum bile acid concentrations in dogs with liver disease.
Jorge Pena-Ramos, Lucy Barker, Rocío Saiz, David J Walker, Simon Tappin, Cassia HZ Hare, Madeleine L Roberts, Tim L Williams, Nicholas Bexfield
Apr 26, 2021
BACKGROUND: Serum bile acids (SBAs) are frequently measured in dogs. However, there is limited data comparing SBAs in different liver diseases diagnosed according to standardized histological criteria. OBJECTIVES: To compare...
The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.
Sarah Foerster, Alerie Guzman de la Fuente, Yoshiteru Kagawa, Theresa Bartels, Yuji Owada, Robin Jm Franklin
Jan 13, 2020
Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara.
Dirk L Christensen, Diana Espino, Rocío Infante-Ramírez, Mónica S Cervantes-Borunda, Rosa P Hernández-Torres, Antonio E Rivera-Cisneros, Daniel Castillo, Kate Westgate, Dijana Terzic, Soren Brage, Christian Hassager, Jens P Goetze, Jesper Kjaergaard
Mar 22, 2018
BACKGROUND: The Mexican Tarahumara are accustomed to running ultra-distance races. No data exist on the acute physiological changes following ultra-distance running and physiological-biomarker associations in this population....
Immune-stem cell crosstalk in the central nervous system
Sonia Cabeza-Fernández, Jessica A White, Christopher E McMurran, José A Gómez-Sánchez, Alerie G de la Fuente
Dec 11, 2022
Resting and postprandial serum bile acid concentrations in dogs with liver disease
Jorge Pena‐Ramos, Lucy Barker, Rocío Saiz, David J. Walker, Simon Tappin, Cassia H. Z. Hare, Madeleine L. Roberts, Tim L. Williams, Nicholas Bexfield
May 06, 2021
Abstract: Background: Serum bile acids (SBAs) are frequently measured in dogs. However, there is limited data comparing SBAs in different liver diseases diagnosed according to standardized histological criteria. Objectives: To...
Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells.
Defining unmet clinical need across the pathway of brain tumor care
William Sage, Rocío Fernández-Méndez, Anna Crofton, Michael J Gifford, Alexey Bannykh, Constantinos Chrysaphinis, Emma Tingley, Helen Bulbeck, Mita Brahmbhatt, John D Pickard, Fiona M Walter, Andrew Brodbelt, Stephen J Price, Alexis J Joannides
Mar 28, 2019
OBJECTIVE: The aim of this study was to determine the experience of patients with brain tumors and their carers across distinct parts of their treatment pathway and identify their views on potential service gaps in need of...
Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders.
I Conejos-Sánchez, E Gallon, A Niño-Pariente, JA Smith, AG De la Fuente, L Di Canio, S Pluchino, RJM Franklin, MJ Vicent
Jan 24, 2020
Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on...
Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing.
Alerie G de la Fuente, Rayner ML Queiroz, Tanay Ghosh, Christopher E McMurran, Juan F Cubillos, Dwight E Bergles, Denise C Fitzgerald, Clare A Jones, Kathryn S Lilley, Colin P Glover, Robin Jm Franklin
May 22, 2020
Following central nervous system (CNS) demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. Although...
Use of selective gut decontamination in critically ill children
Alanna Brown, Paloma Ferrando, Mariana Popa, Gema Milla de la Fuente, John Pappachan, Brian Cuthbertson, Laura Drikite, Richard Feltbower, Theodore Gouliouris, Isobel Sale, Robert Shulman, Lyvonne N Tume, John Myburgh, Kerry Woolfall, David A Harrison, Paul R Mouncey, Kathryn M Rowan, Nazima Pathan
Apr 12, 2022
INTRODUCTION: Healthcare-associated infections (HCAIs) are a major cause of morbidity and mortality in critically ill children. In critically ill adults, there are data that suggest the use of Selective Decontamination of the...
Transcription Factors Evolve Faster Than Their Structural Gene Targets in the Flavonoid Pigment Pathway.
Lucas C Wheeler, Joseph F Walker, Julienne Ng, Rocío Deanna, Amy Dunbar-Wallis, Alice Backes, Pedro H Pezzi, M Virginia Palchetti, Holly M Robertson, Andrew Monaghan, Loreta Brandão de Freitas, Gloria E Barboza, Edwige Moyroud, Stacey D Smith
Mar 28, 2022
An actionable anti-racism plan for geoscience organizations
Hendratta N. Ali, Sarah L. Sheffield, Jennifer E. Bauer, Rocío P. Caballero-Gill, Nicole M. Gasparini, Julie Libarkin, Kalynda K. Gonzales, Jane Willenbring, Erika Amir-Lin, Julia Cisneros, Dipa Desai, Maitri Erwin, Elisabeth Gallant, Kiara Jeannelle Gomez, Benjamin A. Keisling, Robert Mahon, Erika Marín-Spiotta, Leiaka Welcome, Blair Schneider
Jun 23, 2021
Abstract: Geoscience organizations shape the discipline. They influence attitudes and expectations, set standards, and provide benefits to their members. Today, racism and discrimination limit the participation of, and promote...
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR -mutant gliomas
Imran Noorani, Jorge de la Rosa, Yoonha Choi, Alexander Strong, Hannes Ponstingl, M. S. Vijayabaskar, Jusung Lee, Eunmin Lee, Angela Richard-Londt, Mathias Friedrich, Federica Furlanetto, Rocio Fuente, Ruby Banerjee, Fengtang Yang, Frances Law, Colin Watts, Roland Rad, George Vassiliou, Jong Kyoung Kim, Thomas Santarius, Sebastian Brandner, Allan Bradley
Jul 30, 2020
Human forager response to abrupt climate change at 8.2 ka on the Atlantic coast of Europe.
Use of selective gut decontamination in critically ill children
Alanna Brown, Paloma Ferrando, Mariana Popa, Gema Milla de la Fuente, John Pappachan, Brian Cuthbertson, Laura Drikite, Richard Feltbower, Theodore Gouliouris, Isobel Sale, Robert Shulman, Lyvonne N Tume, John Myburgh, Kerry Woolfall, David A Harrison, Paul R Mouncey, Kathryn M Rowan, Nazima Pathan
Mar 17, 2022
INTRODUCTION: Healthcare-associated infections (HCAIs) are a major cause of morbidity and mortality in critically ill children. In critically ill adults, there are data that suggest the use of Selective Decontamination of the...
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas.
Imran Noorani, Jorge de la Rosa, Yoon Ha Choi, Alexander Strong, Hannes Ponstingl, MS Vijayabaskar, Jusung Lee, Eunmin Lee, Angela Richard-Londt, Mathias Friedrich, Federica Furlanetto, Rocio Fuente, Ruby Banerjee, Fengtang Yang, Frances Law, Colin Watts, Roland Rad, George Vassiliou, Jong Kyoung Kim, Thomas Santarius, Sebastian Brandner, Allan Bradley
Aug 14, 2020
Glioma is the most common intrinsic brain tumor and also occurs in the spinal cord. Activating EGFR mutations are common in IDH1 wild-type gliomas. However, the cooperative partners of EGFR driving gliomagenesis remain poorly...
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