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Results: 209
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence:
Ioannis Loisios-Konstantinidis, Rafael L.M. Paraiso, Nikoletta Fotaki, Mark McAllister, Rodrigo Cristofoletti, Jennifer Dressman
Apr 01, 2019
Objectives
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
Establishing virtual bioequivalence and clinically relevant specifications using in vitro biorelevant dissolution testing and physiologically-based population pharmacokinetic modeling. Case example
Ioannis Loisios-Konstantinidis, Rodrigo Cristofoletti, Nikoletta Fotaki, David B Turner, Jennifer Dressman
Feb 15, 2020
Background: Physiologically-based population pharmacokinetic modeling (popPBPK) coupled with in vitro biopharmaceutics tools such as biorelevant dissolution testing can serve as a powerful tool to establish virtual...
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence:
Ioannis Loisios-Konstantinidis, Rafael L.M. Paraiso, Nikoletta Fotaki, Mark McAllister, Rodrigo Cristofoletti, Jennifer Dressman
Apr 01, 2019
Objectives
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
Establishing virtual bioequivalence and clinically relevant specifications using in vitro biorelevant dissolution testing and physiologically-based population pharmacokinetic modeling. Case example
Ioannis Loisios-Konstantinidis, Rodrigo Cristofoletti, Nikoletta Fotaki, David B Turner, Jennifer Dressman
Feb 15, 2020
Background: Physiologically-based population pharmacokinetic modeling (popPBPK) coupled with in vitro biopharmaceutics tools such as biorelevant dissolution testing can serve as a powerful tool to establish virtual...
Corporate social responsibility in the luxury sector
The academic literature on whether consumers respond positively toward corporate social responsibility (hereafter CSR) initiatives in the luxury sector is limited and contradictory. Our research contributes to this on-going...
corporate social responsibility (CSR) Experimental studies luxury experience moral foundations /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/1400/1406 name=Marketing /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Corporate social responsibility in the luxury sector
The academic literature on whether consumers respond positively toward corporate social responsibility (hereafter CSR) initiatives in the luxury sector is limited and contradictory. Our research contributes to this on-going...
corporate social responsibility (CSR) Experimental studies luxury experience moral foundations /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/1400/1406 name=Marketing /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Pockmarks in the fjords of Chilean Patagonia
The fjords of Chilean Patagonia are areas of relatively rapid Holocene sediment delivery from glacial, glacifluvial and fluvial systems. These systems are fed by substantial ice- and snow-melt on the flanks of the Andean...
Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting
Inmaculada León, María José Rodrigo, Ileana Quiñones, Juan Andrés Hernández-Cabrera, Lorna García-Pentón
Mar 20, 2021
Although the brain signatures of adaptive human parenting are well documented, the cortical features associated with maladaptive caregiving are underexplored. We investigated whether cortical thickness and surface area vary in a...
Tracking the COVID-19 crisis with high-resolution transaction data
Vasco M. Carvalho, Juan R. Garcia, Stephen Hansen, Álvaro Ortiz, Tomasa Rodrigo, José V. Rodríguez Mora, Pep Ruiz
Aug 11, 2021
Payments systems generate vast amounts of naturally occurring transaction data rarely used for constructing official statistics. We consider billions of transactions from card data from a large bank, Banco Bilbao Vizcaya...
A Literature Review of E-Government Research in Mexico Utilizing the PRISMA Methodology
This research aims to understand the state of the art in Mexico's e-government research field, research trends, empirical research, e-government access, adoption, and availability of online services. Through a systematic...
Published by: IGI Global Scientific Publishing
Designing E-Government Legal Institutions
The aim of this article is to understand the way digital government laws are designed through the analysis and comparison of general objectives, governance mechanisms and roles assigned to stakeholders of six local state digital...
Published by: IGI Global Scientific Publishing
Regional variation in weight-for-height z-scores and surface area/body mass ratio of Chilean children from birth to 3 years of age.
OBJECTIVE: The objectives of the study were to see how much of the variation in weight-for-height z-scores (WHZ) and surface area/body mass ratio (SA/mass) were associated with regional (county) differences including mean...
A Cross-Country Study on Intention to Use Mobile Banking
This is a cross-country study about intention to use mobile banking considering respondents from Brazil, South Korea, and the United States of America. The purpose of the paper is to analyze the role of an individual's computer...
Published by: IGI Global Scientific Publishing
Amber in prehistoric Iberia
Mercedes Murillo-Barroso, Enrique Peñalver, Primitiva Bueno, Rosa Barroso, Rodrigo de Balbín, Marcos Martinón-Torres
Nov 13, 2018
Provenancing exotic raw materials and reconstructing the nature and routes of exchange is a major concern of prehistoric archaeology. Amber has long been recognised as a key commodity of prehistoric exchange networks in Europe....
Enhancing Preoperative Planning in Orthopedic Trauma Surgery Using a Presentation Software.
Preoperative planning (PP) is critical to ensure a successful outcome in orthopaedic trauma surgery. Since it was first described thirty years ago, no modifications have been made to the original preoperative planning (OPP)...
Tracking the COVID-19 crisis with high-resolution transaction data
Vasco M. Carvalho, Juan R. Garcia, Stephen Hansen, Álvaro Ortiz, Tomasa Rodrigo, José V. Rodríguez Mora, Pep Ruiz
Aug 12, 2021
Payments systems generate vast amounts of naturally occurring transaction data rarely used for constructing official statistics. We consider billions of transactions from card data from a large bank, Banco Bilbao Vizcaya...
Impact of infant 13-valent pneumococcal conjugate vaccine on serotypes in adult pneumonia.
Chamira Rodrigo, Thomas Bewick, Carmen Sheppard, Sonia Greenwood, Tricia M Mckeever, Caroline L Trotter, Mary Slack, Robert George, Wei Shen Lim
Mar 03, 2015
Use of Internet of Things With Data Prediction on Healthcare Environments
Internet of Things (IoT) is a constantly growing paradigm that promises to revolutionize healthcare applications and could be associated with several other techniques. Data prediction is another widely used paradigm, where data...
Information Security & Privacy Security and Forensics Cyber and Network Security Computer Science and Information Technology Physical Sciences and Engineering
Published by: IGI Global Scientific Publishing
Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting.
Inmaculada León, María José Rodrigo, Ileana Quiñones, Juan Andrés Hernández-Cabrera, Lorna García-Pentón
Jun 04, 2021
Although the brain signatures of adaptive human parenting are well documented, the cortical features associated with maladaptive caregiving are underexplored. We investigated whether cortical thickness and surface area vary in a...
The Mystery of Pandora
Domestic violence against women has been a serious social and public health problem faced by contemporary society. This type of violence has grown in recent years, placing the woman not only as a victim of the aggressor but also...
Published by: IGI Global Scientific Publishing
Tracking the COVID-19 crisis with high-resolution transaction data.
Vasco M Carvalho, Juan R Garcia, Stephen Hansen, Álvaro Ortiz, Tomasa Rodrigo, José V Rodríguez Mora, Pep Ruiz
Sep 17, 2021
Payments systems generate vast amounts of naturally occurring transaction data rarely used for constructing official statistics. We consider billions of transactions from card data from a large bank, Banco Bilbao Vizcaya...
Published by: Royal Society open science
Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility of Drosophila to Viral Infection.
It is common to find that major-effect genes are an important cause of variation in susceptibility to infection. Here we have characterized natural variation in a gene called pastrel that explains over half of the genetic...
DCV Drosophila Genetics of immunity natural variation pastrel viral infection Animals Disease Resistance Drosophila Proteins Drosophila melanogaster Genetic Heterogeneity Genomic Structural Variation Insect Viruses Mutation Open Reading Frames Polymorphism Single Nucleotide Regulatory Sequences Nucleic Acid
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