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Perseveration and choice in Parkinson's disease
We have previously shown that patients with Parkinson's disease (PD) perseverate in their choice of action relative to healthy controls, and that this is affected by dopaminergic medication (Hughes LE, Barker RA, Owen AM, Rowe...
Dendritic cells exposed to Human Immunodeficiency Virus-1 transmit a vigorous cytopathic infection to CD4+ T cells
Cameron, P.U., Freudenthal, P.S., Barker, J.M., Gezelter, S., Inaba, K., and Steinman, R.M. Dendritic cells exposed to Human Immunodeficiency Virus-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257...
Published by: American Association for the Advancement of Science
Recent developments in the treatment of Parkinson's Disease.
Parkinson's disease (PD) is a common neurodegenerative disease typified by a movement disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment options for PD are limited, with most of the...
Serum Raman spectroscopy as a diagnostic tool in patients with Huntington's disease.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal CAG expansion in exon 1 of the huntingtin (HTT) gene. Given its genetic basis it is possible to study patients both in the...
Serum Raman spectroscopy as a diagnostic tool in patients with Huntington's disease.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal CAG expansion in exon 1 of the huntingtin (HTT) gene. Given its genetic basis it is possible to study patients both in the...
Published by: Chemical science
Gene and Cell-Based Therapies for Parkinson’s Disease
Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder that carries large health and socioeconomic burdens. Current therapies for PD are ultimately inadequate, both in terms of symptom control and in modification of...
Intracellular SERS nanoprobes for distinction of different neuronal cell types.
Distinction between closely related and morphologically similar cells is difficult by conventional methods especially without labeling. Using nuclear-targeted gold nanoparticles (AuNPs) as intracellular probes we demonstrate the...
Stem Cell-Derived Dopamine Neurons
The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron...
Normal aging and Parkinson's disease are associated with the functional decline of distinct frontal-striatal circuits.
Impaired ability to shift attention between stimuli (i.e. shifting attentional 'set') is a well-established part of the dysexecutive syndrome in Parkinson's Disease (PD), nevertheless cognitive and neural bases of this deficit...
Exploring the predictors of financial impairment in Huntington's disease using the Enroll-HD dataset.
OBJECTIVES: Huntington's disease (HD) is a neurodegenerative disease in which cognitive and behavioural symptoms impair the performance of instrumental activities of daily living, including the handling of finances. We sought to...
Problems with Social Cognition and Decision-Making in Huntington's Disease
Huntington's disease starts slowly and progresses over a 15-20 year period. Motor changes begin subtly, often going unnoticed by patients although they are typically visible to those close to them. At this point, it is the early...
Published by: Brain sciences
Bringing Advanced Therapy Medicinal Products (ATMPs) for Parkinson's Disease to the Clinic
There is much excitement around the use of advanced therapy medicinal products (ATMPs), including cell and gene treatments, in Parkinson's disease (PD). However, taking an ATMP to clinical trials in patients with PD is complex....
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