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Perseveration and choice in Parkinson's disease
We have previously shown that patients with Parkinson's disease (PD) perseverate in their choice of action relative to healthy controls, and that this is affected by dopaminergic medication (Hughes LE, Barker RA, Owen AM, Rowe...
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Dendritic cells exposed to Human Immunodeficiency Virus-1 transmit a vigorous cytopathic infection to CD4+ T cells
Cameron, P.U., Freudenthal, P.S., Barker, J.M., Gezelter, S., Inaba, K., and Steinman, R.M. Dendritic cells exposed to Human Immunodeficiency Virus-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257...
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson’s disease
This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1136/jnnp-2016-313918
Recent developments in the treatment of Parkinson's Disease.
Parkinson's disease (PD) is a common neurodegenerative disease typified by a movement disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment options for PD are limited, with most of the...
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The Origin of Inequality. Origini 3, edited by Andrea Cardarelli, Alberto Cazzella and Marcella Frangipane
The article reviews The Origins of Inequality, a collection of essays brought together by Andrea Cardarelli, Alberto Cazzella and Marcella Frangipane following a series of seminars on this theme at the University of Roma La...
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UK Third Sector grant making
Grant-making in the UK is a big industry, worth between £3 and £4bn per annum , consisting of grant-makers who wish to fund worthy causes aligned to their funding objectives, and charities and community groups who depend on...
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The hunt for better treatments for Huntington's disease.
Roger Barker, Sarah L Mason
Jan 07, 2019
Huntington’s Disease (HD) is an autosomal dominant condition that typically presents in midlife with a combination of motor, cognitive and psychiatric problems along with sleep and metabolic abnormalities. It runs a clinical...
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Intracellular SERS nanoprobes for distinction of different neuronal cell types.
Distinction between closely related and morphologically similar cells is difficult by conventional methods especially without labeling. Using nuclear-targeted gold nanoparticles (AuNPs) as intracellular probes we demonstrate the...
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Stem Cell-Derived Dopamine Neurons
The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron...
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Exploring the predictors of financial impairment in Huntington's disease using the Enroll-HD dataset.
OBJECTIVES: Huntington's disease (HD) is a neurodegenerative disease in which cognitive and behavioural symptoms impair the performance of instrumental activities of daily living, including the handling of finances. We sought to...
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Normal aging and Parkinson's disease are associated with the functional decline of distinct frontal-striatal circuits.
Impaired ability to shift attention between stimuli (i.e. shifting attentional 'set') is a well-established part of the dysexecutive syndrome in Parkinson's Disease (PD), nevertheless cognitive and neural bases of this deficit...
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