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Results: 1263
A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Cora Olpe, Doran Khamis, Maria Chukanova, Nefeli Skoufou-Papoutsaki, Richard Kemp, Kate Marks, Cerys Tatton, Cecilia Lindskog, Anna Nicholson, Roxanne Brunton-Sim, Shalini Malhotra, Rogier Ten Hoopen, Rachael Stanley, Douglas J Winton, Edward Morrissey
Apr 16, 2021
BACKGROUND & AIMS: Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden within colonic crypts exceeds a certain threshold that leads to clonal expansion and ultimately neoplastic transformation....
Colorectal Cancer Initiation crypt fission crypt fusion Intestinal Crypt Adolescent Adult Age Factors Aged Aged 80 and over Cell Proliferation Cell Transformation Neoplastic Colonic Polyps Colorectal Neoplasms Diffusion Epithelial Cells Female Histone Demethylases Humans Intestinal Mucosa Male Middle Aged Models Biological Mutation Neoplastic Stem Cells Proto-Oncogene Proteins p21(ras) Young Adult
The role of [68 Ga]Ga-DOTATATE PET/CT in wild-type KIT/PDGFRA gastrointestinal stromal tumours (GIST).
Luigi Aloj, Olivier Giger, Iosif A Mendichovszky, Ben G Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A Gallagher, Bala Attili, Mary McLean, Robin L Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R Maher, Ruth T Casey
Mar 26, 2021
BACKGROUND: [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor...
The role of [ 68 Ga]Ga-DOTATATE PET/CT in wild-type KIT / PDGFRA gastrointestinal stromal tumours (GIST)
Translating In Vivo Metabolomic Analysis of Succinate Dehydrogenase–Deficient Tumors Into Clinical Utility
Purpose Mutations in the mitochondrial enzyme succinate dehydrogenase (SDH) subunit genes are associated with a wide spectrum of tumors, including pheochromocytomas and paragangliomas...
Ruth T Casey, Mary A McLean, Basetti Madhu, Benjamin G Challis, Rogier Ten Hoopen, Thomas Roberts, Graeme R Clark, Deborah Pitfield, Helen L Simpson, Venkata R Bulusu, Kieren Allinson, Lisa Happerfield, Soo-Mi Park, Alison Marker, Olivier Giger, Eamonn R Maher, Ferdia A Gallagher
Jul 02, 2018
Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.
Ruth T Casey, Mary A McLean, Basetti Madhu, Benjamin G Challis, Rogier Ten Hoopen, Thomas Roberts, Graeme R Clark, Deborah Pittfield, Helen L Simpson, Venkata R Bulusu, Kieran Allinson, Lisa Happerfield, Soo-Mi Park, Alison Marker, Olivier Giger, Eamonn R Maher, Ferdia A Gallagher
Jan 12, 2018
PURPOSE: Mutations in the mitochondrial enzyme succinate dehydrogenase (SDH) subunit genes are associated with a wide spectrum of tumours including phaeochromocytoma and paraganglioma (PPGL) 1, 2, gastrointestinal stromal...
SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice
Ruth T. Casey, Rogier Ten Hoopen, Eguzkine Ochoa, Benjamin G. Challis, James Whitworth, Philip S. Smith, Jose Ezequiel Martin, Graeme R. Clark, Fay Rodger, Mel Maranian, Kieren Allinson, Basetti Madhu, Thomas Roberts, Luis Campos, Joanne Anstee, Soo-Mi Park, Alison Marker, Colin Watts, Venkata R. Bulusu, Olivier T. Giger, Eamonn R. Maher
Jul 14, 2020
Abstract: The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL), wild type gastrointestinal stromal tumour...
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Anna M Nicholson, Cora Olpe, Alice Hoyle, Ann-Sofie Thorsen, Teja Rus, Mathilde Colombé, Roxanne Brunton-Sim, Richard Kemp, Kate Marks, Phil Quirke, Shalini Malhotra, Rogier Ten Hoopen, Ashraf Ibrahim, Cecilia Lindskog, Meagan B Myers, Barbara Parsons, Simon Tavaré, Mark Wilkinson, Edward Morrissey, Douglas J Winton
Aug 16, 2018
We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately...
clone Colon crypt dynamics Epithelium Expansion fission human Mutation Stem Cells Adolescent Adult Aged Aged 80 and over Algorithms Alleles Antigens Nuclear Cell Cycle Proteins Child Colon Epithelial Cells Epithelium Humans Middle Aged Models Statistical Monoamine Oxidase Mutation Stem Cells Young Adult
SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice.
Ruth T Casey, Rogier Ten Hoopen, Eguzkine Ochoa, Benjamin G Challis, James Whitworth, Philip S Smith, Jose Ezequiel Martin, Graeme R Clark, Fay Rodger, Mel Maranian, Kieren Allinson, Basetti Madhu, Thomas Roberts, Luis Campos, Joanne Anstee, Soo-Mi Park, Alison Marker, Colin Watts, Venkata R Bulusu, Olivier T Giger, Eamonn R Maher
Jun 17, 2019
Adolescent Adrenal Gland Neoplasms Adult Aged DNA Methylation Epigenesis Genetic Epigenomics Female Gastrointestinal Stromal Tumors Genes Regulator Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans Male Membrane Proteins Middle Aged Mutation Paraganglioma Pheochromocytoma Promoter Regions Genetic Succinate Dehydrogenase Transcriptome
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Philip S Robinson, Laura E Thomas, Federico Abascal, Hyunchul Jung, Luke MR Harvey, Hannah D West, Sigurgeir Olafsson, Bernard CH Lee, Tim HH Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A Sanders, Stefanie V Lensing, Simon JA Buczacki, Rogier Ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J Campbell, Iñigo Martincorena, Julian R Sampson, Michael R Stratton
Aug 08, 2022
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal...
Program for the Stage Production Ten Little Indians
Curtain Club
Jan 01, 0001
This four-page program details the Curtain Club of Ursinus College's production of Ten Little Indians, held December 7, 1946 in Thompson-Gay Gymnasium. It includes information about the directors, cast, production of the show...
Agatha Christie Curtain Club Ursinus College theater program Thompson-Gay Gymnasium Theatre and Performance Studies Theatre History
Published by: Ursinus College
Reference thresholds for the TEN(HL) test for people with normal hearing.
OBJECTIVE: To estimate normative values and repeatability of thresholds for the TEN(HL) test for diagnosing dead regions in the cochlea, as a function of signal frequency, TEN(HL) level, age and gender. DESIGN: The TEN(HL) test...
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Philip S Robinson, Laura E Thomas, Federico Abascal, Hyunchul Jung, Luke MR Harvey, Hannah D West, Sigurgeir Olafsson, Bernard CH Lee, Tim HH Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A Sanders, Stefanie V Lensing, Simon JA Buczacki, Rogier Ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J Campbell, Iñigo Martincorena, Julian R Sampson, Michael R Stratton
Jul 08, 2022
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal...
Program for the Stage Production Ten Little Indians
Curtain Club
Jan 01, 0001
This four-page program details the Curtain Club of Ursinus College's production of Ten Little Indians, held December 6 and 7, 1957 in Thompson-Gay Gymnasium. It includes information about the directors, cast, production of the...
Agatha Christie Curtain Club Ursinus College theater program Thompson-Gay Gymnasium Theatre and Performance Studies Theatre History
Published by: Ursinus College
One, Five, and Ten-Shot-Based Meta-Learning for Computationally Efficient Head Pose Estimation
Many real-world applications rely on head pose estimation. The performance of head pose estimation has significantly improved with techniques like convolutional neural networks (CNN). However, CNN requires a large amount of data...
Published by: IGI Global Scientific Publishing
Gender, internet experience, internet identification and internet anxiety
Richard Joiner, Jeffrey Gavin, Mark Brosnan, John Cromby, Helen Gregory, Jane Guiller, Pam Maras, Amy Moon
Jul 10, 2012
In 2002, we found gender differences in the use of the Internet. Since then, however, the Internet has changed considerably. We therefore conducted a follow up study in 2012. The study involved 501 students (389 females and 100...
How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults.
OBJECTIVES: To examine age-related differences in self-reported sleep quality and their associations with health outcomes across four domains: physical health, cognitive health, mental health and neural health. SETTING...
Ageing Cognition Healthy ageing Mental Health physical health sleep quality white matter Adolescent Adult Age Factors Aged Aged 80 and over ANISOTROPY Bayes Theorem Cognition Female health status Humans Male Mental Health Middle Aged prevalence Sleep Sleep Wake Disorders United Kingdom white matter Young Adult
Gender, internet experience, internet identification and internet anxiety
Richard Joiner, Jeffrey Gavin, Mark Brosnan, John Cromby, Helen Gregory, Jane Guiller, Pam Maras, Amy Moon
Jul 10, 2012
In 2002, we found gender differences in the use of the Internet. Since then, however, the Internet has changed considerably. We therefore conducted a follow up study in 2012. The study involved 501 students (389 females and 100...
Ten considerations for effectively managing the COVID-19 transition
KB Habersaat, C Betsch, M Danchin, CR Sunstein, R Böhm, A Falk, NT Brewer, SB Omer, M Scherzer, S Sah, EF Fischer, AE Scheel, D Fancourt, S Kitayama, E Dubé, J Leask, M Dutta, NE MacDonald, A Temkina, A Lieberoth, M Jackson, S Lewandowsky, H Seale, N Fietje, P Schmid, M Gelfand, L Korn, S Eitze, L Felgendreff, P Sprengholz, C Salvi, R Butler
Sep 09, 2020
Governments around the world have implemented measures to manage the transmission of coronavirus disease 2019 (COVID-19). While the majority of these measures are proving effective, they have a high social and economic cost, and...
Effect of evidence updates on key determinants of measles vaccination impact
Han Fu, Kaja Abbas, Petra Klepac, Kevin van Zandvoort, Hira Tanvir, Allison Portnoy, Mark Jit
Nov 22, 2021
BACKGROUND: Model-based estimates of measles burden and the impact of measles-containing vaccine (MCV) are crucial for global health priority setting. Recently, evidence from systematic reviews and database analyses have...
Investigating the Impact of Outsourcing on IT Flexibility
Modern healthcare organizations try to leverage their IT infrastructures to enhance the efficiency of processes and the quality of patient services. The flexibility of the IT infrastructure is a critical factor in the process of...
Published by: IGI Global Scientific Publishing
Effect of evidence updates on key determinants of measles vaccination impact
Han Fu, Kaja Abbas, Petra Klepac, Kevin van Zandvoort, Hira Tanvir, Allison Portnoy, Mark Jit
Jan 07, 2022
BACKGROUND: Model-based estimates of measles burden and the impact of measles-containing vaccine (MCV) are crucial for global health priority setting. Recently, evidence from systematic reviews and database analyses have...
Axillary lymphadenopathy at the time of COVID-19 vaccination
Simone Schiaffino, Katja Pinker, Veronica Magni, Andrea Cozzi, Alexandra Athanasiou, Pascal A. T. Baltzer, Julia Camps Herrero, Paola Clauser, Eva M. Fallenberg, Gábor Forrai, Michael H. Fuchsjäger, Thomas H. Helbich, Fleur Kilburn-Toppin, Christiane K. Kuhl, Mihai Lesaru, Ritse M. Mann, Pietro Panizza, Federica Pediconi, Ruud M. Pijnappel, Tamar Sella, Isabelle Thomassin-Naggara, Sophia Zackrisson, Fiona J. Gilbert, Francesco Sardanelli
Aug 26, 2021
Abstract: Unilateral axillary lymphadenopathy is a frequent mild side effect of COVID-19 vaccination. European Society of Breast Imaging (EUSOBI) proposes ten recommendations to standardise its management and reduce unnecessary...
Mutualistic Coupling Between Vocabulary and Reasoning in Young Children
Recent work suggests that the positive manifold of individual differences may arise, or be amplified, by a mechanism called mutualism. Kievit et al. (2017) showed that a latent change score implementation of the mutualism model...
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