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Results: 33
Positron emission tomography-guided magnetic resonance spectroscopy in Alzheimer disease.
Nasim Sheikh-Bahaei, S Ahmad Sajjadi, Roido Manavaki, Mary McLean, John T O'Brien, Jonathan H Gillard
Mar 13, 2018
OBJECTIVE: To determine whether the level of metabolites in magnetic resonance spectroscopy (MRS) is a representative marker of underlying pathological changes identified in positron emission tomographic (PET) images in...
Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease.
Nasim Sheikh-Bahaei, Roido Manavaki, S Ahmad Sajjadi, Andrew N Priest, John T O'Brien, Jonathan H Gillard
Apr 11, 2019
BACKGROUND: Despite the well-documented relationship between lobar cerebral microbleeds (lCMB) and Alzheimer's disease (AD), there is limited knowledge about the role of lCMB in AD pathology. OBJECTIVE: To understand the nature...
Alzheimer’s disease FDG-PET PiB-PET cerebral metabolism cerebral perfusion lobar cerebral microbleeds susceptibility weighted imaging Aged Aged 80 and over Alzheimer Disease Amyloid beta-Peptides Brain cerebral hemorrhage Cognitive Dysfunction Female Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Male Positron-Emission Tomography
Vascular Imaging With $^{18}$F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia
FR Joshi, R Manavaki, TD Fryer, NL Figg, JC Sluimer, FI Aigbirhio, AP Davenport, PJ Kirkpatrick, EA Warburton, JHF Rudd
Apr 05, 2017
This study was funded by a programme grant (RG/10/007/28300) from the British Heart Foundation (BHF). Dr. Joshi was supported by a BHF Clinical Research Training Fellowship (FS/12/29/29463), a British Atherosclerosis Society...
Assessment of early treatment response to neoadjuvant chemotherapy in breast cancer using non-mono-exponential diffusion models
Reem Bedair, Andrew N Priest, Andrew J Patterson, Mary A McLean, Martin J Graves, Roido Manavaki, Andrew B Gill, Oshaani Abeyakoon, John R Griffiths, Fiona J Gilbert
Dec 06, 2016
Breast carcinoma diffusion-weighted MRI Neoadjuvant treatment quantitative evaluation Tumour biomarkers Adult Aged Antineoplastic Combined Chemotherapy Protocols Breast Neoplasms Chemotherapy Adjuvant cyclophosphamide Diffusion Magnetic Resonance Imaging Docetaxel Epirubicin Feasibility Studies Female Fluorouracil Humans Magnetic Resonance Imaging Middle Aged Neoadjuvant Therapy Reproducibility of Results Taxoids
Tess E Wallace, Andrew J Patterson, Oshaani Abeyakoon, Reem Bedair, Roido Manavaki, Mary A McLean, James PB O'Connor, Martin J Graves, Fiona J Gilbert
Jan 22, 2016
A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index.
Julia J Schubert, Mattia Veronese, Tim D Fryer, Roido Manavaki, Manfred G Kitzbichler, Maria A Nettis, Valeria Mondelli, Carmine M Pariante, Edward T Bullmore, NIMA Consortium, Federico E Turkheimer
Feb 24, 2021
BACKGROUND: Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)-targeted positron emission tomography (PET) has been used to assess neuroinflammation in major depressive...
Hypoxia and perfusion in breast cancer
Julia C Carmona-Bozo, Roido Manavaki, Ramona Woitek, Turid Torheim, Gabrielle C Baxter, Corradina Caracò, Elena Provenzano, Martin J Graves, Tim D Fryer, Andrew J Patterson, Fiona J Gilbert
Jun 09, 2020
Reem Bedair, Martin J Graves, Andrew J Patterson, Mary A McLean, Roido Manavaki, Tess Wallace, Scott Reid, Iosif Mendichovszky, John Griffiths, Fiona J Gilbert
Jul 23, 2015
[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Sep 05, 2021
While [18F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of 'off-target' [18F]-AV-1451 binding to neuromelanin in the substantia nigra could be a...
Optoacoustic Imaging Detects Hormone-Related Physiological Changes of Breast Parenchyma.
Oshaani Abeyakoon, Stefan Morscher, Nina Dalhaus, Steven J Ford, Iosif A Mendichovszky, Roido Manavaki, Matthew Wallis, Penelope Moyle, Ramona Woitek, Andrew Patterson, Turid Torheim, James Joseph, Isabel Quiros Gonzalez, Sarah Bohndiek, Fiona J Gilbert
Sep 05, 2018
PURPOSE: Optoacoustic imaging with ultrasound (OPUS) can assess in-vivo perfusion/oxygenation through surrogate measures of oxy, deoxy and total hemoglobin content in tissues. The primary aim of our study was to evaluate the...
[<sup>18</sup>F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Oct 07, 2021
Published by: Brain communications
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Feb 13, 2020
PURPOSE: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging.
Andrej Ćorović, Deepa Gopalan, Christopher Wall, Marta Peverelli, Stephen P Hoole, Patrick A Calvert, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Martin R Bennett, James HF Rudd, Jason M Tarkin
Feb 17, 2023
Post-infarct inflammation and its resolution modulate ischemic injury after myocardial infarction (MI). While cardiac magnetic resonance imaging (MRI) is useful for assessing ventricular function, viability and structural...
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18 F-GE-180 and comparison with 18 F-FDG and DCE-MRI
Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer, Pilar Jimenez-Royo
Dec 22, 2020
Abstract: Purpose: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...
Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.
Negin Holland, P Simon Jones, George Savulich, Julie K Wiggins, Young T Hong, Tim D Fryer, Roido Manavaki, Selena Milicevic Sephton, Istvan Boros, Maura Malpetti, Frank H Hezemans, Franklin I Aigbirhio, Jonathan P Coles, John O'Brien, James B Rowe
Jun 11, 2020
BACKGROUND: Synaptic loss is a prominent and early feature of many neurodegenerative diseases. OBJECTIVES: We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy...
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Jan 27, 2020
PURPOSE:While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.
Elijah Mak, Negin Holland, P Simon Jones, George Savulich, Audrey Low, Maura Malpetti, Sanne S Kaalund, Luca Passamonti, Timothy Rittman, Rafael Romero-Garcia, Roido Manavaki, Guy B Williams, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Jan 25, 2021
Novel Approach to Imaging Active Takayasu Arteritis Using Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging.
Jason M Tarkin, Christopher Wall, Deepa Gopalan, Luigi Aloj, Roido Manavaki, Tim D Fryer, Eric O Aboagye, Martin R Bennett, James E Peters, James HF Rudd, Justin C Mason
Jan 08, 2020
Takayasu arteritis Aortic Diseases Molecular Imaging positron emission tomography Vasculitis Adult Aorta Biomarkers Female Fluorodeoxyglucose F18 Glucocorticoids Humans Immunosuppressive Agents Magnetic Resonance Imaging Middle Aged Molecular Imaging Organometallic Compounds Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals Receptors Somatostatin Takotsubo cardiomyopathy Treatment Outcome
Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain.
Marian Galovic, Kjell Erlandsson, Tim D Fryer, Young T Hong, Roido Manavaki, Hasan Sari, Sarah Chetcuti, Benjamin A Thomas, Martin Fisher, Selena Sephton, Roberto Canales, Joseph J Russell, Kerstin Sander, Erik Årstad, Franklin I Aigbirhio, Ashley M Groves, John S Duncan, Kris Thielemans, Brian F Hutton, Jonathan P Coles, Matthias J Koepp, NEST investigators
May 27, 2021
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