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The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls
BACKGROUND: Modern cognitive neuropsychological models of depression posit that negatively biased emotional ("hot") processing confers risk for depression, while preserved executive function ("cold") cognition promotes...
Disrupted habenula function in major depression.
The habenula is a small, evolutionarily conserved brain structure that plays a central role in aversive processing and is hypothesised to be hyperactive in depression, contributing to the generation of symptoms such as...
The Lancet Psychiatry Commission on psychological treatments research in tomorrow's science
EA Holmes, A Ghaderi, CJ Harmer, PG Ramchandani, P Cuijpers, AP Morrison, JP Roiser, CLH Bockting, RC O'Connor, R Shafran, ML Moulds, MG Craske
Jul 31, 2019
Executive summary
Background
Psychological treatments occupy an important place in
evidence-based mental health treatments. Now is an
exciting time to fuel treatment research: a pressing
demand for improvements is poised...
Measuring cognitive effort without difficulty.
An important finding in the cognitive effort literature has been that sensitivity to the costs of effort varies between individuals, suggesting that some people find effort more aversive than others. It has been suggested this...
Reliability of Fronto-Amygdala Coupling during Emotional Face Processing.
One of the most exciting translational prospects for brain imaging research is the potential use of functional magnetic resonance imaging (fMRI) 'biomarkers' to predict an individual's risk of developing a neuropsychiatric...
Chiral soliton predictions for exotic baryons.
We re-analyze the predictions of chiral-soliton models for the masses and
decay widths of baryons in the exotic antidecuplet of flavour SU(3). The calculated
ranges of the chiral-soliton moment of inertia and the π-nucleon...
Published by: HEP, Cavendish Laboratory, University of Cambridge
The acute and non-acute effects of cannabis on reward processing
Martine Skumlien, Christelle Langley, Will Lawn, Valerie Voon, H Valerie Curran, Jonathan P Roiser, Barbara J Sahakian
Nov 30, 2021
Cannabis use has historically been thought to cause amotivation, but the relationship between cannabis and apathy, anhedonia, and reward processing remains poorly characterised. In this systematic review, we evaluated whether...
The acute and non-acute effects of cannabis on reward processing
Martine Skumlien, Christelle Langley, Will Lawn, Valerie Voon, H Valerie Curran, Jonathan P Roiser, Barbara J Sahakian
Nov 30, 2021
Cannabis use has historically been thought to cause amotivation, but the relationship between cannabis and apathy, anhedonia, and reward processing remains poorly characterised. In this systematic review, we evaluated whether...
The habenula encodes negative motivational value associated with primary punishment in humans.
Rebecca P Lawson, Ben Seymour, Eleanor Loh, Antoine Lutti, Raymond J Dolan, Peter Dayan, Nikolaus Weiskopf, Jonathan P Roiser
May 08, 2019
Learning what to approach, and what to avoid, involves assigning value to environmental cues that predict positive and negative events. Studies in animals indicate that the lateral habenula encodes the previously learned...
Disraeli, the East and Religion
JP Parry
Aug 18, 2017
After the freeholder
JP Betts
Jun 28, 2017
Connection probabilities for conformal loop ensembles
The goal of the present paper is to explain, based on properties of the conformal loop ensembles $\CLE_\kappa$ (both with simple and non-simple loops, i.e., for the whole range $\kappa \in (8/3, 8)$) how to derive the connection...
1867 and the Rule of Wealth
JP Parry
Feb 15, 2017
This essay examines the widespread concern in the 1860s and 1870s with ‘plutocracy’ – the political and social power of commercial wealth. It argues that we should not interpret either the pressure for parliamentary reform in...
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