Search
Results: 44
Polymers of Z α1-antitrypsin are secreted in cell models of disease.
Annamaria Fra, Francesca Cosmi, Adriana Ordoñez, Romina Berardelli, Juan Perez, Noemi A Guadagno, Luciano Corda, Stefan J Marciniak, David A Lomas, Elena Miranda
Feb 12, 2019
An Inquiry Into the Use of Generative AI and Its Implications in Education
The emergence of generative AI technologies has provoked considerable debate among educators regarding their role in education. This study is an investigation of the benefits, disadvantages, and potential strategies for...
Published by: IGI Global Scientific Publishing
Dendritic Cells Charged with Apoptotic Tumor Cells Induce Long-Lived Protective CD4+ and CD8+ T Cell Immunity against B16 Melanoma
Dendritic cells (DCs) are potent APCs and attractive vectors for cancer immunotherapy. Using the B16 melanoma, a poorly immunogenic experimental tumor that expresses low levels of MHC class I products, we investigated whether...
Apoptosis bone marrow cell antigen recognition cytokine release lymph node lymphatic drainage melanoma cell tumor immunity
Published by: Rockefeller University
Three-dimensional morphological analysis of placental terminal villi.
Romina Plitman Mayo, Yassen Abbas, D Stephen Charnock-Jones, Graham J Burton, Gil Marom
Oct 01, 2019
Transport of nutrients and waste between the maternal and fetal circulations during pregnancy takes place at the final branches of the placental villous trees. Therefore, and unsurprisingly, pregnancy complications have been...
A Ramsey characterisation of eventually periodic words
A factorisation $x = u_1 u_2 \cdots$ of an infinite word $x$ on alphabet $X$
is called `monochromatic', for a given colouring of the finite words $X^*$ on
alphabet $X$, if each $u_i$ is the same colour. Wojcik and Zamboni proved...
ROS-Scavenging Enzymes as an Antioxidant Response to High Concentration of Anthracene in the Liverwort Marchantia polymorpha L
Nahuel Spinedi, Romina Storb, Elisabet Aranda, Facundo Romani, Maya Svriz, Santiago A. Varela, Javier E. Moreno, Sebastian Fracchia, Juan Cabrera, Ramón Alberto Batista-García, Inés Ponce de León, J. Martín Scervino
Jul 28, 2021
Marchantia polymorpha L. responds to environmental changes using a myriad set of physiological responses, some unique to the lineage related to the lack of a vascular- and root-system. This study investigates the physiological...
Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer's Disease and in Down Syndrome Dementia.
Ruma Raha-Chowdhury, James W Henderson, Animesh Alexander Raha, Romina Vuono, Anastasia Bickerton, Elizabeth Jones, Robert Fincham, Kieren Allinson, Anthony Holland, Shahid H Zaman
May 28, 2019
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD
Ondrej Cerny, Camilla Godlee, Romina Tocci, Nancy E. Cross, Haoran Shi, James C. Williamson, Eric Alix, Paul J. Lehner, David W. Holden
Aug 11, 2021
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. This requires the...
Association Between Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Genetic Variants and Clinical Progression of Huntington's Disease.
Romina Vuono, Antonina Kouli, Emilie M Legault, Lauriane Chagnon, Kieren S Allinson, Alberto La Spada, REGISTRY Investigators of the European Huntington's Disease Network, Ida Biunno, Roger A Barker, Janelle Drouin-Ouellet
Sep 11, 2019
Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.
Animesh Alexander Raha, James W Henderson, Simon RW Stott, Romina Vuono, Simona Foscarin, Robert P Friedland, Shahid H Zaman, Ruma Raha-Chowdhury
Sep 22, 2016
Alzheimer’ disease choroid plexus macrophages immunomodulation innate immunity Myelination Neurogenesis Neuroinflammation neuroplasticity neuroprotective soluble TREM2 aging Alzheimer Disease Amyloid beta-Protein Precursor Animals Brain Cells Cultured Humans Lipopolysaccharides MACROPHAGES Membrane Glycoproteins meninges Mice Inbred C57BL Mice Transgenic Microglia Neurogenesis Neurons Neuroprotection Presenilin-1 RNA Messenger Rats Sprague-Dawley Receptors Immunologic
Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
Mark A Johnson, Sara Vidoni, Romina Durigon, Sarah F Pearce, Joanna Rorbach, Jiuya He, Gloria Brea-Calvo, Michal Minczuk, Aurelio Reyes, Ian J Holt, Antonella Spinazzola
Nov 13, 2017
Amino acids are essential for cell growth and proliferation for they can serve as precursors of protein synthesis, be remodelled for nucleotide and fat biosynthesis, or be burnt as fuel. Mitochondria are energy producing...
Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells.
Coronavirus disease 2019 (COVID-19)-related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Omicron variant.
Paolo Boscolo-Rizzo, Giancarlo Tirelli, Pierluigi Meloni, Claire Hopkins, Giordano Madeddu, Andrea De Vito, Nicoletta Gardenal, Romina Valentinotti, Margherita Tofanelli, Daniele Borsetto, Jerome R Lechien, Jerry Polesel, Giacomo De Riu, Luigi Angelo Vaira
Mar 31, 2022
BACKGROUND: The aim of this study was to estimate the prevalence of self-reported chemosensory dysfunction in a study cohort of subjects who developed a mild-to-moderate coronavirus disease 2019 (COVID-19) in the period from...
ROS-Scavenging Enzymes as an Antioxidant Response to High Concentration of Anthracene in the Liverwort <i>Marchantia polymorpha</i> L.
Nahuel Spinedi, Romina Storb, Elisabet Aranda, Facundo Romani, Maya Svriz, Santiago A Varela, Javier E Moreno, Sebastian Fracchia, Juan Cabrera, Ramón Alberto Batista-García, Inés Ponce de León, J Martín Scervino
Sep 10, 2021
Marchantia polymorpha L. responds to environmental changes using a myriad set of physiological responses, some unique to the lineage related to the lack of a vascular- and root-system. This study investigates the...
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
Ondrej Cerny, Camilla Godlee, Romina Tocci, Nancy E Cross, Haoran Shi, James C Williamson, Eric Alix, Paul J Lehner, David W Holden
Aug 27, 2021
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. This requires the...
Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease.
David P Breen, Cristina Nombela, Romina Vuono, P Simon Jones, Kate Fisher, David J Burn, David J Brooks, Akhilesh B Reddy, James B Rowe, Roger A Barker
Feb 08, 2016
MPV17L2 is required for ribosome assembly in mitochondria.
Ilaria Dalla Rosa, Romina Durigon, Sarah F Pearce, Joanna Rorbach, Elizabeth MA Hirst, Sara Vidoni, Aurelio Reyes, Gloria Brea-Calvo, Michal Minczuk, Michael W Woellhaf, Johannes M Herrmann, Martijn A Huynen, Ian J Holt, Antonella Spinazzola
Nov 13, 2017
MPV17 is a mitochondrial protein of unknown function, and mutations in MPV17 are associated with mitochondrial deoxyribonucleic acid (DNA) maintenance disorders. Here we investigated its most similar relative, MPV17L2, which is...
ROS-Scavenging Enzymes as an Antioxidant Response to High Concentration of Anthracene in the Liverwort Marchantia polymorpha L.
Nahuel Spinedi, Romina Storb, Elisabet Aranda, Facundo Romani, Maya Svriz, Santiago A Varela, Javier E Moreno, Sebastian Fracchia, Juan Cabrera, Ramón Alberto Batista-García, Inés Ponce de León, J Martín Scervino
Aug 05, 2021
Marchantia polymorpha L. responds to environmental changes using a myriad set of physiological responses, some unique to the lineage related to the lack of a vascular- and root-system. This study investigates the physiological...
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
Janelle Drouin-Ouellet, Shong Lau, Per Ludvik Brattås, Daniella Rylander Ottosson, Karolina Pircs, Daniela A Grassi, Lucy M Collins, Romina Vuono, Annika Andersson Sjöland, Gunilla Westergren-Thorsson, Caroline Graff, Lennart Minthon, Håkan Toresson, Roger A Barker, Johan Jakobsson, Malin Parmar
Nov 27, 2017
Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This technology offers a promising shortcut for obtaining patient- and...
A practical guide for mutational signature analysis in hematological malignancies
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S. Puente, Herve Avet-Loiseau, Peter J. Campbell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli
Jul 04, 2020
Abstract: Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis...
Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.
Mercedes Segovia, Sofia Russo, Mathias Jeldres, Yamil D Mahmoud, Valentina Perez, Maite Duhalde, Pierre Charnet, Matthieu Rousset, Sabina Victoria, Florencia Veigas, Cédric Louvet, Bernard Vanhove, R Andrés Floto, Ignacio Anegon, Maria Cristina Cuturi, M Romina Girotti, Gabriel A Rabinovich, Marcelo Hill
May 09, 2019
TMEM176B Cancer Dendritic Cells immune checkpoint blockers inflammasome Ion channel 3-Pyridinecarboxylic acid 1 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Methyl ester Animals Antibodies Monoclonal Antineoplastic Agents CD8-Positive T-Lymphocytes CHO Cells Cell Line Cell Line Tumor Cell Proliferation Cricetulus Female Humans Inflammasomes Male Membrane Proteins Mice Mice Inbred BALB C Mice Inbred C57BL Neoplasms Xenopus laevis
The coding and long noncoding single-cell atlas of the developing human fetal striatum.
Vittoria Dickinson Bocchi, Paola Conforti, Elena Vezzoli, Dario Besusso, Claudio Cappadona, Tiziana Lischetti, Maura Galimberti, Valeria Ranzani, Raoul Jp Bonnal, Marco De Simone, Grazisa Rossetti, Xiaoling He, Kenji Kamimoto, Ira Espuny-Camacho, Andrea Faedo, Federica Gervasoni, Romina Vuono, Samantha A Morris, Jian Chen, Dan Felsenfeld, Giulio Pavesi, Roger A Barker, Massimiliano Pagani, Elena Cattaneo
May 10, 2021
Deciphering how the human striatum develops is necessary for understanding the diseases that affect this region. To decode the transcriptional modules that regulate this structure during development, we compiled a catalog of...
A practical guide for mutational signature analysis in hematological malignancies.
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S Puente, Herve Avet-Loiseau, Peter J Cambell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli
Jul 15, 2019
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Oct 24, 2022
We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's...
|
|< |
< |
1 |