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Interview with John Chester
John Chester
Jan 01, 0001
In his April 3, 2008 interview with Kristin Malone, John Chester details his service overseas in Europe during WWII. Included are stories of interactions with German soldiers and the rules and regulations of the United States...
Published by: Winthrop University
John Hewson-a Festschrift
John Hewson
Sep 05, 2013
Dr. John Hewson's appointment to Memorial University's Henrietta Harvey Chair in May 1997 marked 37 years of distinguished service as scholar, teacher and administrator.
Dr. Hewson, an APLA member since the early days of our...
Published by: Atlantic Provinces Linguistic Association
Intracellular Sources of ROS/H 2 O 2 in Health and Neurodegeneration
Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors....
Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis.
Matthew A Deragon, William D McCaig, Payal S Patel, Robert J Haluska, Alexa L Hodges, Sergey A Sosunov, Michael P Murphy, Vadim S Ten, Timothy J LaRocca
Dec 22, 2020
We have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of...
John Hewson-a Festschrift
John Hewson
Sep 05, 2013
Dr. John Hewson's appointment to Memorial University's Henrietta Harvey Chair in May 1997 marked 37 years of distinguished service as scholar, teacher and administrator.
Dr. Hewson, an APLA member since the early days of our...
Published by: Atlantic Provinces Linguistic Association
Mitochondrial ROS cause motor deficits induced by synaptic inactivity
Eva Sidlauskaite, Jack W Gibson, Ian L Megson, Philip D Whitfield, Artak Tovmasyan, Ines Batinic-Haberle, Michael P Murphy, Peter R Moult, James N Cobley
Jun 18, 2018
Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. To...
Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration
Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors....
Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.
Elizabeth C Hinchy, Anja V Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R Hall, Georgina Bates, Thomas P Bright, Thomas Krieg, David Carling, Michael P Murphy
Nov 21, 2018
Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal that transmits information from the organelle to the cell. Other mitochondrial signals, such as ATP, are sensed by enzymes, including the...
AMP-activated kinase (AMPK) Hydrogen Peroxide Mitochondria reactive oxygen species (ROS) redox signaling AMP-Activated Protein Kinases Adenosine Diphosphate Adenosine Triphosphate Animals Cell Line Enzyme Activation Humans Hydrogen Peroxide Mice Mitochondria Muscle Fibers Skeletal Oxidation-Reduction Reactive Oxygen Species
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Edward T Chouchani, Victoria R Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y Sundier, Ellen L Robb, Angela Logan, Sergiy M Nadtochiy, Emily NJ Ord, Anthony C Smith, Filmon Eyassu, Rachel Shirley, Chou-Hui Hu, Anna J Dare, Andrew M James, Sebastian Rogatti, Richard C Hartley, Simon Eaton, Ana SH Costa, Paul S Brookes, Sean M Davidson, Michael R Duchen, Kourosh Saeb-Parsy, Michael J Shattock, Alan J Robinson, Lorraine M Work, Christian Frezza, Thomas Krieg, Michael P Murphy
Jan 20, 2020
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many disorders, notably heart attack and stroke. While reperfusion of ischaemic tissue is essential for...
Adenosine Monophosphate Animals Aspartic Acid Citric Acid Cycle Disease Models Animal Electron Transport Electron Transport Complex I Fumarates Ischemia Malates Male Metabolomics Mice Mitochondria Myocardial Infarction Myocardium Myocytes Cardiac NAD Reactive Oxygen Species Reperfusion Injury stroke Succinate Dehydrogenase Succinic Acid
Regulation of neuronal development and function by ROS.
Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well...
John H. Northrop, 1925
The Rockefeller University
Jan 01, 0001
Dr. John H. Northrop. The Dynamics of Pepsin and Trypsin
Lecture delivered November 14th, 1925
Posted with permission
Published by: The Williams & Wilkins Company
The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy
Cancer is one of the world’s deadliest afflictions. Despite recent advances in diagnostic and surgical technologies, as well as improved treatments of some individual tumor types, there is currently no universal cure to prevent...
Ionized gas (plasma) delivery of reactive oxygen species (ROS) into artificial cells
This study was designed to enhance our understanding of how reactive oxygen species (ROS), generated ex situ by ionized gas (plasma), can affect the regulation of signalling processes within cells. A model system, comprising of...
John Bossy
Alexandra Walsham
Oct 10, 2018
John Bossy, who died on 23 October 2015 at the age of 82, had a
long association with Past and Present. He became a member of
the Editorial Board in 1973 and during the course of his career
published a number of seminal articles...
Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster.
Filippo Scialò, Ashwin Sriram, Rhoda Stefanatos, Ruth V Spriggs, Samantha HY Loh, L Miguel Martins, Alberto Sanz
Feb 26, 2021
Reactive Oxygen Species (ROS) are essential cellular messengers required for cellular homeostasis and regulate the lifespan of several animal species. The main site of ROS production is the mitochondrion, and within it...
Ionized gas (plasma) delivery of reactive oxygen species (ROS) into artificial cells
This study was designed to enhance our understanding of how reactive oxygen species (ROS), generated ex situ by ionized gas (plasma), can affect the regulation of signalling processes within cells. A model system, comprising of...
John “Mule” Miles
Joe G. Gonzales
Apr 01, 2020
Imagine being a 14-year-old kid doing a project for history about a topic you enjoy. My group and I decided to research the history of baseball, but more specifically, the history of the Negro League. A league that solely for...
Published by: Digital Commons @ Texas A&M University-San Antonio
John “Mule” Miles
Joe G. Gonzales
Apr 01, 2020
Imagine being a 14-year-old kid doing a project for history about a topic you enjoy. My group and I decided to research the history of baseball, but more specifically, the history of the Negro League. A league that solely for...
Published by: Digital Commons @ Texas A&M University-San Antonio
Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer.
13C nuclear spin hyperpolarization can increase the sensitivity of detection in an MRI experiment by more than 10,000-fold. 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between...
Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.
Ye-Ri Kim, Jeong-In Baek, Sung Hwan Kim, Min-A Kim, Byeonghyeon Lee, Nari Ryu, Kyung-Hee Kim, Deok-Gyun Choi, Hye-Min Kim, Michael P Murphy, Greg Macpherson, Yeon-Sik Choo, Jinwoong Bok, Kyu-Yup Lee, Jeen-Woo Park, Un-Kyung Kim
Jan 02, 2019
Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-producing enzyme which is essential for maintaining the mitochondrial redox balance in cells. We sought to determine whether IDH2 deficiency...
antioxidant Hearing Loss Idh2 MitoQ NADP(+) ROS Animals Apoptosis Biomarkers Disease Models Animal Fluorescent Antibody Technique Hair Cells Auditory Hearing Loss Sensorineural Homozygote Immunohistochemistry Isocitrate Dehydrogenase Mice Mice Knockout Mitochondria Organophosphorus Compounds Oxidation-Reduction Oxidative Stress Reactive Oxygen Species Spiral Ganglion Ubiquinone
JOSHUA LEDERBERG - JOHN VON NEUMANN SYMPOSIUM
The Rockefeller University
Jan 01, 0001
The Joshua Lederberg-John von Neumann Symposium: Toward Quantitative Biology
Published by: The Rockefeller University
John “Mule” Miles
Joe G. Gonzales
Apr 01, 2020
Imagine being a 14-year-old kid doing a project for history about a topic you enjoy. My group and I decided to research the history of baseball, but more specifically, the history of the Negro League. A league that solely for...
Published by: Digital Commons @ Texas A&M University-San Antonio
Structural basis for a complex I mutation that blocks pathological ROS production.
Zhan Yin, Nils Burger, Duvaraka Kula-Alwar, Dunja Aksentijević, Hannah R Bridges, Hiran A Prag, Daniel N Grba, Carlo Viscomi, Andrew M James, Amin Mottahedin, Thomas Krieg, Michael P Murphy, Judy Hirst
Feb 17, 2021
Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point mutation...
Amino Acid Substitution Animals Cryoelectron Microscopy DNA Mitochondrial Disease Models Animal Disease Resistance Electron Transport Electron Transport Complex I Humans Isolated Heart Preparation Leucine Male Mice Mice Transgenic Mitochondria Mitochondrial Membranes Myocardial Reperfusion Injury NAD NADH Dehydrogenase Oxidation-Reduction Point Mutation Proline Reactive Oxygen Species
JOSHUA LEDERBERG - JOHN VON NEUMANN SYMPOSIUM
The Rockefeller University
Jan 01, 0001
The Joshua Lederberg-John von Neumann Symposium: Toward Quantitative Biology
Published by: The Rockefeller University
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling
Anindya Roy Chowdhury, Jacek Zielonka, Balaraman Kalyanaraman, Richard C Hartley, Michael P Murphy, Narayan G Avadhani
Jul 06, 2020
The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK...
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