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p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian YH Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A Malagon, Patricia Valerio, Marcos F Fondevila, Johan Fernø, Maria M Malagon, Raian Contreras, Paul Pfluger, Jens C Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Sep 10, 2018
p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide...
HPG pore
BACKGROUND: The use of nanopore technologies is expected to spread in the future because they are portable and can sequence long fragments of DNA molecules without prior amplification. The first nanopore sequencer available, the...
The Impact of Customer Relationship Management Systems on Dynamic Capabilities at Firms
The banking industry has been forced to restructure its processes to get adapted to a more technological environment as a consequence of the changes experienced in the market. Academic literature has paid special attention to...
Published by: IGI Global Scientific Publishing
The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans.
Chenchun Weng, Joanna Kosalka, Ahmet C Berkyurek, Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang, Eric A Miska
Jan 08, 2019
Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and are essential for fertility in a variety of organisms. In Caenorhabditis elegans, most piRNA...
ELF5 modulates the estrogen receptor cistrome in breast cancer.
Catherine L Piggin, Daniel L Roden, Andrew MK Law, Mark P Molloy, Christoph Krisp, Alexander Swarbrick, Matthew J Naylor, Maria Kalyuga, Warren Kaplan, Samantha R Oakes, David Gallego-Ortega, Susan J Clark, Jason S Carroll, Nenad Bartonicek, Christopher J Ormandy
Feb 13, 2020
Acquired resistance to endocrine therapy is responsible for half of the therapeutic failures in the treatment of breast cancer. Recent findings have implicated increased expression of the ETS transcription factor ELF5 as a...
Genome-wide DNA methylation and gene expression patterns reflect genetic ancestry and environmental differences across the Indonesian archipelago.
Heini M Natri, Katalina S Bobowik, Pradiptajati Kusuma, Chelzie Crenna Darusallam, Guy S Jacobs, Georgi Hudjashov, J Stephen Lansing, Herawati Sudoyo, Nicholas E Banovich, Murray P Cox, Irene Gallego Romero
Jul 03, 2020
Indonesia is the world's fourth most populous country, host to striking levels of human diversity, regional patterns of admixture, and varying degrees of introgression from both Neanderthals and Denisovans. However, it has been...
What do rates of deposition of dental cementum tell us? Functional and evolutionary hypotheses in red deer.
FJ Pérez-Barbería, FE Guinness, M López-Quintanilla, AJ García, L Gallego, J Cappelli, MP Serrano, T Landete-Castillejos
Apr 30, 2020
Cementum is a bone connective tissue that provides a flexible attachment for the tooth to the alveolar bone in many mammalian species. It does not undergo continuous remodelling, unlike non-dental bone, which combined with its...
Worldwide insect declines
Benno I Simmons, Andrew Balmford, Andrew J Bladon, Alec P Christie, Adriana De Palma, Lynn V Dicks, Juan Gallego-Zamorano, Alison Johnston, Philip A Martin, Andy Purvis, Ricardo Rocha, Hannah S Wauchope, Claire FR Wordley, Thomas A Worthington, Tom Finch
Apr 17, 2019
A recent paper claiming evidence of global insect declines achieved huge media attention, including claims of "insectaggedon" and a "collapse of nature." Here, we argue that while many insects are declining in many places around...
Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent.
M Gallego Llorente, ER Jones, A Eriksson, V Siska, KW Arthur, JW Arthur, MC Curtis, JT Stock, M Coltorti, P Pieruccini, S Stretton, F Brock, T Higham, Y Park, M Hofreiter, DG Bradley, J Bhak, R Pinhasi, A Manica
Aug 09, 2017
Where Might We Find Ecologically Intact Communities?
Conservation efforts should target the few remaining areas of the world that represent outstanding examples of ecological integrity and aim to restore ecological integrity to a much broader area of the world with intact...
Andrew J Plumptre, Daniele Baisero, R Travis Belote, Ella Vázquez-Domínguez, Soren Faurby, Włodzimierz Jȩdrzejewski, Henry Kiara, Hjalmar Kühl, Ana Benítez-López, Carlos Luna-Aranguré, Maria Voigt, Serge Wich, William Wint, Juan Gallego-Zamorano, Charlotte Boyd
Apr 29, 2021
Molecular dynamics simulation of the behaviour of water in nano-confined ionic liquid-water mixtures.
B Docampo-Álvarez, V Gómez-González, H Montes-Campos, JM Otero-Mato, T Méndez-Morales, O Cabeza, LJ Gallego, RM Lynden-Bell, VB Ivaništšev, MV Fedorov, LM Varela
Apr 14, 2016
Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation.
Yan Xue, Zhenhui Zhong, C Jake Harris, Javier Gallego-Bartolomé, Ming Wang, Colette Picard, Xueshi Cao, Shan Hua, Ivy Kwok, Suhua Feng, Yasaman Jami-Alahmadi, Jihui Sha, Jason Gardiner, James Wohlschlegel, Steven E Jacobsen
Sep 13, 2021
The Microrchidia (MORC) family of ATPases are required for transposable element (TE) silencing and heterochromatin condensation in plants and animals, and C. elegans MORC-1 has been shown to topologically entrap and condense...
Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data.
Min Hu, Qasim Ayub, José Afonso Guerra-Assunção, Quan Long, Zemin Ning, Ni Huang, Irene Gallego Romero, Lira Mamanova, Pelin Akan, Xin Liu, Alison J Coffey, Daniel J Turner, Harold Swerdlow, John Burton, Michael A Quail, Donald F Conrad, Anton J Enright, Chris Tyler-Smith, Yali Xue
Jan 23, 2018
We have investigated whether regions of the genome showing signs of positive selection in scans based on haplotype structure also show evidence of positive selection when sequence-based tests are applied, whether the target of...
Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent.
Marcos Gallego Llorente, Eppie Jones, Anders Eriksson, Veronika Siska, KW Arthur, JW Arthur, MC Curtis, Jay Stock, M Coltorti, P Pieruccini, S Stretton, F Brock, T Higham, Y Park, M Hofreiter, DG Bradley, J Bhak, R Pinhasi, Andrea Manica
Dec 04, 2015
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many...
The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.
Chandana Basu Mallick, Florin Mircea Iliescu, Märt Möls, Sarah Hill, Rakesh Tamang, Gyaneshwer Chaubey, Rie Goto, Simon YW Ho, Irene Gallego Romero, Federica Crivellaro, Georgi Hudjashov, Niraj Rai, Mait Metspalu, CG Nicholas Mascie-Taylor, Ramasamy Pitchappan, Lalji Singh, Marta Mirazon-Lahr, Kumarasamy Thangaraj, Richard Villems, Toomas Kivisild
Sep 08, 2018
Skin pigmentation is one of the most variable phenotypic traits in humans. A non-synonymous substitution (rs1426654) in the third exon of SLC24A5 accounts for lighter skin in Europeans but not in East Asians. A previous...
The genetics of an early Neolithic pastoralist from the Zagros, Iran.
M Gallego-Llorente, S Connell, ER Jones, DC Merrett, Y Jeon, A Eriksson, V Siska, C Gamba, C Meiklejohn, R Beyer, S Jeon, YS Cho, M Hofreiter, J Bhak, A Manica, R Pinhasi
Oct 18, 2018
The agricultural transition profoundly changed human societies. We sequenced and analysed the first genome (1.39x) of an early Neolithic woman from Ganj Dareh, in the Zagros Mountains of Iran, a site with early evidence for an...
Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago.
Veronika Siska, Eppie Ruth Jones, Sungwon Jeon, Youngjune Bhak, Hak-Min Kim, Yun Sung Cho, Hyunho Kim, Kyusang Lee, Elizaveta Veselovskaya, Tatiana Balueva, Marcos Gallego-Llorente, Michael Hofreiter, Daniel G Bradley, Anders Eriksson, Ron Pinhasi, Jong Bhak, Andrea Manica
Mar 14, 2017
East Asia Russian Far East ancient genetics human population genetics Neolithic Archaeology DNA Mitochondrial Asia Eastern Genome Human Genotype Guanine Nucleotide Exchange Factors Humans Phenotype Polymorphism Single Nucleotide principal component analysis Receptors Ectodysplasin Ubiquitin-Protein Ligases
Upper Palaeolithic genomes reveal deep roots of modern Eurasians.
Eppie R Jones, Gloria Gonzalez-Fortes, Sarah Connell, Veronika Siska, Anders Eriksson, Rui Martiniano, Russell L McLaughlin, Marcos Gallego Llorente, Lara M Cassidy, Cristina Gamba, Tengiz Meshveliani, Ofer Bar-Yosef, Werner Müller, Anna Belfer-Cohen, Zinovi Matskevich, Nino Jakeli, Thomas FG Higham, Mathias Currat, David Lordkipanidze, Michael Hofreiter, Andrea Manica, Ron Pinhasi, Daniel G Bradley
Dec 04, 2015
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.
Maria Kalyuga, David Gallego-Ortega, Heather J Lee, Daniel L Roden, Mark J Cowley, C Elizabeth Caldon, Andrew Stone, Stephanie L Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L Statham, Nicola Armstrong, M Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L Piggin, Cara J Evans, Anita Ledger, Tilman Brummer, Samantha R Oakes, Warren Kaplan, Julia MW Gee, Robert I Nicholson, Robert L Sutherland, Alexander Swarbrick, Matthew J Naylor, Susan J Clark, Jason S Carroll, Christopher J Ormandy
Jan 15, 2021
We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage...
Animals Binding Sites Breast Neoplasms Cell Adhesion Cell Cycle Checkpoints Cell Line Tumor Cell Proliferation Chromatin Immunoprecipitation DNA Neoplasm DNA-Binding Proteins Drug Resistance Neoplasm Estrogens Female Gene Expression Regulation Neoplastic Genome Human Humans Mice Models Biological Phenotype Protein Binding Proto-Oncogene Proteins c-ets Sequence Analysis DNA Transcription Factors Transcription Genetic
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, María T Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
Apr 01, 2022
The copy number variation and stroke (CaNVAS) risk and outcome study.
John W Cole, Taiwo Adigun, Rufus Akinyemi, Onoja Matthew Akpa, Steven Bell, Bowang Chen, Jordi Jimenez Conde, Uxue Lazcano Dobao, Israel Fernandez, Myriam Fornage, Cristina Gallego-Fabrega, Christina Jern, Michael Krawczak, Arne Lindgren, Hugh S Markus, Olle Melander, Mayowa Owolabi, Kristina Schlicht, Martin Söderholm, Vinodh Srinivasasainagendra, Carolina Soriano Tárraga, Martin Stenman, Hemant Tiwari, Margaret Corasaniti, Natalie Fecteau, Beth Guizzardi, Haley Lopez, Kevin Nguyen, Brady Gaynor, Timothy O'Connor, O Colin Stine, Steven J Kittner, Patrick McArdle, Braxton D Mitchell, Huichun Xu, Caspar Grond-Ginsbach
Apr 14, 2021
Case-Control Studies DNA Copy Number Variations Databases Genetic Ethnicity Exome Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male MicroRNAs Outcome Assessment Health Care Phenotype Pilot Projects Polymorphism Single Nucleotide Proteomics Risk Factors stroke
SDSS-IV MaNGA IFS GALAXY SURVEY - SURVEY DESIGN, EXECUTION, and INITIAL DATA QUALITY
R Yan, K Bundy, DR Law, MA Bershady, B Andrews, B Cherinka, AM Diamond-Stanic, N Drory, N MacDonald, JR Sánchez-Gallego, D Thomas, DA Wake, AM Weijmans, KB Westfall, K Zhang, A Aragón-Salamanca, F Belfiore, D Bizyaev, GA Blanc, MR Blanton, J Brownstein, M Cappellari, R D'Souza, E Emsellem, H Fu, P Gaulme, MT Graham, D Goddard, JE Gunn, P Harding, A Jones, K Kinemuchi, C Li, H Li, R Maiolino, S Mao, C Maraston, K Masters, MR Merrifield, D Oravetz, K Pan, JK Parejko, SF Sanchez, D Schlegel, A Simmons, K Thanjavur, J Tinker, C Tremonti, R Van Den Bosch, Z Zheng
Sep 26, 2016
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, María T Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
May 02, 2022
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