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Mesoporous titanium dioxide films using partially fluorinated surfactant templates in ethanol
Mesoporous titanium dioxide films have been produced via a self assembly pathway at the air-ethanol interface using partially fluorinated surfactants as structure directing agents. The high level of surface activity displayed by...
'Power on'
The paper aims to contribute to the sociological analysis of power through the study of the structuration and retrieval of information on the internet. The main argument of the paper is that, paradoxically, in an age when the...
'Power on'
The paper aims to contribute to the sociological analysis of power through the study of the structuration and retrieval of information on the internet. The main argument of the paper is that, paradoxically, in an age when the...
Mesoporous titanium dioxide films using partially fluorinated surfactant templates in ethanol
Mesoporous titanium dioxide films have been produced via a self assembly pathway at the air-ethanol interface using partially fluorinated surfactants as structure directing agents. The high level of surface activity displayed by...
Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface.
During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus....
Tuneable 2D self-assembly of plasmonic nanoparticles at liquid|liquid interfaces
Leonora Velleman, Debabrata Sikdar, Vladimir A. Turek, Anthony R. Kucernak, Steve J. Roser, Alexei A. Kornyshev, Joshua B. Edel
Dec 14, 2016
Understanding the structure and assembly of nanoparticles at liquid|liquid interfaces is paramount to their integration into devices for sensing, catalysis, electronics and optics. However, many difficulties arise when...
Tuneable 2D self-assembly of plasmonic nanoparticles at liquid|liquid interfaces
Leonora Velleman, Debabrata Sikdar, Vladimir A. Turek, Anthony R. Kucernak, Steve J. Roser, Alexei A. Kornyshev, Joshua B. Edel
Dec 14, 2016
Understanding the structure and assembly of nanoparticles at liquid|liquid interfaces is paramount to their integration into devices for sensing, catalysis, electronics and optics. However, many difficulties arise when...
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines.
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-Fabregat, Ricardo Martins-Ferreira, Anna G Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodríguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Nov 29, 2022
BACKGROUND: COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid...
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Jhuma Pramanik, Jani Huuhtanen, Gozde Kar, Roser Vento-Tormo, Tzachi Hagai, Xi Chen, Muzlifah A Haniffa, Jacqueline D Shields, Sarah A Teichmann
May 01, 2020
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines.
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-Fabregat, Ricardo Martins-Ferreira, Anna G Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodríguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Jan 04, 2023
BACKGROUND: COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid...
Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers
Pierre Vande Perre, Daniel Toledano, Carole Corsini, Elsa Escriba, Marine Laporte, Helena Bertet, Kevin Yauy, Alain Toledano, Virginie Galibert, Karen Baudry, Lucie Clotet, Elodie Million, Marie-Christine Picot, David Geneviève, Pascal Pujol
Sep 26, 2019
BRCA1 BRCA2 general practitioners genetic screening Hereditary Breast and Ovarian Cancer Syndrome Adult Aged Aged 80 and over BRCA1 Protein BRCA2 Protein Breast Neoplasms Female general practitioners Genetic Carrier Screening Genetic Counseling Health Knowledge Attitudes practice Humans Middle Aged Referral and Consultation
The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance
Andrea Coppa, Sanjib Guha, Stéphane Fourcade, Janani Parameswaran, Montserrat Ruiz, Ann B Moser, Agatha Schlüter, Michael P Murphy, Jose Miguel Lizcano, Antonio Miranda-Vizuete, Esther Dalfó, Aurora Pujol
Feb 18, 2020
Adrenoleukodystrophy is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). Its pathogenesis is incompletely understood. Here we characterize a nematode model of...
Axonal degeneration Hypodermis Lipid Droplets Mitochondria redox imbalance Peroxisomes X-linked adrenoleukodystrophy ATP Binding Cassette Transporter Subfamily D Member 1 ATP-Binding Cassette Transporters Adrenoleukodystrophy Animals Caenorhabditis elegans Fatty Acids Mice Mice Knockout Subcutaneous Tissue
Inherent mosaicism and extensive mutation of human placentas.
Tim HH Coorens, Thomas RW Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D Young, Raheleh Rahbari, Neil Sebire, Peter J Campbell, D Stephen Charnock-Jones, Gordon CS Smith, Sam Behjati
Feb 24, 2021
Single-cell roadmap of human gonadal development.
Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen, Vladimir Yu Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chédotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Jul 20, 2022
Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. Historically, limited tissue accessibility, a lack of reliable in vitro models and...
Single-cell roadmap of human gonadal development.
Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen, Vladimir Yu Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chédotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Aug 06, 2022
Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. Historically, limited tissue accessibility, a lack of reliable in vitro models and...
Animals Cell Lineage Chromatin Female Germ Cells granulosa cells Humans Immunoglobulins MACROPHAGES Male Membrane Glycoproteins Membrane Proteins Mice Microscopy Fluorescence Ovary PAX8 Transcription Factor Pregnancy Pregnancy Trimester First Pregnancy Trimester Second Receptors Immunologic Sex Differentiation Single-Cell Analysis Testis Transcriptome
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim H H Coorens, Marta N Shahbazi, Antonia Weberling, Bailey A T Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jul 28, 2021
Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in...
Cells Cultured Germ Layers Humans Fibroblast Growth Factors Gene Expression Regulation Developmental Cell Lineage Embryonic Development Embryo Implantation Multigene Family Image Processing Computer-Assisted Embryo Mammalian Gastrulation Bone Morphogenetic Protein 1 Nodal Protein Single-Cell Analysis Wnt Signaling Pathway Spatio-Temporal Analysis RNA-seq
Published by: Nature Communications
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jun 17, 2021
Abstract: Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain...
World Society for Virology first international conference
Maria Söderlund-Venermo, Anupam Varma, Deyin Guo, Douglas P Gladue, Emma Poole, Flor H Pujol, Hanu Pappu, Jesús L Romalde, Laura Kramer, Mariana Baz, Marietjie Venter, Matthew D Moore, Michael M Nevels, Sayeh Ezzikouri, Vikram N Vakharia, William C Wilson, Yashpal S Malik, Zhengli Shi, Ahmed S Abdel-Moneim
Jan 28, 2022
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim HH Coorens, Marta N Shahbazi, Antonia Weberling, Bailey AT Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
May 13, 2021
Bone Morphogenetic Protein 1 Cell Lineage Cells Cultured Embryo Implantation Embryo Mammalian Embryonic Development Fibroblast Growth Factors Gastrulation Gene Expression Regulation Developmental Germ Layers Humans Image Processing Computer-Assisted Multigene Family Nodal Protein RNA-seq Single-Cell Analysis Spatio-Temporal Analysis Wnt Signaling Pathway
Early indicators of disease progression in Fabry disease that may indicate the need for disease-specific treatment initiation
Derralynn A Hughes, Patricio Aguiar, Patrick B Deegan, Fatih Ezgu, Andrea Frustaci, Olivier Lidove, Aleš Linhart, Jean-Claude Lubanda, James C Moon, Kathleen Nicholls, Dau-Ming Niu, Albina Nowak, Uma Ramaswami, Ricardo Reisin, Paula Rozenfeld, Raphael Schiffmann, Einar Svarstad, Mark Thomas, Roser Torra, Bojan Vujkovac, David G Warnock, Michael L West, Jack Johnson, Mark J Rolfe, Sandro Feriozzi
Oct 13, 2020
OBJECTIVES: The PRoposing Early Disease Indicators for Clinical Tracking in Fabry Disease (PREDICT-FD) initiative aimed to reach consensus among a panel of global experts on early indicators of disease progression that may...
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, María T Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
Apr 01, 2022
Spatial multiomics map of trophoblast development in early pregnancy.
Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick CK Wong, Megan A Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J Wright, Elena Prigmore, Sarah A Teichmann, Omer Ali Bayraktar, Ashley Moffett, Oliver Stegle, Margherita Y Turco, Roser Vento-Tormo
Apr 05, 2023
Role of DNA-detection-based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials.
Javier Gandasegui, María Martínez-Valladares, Berta Grau-Pujol, Alejandro J Krolewiecki, Rafael Balaña-Fouce, Woyneshet Gelaye, Lisette van Lieshout, Stella Kepha, Inácio Mandomando, José Muñoz, Stopping Transmission Of intestinal Parasites (STOP) project consortium
Feb 06, 2020
Spatial multiomics map of trophoblast development in early pregnancy.
Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick C K Wong, Megan A Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J Wright, Elena Prigmore, Sarah A Teichmann, Omer Ali Bayraktar, Ashley Moffett, Oliver Stegle, Margherita Y Turco, Roser Vento-Tormo
Apr 17, 2023
The relationship between the human placenta-the extraembryonic organ made by the fetus, and the decidua-the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast...
Myometrium Decidua Organoids Stem Cells Trophoblasts Placenta Humans Transcription Factors maternal-fetal relations Cell Communication Cell Differentiation Cell Movement Pregnancy Pregnancy Trimester First Female Single-Cell Analysis Transcriptome multiomics
Published by: Nature
Disease-related cortical thinning in presymptomatic granulin mutation carriers.
Sergi Borrego-Écija, Roser Sala-Llonch, John van Swieten, Barbara Borroni, Fermín Moreno, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, Robert Laforce, James B Rowe, Elizabeth Finger, Rik Vandenberghe, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Matthis Synofzik, Simon Ducharme, Johannes Levin, Adrian Danek, Alex Gerhard, Markus Otto, Chris Butler, Giovanni Frisoni, Sandro Sorbi, Carolin Heller, Martina Bocchetta, David M Cash, Rhian S Convery, Katrina M Moore, Jonathan D Rohrer, Raquel Sanchez-Valle, Genetic FTD Initiative GENFI
Jan 21, 2021
Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and...
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