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Results: 52
Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface.
During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus....
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Inherent mosaicism and extensive mutation of human placentas.
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines.
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-Fabregat, Ricardo Martins-Ferreira, Anna G Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodríguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Nov 29, 2022
BACKGROUND: COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid...
Single-cell roadmap of human gonadal development.
Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen, Vladimir Yu Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chédotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Jul 20, 2022
Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. Historically, limited tissue accessibility, a lack of reliable in vitro models and...
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines.
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-Fabregat, Ricardo Martins-Ferreira, Anna G Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodríguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Jan 04, 2023
BACKGROUND: COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid...
Single-cell reconstruction of the early maternal-fetal interface in humans.
Roser Vento-Tormo, Mirjana Efremova, Rachel A Botting, Margherita Y Turco, Miquel Vento-Tormo, Kerstin B Meyer, Jong-Eun Park, Emily Stephenson, Krzysztof Polański, Angela Goncalves, Lucy Gardner, Staffan Holmqvist, Johan Henriksson, Angela Zou, Andrew M Sharkey, Ben Millar, Barbara Innes, Laura Wood, Anna Wilbrey-Clark, Rebecca P Payne, Martin A Ivarsson, Steve Lisgo, Andrew Filby, David H Rowitch, Judith N Bulmer, Gavin J Wright, Michael JT Stubbington, Muzlifah Haniffa, Ashley Moffett, Sarah A Teichmann
Dec 10, 2018
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim H H Coorens, Marta N Shahbazi, Antonia Weberling, Bailey A T Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jul 28, 2021
Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in...
Cells Cultured Germ Layers Humans Fibroblast Growth Factors Gene Expression Regulation Developmental Cell Lineage Embryonic Development Embryo Implantation Multigene Family Image Processing Computer-Assisted Embryo Mammalian Gastrulation Bone Morphogenetic Protein 1 Nodal Protein Single-Cell Analysis Wnt Signaling Pathway Spatio-Temporal Analysis RNA-seq
Published by: Nature Communications
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jun 17, 2021
Abstract: Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain...
Single-cell roadmap of human gonadal development.
Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting, Tong Li, Berta Crespo, Stijn van Dongen, Vladimir Yu Kiselev, Elena Prigmore, Mary Herbert, Ashley Moffett, Alain Chédotal, Omer Ali Bayraktar, Azim Surani, Muzlifah Haniffa, Roser Vento-Tormo
Aug 06, 2022
Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. Historically, limited tissue accessibility, a lack of reliable in vitro models and...
Animals Cell Lineage Chromatin Female Germ Cells granulosa cells Humans Immunoglobulins MACROPHAGES Male Membrane Glycoproteins Membrane Proteins Mice Microscopy Fluorescence Ovary PAX8 Transcription Factor Pregnancy Pregnancy Trimester First Pregnancy Trimester Second Receptors Immunologic Sex Differentiation Single-Cell Analysis Testis Transcriptome
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim HH Coorens, Marta N Shahbazi, Antonia Weberling, Bailey AT Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
May 13, 2021
Bone Morphogenetic Protein 1 Cell Lineage Cells Cultured Embryo Implantation Embryo Mammalian Embryonic Development Fibroblast Growth Factors Gastrulation Gene Expression Regulation Developmental Germ Layers Humans Image Processing Computer-Assisted Multigene Family Nodal Protein RNA-seq Single-Cell Analysis Spatio-Temporal Analysis Wnt Signaling Pathway
Spatial multiomics map of trophoblast development in early pregnancy.
Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick CK Wong, Megan A Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J Wright, Elena Prigmore, Sarah A Teichmann, Omer Ali Bayraktar, Ashley Moffett, Oliver Stegle, Margherita Y Turco, Roser Vento-Tormo
Apr 05, 2023
Spatial multiomics map of trophoblast development in early pregnancy.
Anna Arutyunyan, Kenny Roberts, Kevin Troulé, Frederick C K Wong, Megan A Sheridan, Ilia Kats, Luz Garcia-Alonso, Britta Velten, Regina Hoo, Elias R Ruiz-Morales, Carmen Sancho-Serra, Jarrod Shilts, Louis-Francois Handfield, Luca Marconato, Elizabeth Tuck, Lucy Gardner, Cecilia Icoresi Mazzeo, Qian Li, Iva Kelava, Gavin J Wright, Elena Prigmore, Sarah A Teichmann, Omer Ali Bayraktar, Ashley Moffett, Oliver Stegle, Margherita Y Turco, Roser Vento-Tormo
Apr 17, 2023
The relationship between the human placenta-the extraembryonic organ made by the fetus, and the decidua-the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast...
Myometrium Decidua Organoids Stem Cells Trophoblasts Placenta Humans Transcription Factors maternal-fetal relations Cell Communication Cell Differentiation Cell Movement Pregnancy Pregnancy Trimester First Female Single-Cell Analysis Transcriptome multiomics
Published by: Nature
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, María T Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
Apr 01, 2022
Mesoporous titanium dioxide films using partially fluorinated surfactant templates in ethanol
Mesoporous titanium dioxide films have been produced via a self assembly pathway at the air-ethanol interface using partially fluorinated surfactants as structure directing agents. The high level of surface activity displayed by...
'Power on'
The paper aims to contribute to the sociological analysis of power through the study of the structuration and retrieval of information on the internet. The main argument of the paper is that, paradoxically, in an age when the...
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, María T Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
May 02, 2022
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park, Rachel A Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J Kunz, Issac Goh, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, Kenny Roberts, Veronika R Kedlian, John R Ferdinand, Xiaoling He, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa T Mahbubani, Krzysztof Polanski, Lira Mamanova, Liam Bolt, David Crossland, Fabrizio de Rita, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, Omer A Bayraktar, Roger A Barker, Kerstin B Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R Clatworthy, Tom Taghon, Muzlifah Haniffa, Sarah A Teichmann
Mar 19, 2020
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell...
A cellular census of human lungs identifies novel cell states in health and in asthma.
Felipe A Vieira Braga, Gozde Kar, Marijn Berg, Orestes A Carpaij, Krzysztof Polanski, Lukas M Simon, Sharon Brouwer, Tomás Gomes, Laura Hesse, Jian Jiang, Eirini S Fasouli, Mirjana Efremova, Roser Vento-Tormo, Carlos Talavera-López, Marnix R Jonker, Karen Affleck, Subarna Palit, Paulina M Strzelecka, Helen V Firth, Krishnaa T Mahbubani, Ana Cvejic, Kerstin B Meyer, Kourosh Saeb-Parsy, Marjan Luinge, Corry-Anke Brandsma, Wim Timens, Ilias Angelidis, Maximilian Strunz, Gerard H Koppelman, Antoon J van Oosterhout, Herbert B Schiller, Fabian J Theis, Maarten van den Berge, Martijn C Nawijn, Sarah A Teichmann
May 03, 2019
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
Matthew D Young, Thomas J Mitchell, Felipe A Vieira Braga, Maxine GB Tran, Benjamin J Stewart, John R Ferdinand, Grace Collord, Rachel A Botting, Dorin-Mirel Popescu, Kevin W Loudon, Roser Vento-Tormo, Emily Stephenson, Alex Cagan, Sarah J Farndon, Martin Del Castillo Velasco-Herrera, Charlotte Guzzo, Nathan Richoz, Lira Mamanova, Tevita Aho, James N Armitage, Antony CP Riddick, Imran Mushtaq, Stephen Farrell, Dyanne Rampling, James Nicholson, Andrew Filby, Johanna Burge, Steven Lisgo, Patrick H Maxwell, Susan Lindsay, Anne Y Warren, Grant D Stewart, Neil Sebire, Nicholas Coleman, Muzlifah Haniffa, Sarah A Teichmann, Menna Clatworthy, Sam Behjati
Nov 13, 2018
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal...
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro.
Luz Garcia-Alonso, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C Fernando, Lucy Gardner, Benjamin Woodhams, Anna Arutyunyan, Krzysztof Polanski, Regina Hoo, Carmen Sancho-Serra, Tong Li, Kwasi Kwakwa, Elizabeth Tuck, Valentina Lorenzi, Hassan Massalha, Martin Prete, Vitalii Kleshchevnikov, Aleksandra Tarkowska, Tarryn Porter, Cecilia Icoresi Mazzeo, Stijn van Dongen, Monika Dabrowska, Vasyl Vaskivskyi, Krishnaa T Mahbubani, Jong-Eun Park, Mercedes Jimenez-Linan, Lia Campos, Vladimir Yu Kiselev, Cecilia Lindskog, Paul Ayuk, Elena Prigmore, Michael R Stratton, Kourosh Saeb-Parsy, Ashley Moffett, Luiza Moore, Omer A Bayraktar, Sarah A Teichmann, Margherita Y Turco, Roser Vento-Tormo
Jan 28, 2022
The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human uterus and...
'Power on'
The paper aims to contribute to the sociological analysis of power through the study of the structuration and retrieval of information on the internet. The main argument of the paper is that, paradoxically, in an age when the...
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
Luz Garcia-Alonso, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C. Fernando, Lucy Gardner, Benjamin Woodhams, Anna Arutyunyan, Krzysztof Polanski, Regina Hoo, Carmen Sancho-Serra, Tong Li, Kwasi Kwakwa, Elizabeth Tuck, Valentina Lorenzi, Hassan Massalha, Martin Prete, Vitalii Kleshchevnikov, Aleksandra Tarkowska, Tarryn Porter, Cecilia Icoresi Mazzeo, Stijn van Dongen, Monika Dabrowska, Vasyl Vaskivskyi, Krishnaa T. Mahbubani, Jong-Eun Park, Mercedes Jimenez-Linan, Lia Campos, Vladimir Yu. Kiselev, Cecilia Lindskog, Paul Ayuk, Elena Prigmore, Michael R. Stratton, Kourosh Saeb-Parsy, Ashley Moffett, Luiza Moore, Omer A. Bayraktar, Sarah A. Teichmann, Margherita Y. Turco, Roser Vento-Tormo
Dec 24, 2021
Abstract: The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human...
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro.
Luz Garcia-Alonso, Louis-François Handfield, Kenny Roberts, Konstantina Nikolakopoulou, Ridma C Fernando, Lucy Gardner, Benjamin Woodhams, Anna Arutyunyan, Krzysztof Polanski, Regina Hoo, Carmen Sancho-Serra, Tong Li, Kwasi Kwakwa, Elizabeth Tuck, Valentina Lorenzi, Hassan Massalha, Martin Prete, Vitalii Kleshchevnikov, Aleksandra Tarkowska, Tarryn Porter, Cecilia Icoresi Mazzeo, Stijn van Dongen, Monika Dabrowska, Vasyl Vaskivskyi, Krishnaa Mahbubani, Jong-Eun Park, Mercedes Jimenez-Linan, Lia Campos, Vladimir Yu Kiselev, Cecilia Lindskog, Paul Ayuk, Elena Prigmore, Michael R Stratton, Kourosh Saeb-Parsy, Ashley Moffett, Luiza Moore, Omer A Bayraktar, Sarah Teichmann, Margherita Y Turco, Roser Vento-Tormo
Dec 24, 2021
The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human uterus and...
Mesoporous titanium dioxide films using partially fluorinated surfactant templates in ethanol
Mesoporous titanium dioxide films have been produced via a self assembly pathway at the air-ethanol interface using partially fluorinated surfactants as structure directing agents. The high level of surface activity displayed by...
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