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Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation.
Defects in chromosome-microtubule attachment can cause chromosomal instability (CIN), frequently associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular...
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation.
Defects in chromosome-microtubule attachment can cause chromosomal instability (CIN), frequently associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular...
Selection of oncogenic mutant clones in normal human skin varies with body site.
Joanna C Fowler, Charlotte King, Christopher Bryant, Michael Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Oct 23, 2020
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by...
Human keratinocytes have two interconvertible modes of proliferation.
Amit Roshan, Kasumi Murai, Joanna Fowler, Benjamin D Simons, Varvara Nikolaidou-Neokosmidou, Philip H Jones
Nov 23, 2015
microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells.
Reema Roshan, Ashwani Choudhary, Aksheev Bhambri, Bhawani Bakshi, Tanay Ghosh, Beena Pillai
Aug 04, 2017
BACKGROUND: Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the...
Development of a new method to assess fuel saving using gear shift indicators
European regulations set the emissions requirements for new vehicles at 130 g CO2/km, with an additional 10 g CO2/km to be achieved by additional complementary measures, including gear shift indicators. However, there is...
Analysis of different uniflow scavenging options for a medium-duty 2-stroke engine for a U.S. light-truck application
Jamie Turner, Robert Head, Roshan Wijetunge, Junseok Chang, Nayan Engineer, Dave Blundell, Paul Burke
Oct 31, 2020
The work presented here seeks to compare different means of providing uniflow scavenging for a 2-stroke engine suitable to power a US light-duty truck. Through the ‘end-to-end’ nature of the uniflow scavenging process, it can in...
Analysis of different uniflow scavenging options for a medium-duty 2-stroke engine for a U.S. light-truck application
Jamie Turner, Robert Head, Roshan Wijetunge, Junseok Chang, Nayan Engineer, Dave Blundell, Paul Burke
Oct 31, 2020
The work presented here seeks to compare different means of providing uniflow scavenging for a 2-stroke engine suitable to power a US light-duty truck. Through the ‘end-to-end’ nature of the uniflow scavenging process, it can in...
2-Stroke Engine Options for Automotive Use:
James Turner, Robert A. Head, Junseok Chang, Nayan Engineer, Roshan S. Wijetunge, David W. Blundell, Paul Burke
Jan 15, 2019
The work presented here seeks to compare different means of providing scavenging systems for an automotive 2-stroke engine. It follows on from previous work solely investigating uniflow scavenging systems, and aims to provide...
DigitalAir<sup>™</sup> Camless FVVA System - Part 2, Gasoline Engine Performance Opportunities
Stephen J. Charlton, Charles E. Price, Jeff Rogers, Jamie Turner, Roshan S. Wijetunge, William Anderson
Mar 28, 2017
The paper describes a completely new approach to fully variable valve actuation (FVVA), which allows almost unlimited continuously variable control of intake and exhaust valve opening and closing events, and duration without...
Evaluation of NeuroPage as a memory aid for people with multiple sclerosis
Memory problems are reported in 40%-60% of people with multiple sclerosis (MS). These problems affect independence and may limit the ability to benefit from rehabilitation. Our aim was to evaluate the effectiveness of NeuroPage...
Development of a new method to assess fuel saving using gear shift indicators
European regulations set the emissions requirements for new vehicles at 130 g CO2/km, with an additional 10 g CO2/km to be achieved by additional complementary measures, including gear shift indicators. However, there is...
DigitalAir<sup>™</sup> Camless FVVA System - Part 2, Gasoline Engine Performance Opportunities
Stephen J. Charlton, Charles E. Price, Jeff Rogers, Jamie Turner, Roshan S. Wijetunge, William Anderson
Mar 28, 2017
The paper describes a completely new approach to fully variable valve actuation (FVVA), which allows almost unlimited continuously variable control of intake and exhaust valve opening and closing events, and duration without...
2-Stroke Engine Options for Automotive Use:
James Turner, Robert A. Head, Junseok Chang, Nayan Engineer, Roshan S. Wijetunge, David W. Blundell, Paul Burke
Jan 15, 2019
The work presented here seeks to compare different means of providing scavenging systems for an automotive 2-stroke engine. It follows on from previous work solely investigating uniflow scavenging systems, and aims to provide...
The impact of terrestrial protected areas on vegetation extent and condition
Roshan Sharma, Johanna Eklund, Megan Barnes, Jonas Geldmann, Judith Schleicher, Robert L. Pressey, Marco Gutierrez, Simon Jones, Ascelin Gordon
Jun 06, 2020
Abstract: Background: Establishing protected areas is a key approach to protecting nature. However, protected areas are often biased towards remote and less productive lands. It is important to evaluate the impacts protected...
Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
Prerana Shrestha
Jan 01, 0001
Mammalian neocortex is the most complex structure in the brain. Considered the seat of executive function, the neocortex subserves diverse cognitive processes such as decision-making, motor planning, sensory discrimination and...
Published by: Rockefeller University
Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke.
Alicja Regina Rudnicka, Roshan Welikala, Sarah Barman, Paul J Foster, Robert Luben, Shabina Hayat, Kay-Tee Khaw, Peter Whincup, David Strachan, Christopher G Owen
Sep 30, 2022
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Nov 20, 2022
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and...
A new Himalayan crisis? Exploring transformative resilience pathways
This paper demonstrates that a new crisis has emerged in the Himalayas in recent years, as five decades of well-intentioned policy responses failed to tackle escalating environment and development challenges. It then suggests...
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 16, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
Reduction of response time in transmissive optically addressed spatial light modulator using solution-based ZnO NP/PEDOT
Abstract: An optically addressed spatial light modulator (OASLM) works by using the intensity of a ‘write’ light to modulate the phase of a ‘read’ light. OASLM using ZnO nanoparticles (NPs) as a photoconductor is important to...
High-Resolution Electrochemical Transistors Defined by Mold-Guided Drying of PEDOT
Ion-sensitive transistors with nanoscale or microscale dimensions are promising for high-resolution electrophysiological recording and sensing. Technology that can pattern polymer functional materials directly from a solution...
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