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Results: 78804
Characterization of Folding Cores in the Cyclophilin A-Cyclosporin A Complex
Jack W. Heal, Stephen A. Wells, Claudia A. Blindauer, Robert B. Freedman, Rudolf A. Roemer
Apr 07, 2015
Determining the folding core of a protein yields information about its folding process and dynamics. The experimental procedures for identifying the amino acids that make up the folding core include hydrogen-deuterium exchange...
Characterization of Folding Cores in the Cyclophilin A-Cyclosporin A Complex
Jack W. Heal, Stephen A. Wells, Claudia A. Blindauer, Robert B. Freedman, Rudolf A. Roemer
Apr 07, 2015
Determining the folding core of a protein yields information about its folding process and dynamics. The experimental procedures for identifying the amino acids that make up the folding core include hydrogen-deuterium exchange...
Bounds in Tree-Based Approaches to Generate Project Portfolios in the Presence of Interactions
Portfolio decision models have become an important branch of decision analysis. Portfolio problems are inherently complex, because of the combinatorial explosion in the number of portfolios that can be constructed even from a...
Published by: IGI Global Scientific Publishing
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Modelling charge transport in data DNA using transfer matrices with diagonal terms
There is increasing evidence that DNA can support a considerable degree of charge transport along the strand by hopping of holes from one base to another, and that this charge transport may be relevant to DNA regulation, damage...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Modelling charge transport in data DNA using transfer matrices with diagonal terms
There is increasing evidence that DNA can support a considerable degree of charge transport along the strand by hopping of holes from one base to another, and that this charge transport may be relevant to DNA regulation, damage...
Mental health outcomes after SARS-CoV-2 vaccination in the United States
BACKGROUND: Worsening of anxiety and depressive symptoms have been widely described during the COVID-19 pandemic. It can be hypothesized that vaccination could link to reduced symptoms of anxiety and/or depression. However, to...
The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms
Beatrice Drexler, Jakob R Passweg, Alexandar Tzankov, Martin Bigler, Alexandre Pa Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C Skoda, Swiss Group for Clinical Cancer Research (SAKK)
Dec 13, 2018
The β-3 sympathomimetic agonist BRL37344 restored nestin-positive cells within the stem cell niche, and thereby normalized blood counts and improved myelofibrosis in a mouse model of JAK2-V617F-positive myeloproliferative...
Causes of death in clozapine-treated patients in a catchment area
Emily Rose, Shanquan Chen, Concha Turrion, Christopher Jenkins, Rudolf N Cardinal, Emilio Fernandez-Egea
May 26, 2020
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder
Jonathan W. Kanen, Karen D. Ersche, Naomi A. Fineberg, Trevor W. Robbins, Rudolf N. Cardinal
Jul 19, 2020
Abstract: Rationale: Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of which have been captured using...
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
The Cambridge Cognitive and Psychiatric Assessment Kit (CamCOPS)
CamCOPS is a free, open-source client–server system for secure data capture in the domain of psychiatry, psychology, and the clinical neurosciences. The client is a cross-platform C++ application, suitable for mobile and offline...
Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder
Jonathan W Kanen, Karen D Ersche, Naomi A Fineberg, Trevor W Robbins, Rudolf N Cardinal
Jul 08, 2019
Addiction Amisulpride Compulsivity Computational modelling Dopamine Obsessive-Compulsive Disorder Pramipexole reinforcement learning Reversal Learning Stimulant use disorder Adult Central Nervous System Stimulants Cognition Dopamine Agonists Dopamine Antagonists Dopamine D2 Receptor Antagonists Double-Blind Method Female Humans Male Middle Aged Models Neurological Obsessive-Compulsive Disorder Receptors Dopamine D2 Receptors Dopamine D3 Reinforcement psychology Reversal Learning Reward Substance-Related Disorders Young Adult
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
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