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Bounds in Tree-Based Approaches to Generate Project Portfolios in the Presence of Interactions
Portfolio decision models have become an important branch of decision analysis. Portfolio problems are inherently complex, because of the combinatorial explosion in the number of portfolios that can be constructed even from a...
Published by: IGI Global Scientific Publishing
Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins
Rudolf Pisa
Jan 01, 0001
Chemotype-specific resistance is a major factor limiting the efficacy of molecularly targeted therapeutics. Analyses of resistance mechanisms to drugs reveal that mutations conferring resistance often arise in the drug's binding...
Published by: Rockefeller University
Mental health outcomes after SARS-CoV-2 vaccination in the United States
BACKGROUND: Worsening of anxiety and depressive symptoms have been widely described during the COVID-19 pandemic. It can be hypothesized that vaccination could link to reduced symptoms of anxiety and/or depression. However, to...
Accessibility and efficiency of mental health services, United Kingdom of Great Britain and Northern Ireland.
PROBLEM: Mental ill health in the United Kingdom of Great Britain and Northern Ireland has been a major driver of labour market exclusion through sickness absence, reduced productivity and job loss. APPROACH: A...
Accessibility and efficiency of mental health services, United Kingdom of Great Britain and Northern Ireland.
Problem
Mental ill health in the United Kingdom of Great Britain and Northern Ireland has been a major driver of labour market exclusion through sickness absence, reduced productivity and job loss.Approach
A...
Humans Mental Health Mental Disorders Mental Health Services Efficiency Organizational Health Services Accessibility Quality of Health Care Northern Ireland United Kingdom Outcome and Process Assessment Health Care
Published by: Bulletin of the World Health Organization
The Cambridge Cognitive and Psychiatric Assessment Kit (CamCOPS)
CamCOPS is a free, open-source client–server system for secure data capture in the domain of psychiatry, psychology, and the clinical neurosciences. The client is a cross-platform C++ application, suitable for mobile and offline...
Prevalence, progress, and subgroup disparities in pharmacological antidepressant treatment of those who screen positive for depressive symptoms
ADL activities of daily living AOR adjusted odds ratio ARC applied research collaboration antidepressants BNF British national formulary CI Confidence interval Depression disparity EMHAP European mental health action plan European gdp gross domestic product GHQ-12 12-item general health questionnaire GNI gross national income per capita GP general practitioner HSE health survey for England IAPT improving access to psychological therapies IMD Index of Multiple Deprivation NHS National Health Service NIHR National Institute for Health Research OR odds ratio SHARE survey of health ageing and retirement in Europe STROBE strengthening the reporting of observational studies in epidemiology UK United Kingdom USA United States of America WHO World Health Organization
Computational psychopharmacology
Abstract: Rationale: Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans...
Computational psychopharmacology
RATIONALE: Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including...
Substitution of the native <i>srfA</i> promoter by constitutive P<i>veg</i> in two <i>B. subtilis </i>strains and evaluation of the effect on surfactin production
Judit Willenbacher, Teresa Mohr, Marius Henkel, Susanne Gebhard, Thorsten Mascher, Christoph Syldatk, Rudolf Hausmann
Apr 01, 2016
The genetic enhancement of Surfactin production increasingly gained attention in the last years, since relatively low product yields limit the industrial application of this biosurfactant. The natural quorum sensing regulation...
Hippocampal lesions facilitate instrumental learning with delayed reinforcement but induce impulsive choice in rats.
BACKGROUND: Animals must frequently act to influence the world even when the reinforcing outcomes of their actions are delayed. Learning with action-outcome delays is a complex problem, and little is known of the neural...
Impaired learning from negative feedback in stimulant use disorder
Addiction Cocaine hierarchical Bayesian modeling Punishment reinforcement learning Reward Adult Amphetamine-Related Disorders Central Nervous System Stimulants Cocaine-Related Disorders Computer Simulation Corpus Striatum Cross-Over Studies Dopamine Dopamine Agonists Dopamine Antagonists Dopamine D2 Receptor Antagonists Double-Blind Method Feedback Humans Male Pramipexole Receptors Dopamine D2 Receptors Dopamine D3 Reinforcement psychology Reward
Early versus late risk factors for deficit and nondeficit schizophrenia.
Setareh Alabaf, Brian Kirkpatrick, Shanquan Chen, Rudolf N Cardinal, Emilio Fernandez-Egea
Apr 12, 2021
AIM: We examined whether timing of known risk factors for schizophrenia may influence the development of schizophrenia with primary negative symptoms. METHOD: This cross-sectional single-centre study in England used a clinical...
Modelling charge transport in data DNA using transfer matrices with diagonal terms
There is increasing evidence that DNA can support a considerable degree of charge transport along the strand by hopping of holes from one base to another, and that this charge transport may be relevant to DNA regulation, damage...
Birth weight, family history of diabetes and diabetes onset in schizophrenia.
Emilio Fernandez-Egea, Ryan Walker, Hisham Ziauddeen, Rudolf N Cardinal, Edward T Bullmore
Mar 14, 2020
INTRODUCTION:The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. OBJECTIVE:To test if abnormal birth...
Published by: BMJ open diabetes research & care
Substitution of the native <i>srfA</i> promoter by constitutive P<i>veg</i> in two <i>B. subtilis </i>strains and evaluation of the effect on surfactin production
Judit Willenbacher, Teresa Mohr, Marius Henkel, Susanne Gebhard, Thorsten Mascher, Christoph Syldatk, Rudolf Hausmann
Apr 01, 2016
The genetic enhancement of Surfactin production increasingly gained attention in the last years, since relatively low product yields limit the industrial application of this biosurfactant. The natural quorum sensing regulation...
Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness
Persisting symptoms and dysfunction after SARS-CoV-2 infection have frequently been observed. However, information on the aftermath of COVID-19 is inadequate. We followed up people with severe mental illness (SMI) infected with...
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