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The emergence of regenerative medicine in organ transplantation
Martin J Hoogduijn, Nuria Montserrat, Luc JW van der Laan, Francesco Dazzi, Norberto Perico, Jens Kastrup, Nicholas Gilbo, Rutger J Ploeg, Valerie Roobrouck, Federica Casiraghi, Christian L Johnson, Marcella Franquesa, Marc H Dahlke, Emma Massey, Sarah Hosgood, Marlies EJ Reinders
May 22, 2020
Regenerative medicine is emerging as a novel field in organ transplantation. In September 2019, the European Cell Therapy and Organ Regeneration Section (ECTORS) of the European Society for Organ Transplantation (ESOT) held its...
A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.
Wilbert Zwart, Rutger Koornstra, Jelle Wesseling, Emiel Rutgers, Sabine Linn, Jason S Carroll
May 02, 2019
BACKGROUND: The Estrogen Receptor alpha (ERα) is the key transcriptional regulator in luminal breast cancer and is therefore the main target for adjuvant treatment of this subtype. Luminal gene signatures are dictated by the...
In situ normothermic regional perfusion versus ex situ normothermic machine perfusion in liver transplantation from donation after circulatory death.
Kayvan Mohkam, David Nasralla, Hynek Mergental, Xavier Muller, Andrew Butler, Wayel Jassem, Charles Imber, Diethard Monbaliu, M Thamara PR Perera, Richard W Laing, Juan Carlos García-Valdecasas, Andreas Paul, Federica Dondero, François Cauchy, Eric Savier, Olivier Scatton, Fabien Robin, Laurent Sulpice, Petru Bucur, Ephrem Salamé, Gabriella Pittau, Marc-Antoine Allard, Pierre Pradat, Guillaume Rossignol, Jean-Yves Mabrut, Rutger J Ploeg, Peter J Friend, Darius F Mirza, Mickaël Lesurtel, Consortium for Organ Preservation in Europe (COPE)
Jun 29, 2022
In situ normothermic regional perfusion (NRP) and ex situ normothermic machine perfusion (NMP) aim to improve the outcomes of liver transplantation (LT) using controlled donation after circulatory death (cDCD). NRP and NMP have...
Incidence, Risk Factors, and Effect on Allograft Survival of Glomerulonephritis Post-transplantation in a United Kingdom Population
Background Post-transplant glomerulonephritis (PTGN) has been associated with inferior long-term allograft survival, and its incidence varies widely in the...
Rute Aguiar, Elli Bourmpaki, Catey Bunce, Bola Coker, Florence Delaney, Leonardo de Jongh, Giovani Oliveira, Alistair Weir, Finola Higgins, Anastasia Spiridou, Syed Hasan, Jonathan Smith, Abdulrahim Mulla, Ben Glampson, Luca Mercuri, Rosa Montero, Maria Hernandez-Fuentes, Candice A Roufosse, Naomi Simmonds, Menna Clatworthy, Adam McLean, Rutger Ploeg, Jim Davies, Kinga Anna Várnai, Kerrie Woods, Graham Lord, Rishi Pruthi, Cormac Breen, Paramit Chowdhury
Jul 28, 2022
Are Self-report Measures Able to Define Individuals as Physically Active or Inactive?
Jostein Steene-Johannessen, Sigmund A Anderssen, Hidde P van der Ploeg, Ingrid JM Hendriksen, Alan E Donnelly, Søren Brage, Ulf Ekelund
Aug 20, 2015
A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk.
Rutger Verbeek, Federico Oldoni, R Preethi Surendran, Ailko H Zwinderman, Kay T Khaw, Erik SG Stroes, Nick J Wareham, S Matthijs Boekholdt, Geesje M Dallinga-Thie
Jul 18, 2019
BACKGROUND: Evidence on the causal link between plasma triglyceride (TG) levels and risk for cardiovascular disease (CVD) has recently emerged. Individuals with the metabolic syndrome have an increased risk for acquiring...
A randomized trial of normothermic preservation in liver transplantation.
David Nasralla, Constantin C Coussios, Hynek Mergental, M Zeeshan Akhtar, Andrew J Butler, Carlo DL Ceresa, Virginia Chiocchia, Susan J Dutton, Juan Carlos García-Valdecasas, Nigel Heaton, Charles Imber, Wayel Jassem, Ina Jochmans, John Karani, Simon R Knight, Peri Kocabayoglu, Massimo Malagò, Darius Mirza, Peter J Morris, Arvind Pallan, Andreas Paul, Mihai Pavel, M Thamara PR Perera, Jacques Pirenne, Reena Ravikumar, Leslie Russell, Sara Upponi, Chris JE Watson, Annemarie Weissenbacher, Rutger J Ploeg, Peter J Friend, Consortium for Organ Preservation in Europe
Jun 12, 2018
Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate...
A systematic literature review of reviews on techniques for physical activity measurement in adults
Kieran P Dowd, Robert Szeklicki, Marco Alessandro Minetto, Marie H Murphy, Angela Polito, Ezio Ghigo, Hidde van der Ploeg, Ulf Ekelund, Janusz Maciaszek, Rafal Stemplewski, Maciej Tomczak, Alan E Donnelly
May 24, 2018
The links between increased participation in Physical Activity (PA) and improvements in health are well established. As this body of evidence has grown, so too has the search for measures of PA with high levels of methodological...
Cardiovascular disease risk associated with elevated lipoprotein(a) attenuates at low low-density lipoprotein cholesterol levels in a primary prevention setting.
Rutger Verbeek, Renate M Hoogeveen, Anne Langsted, Lotte CA Stiekema, Simone L Verweij, G Kees Hovingh, Nicholas J Wareham, Kay-Tee Khaw, S Matthijs Boekholdt, Børge G Nordestgaard, Erik SG Stroes
Apr 05, 2019
AIMS: Lipoprotein(a) (Lp(a)) elevation is a causal risk factor for cardiovascular disease (CVD). It has however been suggested that elevated Lp(a) causes CVD mainly in individuals with high low-density lipoprotein cholesterol...
New global guidelines on sedentary behaviour and health for adults
Paddy C Dempsey, Stuart JH Biddle, Matthew P Buman, Sebastien Chastin, Ulf Ekelund, Christine M Friedenreich, Peter T Katzmarzyk, Michael F Leitzmann, Emmanuel Stamatakis, Hidde P van der Ploeg, Juana Willumsen, Fiona Bull
Dec 11, 2020
Cancer Cardiovascular Chronic Disease Exercise Global Health Guidelines Health Promotion physical activity Public Health Sedentary Type 2 diabetes Adult Cardiovascular Diseases Diabetes mellitus Type 2 Exercise Guidelines as Topic Humans Neoplasms Policy Public Health Risk Factors Sedentary Behavior Systematic Reviews as Topic World Health Organization
Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk
Julian C van Capelleveen, Sang-Rok Lee, Rutger Verbeek, John JP Kastelein, Nicholas J Wareham, Erik SG Stroes, G Kees Hovingh, Kay-Tee Khaw, S Matthijs Boekholdt, Joseph L Witztum, Sotirios Tsimikas
Jul 01, 2019
BACKGROUND: Plasma apolipoprotein C-III (apoC-III) levels are associated with coronary artery disease (CAD) risk. OBJECTIVE: To assess whether lipoprotein-associated apoC-III levels predict risk of CAD events. METHODS: apoC-III...
New global guidelines on sedentary behaviour and health for adults
Paddy C. Dempsey, Stuart J. H. Biddle, Matthew P. Buman, Sebastien Chastin, Ulf Ekelund, Christine M. Friedenreich, Peter T. Katzmarzyk, Michael F. Leitzmann, Emmanuel Stamatakis, Hidde P. van der Ploeg, Juana Willumsen, Fiona Bull
Nov 26, 2020
The melanocortin pathway and energy homeostasis
Giles SH Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M Koerperich, Mark D Ericson, Stephanie E Simonds, Courtney M Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger AH Adan
May 24, 2021
BACKGROUND: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in...
Sedentary Time and Physical Activity Surveillance Through Accelerometer Pooling in Four European Countries.
A Loyen, AM Clarke-Cornwell, SA Anderssen, M Hagströmer, LB Sardinha, K Sundquist, U Ekelund, J Steene-Johannessen, F Baptista, BH Hansen, K Wijndaele, S Brage, J Lakerveld, J Brug, HP van der Ploeg
Jan 20, 2017
Carbon residence time dominates uncertainty in terrestrial vegetation responses to future climate and atmospheric CO2.
Andrew D Friend, Wolfgang Lucht, Tim T Rademacher, Rozenn Keribin, Richard Betts, Patricia Cadule, Philippe Ciais, Douglas B Clark, Rutger Dankers, Pete D Falloon, Akihiko Ito, Ron Kahana, Axel Kleidon, Mark R Lomas, Kazuya Nishina, Sebastian Ostberg, Ryan Pavlick, Philippe Peylin, Sibyll Schaphoff, Nicolas Vuichard, Lila Warszawski, Andy Wiltshire, F Ian Woodward
Jan 27, 2016
World Health Organization 2020 guidelines on physical activity and sedentary behaviour
Fiona C Bull, Salih S Al-Ansari, Stuart Biddle, Katja Borodulin, Matthew P Buman, Greet Cardon, Catherine Carty, Jean-Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C Dempsey, Loretta DiPietro, Ulf Ekelund, Joseph Firth, Christine M Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P Troiano, Hidde P van der Ploeg, Vicky Wari, Juana F Willumsen
Nov 16, 2020
Advancing the global physical activity agenda
Loretta DiPietro, Salih Saad Al-Ansari, Stuart JH Biddle, Katja Borodulin, Fiona C Bull, Matthew P Buman, Greet Cardon, Catherine Carty, Jean-Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C Dempsey, Ulf Ekelund, Joseph Firth, Christine M Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P Troiano, Hidde P van der Ploeg, Juana F Willumsen
Nov 26, 2020
Evaluation of a Melanocortin-4 Receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
IS Farooqi, TH Collet, B Dubern, J Mokrosinski, H Connors, JM Keogh, E Mendes de Oliveira, E Henning, C Poitou-Bernert, JM Oppert, P Tounian, F Marchelli, R Allili, J Le Bihan, D Pépin, JM Lacorte, A Gottesdiener, R Bounds, S Sharma, C Folster, B Henderson, S O'Rahilly, E Stoner, K Gottesdiener, BL Panaro, RD Cone, K Clement, LHT van der Ploeg
Jul 05, 2017
World Health Organization 2020 guidelines on physical activity and sedentary behaviour.
Fiona C Bull, Salih S Al-Ansari, Stuart Biddle, Katja Borodulin, Matthew P Buman, Greet Cardon, Catherine Carty, Jean-Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C Dempsey, Loretta DiPietro, Ulf Ekelund, Joseph Firth, Christine M Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P Troiano, Hidde P van der Ploeg, Vicky Wari, Juana F Willumsen
Dec 03, 2020
The 3rd DBCLS BioHackathon
Toshiaki Katayama, Mark D Wilkinson, Gos Micklem, Shuichi Kawashima, Atsuko Yamaguchi, Mitsuteru Nakao, Yasunori Yamamoto, Shinobu Okamoto, Kenta Oouchida, Hong-Woo Chun, Jan Aerts, Hammad Afzal, Erick Antezana, Kazuharu Arakawa, Bruno Aranda, Francois Belleau, Jerven Bolleman, Raoul Jp Bonnal, Brad Chapman, Peter Ja Cock, Tore Eriksson, Paul Mk Gordon, Naohisa Goto, Kazuhiro Hayashi, Heiko Horn, Ryosuke Ishiwata, Eli Kaminuma, Arek Kasprzyk, Hideya Kawaji, Nobuhiro Kido, Young Joo Kim, Akira R Kinjo, Fumikazu Konishi, Kyung-Hoon Kwon, Alberto Labarga, Anna-Lena Lamprecht, Yu Lin, Pierre Lindenbaum, Luke McCarthy, Hideyuki Morita, Katsuhiko Murakami, Koji Nagao, Kozo Nishida, Kunihiro Nishimura, Tatsuya Nishizawa, Soichi Ogishima, Keiichiro Ono, Kazuki Oshita, Keun-Joon Park, Pjotr Prins, Taro L Saito, Matthias Samwald, Venkata P Satagopam, Yasumasa Shigemoto, Richard Smith, Andrea Splendiani, Hideaki Sugawara, James Taylor, Rutger A Vos, David Withers, Chisato Yamasaki, Christian M Zmasek, Shoko Kawamoto, Kosaku Okubo, Kiyoshi Asai, Toshihisa Takagi
Mar 06, 2013
Variations in accelerometry measured physical activity and sedentary time across Europe - harmonized analyses of 47,497 children and adolescents.
Jostein Steene-Johannessen, Bjørge Herman Hansen, Knut Eirik Dalene, Elin Kolle, Kate Northstone, Niels Christian Møller, Anders Grøntved, Niels Wedderkopp, Susi Kriemler, Angie S Page, Jardena J Puder, John J Reilly, Luis B Sardinha, Esther M F van Sluijs, Lars Bo Andersen, Hidde van der Ploeg, Wolfgang Ahrens, Claudia Flexeder, Marie Standl, Holger Shculz, Luis A Moreno, Stefaan De Henauw, Nathalie Michels, Greet Cardon, Francisco B Ortega, Jonatan Ruiz, Susana Aznar, Mikael Fogelholm, Andrew Decelis, Line Grønholt Olesen, Mads Fiil Hjorth, Rute Santos, Susana Vale, Lars Breum Christiansen, Russ Jago, Laura Basterfield, Christopher G Owen, Claire M Nightingale, Gabriele Eiben, Angela Polito, Fabio Lauria, Jeremy Vanhelst, Charalambos Hadjigeorgiou, Kenn Konstabel, Dénes Molnár, Ole Sprengeler, Yannis Manios, Jaanus Harro, Anthony Kafatos, Sigmund Alfred Anderssen, Ulf Ekelund
Apr 19, 2020
BACKGROUND:Levels of physical activity and variation in physical activity and sedentary time by place and person in European children and adolescents are largely unknown. The objective of the study was to assess the variations...
Determinants of diet and physical activity (DEDIPAC)
Johannes Brug, Hidde P van der Ploeg, Anne Loyen, Wolfgang Ahrens, Oliver Allais, Lene F Andersen, Greet Cardon, Laura Capranica, Sebastien Chastin, Ilse De Bourdeaudhuij, Marieke De Craemer, Alan Donnelly, Ulf Ekelund, Paul Finglas, Marion Flechtner-Mors, Antje Hebestreit, Thomas Kubiak, Massimo Lanza, Nanna Lien, Ciaran MacDonncha, Mario Mazzocchi, Pablo Monsivais, Marie Murphy, Mary Nicolaou, Ute Nöthlings, Donal J O'Gorman, Britta Renner, Gun Roos, Matthijs van den Berg, Matthias B Schulze, Jürgen M Steinacker, Karien Stronks, Dorothee Volkert, Jeroen Lakerveld, DEDIPAC consortium
Feb 13, 2018
The establishment of the Determinants of Diet and Physical Activity (DEDIPAC) Knowledge Hub, 2013–2016, was the first action taken by the ‘Healthy Diet for a Healthy Life’ European Joint Programming Initiative. DEDIPAC aimed to...
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