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Results: 78802
Single-cell epigenomics
Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential...
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes.
Kathleen R Stewart, Lenka Veselovska, Jeesun Kim, Jiahao Huang, Heba Saadeh, Shin-Ichi Tomizawa, Sébastien A Smallwood, Taiping Chen, Gavin Kelsey
Jun 24, 2019
Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms underlying DNA methylation establishment remain poorly...
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.
Lenka Gahurova, Shin-Ichi Tomizawa, Sébastien A Smallwood, Kathleen R Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R Andrews, Taiping Chen, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as...
Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.
Steffen Rulands, Heather J Lee, Stephen J Clark, Christof Angermueller, Sébastien A Smallwood, Felix Krueger, Hisham Mohammed, Wendy Dean, Jennifer Nichols, Peter Rugg-Gunn, Gavin Kelsey, Oliver Stegle, Benjamin D Simons, Wolf Reik
Oct 18, 2018
DNA Methylation biophysical modeling dynamics Embryo epigenetic Pluripotency Stem Cells Animals Cell Differentiation Cellular Reprogramming CpG Islands DNA (Cytosine-5-)-Methyltransferases DNA Methylation Embryo Mammalian Epigenesis Genetic Epigenomics Gene Expression Regulation Developmental Genome Genomic Imprinting Germ Cells Male Mice Mice Inbred C57BL Mouse embryonic stem cells Pluripotent Stem Cells
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Markus Tschurtschenthaler, Priyadarshini Kachroo, Femke-Anouska Heinsen, Timon Erik Adolph, Malte Christoph Rühlemann, Johanna Klughammer, Felix Albert Offner, Ole Ammerpohl, Felix Krueger, Sébastien Smallwood, Silke Szymczak, Arthur Kaser, Andre Franke
Sep 13, 2016
Subcellular localisation modulates ubiquitylation and degradation of Ascl1.
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Life Turned Against Itself
Jean-Sébastien Hardy
Dec 20, 2016
Michel Henry is known to be the contemporary thinker who has given the most privileged status and the deepest philosophical significance to affectivity. His whole work—from his interpretation of Biran’s ontology of subjectivity...
Published by: Memorial University of Newfoundland
A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain
Casey Paquola, Jakob Seidlitz, Oualid Benkarim, Jessica Royer, Petr Klimes, Richard A. I. Bethlehem, Sara Larivière, Reinder Vos de Wael, Raul Rodríguez-Cruces, Jeffery A. Hall, Birgit Frauscher, Jonathan Smallwood, Boris C. Bernhardt
Dec 10, 2020
The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model...
A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain.
Casey Paquola, Jakob Seidlitz, Oualid Benkarim, Jessica Royer, Petr Klimes, Richard AI Bethlehem, Sara Larivière, Reinder Vos de Wael, Raul Rodríguez-Cruces, Jeffery A Hall, Birgit Frauscher, Jonathan Smallwood, Boris C Bernhardt
Jan 25, 2021
The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Negative visual representation of chronic obstructive pulmonary disease occurs online.
Internet images associated with breathlessness and COPD are mainly aimed at clinicians, more likely to be negative, and are gender and culturally exclusive compared with other cardiorespiratory conditions https://bit.ly/2DMfs0r.
Life Turned Against Itself
Jean-Sébastien Hardy
Dec 20, 2016
Michel Henry is known to be the contemporary thinker who has given the most privileged status and the deepest philosophical significance to affectivity. His whole work—from his interpretation of Biran’s ontology of subjectivity...
Published by: Memorial University of Newfoundland
Climatic and societal impacts of a "forgotten" cluster of volcanic eruptions in 1108-1110 CE.
Sébastien Guillet, Christophe Corona, Francis Ludlow, Clive Oppenheimer, Markus Stoffel
May 23, 2020
Recently revised ice core chronologies for Greenland have newly identified one of the largest sulfate deposition signals of the last millennium as occurring between 1108 and 1113 CE. Long considered the product of the 1104 CE...
Published by: Scientific reports
Climatic and societal impacts of a "forgotten" cluster of volcanic eruptions in 1108-1110 CE.
Sébastien Guillet, Christophe Corona, Francis Ludlow, Clive Oppenheimer, Markus Stoffel
Jun 22, 2020
Recently revised ice core chronologies for Greenland have newly identified one of the largest sulfate deposition signals of the last millennium as occurring between 1108 and 1113 CE. Long considered the product of the 1104 CE...
Expanding the light absorption of poly(3-hexylthiophene) by end-functionalization with π-extended porphyrins.
Michèle Chevrier, Sébastien Richeter, Olivier Coulembier, Mathieu Surin, Ahmad Mehdi, Roberto Lazzaroni, Rachel C Evans, Philippe Dubois, Sébastien Clément
Jul 03, 2018
Poly(3-hexylthiophene)s end-functionalized with π-extended porphyrins have been synthesized in a one-pot procedure. The polymers show a broad absorption profile extending to 700 nm and a fibrillar microstructure, which can be...
Attitudes to specialist palliative care and advance care planning in people with COPD
Natasha Smallwood, David Currow, Sara Booth, Anna Spathis, Louis Irving, Jennifer Philip
Dec 07, 2018
BACKGROUND: Chronic obstructive pulmonary disease (COPD) guidelines recommend early access to palliative care together with optimal, disease-directed therapy for people with advanced disease, however, this occurs infrequently....
advance care planning attitudes COPD health professionals Palliative Care Survey Adult advance care planning Attitude of Health Personnel Australia Disease Progression Female Humans Interdisciplinary Communication Male Needs Assessment New Zealand Palliative Medicine Pulmonary Disease Chronic Obstructive Pulmonary Medicine qualitative research Quality Improvement Terminal Care United Kingdom
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
A Historical Institutional Perspective on Public Policy and Employment Insurance in Rural Newfoundland
Adam Vickers
Dec 14, 2010
Why does Employment Insurance play such a dominant role in rural Newfoundland communities? This article gives readers a brief overview of the history of public policy making in rural Newfoundland and Labrador and how it has...
Published by: Memorial University of Newfoundland
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